{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:29:56Z","timestamp":1791098996095,"version":"4.1.0"},"reference-count":15,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2010,8,25]],"date-time":"2010-08-25T00:00:00Z","timestamp":1282694400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0012420","type":"journal-article","created":{"date-parts":[[2010,8,25]],"date-time":"2010-08-25T17:45:59Z","timestamp":1282758359000},"page":"e12420","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":50,"title":["Quantitative, Architectural Analysis of Immune Cell Subsets in Tumor-Draining Lymph Nodes from Breast Cancer Patients and Healthy Lymph Nodes"],"prefix":"10.1371","volume":"5","author":[{"given":"A. Francesca","family":"Setiadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson C.","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holbrook E.","family":"Kohrt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Kapelner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Carcamo-Cavazos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edina B.","family":"Levic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Yadegarynia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris M.","family":"van der Loos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich J.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter P.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,8,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/onc.2009.416","article-title":"Immune infiltration in human tumors: a prognostic factor that should not be ignored.","volume":"29","author":"F Pages","year":"2010","journal-title":"Oncogene"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/jso.21201","article-title":"The evolution of lymph node assessment in breast cancer.","volume":"99","author":"ML Quan","year":"2009","journal-title":"J Surg Oncol"},{"key":"ref3","first-page":"422","article-title":"What are the preoperative factors that can determine the presence of metastases in other axillary nodes in breast cancer when the sentinel node is positive?","volume":"53","author":"A Domenech","year":"2009","journal-title":"Q J Nucl Med Mol Imaging"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e284","DOI":"10.1371\/journal.pmed.0020284","article-title":"Profile of immune cells in axillary lymph nodes predicts disease-free survival in breast cancer.","volume":"2","author":"HE Kohrt","year":"2005","journal-title":"PLoS Med"},{"key":"ref5","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v030.i10","article-title":"An interactive java statistical image segmentation system: GemIdent.","volume":"30","author":"S Holmes","year":"2009","journal-title":"J Stat Soft"},{"key":"ref6","first-page":"1796","article-title":"Ripley's K function.","author":"PM Dixon","year":"2002"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2307\/2346974","article-title":"Simple Monte Carlo tests for spatial pattern.","volume":"26","author":"J Besag","year":"1977","journal-title":"Appl Statist"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1214\/aoms\/1177704472","article-title":"On estimation of a probability density function and mode.","volume":"22","author":"E Parzen","year":"1962","journal-title":"Ann Math Stat"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1369\/jhc.2007.950170","article-title":"Multiple immunoenzyme staining: methods and visualizations for the observation with spectral imaging.","volume":"56","author":"CM van der Loos","year":"2008","journal-title":"J Histochem Cytochem"},{"key":"ref10","article-title":"Immunobiology: the immune system in health and disease","author":"C Janeway","year":"2001"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1126\/science.1125703","article-title":"Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells.","volume":"312","author":"H Qi","year":"2006","journal-title":"Science"},{"key":"ref12","article-title":"Statistical analysis of spatial point patterns","author":"PJ Diggle","year":"2003"},{"key":"ref13","first-page":"13","article-title":"More on spatial data analysis.","volume":"1","author":"R Bivand","year":"2001","journal-title":"R News"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v012.i06","article-title":"Spatstat: an R package for analyzing spatial point patterns.","volume":"12","author":"A Baddeley","year":"2005","journal-title":"J Stat Soft"},{"key":"ref15","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4899-3324-9","article-title":"Density estimation for statistics and data analysis","author":"BW Silverman","year":"1986"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0012420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T18:25:33Z","timestamp":1540319133000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0012420"}},"subtitle":[],"editor":[{"given":"Ludovic","family":"Tailleux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,8,25]]},"references-count":15,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2010,8,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0012420","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,25]]}}}