{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T14:15:27Z","timestamp":1771078527421,"version":"3.50.1"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2009,11,16]],"date-time":"2009-11-16T00:00:00Z","timestamp":1258329600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0007854","type":"journal-article","created":{"date-parts":[[2009,11,13]],"date-time":"2009-11-13T23:08:49Z","timestamp":1258153729000},"page":"e7854","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["Blood-Feeding Induces Reversible Functional Changes in Flight Muscle Mitochondria of Aedes aegypti Mosquito"],"prefix":"10.1371","volume":"4","author":[{"given":"Renata L. S.","family":"Gon\u00e7alves","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina L.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela O.","family":"Paiva-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos H. F.","family":"Sorgine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisa M.","family":"Momoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Henrique M.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos A.","family":"Vannier-Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Galina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro L.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus F.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2009,11,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1042\/bj1340707","article-title":"The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen.","volume":"134","author":"A Boveris","year":"1973","journal-title":"Biochem J"},{"key":"ref2","first-page":"755","article-title":"Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species.","volume":"33","author":"PS Brookes","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0891-5849(03)00464-7","article-title":"Superoxide and hydrogen peroxide production by Drosophila mitochondria.","volume":"35","author":"S Miwa","year":"2003","journal-title":"Free Radic Biol Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.bbabio.2005.08.003","article-title":"The topology of superoxide production by complex III and glycerol 3-phosphate dehydrogenase in Drosophila mitochondria.","volume":"1709","author":"S Miwa","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0014-5793(97)01159-9","article-title":"High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria.","volume":"416","author":"SS Korshunov","year":"1997","journal-title":"FEBS Lett"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/cvr\/cvn104","article-title":"Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species.","volume":"79","author":"T Yu","year":"2008","journal-title":"Cardiovasc Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1073\/pnas.0511154103","article-title":"Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology.","volume":"103","author":"T Yu","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/35008121","article-title":"Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage.","volume":"404","author":"T Nishikawa","year":"2000","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.mad.2006.09.002","article-title":"Structure of cristae in cardiac mitochondria of aged rat.","volume":"127","author":"A Riva","year":"2006","journal-title":"Mech Ageing Dev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/nrm2275","article-title":"Functions and dysfunctions of mitochondrial dynamics.","volume":"8","author":"SA Detmer","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref11","first-page":"483","article-title":"Energetic and respiratory metabolism of molecular contraction.","author":"B Sacktor","year":"1965"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0040-8166(82)90043-X","article-title":"The supply of oxygen to the flight muscles of insects: a theory of tracheole physiology.","volume":"14","author":"VB Wigglesworth","year":"1982","journal-title":"Tissue Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nature03106","article-title":"Insects breathe discontinuously to avoid oxygen toxicity.","volume":"433","author":"SK Hetz","year":"2005","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1042\/BJ20042130","article-title":"Age-associated decline in mitochondrial respiration and electron transport in Drosophila melanogaster.","volume":"390","author":"M Ferguson","year":"2005","journal-title":"Biochem J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"11168","DOI":"10.1073\/pnas.94.21.11168","article-title":"Oxidative damage during aging targets mitochondrial aconitase.","volume":"94","author":"LJ Yan","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"12896","DOI":"10.1073\/pnas.95.22.12896","article-title":"Mitochondrial adenine nucleotide translocase is modified oxidatively during aging.","volume":"95","author":"LJ Yan","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1749-6632.2002.tb02094.x","article-title":"Role of mitochondria in oxidative stress and aging.","volume":"959","author":"G Lenaz","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1126\/science.273.5271.59","article-title":"Oxidative stress, caloric restriction, and aging.","volume":"273","author":"RS Sohal","year":"1996","journal-title":"Science"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e223","DOI":"10.1371\/journal.pbio.0030223","article-title":"Calories do not explain extension of life span by dietary restriction in Drosophila.","volume":"3","author":"W Mair","year":"2005","journal-title":"PLoS Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.cmet.2007.08.011","article-title":"Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress.","volume":"6","author":"TJ Schulz","year":"2007","journal-title":"Cell Metab"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/gerona\/61.1.36","article-title":"The effect of dietary restriction on mitochondrial protein density and flight muscle mitochondrial morphology in Drosophila.","volume":"61","author":"T Magwere","year":"2006","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1126\/science.289.5487.2126","article-title":"Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.","volume":"289","author":"SJ Lin","year":"2000","journal-title":"Science"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/0022-1910(75)90197-3","article-title":"Relationship between protein and proteolytic activity in the midgut of mosquitoes.","volume":"21","author":"H Briegel","year":"1975","journal-title":"J Insect Physiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.ibmb.2004.05.009","article-title":"Utilization of pre-existing energy stores of female Aedes aegypti mosquitoes during the first gonotrophic cycle.","volume":"34","author":"G Zhou","year":"2004","journal-title":"Insect Biochem Mol Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ibmb.2006.01.009","article-title":"Adaptations against heme toxicity in blood-feeding arthropods.","volume":"36","author":"AV Graca-Souza","year":"2006","journal-title":"Insect Biochem Mol Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent.","volume":"193","author":"OH Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0021-9258(19)57191-5","article-title":"Respiratory enzymes in oxidative phosphorylation. III. The steady state.","volume":"217","author":"B Chance","year":"1955","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0021-9258(19)57190-3","article-title":"Respiratory enzymes in oxidative phosphorylation. II. Difference spectra.","volume":"217","author":"B Chance","year":"1955","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR.","volume":"29","author":"MW Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1590\/S0074-02762005000600008","article-title":"Isolation of a fragment homologous to the rp49 constitutive gene of Drosophila in the Neotropical malaria vector Anopheles aquasalis (Diptera: Culicidae).","volume":"100","author":"C Gentile","year":"2005","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1042\/BJ20080973","article-title":"Metabolic pathways in Anopheles stephensi mitochondria.","volume":"415","author":"C Giulivi","year":"2008","journal-title":"Biochem J"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0022-1910(99)00052-9","article-title":"A molecular view of trypsin synthesis in the midgut of Aedes aegypti.","volume":"45","author":"FG Noriega","year":"1999","journal-title":"J Insect Physiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0022-1910(03)00072-6","article-title":"The role of hemolymph proline as a nitrogen sink during blood meal digestion by the mosquito Aedes aegypti.","volume":"49","author":"DA Goldstrohm","year":"2003","journal-title":"J Insect Physiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.ibmb.2004.05.009","article-title":"Utilization of pre-existing energy stores of female Aedes aegypti mosquitoes during the first gonotrophic cycle.","volume":"34","author":"G Zhou","year":"2004","journal-title":"Insect Biochem.Mol.Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S0965-1748(03)00124-3","article-title":"Blood meal induces global changes in midgut gene expression in the disease vector, Aedes aegypti.","volume":"33","author":"HR Sanders","year":"2003","journal-title":"Insect Biochem Mol Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0022-1910(03)00031-3","article-title":"Proline can be utilized as an energy substrate during flight of Aedes aegypti females.","volume":"49","author":"PY Scaraffia","year":"2003","journal-title":"J Insect Physiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0305-0491(75)90057-7","article-title":"Substrates of oxidative metabolism in dipteran flight muscle.","volume":"52","author":"E Bursell","year":"1975","journal-title":"Comp Biochem Physiol B"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1042\/bj0670487","article-title":"The oxidative activity of particulate fractions from mosquitoes.","volume":"67","author":"O Gonda","year":"1957","journal-title":"Biochem J"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1042\/bj0720008","article-title":"Studies on the adenosine triphosphate-phosphate exchange and the hydrolysis of adenosine triphosphate catalysed by a particulate fraction from the mosquito.","volume":"72","author":"Y Avi-Dor","year":"1959","journal-title":"Biochem J"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0965-1748(03)00080-8","article-title":"A catalogue of Anopheles gambiae transcripts significantly more or less expressed following a blood meal.","volume":"33","author":"JM Ribeiro","year":"2003","journal-title":"Insect Biochem Mol Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1365-2583.2005.00567.x","article-title":"Microarray analysis of genes showing variable expression following a blood meal in Anopheles gambiae.","volume":"14","author":"O Marinotti","year":"2005","journal-title":"Insect Mol Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ibmb.2006.01.011","article-title":"Reevaluation of the role of early trypsin activity in the transcriptional activation of the late trypsin gene in the mosquito Aedes aegypti.","volume":"36","author":"SJ Lu","year":"2006","journal-title":"Insect Biochem Mol Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0965-1748(01)00130-8","article-title":"Aedes aegypti peritrophic matrix and its interaction with heme during blood digestion.","volume":"32","author":"V Pascoa","year":"2002","journal-title":"Insect Biochem Mol Biol"},{"key":"ref44","article-title":"Development, Nutrition and Reproduction.","author":"AN Clements","year":"1992"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/0014-5793(94)00424-2","article-title":"Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases.","volume":"345","author":"MW Cleeter","year":"1994","journal-title":"FEBS Lett"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0014-5793(02)03026-0","article-title":"Vampires, Pasteur and reactive oxygen species. Is the switch from aerobic to anaerobic metabolism a preventive antioxidant defence in blood-feeding parasites?","volume":"525","author":"PL Oliveira","year":"2002","journal-title":"FEBS Lett"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"10893","DOI":"10.1074\/jbc.270.18.10893","article-title":"Antioxidant role of Rhodnius prolixus heme-binding protein. Protection against heme-induced lipid peroxidation.","volume":"270","author":"M Dansa-Petretski","year":"1995","journal-title":"J Biol Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1074\/jbc.274.8.4497","article-title":"The yeast frataxin homologue mediates mitochondrial iron efflux. Evidence for a mitochondrial iron cycle.","volume":"274","author":"DC Radisky","year":"1999","journal-title":"J Biol Chem"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"12239","DOI":"10.1073\/pnas.220403797","article-title":"Frataxin activates mitochondrial energy conversion and oxidative phosphorylation.","volume":"97","author":"M Ristow","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.jinsphys.2007.06.009","article-title":"Fate of blood meal iron in mosquitoes.","volume":"53","author":"G Zhou","year":"2007","journal-title":"J Insect Physiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S0965-1748(03)00124-3","article-title":"Blood meal induces global changes in midgut gene expression in the disease vector, Aedes aegypti.","volume":"33","author":"HR Sanders","year":"2003","journal-title":"Insect Biochem Mol Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1083\/jcb.41.2.477","article-title":"Riboflavin and mouse hepatic cell structure and function. II. Division of mitochondria during recovery from simple deficiency.","volume":"41","author":"B Tandler","year":"1969","journal-title":"J Cell Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0092-8674(00)80319-0","article-title":"Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase.","volume":"90","author":"KG Hales","year":"1997","journal-title":"Cell"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.cub.2006.03.062","article-title":"Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function.","volume":"16","author":"GA McQuibban","year":"2006","journal-title":"Curr Biol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/sj.emboj.7601963","article-title":"Fission and selective fusion govern mitochondrial segregation and elimination by autophagy.","volume":"27","author":"G Twig","year":"2008","journal-title":"EMBO J"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1038\/emboj.2009.89","article-title":"SLP-2 is required for stress-induced mitochondrial hyperfusion.","volume":"28","author":"D Tondera","year":"2009","journal-title":"EMBO J"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1371\/journal.pone.0004492","article-title":"Heterozygous mutation of Opa1 in Drosophila shortens lifespan mediated through increased reactive oxygen species production.","volume":"4","author":"S Tang","year":"2009","journal-title":"PLoS One"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1073\/pnas.0812484106","article-title":"Long-lived Indy induces reduced mitochondrial reactive oxygen species production and oxidative damage.","volume":"106","author":"N Neretti","year":"2009","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0007854","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T02:02:08Z","timestamp":1634176928000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0007854"}},"subtitle":[],"editor":[{"given":"Marcelo","family":"Hermes-Lima","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2009,11,16]]},"references-count":58,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2009,11,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0007854","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,16]]}}}