{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:35:27Z","timestamp":1792672527463,"version":"4.5.0"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2010,5,17]],"date-time":"2010-05-17T00:00:00Z","timestamp":1274054400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0010666","type":"journal-article","created":{"date-parts":[[2010,5,17]],"date-time":"2010-05-17T16:46:17Z","timestamp":1274114777000},"page":"e10666","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Potent Cardioprotective Effect of the 4-Anilinoquinazoline Derivative PD153035: Involvement of Mitochondrial KATP Channel Activation"],"prefix":"10.1371","volume":"5","author":[{"given":"Renata A.","family":"Cavalheiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo M.","family":"Marin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana A.","family":"Rocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda M.","family":"Cerqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille C.","family":"Caldeira da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Rittner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia J.","family":"Kowaltowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anibal E.","family":"Vercesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kleber G.","family":"Franchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger F.","family":"Castilho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,5,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.abb.2003.08.037","article-title":"Antioxidants in myocardial ischemia-reperfusion injury: therapeutic potential and basic mechanisms.","volume":"420","author":"N Marczin","year":"2003","journal-title":"Arch Biochem Biophys"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.bbadis.2005.06.003","article-title":"Tissue protection mediated by mitochondrial K<sup>+<\/sup> channels.","volume":"1762","author":"HT Facundo","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.bbabio.2007.05.008","article-title":"The role of mitochondria in protection of the heart by preconditioning.","volume":"1767","author":"AP Halestrap","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00395-009-0004-8","article-title":"The mitochondrial permeability transition pore and ischemia-reperfusion injury.","volume":"104","author":"CP Baines","year":"2009","journal-title":"Basic Res Cardiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1042\/bj3410233","article-title":"The mitochondrial permeability transition pore and its role in cell death.","volume":"341","author":"M Crompton","year":"1999","journal-title":"Biochem J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0014-5793(01)02316-X","article-title":"Mitochondrial permeability transition and oxidative stress.","volume":"495","author":"AJ Kowaltowski","year":"2001","journal-title":"FEBS Lett"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1093\/cvr\/27.10.1790","article-title":"On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury.","volume":"27","author":"MR Duchen","year":"1993","journal-title":"Cardiovasc Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10863-005-4130-1","article-title":"Mitochondrial ATP-sensitive K<sup>+<\/sup> channels prevent oxidative stress, permeability transition and cell death.","volume":"37","author":"HT Facundo","year":"2005","journal-title":"J Bioenerg Biomembr"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1056\/NEJMoa071142","article-title":"Effect of cyclosporine on reperfusion injury in acute myocardial infarction.","volume":"359","author":"C Piot","year":"2008","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","article-title":"Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.","volume":"74","author":"CE Murry","year":"1986","journal-title":"Circulation"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"18092","DOI":"10.1074\/jbc.273.29.18092","article-title":"Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes.","volume":"273","author":"TL Vanden Hoek","year":"1998","journal-title":"J Biol Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0005-2728(03)00109-9","article-title":"Mitochondrial potassium transport: the role of the mitochondrial ATP-sensitive K<sup>+<\/sup> channel in cardiac function and cardioprotection.","volume":"1606","author":"KD Garlid","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"H921","DOI":"10.1152\/ajpheart.00421.2003","article-title":"K<sub>ATP<\/sub> channels and myocardial preconditioning: an update.","volume":"285","author":"GJ Gross","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.freeradbiomed.2005.08.041","article-title":"Ischemic preconditioning requires increases in reactive oxygen release independent of mitochondrial K<sup>+<\/sup> channel activity.","volume":"40","author":"HT Facundo","year":"2006","journal-title":"Free Radic Biol Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1093\/cvr\/26.11.1054","article-title":"Blockade of ischaemic preconditioning in dogs by the novel ATP dependent potassium channel antagonist sodium 5-hydroxydecanoate.","volume":"26","author":"JA Auchampach","year":"1992","journal-title":"Cardiovasc Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"13578","DOI":"10.1016\/S0021-9258(19)57796-1","article-title":"State-dependent inhibition of the mitochondrial K<sub>ATP<\/sub> channel by glyburide and 5-hydroxydecanoate.","volume":"273","author":"M Jab\u016frek","year":"1998","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0008-6363(01)00358-3","article-title":"Adenosine, adenosine receptors and myocardial protection: an updated overview.","volume":"52","author":"K Mubagwa","year":"2001","journal-title":"Cardiovasc Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev.physiol.62.1.79","article-title":"Ischemic preconditioning: from adenosine receptor to K<sub>ATP<\/sub> channel.","volume":"62","author":"MV Cohen","year":"2000","journal-title":"Annu Rev Physiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00395-009-0001-y","article-title":"The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial K<sub>ATP<\/sub> channels.","volume":"104","author":"AP Wojtovich","year":"2009","journal-title":"Basic Res Cardiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1161\/01.RES.0000178451.08719.5b","article-title":"Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria.","volume":"97","author":"AD Costa","year":"2005","journal-title":"Circ Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.cardiores.2006.01.017","article-title":"Survival kinases in ischemic preconditioning and postconditioning.","volume":"70","author":"DJ Hausenloy","year":"2006","journal-title":"Cardiovasc Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nm0502-459","article-title":"ErbB2 is essential in the prevention of dilated cardiomyopathy.","volume":"8","author":"SA Crone","year":"2002","journal-title":"Nat Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0898-6568(98)00036-9","article-title":"Signalling pathways for cardiac hypertrophy.","volume":"10","author":"T Yamazaki","year":"1998","journal-title":"Cell Signal"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1096\/fasebj.12.9.665","article-title":"Activation of EGF receptor by oxidized LDL.","volume":"12","author":"I Suc","year":"1998","journal-title":"FASEB J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1161\/01.CIR.0000030181.63741.56","article-title":"Angiotensin II-induced cardiac hypertrophy and hypertension are attenuated by epidermal growth factor receptor antisense.","volume":"106","author":"S Kagiyama","year":"2002","journal-title":"Circulation"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"H99","DOI":"10.1152\/ajpheart.00901.2004","article-title":"EGF receptor-dependent JNK activation is involved in arsenite-induced p21Cip1\/Waf1 upregulation and endothelial apoptosis.","volume":"289","author":"N Nuntharatanapong","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"C82","DOI":"10.1152\/ajpcell.00287.2006","article-title":"Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system.","volume":"292","author":"PK Mehta","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1126\/science.8066447","article-title":"A specific inhibitor of the epidermal growth factor receptor tyrosine kinase.","volume":"265","author":"DW Fry","year":"1994","journal-title":"Science"},{"key":"ref29","first-page":"429","article-title":"Syntheses of some 4-anilinoquinazoline derivatives.","volume":"3","author":"SA Rocco","year":"2004","journal-title":"Synthesis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"H556","DOI":"10.1152\/ajpheart.00534.2001","article-title":"Load-induced focal adhesion kinase activation in the myocardium: role of stretch and contractile activity.","volume":"282","author":"PP Domingos","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1073\/pnas.95.6.2979","article-title":"HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte.","volume":"95","author":"WC Claycomb","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0022-4804(03)00248-8","article-title":"HL-1 myocytes exhibit PKC and K<sub>ATP<\/sub> channel-dependent delta opioid preconditioning.","volume":"114","author":"EM Seymour","year":"2003","journal-title":"J Surg Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF01953772","article-title":"Fluorometric estimation of dead cells in cell suspensions.","volume":"36","author":"U Karsten","year":"1980","journal-title":"Experientia"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"H649","DOI":"10.1152\/ajpheart.2001.280.2.H649","article-title":"Bioenergetic consequences of opening the ATP-sensitive K<sup>+<\/sup> channel of heart mitochondria.","volume":"280","author":"AJ Kowaltowski","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.freeradbiomed.2007.01.001","article-title":"Mitochondrial ATP-sensitive K<sup>+<\/sup> channels are redox-sensitive pathways that control reactive oxygen species production.","volume":"42","author":"HT Facundo","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0076-6879(79)56030-3","article-title":"Measurements of cation transport with metallochromic indicators.","volume":"56","author":"A Scarpa","year":"1979","journal-title":"Methods Enzymol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1161\/01.RES.81.6.1072","article-title":"Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K<sup>+<\/sup> channels. Possible mechanism of cardioprotection.","volume":"81","author":"KD Garlid","year":"1997","journal-title":"Circ Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"10607","DOI":"10.1073\/pnas.0701286104","article-title":"Activation of AMP-activated protein kinase by human EGF receptor 2\/EGF receptor tyrosine kinase inhibitor protects cardiac cells.","volume":"104","author":"NL Spector","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0005-2728(03)00108-7","article-title":"Mitochondrial potassium transport: the K<sup>+<\/sup> cycle.","volume":"1606","author":"KD Garlid","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"32562","DOI":"10.1074\/jbc.M401115200","article-title":"Functional distinctions between the mitochondrial ATP-dependent K<sup>+<\/sup> channel (mitoK<sub>ATP<\/sub>) and its inward rectifier subunit (mitoKIR).","volume":"279","author":"GD Mironova","year":"2004","journal-title":"J Biol Chem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.bbabio.2006.05.002","article-title":"Mitochondrial potassium channels: from pharmacology to function.","volume":"1757","author":"A Szewczyk","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1023\/A:1020256502583","article-title":"Opening of mitochondrial K<sup>+<\/sup> channels increases ischemic ATP levels by preventing hydrolysis.","volume":"34","author":"E Belisle","year":"2002","journal-title":"J Bioenerg Biomembr"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"H284","DOI":"10.1152\/ajpheart.00034.2002","article-title":"Mechanisms by which opening the mitochondrial ATP- sensitive K<sup>+<\/sup> channel protects the ischemic heart.","volume":"283","author":"P Dos Santos","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1161\/hh2201.100205","article-title":"Mitochondrial ATP-sensitive potassium channels attenuate matrix Ca<sup>2+<\/sup> overload during simulated ischemia and reperfusion: possible mechanism of cardioprotection.","volume":"89","author":"M Murata","year":"2001","journal-title":"Circ Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1161\/hh2201.100341","article-title":"Opening of mitochondrial K<sub>ATP<\/sub> channels attenuates the ouabain-induced calcium overload in mitochondria.","volume":"89","author":"H Ishida","year":"2001","journal-title":"Circ Res"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1124\/pr.55.1.7","article-title":"Pharmacological agents that directly modulate insulin secretion.","volume":"55","author":"ME Doyle","year":"2003","journal-title":"Pharmacol Rev"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.2337\/db08-0506","article-title":"An EGFR Tyrosine-Kinase Inhibitor (PD153035) Improves Glucose Tolerance and Insulin Action in High-Fat Diet-Fed Mice.","volume":"58","author":"PO Prada","year":"2009","journal-title":"Diabetes"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0163-7258(98)00050-3","article-title":"Inhibition of the epidermal growth factor receptor family of tyrosine kinases as an approach to cancer chemotherapy: progression from reversible to irreversible inhibitors.","volume":"82","author":"DW Fry","year":"1999","journal-title":"Pharmacol Ther"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2165\/00003495-200060001-00003","article-title":"Epidermal growth factor receptor tyrosine kinase inhibitors as anticancer agents.","volume":"60","author":"F Ciardiello","year":"2000","journal-title":"Drugs"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2174\/1385272003376094","article-title":"Synthesis of 4-(phenylamino)pyrimidine derivatives as ATP-competitive protein kinase inhibitors with potential for cancer chemotherapy.","volume":"4","author":"GW Rewcastle","year":"2000","journal-title":"Curr Org Chem"},{"key":"ref51","first-page":"1579","article-title":"Clinical trial design and end points for epidermal growth factor receptor-targeted therapies: implications for drug development and practice.","volume":"9","author":"CL Arteaga","year":"2003","journal-title":"Clin Cancer Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2967\/jnumed.108.056556","article-title":"PET-based biodistribution and radiation dosimetry of epidermal growth factor receptor-selective tracer 11C-PD153035 in humans.","volume":"50","author":"N Liu","year":"2009","journal-title":"J Nucl Med"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/S0960-894X(98)00217-0","article-title":"Search for alpha(1)-adrenoceptor subtypes selective antagonists: Design, synthesis and biological activity of cystazosin, an alpha(1D)-adrenoceptor antagonist.","volume":"8","author":"A Minarini","year":"1998","journal-title":"Bioorg Med Chem Lett"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0010666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T18:47:58Z","timestamp":1635360478000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0010666"}},"subtitle":[],"editor":[{"given":"Marcelo G.","family":"Bonini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,5,17]]},"references-count":53,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2010,5,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0010666","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,17]]}}}