{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T16:56:07Z","timestamp":1773766567405,"version":"3.50.1"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2010,5,25]],"date-time":"2010-05-25T00:00:00Z","timestamp":1274745600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0010792","type":"journal-article","created":{"date-parts":[[2010,5,25]],"date-time":"2010-05-25T22:27:43Z","timestamp":1274826463000},"page":"e10792","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["The T1405N Carbamoyl Phosphate Synthetase Polymorphism Does Not Affect Plasma Arginine Concentrations in Preterm Infants"],"prefix":"10.1371","volume":"5","author":[{"given":"Rob M. J.","family":"Moonen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iballa","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Cavallaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gema","family":"Gonz\u00e1lez-Luis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaap A.","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Villamor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2010,5,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1053\/j.semperi.2008.01.004","article-title":"Necrotizing enterocolitis: recent scientific advances in pathophysiology and prevention.","volume":"32","author":"PW Lin","year":"2008","journal-title":"Semin Perinatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.3748\/wjg.14.2142","article-title":"Necrotizing enterocolitis: a multifactorial disease with no cure.","volume":"14","author":"KL Schnabl","year":"2008","journal-title":"World J Gastroenterol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000215590","article-title":"Necrotizing Enterocolitis - 150 Years of Fruitless Search for the Cause.","volume":"96","author":"M Obladen","year":"2009","journal-title":"Neonatology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"F162","DOI":"10.1136\/adc.2007.115824","article-title":"Enteral feeding for very low birth weight infants: reducing the risk of necrotising enterocolitis.","volume":"93","author":"M Chauhan","year":"2008","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"F395","DOI":"10.1136\/adc.2007.136994","article-title":"Trends in infant mortality from necrotising enterocolitis in England and Wales and the USA.","volume":"93","author":"CM Rees","year":"2008","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"ref6","doi-asserted-by":"crossref","DOI":"10.1203\/PDR.0b013e31819dba7d","article-title":"Biomarkers for Infants at Risk for Necrotizing Enterocolitis: Clues to Prevention?","author":"C Young","year":"2009"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"F124","DOI":"10.1136\/adc.2007.119933","article-title":"Cytokine gene polymorphisms in preterm infants with necrotising enterocolitis: genetic association study.","volume":"94","author":"G Henderson","year":"2009","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0095-5108(03)00063-0","article-title":"Newborn intestinal circulation. Physiology and pathophysiology.","volume":"29","author":"KM Reber","year":"2002","journal-title":"Clin Perinatol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1053\/j.sempedsurg.2005.05.004","article-title":"Mechanisms of nitric oxide-mediated intestinal barrier failure in necrotizing enterocolitis.","volume":"14","author":"JS Upperman","year":"2005","journal-title":"Semin Pediatr Surg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1053\/j.semperi.2008.01.002","article-title":"The role of nitric oxide in intestinal epithelial injury and restitution in neonatal necrotizing enterocolitis.","volume":"32","author":"NK Chokshi","year":"2008","journal-title":"Semin Perinatol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1203\/01.pdr.0000203094.27615.5f","article-title":"Intestinal O2 consumption in necrotizing enterocolitis: role of nitric oxide.","volume":"59","author":"PT Nowicki","year":"2006","journal-title":"Pediatr Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/01.shk.0000239774.02904.65","article-title":"The role of the intestinal barrier in the pathogenesis of necrotizing enterocolitis.","volume":"27","author":"RJ Anand","year":"2007","journal-title":"Shock"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000098411","article-title":"Plasma asymmetric dimethylarginine concentration during the perinatal period.","volume":"92","author":"G Vida","year":"2007","journal-title":"Neonatology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1017\/S0007114507669268","article-title":"Low plasma concentrations of arginine and asymmetric dimethylarginine in premature infants with necrotizing enterocolitis.","volume":"97","author":"MC Richir","year":"2007","journal-title":"Br J Nutr"},{"key":"ref15","first-page":"RA91","article-title":"Asymmetric dimethylarginine (ADMA): an endogenous inhibitor of nitric oxide synthase and a novel cardiovascular risk molecule.","volume":"15","author":"V De Gennaro Colonna","year":"2009","journal-title":"Med Sci Monit"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00726-009-0269-0","article-title":"Amino acids: metabolism, functions, and nutrition.","volume":"37","author":"G Wu","year":"2009","journal-title":"Amino Acids"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jnutbio.2003.11.010","article-title":"Arginine deficiency in preterm infants: biochemical mechanisms and nutritional implications.","volume":"15","author":"G Wu","year":"2004","journal-title":"J Nutr Biochem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1056\/NEJM200106143442404","article-title":"Neonatal pulmonary hypertension\u2014urea-cycle intermediates, nitric oxide production, and carbamoyl-phosphate synthetase function.","volume":"344","author":"DL Pearson","year":"2001","journal-title":"N Engl J Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1067\/mpd.2002.123289","article-title":"Arginine supplementation prevents necrotizing enterocolitis in the premature infant.","volume":"140","author":"HJ Amin","year":"2002","journal-title":"J Pediatr"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1067\/mpd.2000.109145","article-title":"Reduced serum amino acid concentrations in infants with necrotizing enterocolitis.","volume":"137","author":"RM Becker","year":"2000","journal-title":"J Pediatr"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0022-3476(97)70158-6","article-title":"Plasma L-arginine concentrations in premature infants with necrotizing enterocolitis.","volume":"131","author":"SA Zamora","year":"1997","journal-title":"J Pediatr"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1161\/01.HYP.0000112424.06921.52","article-title":"Relationship between carbamoyl-phosphate synthetase genotype and systemic vascular function.","volume":"43","author":"ML Summar","year":"2004","journal-title":"Hypertension"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/sj.bmt.1704943","article-title":"The hemochromatosis C282Y allele: a risk factor for hepatic veno-occlusive disease after hematopoietic stem cell transplantation.","volume":"35","author":"AR Kallianpur","year":"2005","journal-title":"Bone Marrow Transplant"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1203\/PDR.0b013e3180a0324e","article-title":"Carbamoyl phosphate synthetase polymorphisms as a risk factor for necrotizing enterocolitis.","volume":"62","author":"RM Moonen","year":"2007","journal-title":"Pediatr Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0378-4347(93)80062-9","article-title":"Rapid routine determination of amino acids in plasma by high-performance liquid chromatography with a 2\u20133 microns Spherisorb ODS II column.","volume":"620","author":"HM van Eijk","year":"1993","journal-title":"J Chromatogr"},{"key":"ref26","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2009.06.023","article-title":"Quantitative UPLC-MS\/MS analysis of underivatised amino acids in body fluids is a reliable tool for the diagnosis and follow-up of patients with inborn errors of metabolism.","author":"WA Waterval","year":"2009"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jchromb.2006.07.038","article-title":"Chromatographic-mass spectrometric methods for the quantification of L-arginine and its methylated metabolites in biological fluids.","volume":"851","author":"J Martens-Lobenhoffer","year":"2007","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"10480","DOI":"10.1073\/pnas.88.23.10480","article-title":"Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.","volume":"88","author":"JS Pollock","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/01.mpg.0000167497.55321.65","article-title":"A randomized controlled trial of enteral glutamine supplementation in very low birth weight infants: plasma amino acid concentrations.","volume":"41","author":"A van den Berg","year":"2005","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2842S","DOI":"10.1093\/jn\/134.10.2842S","article-title":"Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the \u201cL-arginine paradox\u201d and acts as a novel cardiovascular risk factor.","volume":"134","author":"RH Boger","year":"2004","journal-title":"J Nutr"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1146\/annurev.nutr.26.061505.111320","article-title":"The clinical significance of asymmetric dimethylarginine.","volume":"26","author":"MP Siroen","year":"2006","journal-title":"Annu Rev Nutr"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S1071-5576(02)00192-2","article-title":"Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, in maternal and fetal circulation.","volume":"10","author":"T Maeda","year":"2003","journal-title":"J Soc Gynecol Investig"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/01.PCC.0000144715.03515.55","article-title":"Asymmetric dimethyl arginine and symmetric dimethyl arginine levels in infants with persistent pulmonary hypertension of the newborn.","volume":"5","author":"CM Pierce","year":"2004","journal-title":"Pediatr Crit Care Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1002\/ppul.20886","article-title":"Plasma ADMA concentrations at birth and mechanical ventilation in preterm infants: a prospective pilot study.","volume":"43","author":"MC Richir","year":"2008","journal-title":"Pediatr Pulmonol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1651-2227.2008.01115.x","article-title":"Plasma levels of asymmetric dimethylarginine in premature neonates: its possible involvement in developmental programming of chronic diseases.","volume":"98","author":"G Vida","year":"2009","journal-title":"Acta Paediatr"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.earlhumdev.2005.08.005","article-title":"Umbilical vein plasma concentrations of asymmetrical dimethylarginine are increased in male but not female neonates delivered preterm: a pilot study.","volume":"82","author":"F Mittermayer","year":"2006","journal-title":"Early Hum Dev"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/sj.jp.7211782","article-title":"Emerging trends in acquired neonatal intestinal disease: is it time to abandon Bell&apos;s criteria?","volume":"27","author":"PV Gordon","year":"2007","journal-title":"J Perinatol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1053\/gast.2000.20227","article-title":"Postabsorptive plasma citrulline concentration is a marker of enterocyte mass and intestinal failure in humans.","volume":"119","author":"P Crenn","year":"2000","journal-title":"Gastroenterology"},{"key":"ref39","first-page":"582","article-title":"Plasma nitrite\/nitrate and endothelin-1 concentrations in neonatal sepsis. Acta Paediatr","volume":"92","author":"J Figueras-Aloy","year":"2003"},{"key":"ref40","first-page":"G474","article-title":"Enhanced metabolism of arginine and glutamine in enterocytes of cortisol-treated pigs.","volume":"272","author":"NE Flynn","year":"1997","journal-title":"Am J Physiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1093\/jn\/127.5.732","article-title":"Glucocorticoids play an important role in mediating the enhanced metabolism of arginine and glutamine in enterocytes of postweaning pigs.","volume":"127","author":"NE Flynn","year":"1997","journal-title":"J Nutr"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1093\/jn\/129.4.799","article-title":"Glucocorticoids mediate the enhanced expression of intestinal type II arginase and argininosuccinate lyase in postweaning pigs.","volume":"129","author":"NE Flynn","year":"1999","journal-title":"J Nutr"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0010792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T13:00:26Z","timestamp":1559134826000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0010792"}},"subtitle":[],"editor":[{"given":"Daniel","family":"Tom\u00e9","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2010,5,25]]},"references-count":42,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2010,5,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0010792","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,25]]}}}