{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:44:05Z","timestamp":1790754245891,"version":"4.1.0"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2010,7,12]],"date-time":"2010-07-12T00:00:00Z","timestamp":1278892800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0011534","type":"journal-article","created":{"date-parts":[[2010,7,12]],"date-time":"2010-07-12T20:53:34Z","timestamp":1278968014000},"page":"e11534","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":50,"title":["Unconventional Transcriptional Response to Environmental Enrichment in a Mouse Model of Rett Syndrome"],"prefix":"10.1371","volume":"5","author":[{"given":"Bredford","family":"Kerr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela A.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherina","family":"Walz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan I.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,7,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/ana.410140412","article-title":"A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett&apos;s syndrome: report of 35 cases.","volume":"14","author":"B Hagberg","year":"1983","journal-title":"Ann Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/ajmg.1320250503","article-title":"Rett syndrome. History and general overview.","author":"A Rett","year":"1986","journal-title":"Am J Med Genet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.neuron.2007.10.001","article-title":"The story of Rett syndrome: from clinic to neurobiology.","volume":"56","author":"M Chahrour","year":"2007","journal-title":"Neuron"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jpeds.2005.10.037","article-title":"Rett syndrome in Australia: a review of the epidemiology.","volume":"148","author":"CL Laurvick","year":"2006","journal-title":"J Pediatr"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/85899","article-title":"A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome.","volume":"27","author":"J Guy","year":"2001","journal-title":"Nat Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/85906","article-title":"Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice.","volume":"27","author":"RZ Chen","year":"2001","journal-title":"Nat Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/brain\/awl022","article-title":"Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice.","volume":"129","author":"GJ Pelka","year":"2006","journal-title":"Brain"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"6033","DOI":"10.1073\/pnas.0401626101","article-title":"Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice.","volume":"101","author":"S Luikenhuis","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.nbd.2005.07.005","article-title":"Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome.","volume":"21","author":"Y Asaka","year":"2006","journal-title":"Neurobiol Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1523\/JNEUROSCI.2623-05.2006","article-title":"Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome.","volume":"26","author":"P Moretti","year":"2006","journal-title":"J Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"12560","DOI":"10.1073\/pnas.0506071102","article-title":"Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome.","volume":"102","author":"VS Dani","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.cub.2006.02.062","article-title":"MeCP2-dependent transcriptional repression regulates excitatory neurotransmission.","volume":"16","author":"ED Nelson","year":"2006","journal-title":"Curr Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuron.2007.08.018","article-title":"MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number.","volume":"56","author":"HT Chao","year":"2007","journal-title":"Neuron"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1126\/science.1086446","article-title":"Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2.","volume":"302","author":"WG Chen","year":"2003","journal-title":"Science"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1126\/science.1090842","article-title":"DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation.","volume":"302","author":"K Martinowich","year":"2003","journal-title":"Science"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.1153252","article-title":"MeCP2, a key contributor to neurological disease, activates and represses transcription.","volume":"320","author":"M Chahrour","year":"2008","journal-title":"Science"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neuron.2006.09.037","article-title":"Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation.","volume":"52","author":"Z Zhou","year":"2006","journal-title":"Neuron"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1111\/j.1582-4934.2008.00377.x","article-title":"DLX5 expression is monoallelic and Dlx5 is up-regulated in the Mecp2-null frontal cortex.","volume":"12","author":"M Miyano","year":"2008","journal-title":"J Cell Mol Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1093\/hmg\/ddm007","article-title":"FXYD1 is an MeCP2 target gene overexpressed in the brains of Rett syndrome patients and Mecp2-null mice.","volume":"16","author":"V Deng","year":"2007","journal-title":"Hum Mol Genet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/mrdd.20017","article-title":"Environmental complexity and central nervous system development and function.","volume":"10","author":"MH Lewis","year":"2004","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/ana.10094","article-title":"Environmental enrichment slows disease progression in R6\/2 Huntington&apos;s disease mice.","volume":"51","author":"E Hockly","year":"2002","journal-title":"Ann Neurol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/35008142","article-title":"Delaying the onset of Huntington&apos;s in mice.","volume":"404","author":"DA van","year":"2000","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.cell.2005.01.015","article-title":"Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice.","volume":"120","author":"O Lazarov","year":"2005","journal-title":"Cell"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1111\/j.1460-9568.2008.06305.x","article-title":"Environmental enrichment ameliorates a motor coordination deficit in a mouse model of Rett syndrome\u2014Mecp2 gene dosage effects and BDNF expression.","volume":"27","author":"M Kondo","year":"2008","journal-title":"Eur J Neurosci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbr.2008.07.008","article-title":"Environmental enrichment alters locomotor behaviour and ventricular volume in Mecp2 1lox mice.","volume":"196","author":"N Nag","year":"2009","journal-title":"Behav Brain Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.neuroscience.2007.02.009","article-title":"Behavioral and anatomical abnormalities in Mecp2 mutant mice: a model for Rett syndrome.","volume":"146","author":"NA Stearns","year":"2007","journal-title":"Neuroscience"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bbr.2006.07.030","article-title":"Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains.","volume":"176","author":"SS Moy","year":"2007","journal-title":"Behav Brain Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.1138389","article-title":"Reversal of neurological defects in a mouse model of Rett syndrome.","volume":"315","author":"J Guy","year":"2007","journal-title":"Science"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1073\/pnas.0610593104","article-title":"Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2.","volume":"104","author":"E Giacometti","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1093\/hmg\/ddm185","article-title":"Cell-specific expression of wild-type MeCP2 in mouse models of Rett syndrome yields insight about pathogenesis.","volume":"16","author":"M Alvarez-Saavedra","year":"2007","journal-title":"Hum Mol Genet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nn.2275","article-title":"Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology.","volume":"12","author":"N Ballas","year":"2009","journal-title":"Nat Neurosci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1111\/1469-7610.00236","article-title":"The Rett Syndrome Behaviour Questionnaire (RSBQ): refining the behavioural phenotype of Rett syndrome.","volume":"43","author":"RH Mount","year":"2002","journal-title":"J Child Psychol Psychiatry"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"18267","DOI":"10.1073\/pnas.0608702103","article-title":"Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome.","volume":"103","author":"BE McGill","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.nlm.2004.02.002","article-title":"Environmental enrichment results in cortical and subcortical changes in levels of synaptophysin and PSD-95 proteins.","volume":"81","author":"J Nithianantharajah","year":"2004","journal-title":"Neurobiol Learn Mem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.tins.2008.12.004","article-title":"Enrich the environment to empower the brain.","volume":"32","author":"A Sale","year":"2009","journal-title":"Trends Neurosci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nature05772","article-title":"Recovery of learning and memory is associated with chromatin remodelling.","volume":"447","author":"A Fischer","year":"2007","journal-title":"Nature"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nature01273","article-title":"Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex.","volume":"420","author":"JT Trachtenberg","year":"2002","journal-title":"Nature"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0011534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T16:06:35Z","timestamp":1540224395000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0011534"}},"subtitle":[],"editor":[{"given":"Katrina","family":"Gwinn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,7,12]]},"references-count":37,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2010,7,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0011534","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,12]]}}}