{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:41:55Z","timestamp":1783464115336,"version":"3.55.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2010,6,24]],"date-time":"2010-06-24T00:00:00Z","timestamp":1277337600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0011302","type":"journal-article","created":{"date-parts":[[2010,6,24]],"date-time":"2010-06-24T20:33:51Z","timestamp":1277411631000},"page":"e11302","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":79,"title":["Androgen Excess Produces Systemic Oxidative Stress and Predisposes to \u03b2-Cell Failure in Female Mice"],"prefix":"10.1371","volume":"5","author":[{"given":"Suhuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Mauvais-Jarvis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,6,24]]},"reference":[{"key":"ref1","first-page":"51","article-title":"Le virilisme pilaire et son association a l&apos;insuffisance glycolytique (diabete des femmes a barbe).","volume":"86","author":"C Achard","year":"1921","journal-title":"Bull Acad Natl Med Paris"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0002-9378(15)30642-6","article-title":"Amenorreha associated with bilateral polycystic ovaries.","volume":"20","author":"J Stein","year":"1935","journal-title":"Am J obstet Gynecol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.2337\/diab.38.9.1165","article-title":"Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome.","volume":"38","author":"A Dunaif","year":"1989","journal-title":"Diabetes"},{"key":"ref4","first-page":"4420","article-title":"Effects of methyltestosterone on insulin secretion and sensitivity in women.","volume":"83","author":"MP Diamond","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"ref5","first-page":"E555","article-title":"Effects of testosterone on muscle insulin sensitivity and morphology in female rats.","volume":"259","author":"A Holmang","year":"1990","journal-title":"Am J Physiol"},{"key":"ref6","first-page":"E851","article-title":"Effects of short-term testosterone exposure on insulin sensitivity of muscles in female rats.","volume":"262","author":"A Holmang","year":"1992","journal-title":"Am J Physiol"},{"key":"ref7","first-page":"1241","article-title":"Defects in beta-cell function in functional ovarian hyperandrogenism.","volume":"76","author":"NM O'Meara","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"ref8","first-page":"942","article-title":"Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome.","volume":"81","author":"A Dunaif","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"ref9","first-page":"1052","article-title":"Enhanced early insulin response to glucose in relation to insulin resistance in women with polycystic ovary syndrome and normal glucose tolerance.","volume":"78","author":"J Holte","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1210\/jc.2004-1006","article-title":"beta-Cell function: a key pathological determinant in polycystic ovary syndrome.","volume":"90","author":"MO Goodarzi","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1210\/endo-103-4-1518","article-title":"Sex differences in the multiple-dose streptozotocin model of diabetes.","volume":"103","author":"AA Rossini","year":"1978","journal-title":"Endocrinology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/BF00251924","article-title":"Testosterone effect on experimental diabetes mellitus in encephalomyocarditis (EMC) virus infected mice.","volume":"18","author":"PL Morrow","year":"1980","journal-title":"Diabetologia"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"710","DOI":"10.2337\/diab.29.9.710","article-title":"Androgen sensitization of streptozotocin-induced diabetes in mice.","volume":"29","author":"NK Maclaren","year":"1980","journal-title":"Diabetes"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"724","DOI":"10.2337\/diab.31.8.724","article-title":"Induction of insulin-dependent diabetes by streptozotocin. Inhibition by estrogens and potentiation by androgens.","volume":"31","author":"SG Paik","year":"1982","journal-title":"Diabetes"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1089\/ars.1999.1.1-71","article-title":"Androgen-induced oxidative stress in human LNCaP prostate cancer cells is associated with multiple mitochondrial modifications.","volume":"1","author":"MO Ripple","year":"1999","journal-title":"Antioxid Redox Signal"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1152\/japplphysiol.00012.2008","article-title":"Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosis.","volume":"105","author":"WH Kan","year":"2008","journal-title":"J Appl Physiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1007\/s00421-002-0668-3","article-title":"\u201cOxidative stress\u201d: effects of mild endurance training and testosterone treatment on rat gastrocnemius muscle.","volume":"87","author":"O Pansarasa","year":"2002","journal-title":"Eur J Appl Physiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1210\/jc.2005-1696","article-title":"Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome.","volume":"91","author":"F Gonzalez","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"9232","DOI":"10.1073\/pnas.0602956103","article-title":"Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice.","volume":"103","author":"C Le May","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.2337\/db09-0257","article-title":"Importance of extranuclear estrogen receptor-alpha and membrane G protein-coupled estrogen receptor in pancreatic islet survival.","volume":"58","author":"S Liu","year":"2009","journal-title":"Diabetes"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/2271217a0","article-title":"X-linked gene for testicular feminization in the mouse.","volume":"227","author":"MF Lyon","year":"1970","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1210\/mend-5-4-573","article-title":"A frameshift mutation destabilizes androgen receptor messenger RNA in the Tfm mouse.","volume":"5","author":"NJ Charest","year":"1991","journal-title":"Mol Endocrinol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1210\/endo.135.4.7925099","article-title":"Abnormal Leydig cell development at puberty in the androgen-resistant Tfm mouse.","volume":"135","author":"L Murphy","year":"1994","journal-title":"Endocrinology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00109-003-0450-y","article-title":"Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes.","volume":"81","author":"MY Donath","year":"2003","journal-title":"J Mol Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.2337\/diabetes.50.2007.S58","article-title":"beta-cell apoptosis: stimuli and signaling.","volume":"50","author":"T Mandrup-Poulsen","year":"2001","journal-title":"Diabetes"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-1-4615-1833-4_4","article-title":"The analysis of free radicals, lipid peroxides, antioxidant enzymes and compounds related to oxidative stress as applied to the clinical chemistry laboratory.","volume":"366","author":"D Armstrong","year":"1994","journal-title":"Adv Exp Med Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1172\/JCI21625","article-title":"Increased oxidative stress in obesity and its impact on metabolic syndrome.","volume":"114","author":"S Furukawa","year":"2004","journal-title":"J Clin Invest"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1128\/MCB.24.5.1844-1854.2004","article-title":"The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction.","volume":"24","author":"K Mahadev","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1161\/01.CIR.0000012917.74432.66","article-title":"Superoxide production and expression of nox family proteins in human atherosclerosis.","volume":"105","author":"D Sorescu","year":"2002","journal-title":"Circulation"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1084\/jem.175.5.1409","article-title":"Androgen treatment prevents diabetes in nonobese diabetic mice.","volume":"175","author":"HS Fox","year":"1992","journal-title":"J Exp Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"5870","DOI":"10.1158\/0008-5472.CAN-04-0655","article-title":"Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin.","volume":"64","author":"N Yin","year":"2004","journal-title":"Cancer Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/08916939508995702","article-title":"Association of an androgen-responsive T cell phenotype with murine diabetes and Idd2.","volume":"20","author":"RB Pearce","year":"1995","journal-title":"Autoimmunity"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"5369","DOI":"10.4049\/jimmunol.168.10.5369","article-title":"Molecular mechanisms for gender differences in susceptibility to T cell-mediated autoimmune diabetes in nonobese diabetic mice.","volume":"168","author":"M Bao","year":"2002","journal-title":"J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/labinvest.3780231","article-title":"Sex steroids influence pancreatic islet hypertrophy and subsequent autoimmune infiltration in nonobese diabetic (NOD) and NODscid mice.","volume":"81","author":"JG Rosmalen","year":"2001","journal-title":"Lab Invest"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1007\/s00125-004-1367-x","article-title":"Generation of hydrogen peroxide and failure of antioxidative responses in pancreatic islets of male C57BL\/6 mice are associated with diabetes induced by multiple low doses of streptozotocin.","volume":"47","author":"NT Friesen","year":"2004","journal-title":"Diabetologia"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1034\/j.1600-0773.2002.900605.x","article-title":"Generation of hydroxyl radicals mediated by streptozotocin in pancreatic islets of mice in vitro.","volume":"90","author":"L Gille","year":"2002","journal-title":"Pharmacol Toxicol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"5539","DOI":"10.1210\/en.2009-0640","article-title":"Androgens induce dopaminergic neurotoxicity via caspase-3-dependent activation of protein kinase Cdelta.","volume":"150","author":"RL Cunningham","year":"2009","journal-title":"Endocrinology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/en.2003-0789","article-title":"Dihydrotestosterone promotes vascular cell adhesion molecule-1 expression in male human endothelial cells via a nuclear factor-kappaB-dependent pathway.","volume":"145","author":"AK Death","year":"2004","journal-title":"Endocrinology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1210\/endo.143.3.8679","article-title":"Testosterone (T) enhances apoptosis-related damage in human vascular endothelial cells.","volume":"143","author":"S Ling","year":"2002","journal-title":"Endocrinology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0011302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T11:47:46Z","timestamp":1559216866000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0011302"}},"subtitle":[],"editor":[{"given":"Krisztian","family":"Stadler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,6,24]]},"references-count":39,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2010,6,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0011302","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,24]]}}}