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Cardiol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/S0022-2275(20)31498-X","article-title":"Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis.","volume":"42","author":"AD Attie","year":"2001","journal-title":"J Lipid Res"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1161\/01.ATV.0000175756.56818.ee","article-title":"PPARalpha, but not PPARgamma, activators decrease macrophage-laden atherosclerotic lesions in a nondiabetic mouse model of mixed dyslipidemia.","volume":"25","author":"N Hennuyer","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1124\/pr.59.3.1","article-title":"Membrane prostaglandin E synthase-1: a novel therapeutic target.","volume":"59","author":"B Samuelsson","year":"2007","journal-title":"Pharmacol Rev"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1161\/01.ATV.0000133192.39901.be","article-title":"Balance between PGD synthase and PGE synthase is a major determinant of atherosclerotic plaque instability in humans.","volume":"24","author":"F Cipollone","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref90","article-title":"Dengue guidelines for diagnosis, treatment, prevention and control: new edition","year":"2009"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1158\/1078-0432.CCR-06-2940","article-title":"Gene expression signatures predict outcome in non-muscle-invasive bladder carcinoma: a multicenter validation study.","volume":"13","author":"L Dyrskjot","year":"2007","journal-title":"Clin Cancer Res"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1073\/pnas.252784499","article-title":"Individuality and variation in gene expression patterns in human blood.","volume":"100","author":"AR Whitney","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1152\/physiolgenomics.00080.2005","article-title":"Variation in gene expression profiles of peripheral blood mononuclear cells from healthy volunteers.","volume":"22","author":"JJ Eady","year":"2005","journal-title":"Physiol Genomics"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.2353\/ajpath.2007.060872","article-title":"Pathophysiology of sepsis.","volume":"170","author":"DG Remick","year":"2007","journal-title":"Am J Pathol"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.injury.2007.10.003","article-title":"Systemic inflammation after trauma.","volume":"38","author":"A Lenz","year":"2007","journal-title":"Injury"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1574-695X.2007.00273.x","article-title":"Dengue virus-specific suppressor T cells: current perspectives.","volume":"50","author":"UC Chaturvedi","year":"2007","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1086\/314680","article-title":"Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity.","volume":"179","author":"S Green","year":"1999","journal-title":"J Infect Dis"},{"key":"ref98","first-page":"CD003488","article-title":"Corticosteroids for treating dengue shock syndrome.","volume":"3","author":"R Panpanich","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.trstmh.2008.07.022","article-title":"Corticosteroids in the treatment of dengue illness.","volume":"103","author":"S Rajapakse","year":"2009","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1186\/cc8211","article-title":"Matrix metalloproteinases and their inhibitors as biomarkers of severity in sepsis.","volume":"14","author":"L Lorente","year":"2010","journal-title":"Crit Care"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1161\/01.RES.0000126921.29919.51","article-title":"Proteoglycans in atherosclerosis and restenosis: key roles for versican.","volume":"94","author":"TN Wight","year":"2004","journal-title":"Circ Res"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/bja\/aeh163","article-title":"Physiology of the endothelium.","volume":"93","author":"HF Galley","year":"2004","journal-title":"Br J Anaesth"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.bcp.2007.07.004","article-title":"Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease.","volume":"75","author":"JD Raffetto","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1189\/jlb.1008647","article-title":"The endogenous Toll-like receptor 4 agonist S100A8\/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer.","volume":"86","author":"JM Ehrchen","year":"2009","journal-title":"J Leukoc Biol"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.it.2007.06.002","article-title":"Neutrophil granules: a library of innate immunity proteins.","volume":"28","author":"N Borregaard","year":"2007","journal-title":"Trends Immunol"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"H1817","DOI":"10.1152\/ajpheart.00472.2008","article-title":"Human neutrophil peptides: a novel potential mediator of inflammatory cardiovascular diseases.","volume":"295","author":"K Quinn","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref107","first-page":"246","article-title":"Dengue virus and endothelial cell: a related phenomenon to thrombocytopenia and granulocytopenia in dengue hemorrhagic fever.","volume":"24","author":"P Butthep","year":"1993","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.4049\/jimmunol.173.10.5901","article-title":"TLR signaling: an emerging bridge from innate immunity to atherogenesis.","volume":"173","author":"KS Michelsen","year":"2004","journal-title":"J Immunol"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1172\/JCI200525102","article-title":"Inflammation, stress, and diabetes.","volume":"115","author":"KE Wellen","year":"2005","journal-title":"J Clin Invest"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/112_2008_802","article-title":"Lipid homeostasis in macrophages - implications for atherosclerosis.","volume":"160","author":"G Schmitz","year":"2008","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1111\/j.1572-0241.2006.00543.x","article-title":"Resistin serum levels are associated with insulin resistance, disease severity, clinical complications, and prognosis in patients with chronic liver diseases.","volume":"101","author":"E Yagmur","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1086\/339539","article-title":"Changes in the plasma lipid profile as a potential predictor of clinical outcome in dengue hemorrhagic fever.","volume":"34","author":"EC van Gorp","year":"2002","journal-title":"Clin Infect Dis"},{"key":"ref113","article-title":"Different patterns of oxidized lipid products in plasma and urine of dengue fever, stroke and Parkinsons disease patients.","author":"CY Lee","year":"2008"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/09537100802155284","article-title":"Oxidative stress in severe dengue viral infection: association of thrombocytopenia with lipid peroxidation.","volume":"19","author":"R Soundravally","year":"2008","journal-title":"Platelets"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/j.1365-3156.2009.02261.x","article-title":"Serum lipid profile: a predictor of clinical outcome in dengue infection.","volume":"14","author":"JC Suvarna","year":"2009","journal-title":"Trop Med Int Health"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ccc.2005.08.008","article-title":"Dyslipidemia in the critically ill.","volume":"22","author":"PE Marik","year":"2006","journal-title":"Crit Care Clin"},{"key":"ref117","first-page":"305","article-title":"Forget glucose: what about lipids in critical illness?","volume":"11","author":"PS Kruger","year":"2009","journal-title":"Crit Care Resusc"},{"key":"ref118","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.virol.2009.03.025","article-title":"Cholesterol biosynthesis modulation regulates dengue viral replication.","volume":"389","author":"C Rothwell","year":"2009","journal-title":"Virology"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1086\/315215","article-title":"Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity.","volume":"181","author":"DW Vaughn","year":"2000","journal-title":"J Infect Dis"},{"key":"ref120","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/(SICI)1096-9071(200004)60:4<432::AID-JMV11>3.0.CO;2-7","article-title":"Prospective study of the duration and magnitude of viraemia in children hospitalised during the 1996\u20131997 dengue-2 outbreak in French Polynesia.","volume":"60","author":"B Murgue","year":"2000","journal-title":"J Med Virol"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/tropej\/45.1.4","article-title":"Status of antioxidants and other biochemical abnormalities in children with dengue fever.","volume":"45","author":"G Ray","year":"1999","journal-title":"J Trop Pediatr"},{"key":"ref122","first-page":"378","article-title":"Is dengue severity related to nutritional status?","volume":"36","author":"S Kalayanarooj","year":"2005","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"ref123","doi-asserted-by":"crossref","first-page":"370","DOI":"10.4269\/ajtmh.2005.72.370","article-title":"Association between sex, nutritional status, severity of dengue hemorrhagic fever, and immune status in infants with dengue hemorrhagic fever.","volume":"72","author":"TH Nguyen","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"ref124","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1371\/journal.pmed.0040115","article-title":"Malnutrition and infection: complex mechanisms and global impacts.","volume":"4","author":"UE Schaible","year":"2007","journal-title":"PLoS Med"},{"key":"ref125","doi-asserted-by":"crossref","first-page":"6498","DOI":"10.4049\/jimmunol.169.11.6498","article-title":"Lipopolysaccharide-induced leukocyte lipid body formation in vivo: innate immunity elicited intracellular Loci involved in eicosanoid metabolism.","volume":"169","author":"P Pacheco","year":"2002","journal-title":"J Immunol"},{"key":"ref126","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.4049\/jimmunol.171.4.2090","article-title":"Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes.","volume":"171","author":"EF de Assis","year":"2003","journal-title":"J Immunol"},{"key":"ref127","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1365-3083.2009.02255.x","article-title":"Innate immune responses to danger signals in systemic inflammatory response syndrome and sepsis.","volume":"69","author":"A Castellheim","year":"2009","journal-title":"Scand J Immunol"},{"key":"ref128","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.coi.2005.06.002","article-title":"Alarmins: chemotactic activators of immune responses.","volume":"17","author":"JJ Oppenheim","year":"2005","journal-title":"Curr Opin Immunol"},{"key":"ref129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.0306164","article-title":"DAMPs, PAMPs and alarmins: all we need to know about danger.","volume":"81","author":"ME Bianchi","year":"2007","journal-title":"J Leukoc Biol"},{"key":"ref130","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/CCM.0b013e31819267fb","article-title":"Molecular biology of inflammation and sepsis: a primer.","volume":"37","author":"I Cinel","year":"2009","journal-title":"Crit Care Med"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2174\/156652410790963358","article-title":"Approaching clinical reality: markers for monitoring systemic inflammation and sepsis.","volume":"10","author":"RA Claus","year":"2010","journal-title":"Curr Mol Med"},{"key":"ref132","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.freeradbiomed.2010.01.006","article-title":"Linking oxidative stress to inflammation: Toll-like receptors.","volume":"48","author":"R Gill","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"ref133","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1073\/pnas.0506803102","article-title":"Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria.","volume":"103","author":"FP Mockenhaupt","year":"2006","journal-title":"Proc Natl Acad Sci U S 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