{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:07:57Z","timestamp":1791119277980,"version":"4.1.0"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2010,2,19]],"date-time":"2010-02-19T00:00:00Z","timestamp":1266537600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0009296","type":"journal-article","created":{"date-parts":[[2010,2,18]],"date-time":"2010-02-18T17:50:00Z","timestamp":1266515400000},"page":"e9296","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":100,"title":["Sugar Overconsumption during Adolescence Selectively Alters Motivation and Reward Function in Adult Rats"],"prefix":"10.1371","volume":"5","author":[{"given":"Leandro F.","family":"Vendruscolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliou B.","family":"Gueye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Darnaud\u00e9ry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge H.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Cador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,2,19]]},"reference":[{"key":"ref1","first-page":"56","article-title":"Time, sugar and sweetness.","volume":"2(4)","author":"SW Mintz","year":"1979","journal-title":"Marx Persp"},{"key":"ref2","article-title":"Liquid Candy: How Soft Drinks Are Harming Americans&apos; Health. 2<sup>nd<\/sup> ed.","author":"MF Jacobson","year":"2005"},{"key":"ref3","article-title":"Diet, Nutrition and the Prevention of Chronic Diseases. Joint WHO\/FAO Expert consultation. WHO Technical Report Series 916.","year":"2003"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1038\/oby.2003.179","article-title":"The sweetening of the world&apos;s diet.","volume":"11","author":"BM Popkin","year":"2003","journal-title":"Obes Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0002-8223(00)00018-3","article-title":"Food sources of added sweeteners in the diets of Americans.","volume":"100 (1)","author":"JF Guthrie","year":"2000","journal-title":"J Am Diet Assoc"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1054-139X(03)00248-9","article-title":"Children and adolescents&apos; choices of foods and beverages high in added sugars are associated with intakes of key nutrients and food groups.","volume":"34 (1)","author":"CD Frary","year":"2004","journal-title":"J Adolesc Health"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0149-7634(00)00014-2","article-title":"The adolescent brain and age-related behavioral manifestations.","volume":"24","author":"LP Spear","year":"2000","journal-title":"Neurosci Biobehav Rev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0149-7634(03)00005-8","article-title":"Trajectories of brain development: point of vulnerability or window of opportunity?","volume":"27","author":"SL Andersen","year":"2003","journal-title":"Neurosci Biobehav Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/nrn2513","article-title":"Why do many psychiatric disorders emerge during adolescence?","volume":"9 (12)","author":"T Paus","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/oby.2004.94","article-title":"Sugar-added beverages and adolescent weight change.","volume":"12 (5)","author":"CS Berkey","year":"2004","journal-title":"Obes Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S1499-4046(06)60390-4","article-title":"Are soft drinks getting a bum rap? We don&apos;t think so.","volume":"36 (5)","author":"AA White","year":"2004","journal-title":"J Nutr Educ Behav"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e3221","DOI":"10.1371\/journal.pone.0003221","article-title":"Sucrose exposure in early life alters adult motivation and weight gain.","volume":"3 (9)","author":"CR Frazier","year":"2008","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1126\/science.451607","article-title":"Sucrose consumption early in life fails to modify the appetite of adult rats for sweet foods.","volume":"205 (4403)","author":"JJ Wurtman","year":"1979","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.coph.2008.12.014","article-title":"Dissecting components of reward: \u2018liking\u2019, \u2018wanting\u2019, and learning.","volume":"9 (1)","author":"KC Berridge","year":"2009","journal-title":"Curr Opin Pharmacol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/alcalc\/agh037","article-title":"High ethanol preferring rats fail to show dependence following short- or long-term ethanol exposure.","volume":"39 (3)","author":"P Morm\u00e8de","year":"2004","journal-title":"Alcohol Alcohol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e698","DOI":"10.1371\/journal.pone.0000698","article-title":"Intense sweetness surpasses cocaine reward.","volume":"2 (1)","author":"M Lenoir","year":"2007","journal-title":"PLoS One"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nn1452","article-title":"How can drug addiction help us understand obesity?","volume":"8 (5)","author":"ND Volkow","year":"2005","journal-title":"Nat Neurosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1467-3010.2007.00604.x","article-title":"Is sweetness addictive?","volume":"32 (S1)","author":"A Drewnowski","year":"2007","journal-title":"Nutr Bull"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neubiorev.2007.04.019","article-title":"Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake.","volume":"32 (1)","author":"NM Avena","year":"2008","journal-title":"Neurosci Biobehav Rev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1037\/a0016504","article-title":"Trait impulsivity predicts escalation of sucrose seeking and hypersensitivity to sucrose-associated stimuli.","volume":"123 (4)","author":"L Diergaarde","year":"2009","journal-title":"Behav Neurosci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00213-007-0868-y","article-title":"Naloxone attenuates incubated sucrose craving in rats.","volume":"194 (4)","author":"JW Grimm","year":"2007","journal-title":"Psychopharmacology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3945\/jn.108.097584","article-title":"Sugar and fat bingeing have notable differences in addictive-like behavior.","volume":"139 (3)","author":"NM Avena","year":"2009","journal-title":"J Nutr"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.pbb.2009.04.008","article-title":"Escalation of food-maintained responding and sensitivity to the locomotor stimulant effects of cocaine in mice.","volume":"93 (1)","author":"JE Goeders","year":"2009","journal-title":"Pharmacol Biochem Behav"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"7163","DOI":"10.1523\/JNEUROSCI.5345-05.2006","article-title":"Food-induced behavioral sensitization, its cross-sensitization to cocaine and morphine, pharmacological blockade, and effect on food intake.","volume":"26 (27)","author":"J Le Merrer","year":"2006","journal-title":"J Neurosci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/oby.2002.66","article-title":"Evidence that intermittent, excessive sugar intake causes endogenous opioid dependence.","volume":"10 (6)","author":"C Colantuoni","year":"2002","journal-title":"Obes Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0892-0362(02)00349-5","article-title":"Animal models of periadolescent substance abuse.","volume":"25 (3)","author":"RF Smith","year":"2003","journal-title":"Neurotoxicol Teratol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/FBP.0b013e3282f3cfbe","article-title":"Chronic methylphenidate treatment during adolescence increases anxiety-related behaviors and ethanol drinking in adult spontaneously hypertensive rats.","volume":"19 (1)","author":"LF Vendruscolo","year":"2008","journal-title":"Behav Pharmacol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.phrs.2009.03.006","article-title":"Neurobiological alterations at adult age triggered by adolescent exposure to cannabinoids.","volume":"60 (2)","author":"N Realini","year":"2009","journal-title":"Pharmacol Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/npp.2008.220","article-title":"Nicotine exposure during adolescence induces a depression-like state in adulthood.","volume":"34 (6)","author":"SD I\u00f1iguez","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00213-006-0521-1","article-title":"Opioids for hedonic experience and dopamine to get ready for it.","volume":"191 (3)","author":"MF Barbano","year":"2007","journal-title":"Psychopharmacology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/npp.2009.110","article-title":"Neurocircuitry of Addiction.","volume":"35 (1)","author":"GF Koob","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/sj.ijo.0801229","article-title":"Liquid versus solid carbohydrate: effects on food intake and body weight.","volume":"24 (6)","author":"DP DiMeglio","year":"2000","journal-title":"Int J Obes Relat Metab Disord"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.cell.2009.10.001","article-title":"Common Sense about Taste: From Mammals to Insects.","volume":"139","author":"DA Yarmolinsky","year":"2009","journal-title":"Cell"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00213-005-2180-z","article-title":"Transition to drug addiction: a negative reinforcement model based on an allostatic decrease in reward function.","volume":"180 (3)","author":"SH Ahmed","year":"2005","journal-title":"Psychopharmacology"},{"key":"ref35","first-page":"R866","article-title":"T1R3 taste receptor is critical for sucrose but not Polycose taste.","volume":"296 (4)","author":"S Zukerman","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.neuron.2008.01.032","article-title":"Food reward in the absence of taste receptor signaling.","volume":"57 (6)","author":"IE de Araujo","year":"2008","journal-title":"Neuron"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1523\/JNEUROSCI.4037-08.2009","article-title":"Dramatically decreased cocaine self-administration in dopamine but not serotonin transporter knock-out mice.","volume":"29 (4)","author":"M Thomsen","year":"2009","journal-title":"J Neurosci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nn1429","article-title":"The subthalamic nucleus exerts opposite control on cocaine and \u2018natural\u2019 rewards.","volume":"8 (4)","author":"C Baunez","year":"2005","journal-title":"Nat Neurosci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0031-9384(02)00760-6","article-title":"Nucleus accumbens cell firing during goal-directed behaviors for cocaine vs. \u2018natural\u2019 reinforcement.","volume":"76","author":"RM Carelli","year":"2002","journal-title":"Physiol Behav"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"8251","DOI":"10.1523\/JNEUROSCI.22-18-08251.2002","article-title":"Selective reward deficit in mice lacking beta-endorphin and enkephalin.","volume":"22 (18)","author":"MD Hayward","year":"2002","journal-title":"J Neurosci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/oby.2002.66","article-title":"Evidence that intermittent, excessive sugar intake causes endogenous opioid dependence.","volume":"10 (6)","author":"C Colantuoni","year":"2002","journal-title":"Obes Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.molbrainres.2004.02.013","article-title":"Opiate-like effects of sugar on gene expression in reward areas of the rat brain.","volume":"124 (2)","author":"R Spangler","year":"2004","journal-title":"Brain Res Mol Brain Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1053\/comp.2002.32356","article-title":"Sensitivity to the rewarding effects of food and exercise in the eating disorders.","volume":"43 (3)","author":"C Davis","year":"2002","journal-title":"Compr Psychiatry"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1038\/oby.2009.52","article-title":"Dopamine for \u201cwanting\u201d and opioids for \u201cliking\u201d: a comparison of obese adults with and without binge eating.","volume":"17 (6)","author":"CA Davis","year":"2009","journal-title":"Obesity"},{"key":"ref45","article-title":"Diagnostic and statistical manual of mental disorders. 4<sup>th<\/sup> ed.","year":"1994"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/3218","article-title":"The global burden of disease, 1990-2020.","volume":"4 (11)","author":"AD Lopez","year":"1998","journal-title":"Nat Med"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1192\/bjp.bp.108.061820","article-title":"Confectionery consumption in childhood and adult violence.","volume":"195 (4)","author":"SC Moore","year":"2009","journal-title":"Br J Psychiatry"},{"key":"ref48","article-title":"The invisible plague: the rise of mental illness from 1750 to the present.","author":"EF Torrey","year":"2001"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1126\/science.2820058","article-title":"Cocaine receptors on dopamine transporters are related to self-administration of cocaine.","volume":"237","author":"MC Ritz","year":"1987","journal-title":"Science"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s002130050702","article-title":"Progressive-ratio schedules of drug delivery in the analysis of drug self-administration: a review.","volume":"139 (3)","author":"D Stafford","year":"1998","journal-title":"Psychopharmacology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0009296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T04:12:30Z","timestamp":1634962350000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0009296"}},"subtitle":[],"editor":[{"given":"Georges","family":"Chapouthier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,2,19]]},"references-count":50,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,2,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0009296","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,19]]}}}