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Klee","year":"2006","journal-title":"J Appl Microbiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1126\/science.2536191","article-title":"Chromosomal rearrangement generating a composite gene for a developmental transcription factor.","volume":"243","author":"P Stragier","year":"1989","journal-title":"Science"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1101\/gad.4.4.525","article-title":"The <italic>Bacillus subtilis<\/italic> gene for the development transcription factor sigma K is generated by excision of a dispensable DNA element containing a sporulation recombinase gene.","volume":"4","author":"B Kunkel","year":"1990","journal-title":"Genes Dev"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nature01582","article-title":"Genome sequence of <italic>Bacillus cereus<\/italic> and comparative analysis with <italic>Bacillus anthracis<\/italic>.","volume":"423","author":"N Ivanova","year":"2003","journal-title":"Nature"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1128\/jb.172.2.1092-1098.1990","article-title":"The <italic>cisA<\/italic> cistron of <italic>Bacillus subtilis<\/italic> sporulation gene <italic>spoIVC<\/italic> encodes a protein homologous to a site-specific recombinase.","volume":"172","author":"T Sato","year":"1990","journal-title":"J Bacteriol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1046\/j.1365-2958.2003.03471.x","article-title":"Efficient sporulation in <italic>Clostridium difficile<\/italic> requires disruption of the \u03c3<sup>K<\/sup> gene.","volume":"48","author":"JD Haraldsen","year":"2003","journal-title":"Mol Microbiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1128\/JB.01313-06","article-title":"Complete sequence analysis of novel plasmids from emetic and periodontal <italic>Bacillus cereus<\/italic> isolates reveals a common 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virulence plasmids.","volume":"71","author":"A Bourgogne","year":"2003","journal-title":"Infect Immun"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1046\/j.1365-2958.2003.03345.x","article-title":"A plasmid-encoded regulator couples the synthesis of toxins and surface structures in <italic>Bacillus anthracis<\/italic>.","volume":"47","author":"T Mignot","year":"2003","journal-title":"Mol Microbiol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.tim.2008.01.010","article-title":"Commingling regulatory systems following acquisition of virulence plasmids by <italic>Bacillus anthracis<\/italic>.","volume":"16","author":"M Perego","year":"2008","journal-title":"Trends Microbiol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"6972","DOI":"10.1128\/JB.187.20.6972-6981.2005","article-title":"Characterization of sporulation histidine kinases of <italic>Bacillus anthracis<\/italic>.","volume":"187","author":"RL Brunsing","year":"2005","journal-title":"J Bacteriol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1128\/JB.162.2.543-550.1985","article-title":"Mating system for transfer of plasmids among <italic>Bacillus anthracis<\/italic>, <italic>Bacillus cereus<\/italic>, and <italic>Bacillus thuringiensis<\/italic>.","volume":"162","author":"L Battisti","year":"1985","journal-title":"J Bacteriol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1128\/AEM.72.5.3168-3174.2006","article-title":"<italic>Bacillus anthracis<\/italic> multiplication, persistence, and genetic exchange in the rhizosphere of grass plants.","volume":"72","author":"E Saile","year":"2006","journal-title":"Appl Environ Microbiol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.mimet.2003.10.005","article-title":"Artificial soil microcosms: a tool for studying microbial autecology under controlled conditions.","volume":"56","author":"RJ Ellis","year":"2004","journal-title":"J Microbiol Methods"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"4970","DOI":"10.1128\/AEM.03076-05","article-title":"Analysis of the life cycle of the soil saprophyte <italic>Bacillus cereus<\/italic> in liquid soil extract and in soil.","volume":"72","author":"S Vilain","year":"2006","journal-title":"Appl Environ Microbiol"},{"key":"ref78","first-page":"277","article-title":"Die Aetiologie der Milzbrand-Krankheit, begr\u00fcndet auf die Entwicklungsgeschichte des <italic>Bacillus anthracis<\/italic>.","volume":"2","author":"R Koch","year":"1876","journal-title":"Beitr\u00e4ge zur Biologie der Pflanzen"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"e122","DOI":"10.1371\/journal.ppat.0020122","article-title":"Anthrax, but not <italic>Bacillus anthracis<\/italic>?","volume":"2","author":"R Okinaka","year":"2006","journal-title":"PLoS Pathog"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1128\/jb.178.2.377-384.1996","article-title":"Identification of a region of genetic variability among <italic>Bacillus anthracis<\/italic> strains and related species.","volume":"178","author":"GL Andersen","year":"1996","journal-title":"J Bacteriol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3233\/ISB-00108","article-title":"YACOP: Enhanced gene prediction obtained by a combination of existing methods.","volume":"3","author":"M Tech","year":"2003","journal-title":"In Silico Biol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1093\/nar\/gkg148","article-title":"The ERGO genome analysis and discovery system.","volume":"31","author":"R Overbeek","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1093\/bioinformatics\/btn529","article-title":"Artemis and ACT: viewing, annotating and comparing sequences stored in a relational database.","volume":"24","author":"T Carver","year":"2008","journal-title":"Bioinformatics"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.","volume":"25","author":"SF Altschul","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"ref85","first-page":"164","article-title":"PHYLIP - Phylogeny Inference Package (Version 3.2).","volume":"5","author":"J Felsenstein","year":"1989","journal-title":"Cladistics"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1093\/molbev\/msm092","article-title":"MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0.","volume":"24","author":"K Tamura","year":"2007","journal-title":"Mol Biol Evol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1128\/JB.01347-08","article-title":"The complete genome sequence of <italic>Bacillus anthracis<\/italic> Ames \u201cAncestor\u201d.","volume":"191","author":"J Ravel","year":"2009","journal-title":"J Bacteriol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/nar\/gkh258","article-title":"The genome sequence of <italic>Bacillus cereus<\/italic> ATCC 10987 reveals metabolic adaptations and a large plasmid related to <italic>Bacillus anthracis<\/italic> pXO1.","volume":"32","author":"DA Rasko","year":"2004","journal-title":"Nucleic Acids Res"}],"container-title":["PLoS 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