{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:21:18Z","timestamp":1791141678793,"version":"4.1.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2010,8,24]],"date-time":"2010-08-24T00:00:00Z","timestamp":1282608000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0012365","type":"journal-article","created":{"date-parts":[[2010,8,24]],"date-time":"2010-08-24T19:51:15Z","timestamp":1282679475000},"page":"e12365","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":85,"title":["Production of TNF-\u03b1, IL-12(p40) and IL-17 Can Discriminate between Active TB Disease and Latent Infection in a West African Cohort"],"prefix":"10.1371","volume":"5","author":[{"given":"Jayne S.","family":"Sutherland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bouke C.","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Jeffries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifedayo M.","family":"Adetifa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin O. C.","family":"Ota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,8,24]]},"reference":[{"key":"ref1","article-title":"WHO 2008 Tuberculosis Facts."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.tube.2007.07.001","article-title":"Half-truths and selective memory: Interferon gamma, CD4+ T cells and protective memory against tuberculosis.","volume":"87","author":"L Goldsack","year":"2007","journal-title":"Tuberculosis"},{"key":"ref3","article-title":"Gamma interferon - key, but not sufficient for protection against TB?","author":"H Dockrell","year":"2007","journal-title":"Microbiol Today November"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1086\/529049","article-title":"T Cells and Tuberculosis: Beyond Interferon-gamma.","volume":"197","author":"A Lalvani","year":"2008","journal-title":"J Infect Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1056\/NEJMoa011110","article-title":"Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent.","volume":"345","author":"J Keane","year":"2001","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1086\/341314","article-title":"Human host defense and cytokines in mycobacterial infectious diseases: interleukin-18 cannot compensate for genetic defects in the interleukin-12 system.","volume":"35","author":"FA Verreck","year":"2002","journal-title":"Clin Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1440-1843.2005.00710.x","article-title":"Serum IL-18 levels in tuberculosis: comparison with pneumonia, lung cancer and healthy controls.","volume":"10","author":"M Akgun","year":"2005","journal-title":"Respirology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ni1449","article-title":"IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during <italic>Mycobacterium tuberculosis<\/italic> challenge.","volume":"8","author":"SA Khader","year":"2007","journal-title":"Nat Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1056\/NEJM199612263352602","article-title":"A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection.","volume":"335","author":"MJ Newport","year":"1996","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1574-695X.1997.tb01046.x","article-title":"Circulating profile of Th1 and Th2 cytokines in tuberculosis patients with different degrees of pulmonary involvement.","volume":"18","author":"D Dlugovitzky","year":"1997","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2249.2009.03875.x","article-title":"Differential cytokine secretion and early treatment response in patients with pulmonary tuberculosis.","volume":"156","author":"JF Djoba Siawaya","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"ref12","first-page":"753","article-title":"Ex vivo evaluation of PPD-specific IFN-\u03b3 or IL-5 secreting cells in the peripheral blood and lungs of patients with tuberculosis.","volume":"9","author":"M Morosini","year":"2005","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.4049\/jimmunol.180.3.1962","article-title":"Distinct, specific IL-17 and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response.","volume":"180","author":"TJ Scriba","year":"2008","journal-title":"J Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/44385","article-title":"Two subsets of memory T lymphocytes with distinct homing potentials and effector functions.","volume":"401","author":"F Sallusto","year":"1999","journal-title":"Nature"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1471-2334-7-83","article-title":"T-cell and serological responses to Erp, an exported Mycobacterium tuberculosis protein, in tuberculosis patients and healthy individuals.","volume":"7","author":"V Martinez","year":"2007","journal-title":"BMC Infect Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1128\/CVI.13.2.179-186.2006","article-title":"Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with <italic>Mycobacterium tuberculosis<\/italic>.","volume":"13","author":"A Demissie","year":"2006","journal-title":"Clin Vaccine Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/1471-2334-9-182","article-title":"New tools for detecting latent tuberculosis infection: evaluaton of RD1-specific long-term response.","volume":"9","author":"O Butera","year":"2009","journal-title":"BMC Infect Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1183\/09031936.00140009","article-title":"Response to Rv2628 latency antigen associates with cured tuberculosis and remote infection.","volume":"36","author":"D Goletti","year":"2009","journal-title":"Eur Respir J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1128\/CDLI.7.2.155-160.2000","article-title":"Diagnosis of tuberculosis based on the two specific antigens ESAT-6 and CFP10.","volume":"7","author":"LA van Pinxteren","year":"2000","journal-title":"Clin Diagn Lab Immunol 2000"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e9051","DOI":"10.1371\/journal.pone.0009051","article-title":"Role of QuantiFERON-TB Gold, Interferon Gamma Inducible Protein-10 and Tuberculin Skin Test in active tuberculosis diagnosis.","volume":"5","author":"B Syed Ahamed Kabeer","year":"2010","journal-title":"PLoS ONE"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3973","DOI":"10.4049\/jimmunol.179.6.3973","article-title":"Induction of CD8 T cells against a novel epitope in TB10.4: correlation with mycobacterial virulence and the presence of a functional region of difference-1.","volume":"179","author":"R Billeskov","year":"2007","journal-title":"J Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1086\/502977","article-title":"Mycobacterium africanum elicits an attenuated T cell response to early secreted antigenic target, 6 kDa, in patients with tuberculosis and their household contacts.","volume":"193","author":"BC de Jong","year":"2006","journal-title":"J Infect Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.4049\/jimmunol.177.3.1416","article-title":"Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection.","volume":"177","author":"A Cruz","year":"2006","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/eji.200838693","article-title":"Pattern and diversity of cytokine production differentiates between Mycobacterium tuberculosis infection and disease.","volume":"39","author":"JS Sutherland","year":"2009","journal-title":"Eur J Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1473-3099(09)70042-8","article-title":"Biomarkers for tuberculosis disease activity, cure, and relapse.","volume":"9","author":"R Wallis","year":"2009","journal-title":"Lancet Infect Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1471-2466-9-21","article-title":"Host markers in Quantiferon supernatants differentiate active TB from latent TB infection: preliminary report.","volume":"9","author":"NN Chegou","year":"2009","journal-title":"BMC Pulm Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1128\/CVI.00111-09","article-title":"Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa.","volume":"16","author":"GF Black","year":"2009","journal-title":"Clin Vaccine Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.drudis.2009.10.005","article-title":"The quest for biomarkers in tuberculosis.","volume":"15","author":"S Parida","year":"2010","journal-title":"Drug Disc Today"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1086\/591504","article-title":"Progression to active tuberculosis, but not transmission, varies by Mycobacterium tuberculosis lineage in The Gambia.","volume":"198","author":"BC de Jong","year":"2008","journal-title":"J Infect Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1128\/JCM.01216-08","article-title":"Use of spoligotyping and large sequence polymorphisms to study the population structure of the Mycobacterium tuberculosis complex in a cohort study of consecutive smear-positive tuberculosis cases in The Gambia.","volume":"47","author":"BC de Jong","year":"2009","journal-title":"J Clin Microbiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.2517-6161.1987.tb01685.x","article-title":"Exponential dispersion models (with discussion).","volume":"49","author":"B J\u00f8rgensen","year":"1987","journal-title":"J R Stat Soc Ser B Stat Methodol"},{"key":"ref32","article-title":"An Introduction to Support Vector Machines and other Kernel-based Learning Methods. First Ed","author":"N Cristianini","year":"2000"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0012365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:39:17Z","timestamp":1740443957000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0012365"}},"subtitle":[],"editor":[{"given":"Delia","family":"Goletti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,8,24]]},"references-count":32,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2010,8,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0012365","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,24]]}}}