{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:26:49Z","timestamp":1791106009630,"version":"4.1.0"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2010,7,2]],"date-time":"2010-07-02T00:00:00Z","timestamp":1278028800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0011399","type":"journal-article","created":{"date-parts":[[2010,7,2]],"date-time":"2010-07-02T20:44:41Z","timestamp":1278103481000},"page":"e11399","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Synaptic Maturation at Cortical Projections to the Lateral Amygdala in a Mouse Model of Rett Syndrome"],"prefix":"10.1371","volume":"5","author":[{"given":"Fr\u00e9d\u00e9ric","family":"Gambino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malik","family":"Khelfaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Poulain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Bienvenu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamel","family":"Chelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Humeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,7,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrg1878","article-title":"Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized.","volume":"7","author":"T Bienvenu","year":"2006","journal-title":"Nat Rev Genet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.neuron.2007.10.001","article-title":"The story of Rett syndrome: from clinic to neurobiology.","volume":"56","author":"M Chahrour","year":"2007","journal-title":"Neuron"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuron.2007.08.018","article-title":"Mecp2 controls excitatory synaptic strength by regulating glutamatergic synapse number.","volume":"56","author":"HT Chao","year":"2007","journal-title":"Neuron"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.biopsych.2008.10.036","article-title":"Rett syndrome and the impact of Mecp2 associated transcriptional mechanisms on neurotransmission.","volume":"65","author":"LM Monteggia","year":"2009","journal-title":"Biol Psychiatry"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.neuron.2006.01.014","article-title":"The ups and downs of BDNF in Rett syndrome.","volume":"49","author":"YE Sun","year":"2006","journal-title":"Neuron"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/85906","article-title":"Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice.","volume":"27","author":"RZ Chen","year":"2001","journal-title":"Nat Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1523\/JNEUROSCI.4225-08.2009","article-title":"Mecp2-mediated transcription repression in the basolateral amygdala may underlie heightened anxiety in a mouse model of Rett syndrome.","volume":"29","author":"M Adachi","year":"2009","journal-title":"J Neurosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.neuroscience.2007.02.009","article-title":"Behavioral and anatomical abnormalities in Mecp2 mutant mice: a model for Rett syndrome.","volume":"146","author":"NA Stearns","year":"2007","journal-title":"Neuroscience"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.tins.2007.12.005","article-title":"Neuroanatomy of autism.","volume":"31","author":"DG Amaral","year":"2008","journal-title":"Trends Neurosci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"11263","DOI":"10.1523\/JNEUROSCI.1019-09.2009","article-title":"Intact long-term potentiation but reduced connectivity between neocortical layer 5 pyramidal neurons in a mouse model of Rett syndrome.","volume":"29","author":"VS Dani","year":"2009","journal-title":"J Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.nbd.2005.07.005","article-title":"Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome.","volume":"21","author":"Y Asaka","year":"2006","journal-title":"Neurobiol Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1523\/JNEUROSCI.2623-05.2006","article-title":"Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome.","volume":"26","author":"P Moretti","year":"2006","journal-title":"J Neurosci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.1138389","article-title":"Reversal of neurological defects in a mouse model of Rett syndrome.","volume":"315","author":"J Guy","year":"2007","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2005.12.027","article-title":"The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression.","volume":"49","author":"Q Chang","year":"2006","journal-title":"Neuron"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neuron.2006.09.037","article-title":"Brain-specific phosphorylation of Mecp2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation.","volume":"52","author":"Z Zhou","year":"2006","journal-title":"Neuron"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0896-6273(02)00768-7","article-title":"Mice with truncated Mecp2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3.","volume":"35","author":"M Shahbazian","year":"2002","journal-title":"Neuron"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.neuro.23.1.155","article-title":"Emotion circuits in the brain.","volume":"23","author":"JE LeDoux","year":"2000","journal-title":"Annu Rev Neurosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1146\/annurev.neuro.24.1.897","article-title":"Neurobiology of Pavlovian fear conditioning.","volume":"24","author":"S Maren","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0896-6273(00)80375-X","article-title":"Fear conditioning enhances different temporal components of tone-evoked spike trains in auditory cortex and lateral amygdala.","volume":"19","author":"GJ Quirk","year":"1997","journal-title":"Neuron"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0896-6273(02)00645-1","article-title":"Fear conditioning occludes LTP-induced presynaptic enhancement of synaptic transmission in the cortical pathway to the lateral amygdala.","volume":"34","author":"E Tsvetkov","year":"2002","journal-title":"Neuron"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nature02194","article-title":"Presynaptic induction of heterosynaptic associative plasticity in the mammalian brain.","volume":"426","author":"Y Humeau","year":"2003","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neuron.2004.12.019","article-title":"Dendritic spine heterogeneity determines afferent-specific Hebbian plasticity in the amygdala.","volume":"45","author":"Y Humeau","year":"2005","journal-title":"Neuron"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/nn.2378","article-title":"L-type voltage-dependent Ca(2+) channels mediate expression of presynaptic LTP in amygdala.","volume":"12","author":"E Fourcaudot","year":"2009","journal-title":"Nat Neurosci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/37605","article-title":"Fear conditioning induces a lasting potentiation of synaptic currents in vitro.","volume":"390","author":"MG McKernan","year":"1997","journal-title":"Nature"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.biopsych.2009.07.006","article-title":"Divergence between thalamic and cortical inputs to lateral amygdala during juvenile-adult transition in mice.","volume":"66","author":"BX Pan","year":"2009","journal-title":"Biol Psychiatry"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nn1058","article-title":"Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition.","volume":"6","author":"S Bissi\u00e8re","year":"2003","journal-title":"Nat Neurosci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0166-2236(02)02139-2","article-title":"Vesicle pools and short-term synaptic depression: lessons from a large synapse.","volume":"25","author":"R Schneggenburger","year":"2002","journal-title":"Trends Neurosci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1152\/jn.1999.81.2.930","article-title":"Distinct populations of NMDA receptors at subcortical and cortical inputs to principal cells of the lateral amygdala.","volume":"81","author":"MG Weisskopf","year":"1999","journal-title":"J Neurophysiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1046\/j.1460-9568.1999.00528.x","article-title":"Excitatory synaptic inputs to pyramidal neurons of the lateral amygdala.","volume":"11","author":"NK Mahanty","year":"1999","journal-title":"Eur J Neurosci."},{"key":"ref30","doi-asserted-by":"crossref","first-page":"10947","DOI":"10.1523\/JNEUROSCI.2603-07.2007","article-title":"A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning.","volume":"27","author":"Y Humeau","year":"2007","journal-title":"J Neurosci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.neuron.2008.08.019","article-title":"Multiple roles of calcium ions in the regulation of neurotransmitter release.","volume":"59","author":"E Neher","year":"2008","journal-title":"Neuron"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1126\/science.7916482","article-title":"Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP.","volume":"265","author":"MG Weisskopf","year":"1994","journal-title":"Science"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0092-8674(94)90401-4","article-title":"cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase.","volume":"79","author":"YY Huang","year":"1994","journal-title":"Cell"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0896-6273(00)80099-9","article-title":"Cyclic AMP mediates a presynaptic form of LTP at cerebellar parallel fiber synapses.","volume":"16","author":"PA Salin","year":"1996","journal-title":"Neuron"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"9090","DOI":"10.1523\/JNEUROSCI.19-20-09090.1999","article-title":"Presynaptic long-term potentiation in corticothalamic synapses.","volume":"19","author":"MA Castro-Alamancos","year":"1999","journal-title":"J Neurosci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1113\/jphysiol.2006.121822","article-title":"Bidirectional synaptic plasticity at nociceptive afferents in the rat central amygdala.","volume":"581","author":"M Lopez de Armentia","year":"2007","journal-title":"J Physiol (London)"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0896-6273(00)80524-3","article-title":"Postsynaptic induction and PKA-dependent expression of LTP in the lateral amygdala.","volume":"21","author":"YY Huang","year":"1998","journal-title":"Neuron"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"15130","DOI":"10.1073\/pnas.0806938105","article-title":"cAMP\/PKA signaling and RIM1alpha mediate presynaptic LTP in the lateral amygdala.","volume":"105","author":"E Fourcaudot","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nn1732","article-title":"Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition.","volume":"9","author":"H Shaban","year":"2006","journal-title":"Nat Neurosci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1101\/lm.1190809","article-title":"Enhanced generalization of auditory conditioned fear in juvenile mice.","volume":"16","author":"W Ito","year":"2009","journal-title":"Learn Mem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.neuron.2009.05.026","article-title":"Amygdala inhibitory circuits and the control of fear memory.","volume":"62","author":"I Ehrlich","year":"2009","journal-title":"Neuron"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"8909","DOI":"10.1523\/JNEUROSCI.20-23-08909.2000","article-title":"Putative cortical and thalamic inputs elicit convergent excitation in a population of GABAergic interneurons of the lateral amygdala.","volume":"20","author":"C Szinyei","year":"2000","journal-title":"J Neurosci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"9507","DOI":"10.1523\/JNEUROSCI.3567-04.2004","article-title":"Heterosynaptic long-term potentiation of inhibitory interneurons in the lateral amygdala.","volume":"24","author":"EP Bauer","year":"2004","journal-title":"J Neurosci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1177\/08830738050200082201","article-title":"Mecp2 dysfunction in humans and mice.","volume":"20","author":"HY Zoghbi","year":"2005","journal-title":"J Child Neurol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/hmg\/ddi016","article-title":"Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome.","volume":"14","author":"P Moretti","year":"2005","journal-title":"Hum Mol Genet"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.biopsych.2005.07.025","article-title":"Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice.","volume":"59","author":"T Gemelli","year":"2006","journal-title":"Biol Psychiatry"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.nbd.2009.05.001","article-title":"Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rett-associated MECP2 mutations.","volume":"35","author":"CA Chapleau","year":"2009","journal-title":"Neurobiol Dis"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"10911","DOI":"10.1523\/JNEUROSCI.1810-06.2006","article-title":"Dysregulation of brain-derived neurotrophic factor expression and neurosecretory function in Mecp2 null mice.","volume":"26","author":"H Wang","year":"2006","journal-title":"J Neurosci"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1126\/science.1152089","article-title":"Surface mobility of postsynaptic AMPARs tunes synaptic transmission.","volume":"320","author":"M Heine","year":"2008","journal-title":"Science"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1113\/jphysiol.2007.141788","article-title":"Postnatal development of synaptic transmission in local networks of L5A pyramidal neurons in rat somatosensory cortex.","volume":"585","author":"A Frick","year":"2007","journal-title":"J Physiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0011399","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T18:03:20Z","timestamp":1559239400000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0011399"}},"subtitle":[],"editor":[{"given":"Olivier Jacques","family":"Manzoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,7,2]]},"references-count":50,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2010,7,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0011399","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,2]]}}}