{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:07:15Z","timestamp":1791050835862,"version":"4.1.0"},"reference-count":110,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T00:00:00Z","timestamp":1279238400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0011561","type":"journal-article","created":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T20:30:07Z","timestamp":1279312207000},"page":"e11561","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":41,"title":["Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome"],"prefix":"10.1371","volume":"5","author":[{"given":"Chelsee A.","family":"Hewitt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"King-Hwa","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias D.","family":"Merson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken M.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew E.","family":"Ritchie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie A.","family":"Pritchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon K.","family":"Smyth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamish S.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne K.","family":"Voss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,7,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/S0140-6736(03)12987-X","article-title":"Down&apos;s syndrome.","volume":"361","author":"NJ Roizen","year":"2003","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/1098-2779(2000)6:2<84::AID-MRDD2>3.0.CO;2-P","article-title":"Behavioral phenotype of individuals with Down syndrome.","volume":"6","author":"RS Chapman","year":"2000","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/mrdd.20156","article-title":"Down syndrome: cognitive phenotype.","volume":"13","author":"W Silverman","year":"2007","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.molmed.2006.08.005","article-title":"The challenge of Down syndrome.","volume":"12","author":"SE Antonarakis","year":"2006","journal-title":"Trends Mol Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1001\/archneur.1997.00550140077016","article-title":"Cerebellar volume in adults with Down syndrome.","volume":"54","author":"EH Aylward","year":"1997","journal-title":"Arch Neurol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1176\/ajp.156.4.564","article-title":"MRI volumes of the hippocampus and amygdala in adults with Down&apos;s syndrome with and without dementia.","volume":"156","author":"EH Aylward","year":"1999","journal-title":"Am J Psychiatry"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/00005072-199009000-00006","article-title":"Small cerebral hemispheres in adults with Down&apos;s syndrome: contributions of developmental arrest and lesions of Alzheimer&apos;s disease.","volume":"49","author":"SM de la Monte","year":"1990","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1001\/archneur.1993.00540020062019","article-title":"Cerebral morphologic distinctions between Williams and Down syndromes.","volume":"50","author":"TL Jernigan","year":"1993","journal-title":"Arch Neurol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1212\/WNL.56.7.972","article-title":"Amygdala and hippocampal volumes in children with Down syndrome: a high-resolution MRI study.","volume":"56","author":"JD Pinter","year":"2001","journal-title":"Neurology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1176\/appi.ajp.158.10.1659","article-title":"Neuroanatomy of Down&apos;s syndrome: a high-resolution MRI study.","volume":"158","author":"JD Pinter","year":"2001","journal-title":"Am J Psychiatry"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1212\/WNL.45.2.356","article-title":"Selective neuroanatomic abnormalities in Down&apos;s syndrome and their cognitive correlates: evidence from MRI morphometry.","volume":"45","author":"N Raz","year":"1995","journal-title":"Neurology"},{"key":"ref12","first-page":"181","article-title":"Brain growth in Down syndrome subjects 15 to 22 weeks of gestational age and birth to 60 months.","volume":"9","author":"B Schmidt-Sidor","year":"1990","journal-title":"Clin Neuropathol"},{"key":"ref13","first-page":"227","article-title":"The hippocampus in Down&apos;s syndrome.","volume":"27 (Pt 3)","author":"PE Sylvester","year":"1983","journal-title":"J Ment Defic Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1148\/radiology.214.2.r00fe40533","article-title":"Cerebellar and frontal lobe hypoplasia in fetuses with trisomy 21: usefulness as combined US markers.","volume":"214","author":"TC Winter","year":"2000","journal-title":"Radiology"},{"key":"ref15","first-page":"274","article-title":"Down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis.","volume":"Suppl 7","author":"KE Wisniewski","year":"1990","journal-title":"Am J Med Genet"},{"key":"ref16","first-page":"133","article-title":"Growth and development of the brain in Down syndrome.","volume":"373","author":"L Becker","year":"1991","journal-title":"Prog Clin Biol Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/ana.410200413","article-title":"Dendritic atrophy in children with Down&apos;s syndrome.","volume":"20","author":"LE Becker","year":"1986","journal-title":"Ann Neurol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.pneurobio.2004.08.001","article-title":"On dendrites in Down syndrome and DS murine models: a spiny way to learn.","volume":"74","author":"R Benavides-Piccione","year":"2004","journal-title":"Prog Neurobiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1007\/BF00294247","article-title":"Down&apos;s syndrome and Alzheimer&apos;s disease: dendritic spine counts in the hippocampus.","volume":"79","author":"I Ferrer","year":"1990","journal-title":"Acta Neuropathol"},{"key":"ref20","first-page":"159","article-title":"Neurologic abnormalities.","author":"J Florez","year":"1992"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/00005072-199409000-00011","article-title":"Development of the superior temporal neocortex is anomalous in trisomy 21.","volume":"53","author":"JA Golden","year":"1994","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/cne.901670105","article-title":"Pyramidal cell abnormalities in the motor cortex of a child with Down&apos;s syndrome. A Golgi study.","volume":"167","author":"M Marin-Padilla","year":"1976","journal-title":"J Comp Neurol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0387-7604(89)80082-8","article-title":"Dendrites, dementia and the Down syndrome.","volume":"11","author":"S Takashima","year":"1989","journal-title":"Brain Dev"},{"key":"ref24","first-page":"59","article-title":"Fetal life in Down syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure.","volume":"Suppl","author":"R Weitzdoerfer","year":"2001","journal-title":"J Neural Transm"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00439-009-0696-8","article-title":"Molecular genetic analysis of Down syndrome.","volume":"126","author":"D Patterson","year":"2009","journal-title":"Hum Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/0361-9230(86)90076-6","article-title":"Genetic basis for a mouse model of Down syndrome.","volume":"16","author":"RH Reeves","year":"1986","journal-title":"Brain Res Bull"},{"key":"ref27","first-page":"263","article-title":"Segmental trisomy of murine chromosome 16: a new model system for studying Down syndrome.","volume":"360","author":"MT Davisson","year":"1990","journal-title":"Prog Clin Biol Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"6256","DOI":"10.1073\/pnas.95.11.6256","article-title":"Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities.","volume":"95","author":"H Sago","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/0361-9230(86)90075-4","article-title":"Autosomal aneuploidy in mice: generation and developmental consequences.","volume":"16","author":"JD Gearhart","year":"1986","journal-title":"Brain Res Bull"},{"key":"ref30","first-page":"169","article-title":"Morphogenesis of the brain and craniofacial complex in trisomy 16 mice.","volume":"373","author":"H Grausz","year":"1991","journal-title":"Prog Clin Biol Res"},{"key":"ref31","first-page":"293","article-title":"The neuropathology of the trisomy 16 mouse.","volume":"8","author":"ML Lacey-Casem","year":"1994","journal-title":"Crit Rev Neurobiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0166-4328(97)00116-2","article-title":"Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice.","volume":"90","author":"GE Demas","year":"1998","journal-title":"Behav Brain Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0304-3940(95)12052-6","article-title":"A behavioral assessment of Ts65Dn mice: a putative Down syndrome model.","volume":"199","author":"RM Escorihuela","year":"1995","journal-title":"Neurosci Lett"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0304-3940(98)00317-6","article-title":"Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome.","volume":"247","author":"RM Escorihuela","year":"1998","journal-title":"Neurosci Lett"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"13333","DOI":"10.1073\/pnas.93.23.13333","article-title":"Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome.","volume":"93","author":"DM Holtzman","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0006-8993(02)02500-3","article-title":"Reactivity to object and spatial novelty is normal in older Ts65Dn mice that model Down syndrome and Alzheimer&apos;s disease.","volume":"945","author":"LA Hyde","year":"2002","journal-title":"Brain Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0166-4328(00)00313-2","article-title":"Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function.","volume":"118","author":"LA Hyde","year":"2001","journal-title":"Behav Brain Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/(SICI)1097-0177(200002)217:2<137::AID-DVDY1>3.0.CO;2-N","article-title":"Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice.","volume":"217","author":"JT Richtsmeier","year":"2000","journal-title":"Dev Dyn"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/ajmg.10175","article-title":"Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome.","volume":"107","author":"JT Richtsmeier","year":"2002","journal-title":"Am J Med Genet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1203\/00006450-200011000-00009","article-title":"Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome.","volume":"48","author":"H Sago","year":"2000","journal-title":"Pediatr Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.brainres.2006.05.022","article-title":"Hippocampal hypocellularity in the Ts65Dn mouse originates early in development.","volume":"1104","author":"HA Lorenzi","year":"2006","journal-title":"Brain Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1006\/exnr.1999.7289","article-title":"Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down&apos;s syndrome.","volume":"161","author":"AC Granholm","year":"2000","journal-title":"Exp Neurol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuron.2006.05.022","article-title":"Increased App expression in a mouse model of Down&apos;s syndrome disrupts NGF transport and causes cholinergic neuron degeneration.","volume":"51","author":"A Salehi","year":"2006","journal-title":"Neuron"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"11483","DOI":"10.1523\/JNEUROSCI.3406-07.2007","article-title":"Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome.","volume":"27","author":"L Chakrabarti","year":"2007","journal-title":"J Neurosci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000082142","article-title":"Concurrent generation of subplate and cortical plate neurons in developing trisomy 16 mouse cortex.","volume":"26","author":"A Cheng","year":"2004","journal-title":"Dev Neurosci"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.expneurol.2006.02.005","article-title":"Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome.","volume":"200","author":"S Clark","year":"2006","journal-title":"Exp Neurol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1750-3639.2008.00168.x","article-title":"Cell Cycle Elongation Impairs Proliferation of Cerebellar Granule Cell Precursors in the Ts65Dn Mouse, an Animal Model for Down Syndrome.","volume":"19","author":"A Contestabile","year":"2008","journal-title":"Brain Pathol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/hipo.20308","article-title":"Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice.","volume":"17","author":"A Contestabile","year":"2007","journal-title":"Hippocampus"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1750-3639.2007.00113.x","article-title":"Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome.","volume":"18","author":"S Guidi","year":"2008","journal-title":"Brain Pathol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"6175","DOI":"10.1523\/JNEUROSCI.16-19-06175.1996","article-title":"Consequences of trisomy 16 for mouse brain development: corticogenesis in a model of Down syndrome.","volume":"16","author":"TF Haydar","year":"1996","journal-title":"J Neurosci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"4156","DOI":"10.1523\/JNEUROSCI.20-11-04156.2000","article-title":"Role of founder cell deficit and delayed neuronogenesis in microencephaly of the trisomy 16 mouse.","volume":"20","author":"TF Haydar","year":"2000","journal-title":"J Neurosci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1073\/pnas.0510750103","article-title":"Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice.","volume":"103","author":"RJ Roper","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.neulet.2005.01.039","article-title":"Cell proliferation is reduced in the dentate gyrus of aged but not young Ts65Dn mice, a model of Down syndrome.","volume":"380","author":"N Rueda","year":"2005","journal-title":"Neurosci Lett"},{"key":"ref54","article-title":"Enlarged Brain Ventricles and Impaired Neurogenesis in the Ts1Cje and Ts2Cje Mouse Models of Down Syndrome.","author":"K Ishihara","year":"2009"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1002\/jnr.22131","article-title":"Proliferation deficits and gene expression dysregulation in Down&apos;s syndrome (Ts1Cje) neural progenitor cells cultured from neurospheres.","volume":"87","author":"RX Moldrich","year":"2009","journal-title":"J Neurosci Res"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1126\/science.1553558","article-title":"Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.","volume":"255","author":"BA Reynolds","year":"1992","journal-title":"Science"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"8591","DOI":"10.1073\/pnas.89.18.8591","article-title":"De novo generation of neuronal cells from the adult mouse brain.","volume":"89","author":"LJ Richards","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.8178174","article-title":"Long-distance neuronal migration in the adult mammalian brain.","volume":"264","author":"C Lois","year":"1994","journal-title":"Science"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0896-6273(93)90281-U","article-title":"Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone.","volume":"11","author":"MB Luskin","year":"1993","journal-title":"Neuron"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S0896-6273(00)80130-0","article-title":"Neuronal chain gangs: homotypic contacts support migration into the olfactory bulb.","volume":"16","author":"NA O'Rourke","year":"1996","journal-title":"Neuron"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","article-title":"DAVID: Database for Annotation, Visualization, and Integrated Discovery.","volume":"4","author":"G Dennis Jr","year":"2003","journal-title":"Genome Biol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1242\/dev.125.12.2251","article-title":"In vivo clonal analyses reveal the properties of endogenous neural stem cell proliferation in the adult mammalian forebrain.","volume":"125","author":"CM Morshead","year":"1998","journal-title":"Development"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/BF01190834","article-title":"Bromodeoxyuridine immunohistochemical determination of the lengths of the cell cycle and the DNA-synthetic phase for an anatomically defined population.","volume":"18","author":"RS Nowakowski","year":"1989","journal-title":"J Neurocytol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1523\/JNEUROSCI.12-01-00249.1992","article-title":"Postmitotic death is the fate of constitutively proliferating cells in the subependymal layer of the adult mouse brain.","volume":"12","author":"CM Morshead","year":"1992","journal-title":"J Neurosci"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF01194977","article-title":"BUdR as an S-phase marker for quantitative studies of cytokinetic behaviour in the murine cerebral ventricular zone.","volume":"21","author":"T Takahashi","year":"1992","journal-title":"J Neurocytol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/dbio.1996.0090","article-title":"Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell.","volume":"175","author":"BA Reynolds","year":"1996","journal-title":"Dev Biol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0165-3806(98)00070-4","article-title":"Cytoplasmic abnormalities in cultured cerebellar neurons from the trisomy 16 mouse.","volume":"109","author":"ET Bersu","year":"1998","journal-title":"Brain Res Dev Brain Res"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0169-328X(90)90037-E","article-title":"Increased number of somatostatin-immunoreactive neurons in primary cultures of trisomy 16 mouse neocortex.","volume":"7","author":"MT Caserta","year":"1990","journal-title":"Brain Res Mol Brain Res"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1093\/cercor\/13.7.758","article-title":"Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment.","volume":"13","author":"M Dierssen","year":"2003","journal-title":"Cereb Cortex"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0165-0173(02)00158-3","article-title":"Dendritic spine pathology: cause or consequence of neurological disorders?","volume":"39","author":"JC Fiala","year":"2002","journal-title":"Brain Res Brain Res Rev"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1002\/hipo.10130","article-title":"Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome.","volume":"13","author":"AC Granholm","year":"2003","journal-title":"Hippocampus"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1126\/science.288.5471.1643","article-title":"Uninterrupted MCM2-7 function required for DNA replication fork progression.","volume":"288","author":"K Labib","year":"2000","journal-title":"Science"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.molcel.2006.01.030","article-title":"Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication.","volume":"21","author":"M Pacek","year":"2006","journal-title":"Mol Cell"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1006\/geno.1995.1155","article-title":"Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12.","volume":"28","author":"A Shiratori","year":"1995","journal-title":"Genomics"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1126\/science.1102574","article-title":"Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2.","volume":"306","author":"MJ Daniels","year":"2004","journal-title":"Science"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"5864","DOI":"10.1038\/sj.onc.1209874","article-title":"The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability.","volume":"25","author":"K Gudmundsdottir","year":"2006","journal-title":"Oncogene"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1091\/mbc.E07-06-0556","article-title":"CENP-O class proteins form a stable complex and are required for proper kinetochore function.","volume":"19","author":"T Hori","year":"2008","journal-title":"Mol Biol Cell"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.biolcel.2003.09.008","article-title":"Aurora A, meiosis and mitosis.","volume":"96","author":"R Crane","year":"2004","journal-title":"Biol Cell"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1083\/jcb.200108051","article-title":"Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans.","volume":"155","author":"E Hannak","year":"2001","journal-title":"J Cell Biol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S0140-6736(02)07497-4","article-title":"Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down&apos;s syndrome: a gene expression study.","volume":"359","author":"S Bahn","year":"2002","journal-title":"Lancet"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ajhg.2008.08.012","article-title":"DYRK1A-dosage imbalance perturbs NRSF\/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome.","volume":"83","author":"C Canzonetta","year":"2008","journal-title":"Am J Hum Genet"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.expneurol.2006.12.025","article-title":"Gene expression changes in long term expanded human neural progenitor cells passaged by chopping lead to loss of neurogenic potential in vivo.","volume":"204","author":"L Anderson","year":"2007","journal-title":"Exp Neurol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.mcn.2005.08.003","article-title":"The cellular fate of cortical progenitors is not maintained in neurosphere cultures.","volume":"30","author":"O Machon","year":"2005","journal-title":"Mol Cell Neurosci"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1046\/j.1460-9568.2003.02824.x","article-title":"The in vivo positional identity gene expression code is not preserved in neural stem cells grown in culture.","volume":"18","author":"J Santa-Olalla","year":"2003","journal-title":"Eur J Neurosci"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/j.1460-9568.2008.06092.x","article-title":"The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb\/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development.","volume":"27","author":"B Hammerle","year":"2008","journal-title":"Eur J Neurosci"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/jnen\/63.5.429","article-title":"Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration.","volume":"63","author":"I Branchi","year":"2004","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.1074\/jbc.M310794200","article-title":"Characterization of cyclin L2, a novel cyclin with an arginine\/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors.","volume":"279","author":"K de Graaf","year":"2004","journal-title":"J Biol Chem"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1093\/cercor\/13.6.592","article-title":"Cell output, cell cycle duration and neuronal specification: a model of integrated mechanisms of the neocortical proliferative process.","volume":"13","author":"VS Caviness Jr","year":"2003","journal-title":"Cereb Cortex"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1101\/gad.377106","article-title":"p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex.","volume":"20","author":"L Nguyen","year":"2006","journal-title":"Genes Dev"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1007\/s00018-009-0123-2","article-title":"Function and regulation of Dyrk1A: towards understanding Down syndrome.","volume":"66","author":"J Park","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ajhg.2008.09.010","article-title":"Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome.","volume":"83","author":"J Ortiz-Abalia","year":"2008","journal-title":"Am J Hum Genet"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1038\/sj.npp.1301535","article-title":"Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test.","volume":"33","author":"AC Costa","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nn1860","article-title":"Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.","volume":"10","author":"F Fernandez","year":"2007","journal-title":"Nat Neurosci"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.expneurol.2008.11.021","article-title":"Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model.","volume":"216","author":"J Lockrow","year":"2009","journal-title":"Exp Neurol"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neulet.2007.12.039","article-title":"Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome.","volume":"433","author":"N Rueda","year":"2008","journal-title":"Neurosci Lett"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"597","DOI":"10.2217\/14622416.8.6.597","article-title":"High-resolution DNA melting analysis for simple and efficient molecular diagnostics.","volume":"8","author":"GH Reed","year":"2007","journal-title":"Pharmacogenomics"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1198\/016214504000000683","article-title":"A Model Based Background Adjustment for Oligonucleotide Expression Arrays.","volume":"99","author":"Z Wu","year":"2004","journal-title":"J Amer Stat Assoc"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"Article3","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical bayes methods for assessing differential expression in microarray experiments.","volume":"3","author":"GK Smyth","year":"2004","journal-title":"Stat Appl Genet Mol Biol"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: a Practical and Powerful Approach to Multiple Testing.","volume":"57","author":"Y Benjamini","year":"1995","journal-title":"J R Statist Soc"},{"key":"ref100","first-page":"397","article-title":"Limma: linear models for microarray data.","author":"GK Smyth","year":"2005"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1467-9868.2005.00515.x","article-title":"Estimating the proportion of true null hypotheses, with application to DNA microarray data.","volume":"67","author":"M Langaas","year":"2005","journal-title":"Journal of the Royal Statistical Society Series B (Statistical Methodology)"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"11359","DOI":"10.1523\/JNEUROSCI.2247-06.2006","article-title":"The transcriptional coactivator Querkopf controls adult neurogenesis.","volume":"26","author":"TD Merson","year":"2006","journal-title":"J Neurosci"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/35089085","article-title":"Purification of a pluripotent neural stem cell from the adult mouse brain.","volume":"412","author":"RL Rietze","year":"2001","journal-title":"Nature"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1242\/dev.117.1.253","article-title":"Capacity to form choroid plexus-like cells in vitro is restricted to specific regions of the mouse neural ectoderm.","volume":"117","author":"T Thomas","year":"1993","journal-title":"Development"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1038\/sj.emboj.7601234","article-title":"C3G regulates the size of the cerebral cortex neural precursor population.","volume":"25","author":"AK Voss","year":"2006","journal-title":"Embo J"},{"key":"ref106","first-page":"37","article-title":"Quantitative histology of Wallerian degeneration: I. Nuclear population in rabbit sciatic nerve.","volume":"80","author":"M Abercrombie","year":"1946","journal-title":"J Anat"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1242\/dev.127.12.2537","article-title":"Querkopf, a MYST family histone acetyltransferase, is required for normal cerebral cortex development.","volume":"127","author":"T Thomas","year":"2000","journal-title":"Development"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nmeth741","article-title":"Stem cell proliferative history in tissue revealed by temporal halogenated thymidine analog discrimination.","volume":"2","author":"CJ Vega","year":"2005","journal-title":"Nat Methods"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"5449","DOI":"10.1242\/dev.127.24.5449","article-title":"Taube nuss is a novel gene essential for the survival of pluripotent cells of early mouse embryos.","volume":"127","author":"AK Voss","year":"2000","journal-title":"Development"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"14895","DOI":"10.1073\/pnas.93.25.14895","article-title":"Network of tangential pathways for neuronal migration in adult mammalian brain.","volume":"93","author":"F Doetsch","year":"1996","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0011561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T01:43:55Z","timestamp":1740275035000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0011561"}},"subtitle":[],"editor":[{"given":"Syed A.","family":"Aziz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,7,16]]},"references-count":110,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2010,7,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0011561","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,16]]}}}