{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T10:29:36Z","timestamp":1719916176166},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2010,7,8]],"date-time":"2010-07-08T00:00:00Z","timestamp":1278547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0011475","type":"journal-article","created":{"date-parts":[[2010,7,8]],"date-time":"2010-07-08T20:15:36Z","timestamp":1278620136000},"page":"e11475","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Loss of Androgen Receptor-Dependent Growth Suppression by Prostate Cancer Cells Can Occur Independently from Acquiring Oncogenic Addiction to Androgen Receptor Signaling"],"prefix":"10.1371","volume":"5","author":[{"given":"Jason M.","family":"D'Antonio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald J.","family":"Vander Griend","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizamma","family":"Antony","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Ndikuyeze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan L.","family":"Dalrymple","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahriar","family":"Koochekpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"Isaacs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2010,7,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/pros.10213","article-title":"Prostate-specific antigen (PSA) protein does not affect growth of prostate cancer cells in vitro or prostate cancer xenografts in vivo.","volume":"56","author":"SR Denmeade","year":"2003","journal-title":"Prostate"},{"key":"ref2","first-page":"1","article-title":"Androgen induction of in vitro prostate cell differentiation.","volume":"13","author":"DC Whitacre","year":"2002","journal-title":"Cell Growth Differ"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1677\/joe.0.1700287","article-title":"Androgen induces differentiation of a human papillomavirus 16 E6\/E7 immortalized prostate epithelial cell line.","volume":"170","author":"MT Ling","year":"2001","journal-title":"J Endocrinol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"8867","DOI":"10.1158\/0008-5472.CAN-04-2938","article-title":"Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells.","volume":"64","author":"R Berger","year":"2004","journal-title":"Cancer Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"12679","DOI":"10.1073\/pnas.0704940104","article-title":"Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor.","volume":"104","author":"CT Wu","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1210\/en.2006-1223","article-title":"Disruption of prostate epithelial androgen receptor impedes prostate lobe-specific growth and function.","volume":"148","author":"U Simanainen","year":"2007","journal-title":"Endocrinology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/nm0104-26","article-title":"Androgen receptor outwits prostate cancer drugs.","volume":"10","author":"JT Isaacs","year":"2004","journal-title":"Nat Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1002\/pros.20483","article-title":"PC3, but not DU145, human prostate cancer cells retain the coregulators required for tumor suppressor ability of androgen receptor.","volume":"66","author":"IV Litvinov","year":"2006","journal-title":"Prostate"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/jnci\/92.17.1367","article-title":"Apoptosis: translating theory to therapy for prostate cancer.","volume":"92","author":"JT Isaacs","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"647","DOI":"10.4161\/cc.6.6.4028","article-title":"Stabilizing androgen receptor in mitosis inhibits prostate cancer proliferation.","volume":"6","author":"DJ Vander Griend","year":"2007","journal-title":"Cell Cycle"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nrc801","article-title":"A history of prostate cancer treatment.","volume":"2","author":"SR Denmeade","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"9209","DOI":"10.1158\/0008-5472.CAN-04-2442","article-title":"Androgen-independent prostate cancer is a heterogeneous group of diseases: lessons from a rapid autopsy program.","volume":"64","author":"RB Shah","year":"2004","journal-title":"Cancer Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/pros.10290","article-title":"Molecular characterization of human prostate carcinoma cell lines.","volume":"57","author":"A van Bokhoven","year":"2003","journal-title":"Prostate"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1210\/me.2007-0223","article-title":"Androgen receptor structural and functional elements: role and regulation in prostate cancer.","volume":"21","author":"SM Dehm","year":"2007","journal-title":"Mol Endocrinol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1593\/neo.08428","article-title":"Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.","volume":"10","author":"W Liu","year":"2008","journal-title":"Neoplasia"},{"key":"ref16","first-page":"1008","article-title":"Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells.","volume":"62","author":"OL Zegarra-Moro","year":"2002","journal-title":"Cancer Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1475-2867-5-8","article-title":"Androgen receptor signaling is required for androgen-sensitive human prostate cancer cell proliferation and survival.","volume":"5","author":"Q Yang","year":"2005","journal-title":"Cancer Cell Int"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1158\/1078-0432.CCR-08-1726","article-title":"In vivo knockdown of the androgen receptor results in growth inhibition and regression of well-established, castration-resistant prostate tumors.","volume":"15","author":"R Snoek","year":"2009","journal-title":"Clin Cancer Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1158\/0008-5472.CAN-07-3293","article-title":"Oncogene addiction.","volume":"68","author":"IB Weinstein","year":"2008","journal-title":"Cancer Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/pros.20053","article-title":"Establishment and characterization of a primary androgen-responsive African-American prostate cancer cell line, E006AA.","volume":"60","author":"S Koochekpour","year":"2004","journal-title":"Prostate"},{"key":"ref21","article-title":"ISCN 2005: an international system for human cytogenetic nomenclature (2005): recommendations of the International Standing Committee on Human Cytogenetic Nomenclature.","author":"LG Shaffer","year":"2005"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/pros.10199","article-title":"Dissociation between androgen responsiveness for malignant growth vs. expression of prostate specific differentiation markers PSA, hK2, and PSMA in human prostate cancer models.","volume":"54","author":"SR Denmeade","year":"2003","journal-title":"Prostate"},{"key":"ref23","first-page":"5038","article-title":"Conversion from a paracrine to an autocrine mechanism of androgen-stimulated growth during malignant transformation of prostatic epithelial cells.","volume":"61","author":"J Gao","year":"2001","journal-title":"Cancer Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.2353\/ajpath.2010.080747","article-title":"Loss of Nkx3.1 expression in bacterial prostatitis: a potential link between inflammation and neoplasia.","volume":"176","author":"M Khalili","year":"2010","journal-title":"Am J Pathol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/pros.20187","article-title":"Molecular characterization of an improved vector for evaluation of the tumor suppressor versus oncogene abilities of the androgen receptor.","volume":"61","author":"IV Litvinov","year":"2004","journal-title":"Prostate"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/sj.cgt.7700385","article-title":"A novel method for the determination of basal gene expression of tissue-specific promoters: an analysis of prostate-specific promoters.","volume":"8","author":"HG van der Poel","year":"2001","journal-title":"Cancer Gene Ther"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.molcel.2005.07.018","article-title":"Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking.","volume":"19","author":"Q Wang","year":"2005","journal-title":"Mol Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/ijc.2910260521","article-title":"Expression of metastatic potential of tumor cells in young nude mice is correlated with low levels of natural killer cell-mediated cytotoxicity.","volume":"26","author":"N Hanna","year":"1980","journal-title":"Int J Cancer"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1182\/blood-2001-12-0207","article-title":"NOD\/SCID\/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells.","volume":"100","author":"M Ito","year":"2002","journal-title":"Blood"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1177\/002215540104900214","article-title":"Epithelial cell differentiation pathways in the human prostate: identification of intermediate phenotypes by keratin expression.","volume":"49","author":"DL Hudson","year":"2001","journal-title":"J Histochem Cytochem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1210\/jc.2002-022038","article-title":"Is the Achilles&apos; heel for prostate cancer therapy a gain of function in androgen receptor signaling?","volume":"88","author":"IV Litvinov","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/CS20040241","article-title":"Prostate epithelial cell differentiation and its relevance to the understanding of prostate cancer therapies.","volume":"108","author":"RM Long","year":"2005","journal-title":"Clin Sci (Lond)"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.1073\/pnas.0401123101","article-title":"Structural basis of androgen receptor binding to selective androgen response elements.","volume":"101","author":"PL Shaffer","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1096-7192(03)00003-9","article-title":"Selective DNA recognition by the androgen receptor as a mechanism for hormone-specific regulation of gene expression.","volume":"78","author":"G Verrijdt","year":"2003","journal-title":"Mol Genet Metab"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1093\/nar\/gkm198","article-title":"A promoting role of androgen receptor in androgen-sensitive and -insensitive prostate cancer cells.","volume":"35","author":"TH Li","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1073\/pnas.59.2.632","article-title":"A two-step mechanism for the interaction of estradiol with rat uterus.","volume":"59","author":"EV Jensen","year":"1968","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S0021-9258(18)52466-2","article-title":"Transcriptional activation and nuclear targeting signals of the human androgen receptor.","volume":"266","author":"JA Simental","year":"1991","journal-title":"J Biol Chem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1210\/mend.14.8.0497","article-title":"Dynamics of intracellular movement and nucleocytoplasmic recycling of the ligand-activated androgen receptor in living cells.","volume":"14","author":"RK Tyagi","year":"2000","journal-title":"Mol Endocrinol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/jcp.20741","article-title":"1,25-dihydroxyvitamin D3 transcriptionally represses p45Skp2 expression via the Sp1 sites in human prostate cancer cells.","volume":"209","author":"YC Huang","year":"2006","journal-title":"J Cell Physiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"48366","DOI":"10.1074\/jbc.M209074200","article-title":"Involvement of proteasome in the dynamic assembly of the androgen receptor transcription complex.","volume":"277","author":"Z Kang","year":"2002","journal-title":"J Biol Chem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"30828","DOI":"10.1074\/jbc.M301208200","article-title":"A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4.","volume":"278","author":"AL Amir","year":"2003","journal-title":"J Biol Chem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/352497a0","article-title":"Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA.","volume":"352","author":"BF Luisi","year":"1991","journal-title":"Nature"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1093\/humupd\/7.3.314","article-title":"Disorders linked to insufficient androgen action in male children.","volume":"7","author":"C Sultan","year":"2001","journal-title":"Hum Reprod Update"},{"key":"ref44","first-page":"409","article-title":"Amino acid substitutions in the DNA-binding domain of the human androgen receptor are a frequent cause of receptor-binding positive androgen resistance.","volume":"6","author":"S Zoppi","year":"1992","journal-title":"Mol Endocrinol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1158\/1078-0432.CCR-08-2036","article-title":"Fluorescence in situ hybridization analysis of circulating tumor cells in metastatic prostate cancer.","volume":"15","author":"MA Leversha","year":"2009","journal-title":"Clin Cancer Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0011475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T03:29:11Z","timestamp":1635650951000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0011475"}},"subtitle":[],"editor":[{"given":"Janine","family":"Santos","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2010,7,8]]},"references-count":45,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2010,7,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0011475","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,8]]}}}