{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:08:33Z","timestamp":1791079713390,"version":"4.1.0"},"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2010,2,18]],"date-time":"2010-02-18T00:00:00Z","timestamp":1266451200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0009258","type":"journal-article","created":{"date-parts":[[2010,2,17]],"date-time":"2010-02-17T23:09:44Z","timestamp":1266448184000},"page":"e9258","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":150,"title":["Atopic Dermatitis-Like Disease and Associated Lethal Myeloproliferative Disorder Arise from Loss of Notch Signaling in the Murine Skin"],"prefix":"10.1371","volume":"5","author":[{"given":"Alexis","family":"Dumortier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9-Dante","family":"Durham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Di Piazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Vauclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gis\u00e8le","family":"Ferrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Ferrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadmehr","family":"Demehri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda Li","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Farr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren J.","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Kopan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Miele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Hohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Finke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy","family":"Radtke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,2,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nrg758","article-title":"Getting under the skin of epidermal morphogenesis.","volume":"3","author":"E Fuchs","year":"2002","journal-title":"Nat Rev Genet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.284.5415.770","article-title":"Notch signaling: cell fate control and signal integration in development.","volume":"284","author":"S Artavanis-Tsakonas","year":"1999","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1016\/j.febslet.2006.03.024","article-title":"Multiple functions of Notch signaling in self-renewing organs and cancer.","volume":"580","author":"A Wilson","year":"2006","journal-title":"FEBS Lett"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.cell.2007.03.011","article-title":"SnapShot: notch signaling pathway.","volume":"128","author":"MX Ilagan","year":"2007","journal-title":"Cell"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1093\/emboj\/20.13.3427","article-title":"Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation.","volume":"20","author":"A Rangarajan","year":"2001","journal-title":"Embo J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0960-9822(03)00081-2","article-title":"Notch\/RBP-J signaling regulates epidermis\/hair fate determination of hair follicular stem cells.","volume":"13","author":"N Yamamoto","year":"2003","journal-title":"Curr Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.devcel.2004.09.014","article-title":"gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis.","volume":"7","author":"Y Pan","year":"2004","journal-title":"Dev Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.devcel.2005.02.016","article-title":"Integration of Notch 1 and calcineurin\/NFAT signaling pathways in keratinocyte growth and differentiation control.","volume":"8","author":"C Mammucari","year":"2005","journal-title":"Dev Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1101\/gad.341405","article-title":"p21WAF1\/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation.","volume":"19","author":"V Devgan","year":"2005","journal-title":"Genes Dev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1101\/gad.1477606","article-title":"Canonical notch signaling functions as a commitment switch in the epidermal lineage.","volume":"20","author":"C Blanpain","year":"2006","journal-title":"Genes Dev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1242\/dev.02644","article-title":"Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis.","volume":"133","author":"S Estrach","year":"2006","journal-title":"Development"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.devcel.2008.01.017","article-title":"Multiple roles of Notch signaling in the regulation of epidermal development.","volume":"14","author":"M Moriyama","year":"2008","journal-title":"Dev Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1371\/journal.pbio.0060123","article-title":"Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity.","volume":"6","author":"S Demehri","year":"2008","journal-title":"PLoS Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ydbio.2005.05.018","article-title":"Notch1 is essential for postnatal hair follicle development and homeostasis.","volume":"284","author":"S Vauclair","year":"2005","journal-title":"Dev Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/ng1099","article-title":"Notch1 functions as a tumor suppressor in mouse skin.","volume":"33","author":"M Nicolas","year":"2003","journal-title":"Nat Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"7438","DOI":"10.1158\/0008-5472.CAN-06-0793","article-title":"Impaired notch signaling promotes de novo squamous cell carcinoma formation.","volume":"66","author":"A Proweller","year":"2006","journal-title":"Cancer Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1084\/jem.20061442","article-title":"Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation.","volume":"204","author":"V Besseyrias","year":"2007","journal-title":"J Exp Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/intimm\/dxf030","article-title":"Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision.","volume":"14","author":"H Han","year":"2002","journal-title":"Int Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.1093\/nar\/27.22.4324","article-title":"Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases.","volume":"27","author":"AK Indra","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nri1996","article-title":"Steady-state and inflammatory dendritic-cell development.","volume":"7","author":"K Shortman","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/nri2455","article-title":"Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells.","volume":"8","author":"M Merad","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/ni805","article-title":"Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.","volume":"3","author":"V Soumelis","year":"2002","journal-title":"Nat Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1084\/jem.20041503","article-title":"Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin.","volume":"202","author":"J Yoo","year":"2005","journal-title":"J Exp Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"14795","DOI":"10.1073\/pnas.0507385102","article-title":"Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin.","volume":"102","author":"M Li","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1101\/gad.1484707","article-title":"Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1\/2 and MRCKalpha kinases.","volume":"21","author":"K Lefort","year":"2007","journal-title":"Genes Dev"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1365-2133.2005.07077.x","article-title":"Atopic dermatitis and cancer risk.","volume":"154","author":"H Wang","year":"2006","journal-title":"Br J Dermatol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1023\/B:CACO.0000027506.55846.5d","article-title":"Prior medical conditions and medication use and risk of non-Hodgkin lymphoma in Connecticut United States women.","volume":"15","author":"Y Zhang","year":"2004","journal-title":"Cancer Causes Control"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1471-2458-4-51","article-title":"Allergic conditions and risk of hematological malignancies in adults: a cohort study.","volume":"4","author":"KC Soderberg","year":"2004","journal-title":"BMC Public Health"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/sj.jid.5700622","article-title":"Risk of lymphoma following exposure to calcineurin inhibitors and topical steroids in patients with atopic dermatitis.","volume":"127","author":"FM Arellano","year":"2007","journal-title":"J Invest Dermatol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1084\/jem.20031975","article-title":"A role for thymic stromal lymphopoietin in CD4(+) T cell development.","volume":"200","author":"A Al-Shami","year":"2004","journal-title":"J Exp Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4049\/jimmunol.162.2.677","article-title":"Thymic stromal lymphopoietin: a cytokine that promotes the development of IgM+ B cells in vitro and signals via a novel mechanism.","volume":"162","author":"SD Levin","year":"1999","journal-title":"J Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/eji.1830260103","article-title":"Characterization of thymic stromal-derived lymphopoietin (TSLP) in murine B cell development in vitro.","volume":"26","author":"RJ Ray","year":"1996","journal-title":"Eur J Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/ni1452","article-title":"Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development.","volume":"8","author":"A Astrakhan","year":"2007","journal-title":"Nat Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1002\/eji.200526318","article-title":"A B220+ CD117+ CD19- hematopoietic progenitor with potent lymphoid and myeloid developmental potential.","volume":"35","author":"G Balciunaite","year":"2005","journal-title":"Eur J Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1182\/blood-2002-05-1336","article-title":"Ikaros regulates neutrophil differentiation.","volume":"101","author":"A Dumortier","year":"2003","journal-title":"Blood"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1182\/blood-2004-01-0272","article-title":"G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow.","volume":"106","author":"CL Semerad","year":"2005","journal-title":"Blood"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/S0190-9622(03)02539-8","article-title":"Consensus conference on pediatric atopic dermatitis.","volume":"49","author":"LF Eichenfield","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"S128","DOI":"10.1016\/j.jaci.2003.09.032","article-title":"Immune mechanisms leading to atopic dermatitis.","volume":"112","author":"N Novak","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0165-2427(02)00066-1","article-title":"Immune dysregulation in atopic dermatitis.","volume":"87","author":"JD Sinke","year":"2002","journal-title":"Vet Immunol Immunopathol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nature05505","article-title":"Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis.","volume":"445","author":"Y Zheng","year":"2007","journal-title":"Nature"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/nm.1995","article-title":"Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis.","volume":"15","author":"R Caruso","year":"2009","journal-title":"Nat Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1067\/mai.2003.1414","article-title":"Polarized in vivo expression of IL-11 and IL-17 between acute and chronic skin lesions.","volume":"111","author":"M Toda","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1038\/jid.2008.111","article-title":"Possible pathogenic role of Th17 cells for atopic dermatitis.","volume":"128","author":"C Koga","year":"2008","journal-title":"J Invest Dermatol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"7420","DOI":"10.4049\/jimmunol.181.10.7420","article-title":"Low expression of the IL-23\/Th17 pathway in atopic dermatitis compared to psoriasis.","volume":"181","author":"E Guttman-Yassky","year":"2008","journal-title":"J Immunol"},{"key":"ref45","first-page":"1092","article-title":"Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways.","volume":"159","author":"KE Nograles","year":"2008","journal-title":"Br J Dermatol"},{"key":"ref46","first-page":"321","article-title":"A thymic stromal cell line supports in vitro development of surface IgM+ B cells and produces a novel growth factor affecting B and T lineage cells.","volume":"22","author":"SL Friend","year":"1994","journal-title":"Exp Hematol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1084\/jem.192.5.671","article-title":"Molecular cloning and biological characterization of a novel murine lymphoid growth factor.","volume":"192","author":"JE Sims","year":"2000","journal-title":"J Exp Med"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"6720","DOI":"10.4049\/jimmunol.178.11.6720","article-title":"Cutting edge: direct action of thymic stromal lymphopoietin on activated human CD4+ T cells.","volume":"178","author":"I Rochman","year":"2007","journal-title":"J Immunol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"7699","DOI":"10.4049\/jimmunol.181.11.7699","article-title":"The role of thymic stromal lymphopoietin in CD8+ T cell homeostasis.","volume":"181","author":"Y Rochman","year":"2008","journal-title":"J Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev.immunol.25.022106.141718","article-title":"TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation.","volume":"25","author":"YJ Liu","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/ni1247","article-title":"Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice.","volume":"6","author":"B Zhou","year":"2005","journal-title":"Nat Immunol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"8183","DOI":"10.4049\/jimmunol.174.12.8183","article-title":"Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity.","volume":"174","author":"S Ying","year":"2005","journal-title":"J Immunol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"336","DOI":"10.4049\/jimmunol.167.1.336","article-title":"Human thymic stromal lymphopoietin preferentially stimulates myeloid cells.","volume":"167","author":"PA Reche","year":"2001","journal-title":"J Immunol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1084\/jem.20062211","article-title":"Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells.","volume":"204","author":"Z Allakhverdi","year":"2007","journal-title":"J Exp Med"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/j.1432-0436.2004.07208006.x","article-title":"Activation of Notch1 in the hair follicle leads to cell-fate switch and Mohawk alopecia.","volume":"72","author":"H Uyttendaele","year":"2004","journal-title":"Differentiation"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/gene.20061","article-title":"Notch pathway is dispensable for adipocyte specification.","volume":"40","author":"AM Nichols","year":"2004","journal-title":"Genesis"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/nri1500","article-title":"The immunogenetics of asthma and eczema: a new focus on the epithelium.","volume":"4","author":"W Cookson","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.it.2007.04.007","article-title":"The epithelium takes centre stage in asthma and atopic dermatitis.","volume":"28","author":"ST Holgate","year":"2007","journal-title":"Trends Immunol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1084\/jem.20082242","article-title":"Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome.","volume":"206","author":"A Briot","year":"2009","journal-title":"J Exp Med"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"11736","DOI":"10.1073\/pnas.0604575103","article-title":"Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.","volume":"103","author":"M Li","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nm1084","article-title":"Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation.","volume":"10","author":"T Araki","year":"2004","journal-title":"Nat Med"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.cell.2004.10.010","article-title":"JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells.","volume":"119","author":"E Passegue","year":"2004","journal-title":"Cell"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.ccr.2004.10.015","article-title":"MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.","volume":"6","author":"BJ Huntly","year":"2004","journal-title":"Cancer Cell"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.cell.2007.05.014","article-title":"A Microenvironment-Induced Myeloproliferative Syndrome Caused by Retinoic Acid Receptor gamma Deficiency.","volume":"129","author":"CR Walkley","year":"2007","journal-title":"Cell"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.immuni.2005.02.009","article-title":"Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha.","volume":"22","author":"RA Rupec","year":"2005","journal-title":"Immunity"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/ni956","article-title":"Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development.","volume":"4","author":"CA Vosshenrich","year":"2003","journal-title":"Nat Immunol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1182\/blood-2003-05-1557","article-title":"Overexpression of murine TSLP impairs lymphopoiesis and myelopoiesis.","volume":"103","author":"MJ Osborn","year":"2004","journal-title":"Blood"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S1074-7613(00)80054-0","article-title":"Deficient T cell fate specification in mice with an induced inactivation of Notch1.","volume":"10","author":"F Radtke","year":"1999","journal-title":"Immunity"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1182\/blood.V84.6.1737.1737","article-title":"Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization.","volume":"84","author":"GJ Lieschke","year":"1994","journal-title":"Blood"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1084\/jem.180.5.1955","article-title":"Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.","volume":"180","author":"JJ Peschon","year":"1994","journal-title":"J Exp Med"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1182\/blood-2007-02-074245","article-title":"Increased TSLP availability restores T- and B-cell compartments in adult IL-7 deficient mice.","volume":"110","author":"S Chappaz","year":"2007","journal-title":"Blood"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0009258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T08:50:26Z","timestamp":1685436626000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0009258"}},"subtitle":[],"editor":[{"given":"Jacques","family":"Zimmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,2,18]]},"references-count":71,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,2,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0009258","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,18]]}}}