{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:57:22Z","timestamp":1787021842930,"version":"build-2736575974"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2010,7,15]],"date-time":"2010-07-15T00:00:00Z","timestamp":1279152000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0011606","type":"journal-article","created":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T16:30:22Z","timestamp":1279297822000},"page":"e11606","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":47,"title":["Differential Regulation of the PGC Family of Genes in a Mouse Model of Staphylococcus aureus Sepsis"],"prefix":"10.1371","volume":"5","author":[{"given":"Timothy E.","family":"Sweeney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagir B.","family":"Suliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Hollingsworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude A.","family":"Piantadosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,7,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0092-8674(00)80611-X","article-title":"Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1.","volume":"98","author":"Z Wu","year":"1999","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1196\/annals.1427.006","article-title":"Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator.","volume":"1147","author":"RC Scarpulla","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S1097-2765(01)00390-2","article-title":"Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.","volume":"8","author":"P Puigserver","year":"2001","journal-title":"Mol Cell"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.cardiores.2004.07.005","article-title":"Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis.","volume":"64","author":"HB Suliman","year":"2004","journal-title":"Cardiovasc Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bbalip.2005.08.001","article-title":"Atorvastatin prevents peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cells.","volume":"1736","author":"A Planavila","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1164\/rccm.200701-161OC","article-title":"Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis.","volume":"176","author":"DW Haden","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1006\/abbi.1997.0264","article-title":"Oxidative metabolism in rat hepatocytes and mitochondria during sepsis.","volume":"345","author":"SP Kantrow","year":"1997","journal-title":"Arch Biochem Biophys"},{"key":"ref8","first-page":"219","article-title":"Cytopathic hypoxia. Mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis.","volume":"17","author":"MP Fink","year":"2001","journal-title":"Crit Care Clin"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.mito.2004.07.023","article-title":"Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome.","volume":"4","author":"ED Crouser","year":"2004","journal-title":"Mitochondrion"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.2174\/138161208784980572","article-title":"Sepsis: links between pathogen sensing and organ damage.","volume":"14","author":"E Crouser","year":"2008","journal-title":"Curr Pharm Des"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care.","volume":"29","author":"DC Angus","year":"2001","journal-title":"Crit Care Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/jcb.20743","article-title":"Nuclear control of respiratory gene expression in mammalian cells.","volume":"97","author":"RC Scarpulla","year":"2006","journal-title":"J Cell Biochem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.bbrc.2009.08.062","article-title":"Toll-like receptors and innate immunity.","volume":"388","author":"H Kumar","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1074-7613(00)80119-3","article-title":"Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.","volume":"11","author":"O Takeuchi","year":"1999","journal-title":"Immunity"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1096\/fj.04-3500fje","article-title":"Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli.","volume":"19","author":"HB Suliman","year":"2005","journal-title":"FASEB J"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ymgme.2007.03.011","article-title":"Energizing miRNA research: a review of the role of miRNAs in lipid metabolism, with a prediction that miR-103\/107 regulates human metabolic pathways.","volume":"91","author":"BR Wilfred","year":"2007","journal-title":"Mol Genet Metab"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e5610","DOI":"10.1371\/journal.pone.0005610","article-title":"miRNA in the regulation of skeletal muscle adaptation to acute endurance exercise in C57Bl\/6J male mice.","volume":"4","author":"A Safdar","year":"2009","journal-title":"PLoS One"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00018-007-7355-9","article-title":"Functional aspects of animal microRNAs.","volume":"65","author":"AE Williams","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.4049\/jimmunol.162.7.3749","article-title":"Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product.","volume":"162","author":"K Hoshino","year":"1999","journal-title":"J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"4724","DOI":"10.1016\/S0021-9258(18)62854-6","article-title":"The metabolism of rat brain mitochondria. Preparation and characterization.","volume":"245","author":"JB Clark","year":"1970","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1101\/gr.3007205","article-title":"Mulan: multiple-sequence local alignment and visualization for studying function and evolution.","volume":"15","author":"I Ovcharenko","year":"2005","journal-title":"Genome Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.","volume":"120","author":"BP Lewis","year":"2005","journal-title":"Cell"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1006\/jmbi.1999.2700","article-title":"Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure.","volume":"288","author":"DH Mathews","year":"1999","journal-title":"J Mol Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1093\/nar\/gkg595","article-title":"Mfold web server for nucleic acid folding and hybridization prediction.","volume":"31","author":"M Zuker","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/jcb.21625","article-title":"Maintenance of mitochondrial DNA copy number and expression are essential for preservation of mitochondrial function and cell growth.","volume":"103","author":"JY Jeng","year":"2008","journal-title":"J Cell Biochem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"C572","DOI":"10.1152\/ajpcell.00481.2009","article-title":"PGC-1alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle.","volume":"298","author":"T Geng","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1152\/japplphysiol.01231.2007","article-title":"Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake.","volume":"104","author":"JA Calvo","year":"2008","journal-title":"J Appl Physiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.4049\/jimmunol.165.10.5392","article-title":"Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection.","volume":"165","author":"O Takeuchi","year":"2000","journal-title":"J Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"132","DOI":"10.2353\/ajpath.2008.070567","article-title":"Both TLR2 and TLR4 are required for the effective immune response in Staphylococcus aureus-induced experimental murine brain abscess.","volume":"172","author":"W Stenzel","year":"2008","journal-title":"Am J Pathol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1111\/j.1462-5822.2007.00965.x","article-title":"How important are Toll-like receptors for antimicrobial responses?","volume":"9","author":"S Carpenter","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/intimm\/dxp017","article-title":"The roles of TLRs, RLRs and NLRs in pathogen recognition.","volume":"21","author":"T Kawai","year":"2009","journal-title":"Int Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.coi.2009.01.005","article-title":"Regulation of the cytosolic DNA-sensing system in innate immunity: a current view.","volume":"21","author":"H Yanai","year":"2009","journal-title":"Curr Opin Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1210\/er.2006-0037","article-title":"Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism.","volume":"27","author":"C Handschin","year":"2006","journal-title":"Endocr Rev"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4161\/rna.6.1.7534","article-title":"MicroRNAs identified in highly purified liver-derived mitochondria may play a role in apoptosis.","volume":"6","author":"BT Kren","year":"2009","journal-title":"RNA Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1101\/gad.1661708","article-title":"Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart.","volume":"22","author":"L Lai","year":"2008","journal-title":"Genes Dev"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"21379","DOI":"10.1074\/jbc.M109.018911","article-title":"PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons.","volume":"284","author":"P Wareski","year":"2009","journal-title":"J Biol Chem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0011606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T20:43:55Z","timestamp":1740257035000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0011606"}},"subtitle":[],"editor":[{"given":"Frank R.","family":"DeLeo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,7,15]]},"references-count":36,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2010,7,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0011606","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,15]]}}}