{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:07:21Z","timestamp":1791500841148,"version":"4.3.4"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2009,11,12]],"date-time":"2009-11-12T00:00:00Z","timestamp":1257984000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0007818","type":"journal-article","created":{"date-parts":[[2009,11,11]],"date-time":"2009-11-11T19:59:50Z","timestamp":1257969590000},"page":"e7818","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":45,"title":["Genetic Association Analysis of the Functional c.714T>G Polymorphism and Mucosal Expression of Dectin-1 in Inflammatory Bowel Disease"],"prefix":"10.1371","volume":"4","author":[{"given":"Hilbert S.","family":"de Vries","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo S.","family":"Plantinga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Han","family":"van Krieken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinke","family":"Stienstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad A.","family":"van Bodegraven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora A. M.","family":"Festen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinse K.","family":"Weersma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Bart A.","family":"Crusius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald K.","family":"Linskens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo A. B.","family":"Joosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai G.","family":"Netea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk J.","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2009,11,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1053\/j.gastro.2007.11.059","article-title":"Microbial influences in inflammatory bowel diseases.","volume":"134","author":"RB Sartor","year":"2008","journal-title":"Gastroenterology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature06005","article-title":"Unravelling the pathogenesis of inflammatory bowel disease.","volume":"448","author":"RJ Xavier","year":"2007","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1136\/gut.29.7.990","article-title":"Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking.","volume":"29","author":"C Tysk","year":"1988","journal-title":"Gut"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1053\/j.gastro.2007.08.032","article-title":"The genetics of inflammatory bowel disease.","volume":"133","author":"JH Cho","year":"2007","journal-title":"Gastroenterology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"8869","DOI":"10.1074\/jbc.C200651200","article-title":"Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection.","volume":"278","author":"SE Girardin","year":"2003","journal-title":"J Biol Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1074\/jbc.C200673200","article-title":"Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease.","volume":"278","author":"N Inohara","year":"2003","journal-title":"J Biol Chem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nature04926","article-title":"Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity.","volume":"442","author":"O Gross","year":"2006","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/ni1426","article-title":"The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens.","volume":"8","author":"YM Hsu","year":"2007","journal-title":"Nat Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/ni1460","article-title":"Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17.","volume":"8","author":"S LeibundGut-Landmann","year":"2007","journal-title":"Nat Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.ajhg.2008.03.016","article-title":"Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.","volume":"82","author":"A Zhernakova","year":"2008","journal-title":"Am J Hum Genet"},{"key":"ref11","article-title":"A family with human dectin-1 deficiency and mucocutanous fungal infections.","author":"B Ferwerda","journal-title":"New England Journal of Medicine, In press"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1086\/604714","article-title":"Early stop polymorphism in human DECTIN-1 is associated with increased candida colonization in hematopoietic stem cell transplant recipients.","volume":"49","author":"TS Plantinga","year":"2009","journal-title":"Clin Infect Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/ibd.20339","article-title":"Role of the novel th17 cytokine IL-17F in inflammatory bowel disease (IBD): Upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.Hisl6lArg polymorphism in IBD.","volume":"14","author":"J Seiderer","year":"2008","journal-title":"Inflammatory Bowel Diseases"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.immuni.2007.08.013","article-title":"Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells.","volume":"27","author":"AJ van Beelen","year":"2007","journal-title":"Immunity"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1053\/j.gastro.2006.02.009","article-title":"Candida albicans is an immunogen for anti-Saccharomyces cerevisiae antibody markers of Crohn's disease.","volume":"130","author":"A Standaert-Vitse","year":"2006","journal-title":"Gastroenterology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1136\/gut.42.6.788","article-title":"Anti-Saccharomyces cerevisiae mannan antibodies combined with antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease: prevalence and diagnostic role.","volume":"42","author":"JF Quinton","year":"1998","journal-title":"Gut"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJMra020831","article-title":"Inflammatory bowel disease.","volume":"347","author":"DK Podolsky","year":"2002","journal-title":"New England Journal of Medicine"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00054725-200002000-00002","article-title":"A simple classification of Crohn's disease: Report of the Working Party for the world congresses of gastroenterology, Vienna 1998.","volume":"6","author":"C Gasche","year":"2000","journal-title":"Inflammatory Bowel Diseases"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1155\/2005\/269076","article-title":"Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology.","volume":"19","author":"MS Silverberg","year":"2005","journal-title":"Can J Gastroenterol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.dld.2006.06.042","article-title":"CARD15 in inflammatory bowel disease and Crohn's disease phenotypes: An association study and pooled analysis.","volume":"38","author":"LE Oostenbrug","year":"2006","journal-title":"Digestive and Liver Disease"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1111\/j.1462-5822.2008.01188.x","article-title":"Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages.","volume":"10","author":"G Ferwerda","year":"2008","journal-title":"Cellular Microbiology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.4049\/jimmunol.169.7.3876","article-title":"The beta-glucan receptor, dectin-1, is predominantly expressed on the, surface of cells of the monocyte\/macrophage and neutrophil lineages.","volume":"169","author":"PR Taylor","year":"2002","journal-title":"Journal of Immunology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1189\/jlb.0104031","article-title":"Expression of the beta-glucan receptor, dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions.","volume":"76","author":"DM Reid","year":"2004","journal-title":"Journal of Leukocyte Biology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.4049\/jimmunol.169.7.3876","article-title":"The beta-glucan receptor, dectin-1, is predominantly expressed on the, surface of cells of the monocyte\/macrophage and neutrophil lineages.","volume":"169","author":"PR Taylor","year":"2002","journal-title":"Journal of Immunology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"43818","DOI":"10.1074\/jbc.M107715200","article-title":"Characterization of the human beta -glucan receptor and its alternatively spliced isoforms.","volume":"276","author":"JA Willment","year":"2001","journal-title":"J Biol Chem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1002\/ibd.20402","article-title":"Current understanding of fungal microflora in inflammatory bowel disease pathogenesis.","volume":"14","author":"D Underhill","year":"2008","journal-title":"Inflammatory Bowel Diseases"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1097\/01.MIB.0000183423.38037.f3","article-title":"Genotype-phenotype analysis in childhood-onset Crohn's disease: NOD2\/CARDI 5 variants consistently predict phenotypic characteristics of severe disease.","volume":"11","author":"RK Russell","year":"2005","journal-title":"Inflammatory Bowel Diseases"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0007818","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T15:45:53Z","timestamp":1558626353000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0007818"}},"subtitle":[],"editor":[{"given":"Stefan","family":"Bereswill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,11,12]]},"references-count":27,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2009,11,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0007818","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,12]]}}}