{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:52:27Z","timestamp":1791121947223,"version":"4.1.0"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2010,9,13]],"date-time":"2010-09-13T00:00:00Z","timestamp":1284336000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0012682","type":"journal-article","created":{"date-parts":[[2010,9,13]],"date-time":"2010-09-13T15:56:29Z","timestamp":1284393389000},"page":"e12682","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":166,"title":["Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies"],"prefix":"10.1371","volume":"5","author":[{"given":"Yan","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bourhis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Stawicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venita I.","family":"DeAlmeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bob Y.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khanhky","family":"Phamluong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim C.","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A. D.","family":"Carano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Solloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnee","family":"Rubinfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami N.","family":"Hannoush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Polakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,9,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1101\/gad.1686208","article-title":"Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice.","volume":"22","author":"T Grigoryan","year":"2008","journal-title":"Genes Dev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1242\/dev.033910","article-title":"Towards an integrated view of Wnt signaling in development.","volume":"136","author":"R van Amerongen","year":"2009","journal-title":"Development"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/35035117","article-title":"LDL-receptor-related proteins in Wnt signal transduction.","volume":"407","author":"K Tamai","year":"2000","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0960-9822(01)00290-1","article-title":"Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.","volume":"11","author":"MV Sem\u00ebnov","year":"2001","journal-title":"Curr Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1097-2765(03)00484-2","article-title":"A mechanism for Wnt coreceptor activation.","volume":"13","author":"K Tamai","year":"2004","journal-title":"Mol Cell"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.1074\/jbc.M508657200","article-title":"The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity.","volume":"281","author":"K Mi","year":"2006","journal-title":"J Biol Chem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1126\/science.1137065","article-title":"Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation.","volume":"316","author":"J Bilic","year":"2007","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1242\/jcs.002956","article-title":"Dynamic recruitment of axin by Dishevelled protein assemblies.","volume":"120","author":"T Schwarz-Romond","year":"2007","journal-title":"J Cell Sci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"8032","DOI":"10.1073\/pnas.0803025105","article-title":"LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3&apos;s phosphorylation of beta-catenin.","volume":"105","author":"CS Cselenyi","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e4046","DOI":"10.1371\/journal.pone.0004046","article-title":"Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt\/beta-catenin signaling.","volume":"3","author":"S Piao","year":"2008","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1242\/dev.013540","article-title":"Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation\/activation via frizzled, dishevelled and axin functions.","volume":"135","author":"X Zeng","year":"2008","journal-title":"Development"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e4926","DOI":"10.1371\/journal.pone.0004926","article-title":"Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6.","volume":"4","author":"G Wu","year":"2009","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/88556","article-title":"Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair.","volume":"8","author":"H Jeon","year":"2001","journal-title":"Nat Struct Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"9172","DOI":"10.1074\/jbc.M109.092130","article-title":"Reconstitution of a Frizzled8-Wnt3a-LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6.","volume":"285","author":"E Bourhis","year":"2010","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/0092-8674(91)90064-6","article-title":"Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor.","volume":"67","author":"I Rebay","year":"1991","journal-title":"Cell"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.1002\/j.1460-2075.1996.tb00872.x","article-title":"The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade.","volume":"15","author":"T Davis-Smyth","year":"1996","journal-title":"EMBO J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1006\/bbrc.1997.6156","article-title":"Identification of the extracellular domains of Flt-1 that mediate ligand interactions.","volume":"231","author":"SA Cunningham","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"5825","DOI":"10.1128\/MCB.23.16.5825-5835.2003","article-title":"A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor.","volume":"23","author":"G Liu","year":"2003","journal-title":"Mol Cell Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.1242\/dev.01318","article-title":"Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.","volume":"131","author":"F Cong","year":"2004","journal-title":"Development"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.jmb.2004.05.051","article-title":"High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold.","volume":"340","author":"CV Lee","year":"2004","journal-title":"J Mol Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.1158\/0008-5472.CAN-07-0266","article-title":"The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo.","volume":"67","author":"VI DeAlmeida","year":"2007","journal-title":"Cancer Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ccr.2004.09.032","article-title":"An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells.","volume":"6","author":"A Bafico","year":"2004","journal-title":"Cancer Cell"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1038\/onc.2009.82","article-title":"Wnt pathway aberrations including autocrine Wnt activation occur at high frequency in human non-small-cell lung carcinoma.","volume":"28","author":"G Akiri","year":"2009","journal-title":"Oncogene"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1158\/0008-5472.CAN-07-3220","article-title":"Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling.","volume":"68","author":"Y Guo","year":"2008","journal-title":"Cancer Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cell.2009.04.030","article-title":"WNT\/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis.","volume":"138","author":"DX Nguyen","year":"2009","journal-title":"Cell"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/sj.cdd.4402306","article-title":"Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5.","volume":"15","author":"C Adams","year":"2008","journal-title":"Cell Death Differ"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"8520","DOI":"10.1038\/sj.onc.1207892","article-title":"DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin\/TCF pathway.","volume":"23","author":"A Niida","year":"2004","journal-title":"Oncogene"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.devcel.2005.02.017","article-title":"Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation.","volume":"8","author":"DA Glass 2nd","year":"2005","journal-title":"Dev Cell"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1073\/pnas.96.7.3540","article-title":"Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand.","volume":"96","author":"H Hsu","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","article-title":"Evolutionary dynamics of the Wnt gene family: a lophotrochozoan perspective.","author":"SJ Cho","year":"2010","journal-title":"Mol Biol Evol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1091\/mbc.E08-12-1252","article-title":"The first propeller domain of LRP6 regulates sensitivity to DKK1.","volume":"20","author":"ME Binnerts","year":"2009","journal-title":"Mol Biol Cell"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jim.2009.11.016","article-title":"Detection of endogenous LRP6 expressed on human cells by monoclonal antibodies specific for the native conformation.","volume":"352","author":"N Yasui","year":"2010","journal-title":"J Immunol Methods"},{"key":"ref33","article-title":"Origin Matters: Differences in Embryonic Tissue Origin and Wnt Signaling Determine the Osteogenic Potential and Healing Capacity of Frontal and Parietal Calvarial Bones.","author":"N Quarto","year":"2009","journal-title":"J Bone Miner Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1242\/dev.027706","article-title":"Glucocorticoid-dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice.","volume":"136","author":"H Zhou","year":"2009","journal-title":"Development"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e6191","DOI":"10.1371\/journal.pone.0006191","article-title":"Wnt signaling is regulated by endoplasmic reticulum retention.","volume":"4","author":"JS Zoltewicz","year":"2009","journal-title":"PLoS One"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nchembio.152","article-title":"Inhibition of Wnt signaling by Dishevelled PDZ peptides.","volume":"5","author":"Y Zhang","year":"2009","journal-title":"Nat Chem Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e8611","DOI":"10.1371\/journal.pone.0008611","article-title":"Stromal cell-derived factor-1\/CXCL12 contributes to MMTV-Wnt1 tumor growth involving Gr1+CD11b+ cells.","volume":"5","author":"BY Liu","year":"2010","journal-title":"PLoS One"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1006\/jmbi.1997.1116","article-title":"Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library.","volume":"270","author":"S Atwell","year":"1997","journal-title":"J Mol Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-1-59745-104-8_3","article-title":"Assessing new bone formation in neonatal calvarial organ cultures.","volume":"455","author":"KS Mohammad","year":"2008","journal-title":"Methods Mol Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"7291","DOI":"10.1128\/MCB.00773-07","article-title":"Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor.","volume":"27","author":"Z Khan","year":"2007","journal-title":"Mol Cell Biol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0012682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T13:40:12Z","timestamp":1559655612000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0012682"}},"subtitle":[],"editor":[{"given":"Carl-Philipp","family":"Heisenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,9,13]]},"references-count":40,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2010,9,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0012682","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,13]]}}}