{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:19:07Z","timestamp":1790659147577,"version":"4.1.0"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2010,10,12]],"date-time":"2010-10-12T00:00:00Z","timestamp":1286841600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0013262","type":"journal-article","created":{"date-parts":[[2010,10,12]],"date-time":"2010-10-12T19:06:46Z","timestamp":1286910406000},"page":"e13262","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":85,"title":["Tumor Necrosis Factor-\u03b1 Regulates Distinct Molecular Pathways and Gene Networks in Cultured Skeletal Muscle Cells"],"prefix":"10.1371","volume":"5","author":[{"given":"Shephali","family":"Bhatnagar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siva K.","family":"Panguluri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay K.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Dahiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Lundy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,10,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.2741\/2680","article-title":"Impact of physical exercise on alterations in the skeletal muscle in patients with chronic heart failure.","volume":"13","author":"V Adams","year":"2008","journal-title":"Front Biosci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00134-005-0029-x","article-title":"Muscle force and fatigue in patients with sepsis and multiorgan failure.","volume":"32","author":"M Eikermann","year":"2006","journal-title":"Intensive Care Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"E453","DOI":"10.1152\/ajpendo.00204.2007","article-title":"Regulation of muscle protein synthesis during sepsis and inflammation.","volume":"293","author":"CH Lang","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/01.mco.0000165002.08955.5b","article-title":"Pathophysiology of peripheral muscle wasting in cardiac cachexia.","volume":"8","author":"GS Filippatos","year":"2005","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/00002281-200111000-00005","article-title":"Effect of tumor necrosis factor-alpha on skeletal muscle metabolism.","volume":"13","author":"YP Li","year":"2001","journal-title":"Curr Opin Rheumatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/00075197-200405000-00005","article-title":"Proinflammatory cytokines and skeletal muscle.","volume":"7","author":"U Spate","year":"2004","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nri1184","article-title":"Signalling pathways of the TNF superfamily: a double-edged sword.","volume":"3","author":"BB Aggarwal","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0962-8924(01)02064-5","article-title":"Signal transduction by tumor necrosis factor and its relatives.","volume":"11","author":"V Baud","year":"2001","journal-title":"Trends Cell Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"35113","DOI":"10.1074\/jbc.M705329200","article-title":"Tumor necrosis factor-alpha augments matrix metalloproteinase-9 production in skeletal muscle cells through the activation of transforming growth factor-beta-activated kinase 1 (TAK1)-dependent signaling pathway.","volume":"282","author":"AK Srivastava","year":"2007","journal-title":"J Biol Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s00109-008-0373-8","article-title":"Nuclear factor-kappa B signaling in skeletal muscle atrophy.","volume":"86","author":"H Li","year":"2008","journal-title":"J Mol Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1158\/1078-0432.CCR-06-2307","article-title":"Cancer cachexia signaling pathways continue to emerge yet much still points to the proteasome.","volume":"13","author":"S Acharyya","year":"2007","journal-title":"Clin Cancer Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00109-004-0555-y","article-title":"Nuclear factor-kappaB: its role in health and disease.","volume":"82","author":"A Kumar","year":"2004","journal-title":"J Mol Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2004.09.027","article-title":"IKKbeta\/NF-kappaB activation causes severe muscle wasting in mice.","volume":"119","author":"D Cai","year":"2004","journal-title":"Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1172\/JCI200421696","article-title":"Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophy.","volume":"114","author":"RB Hunter","year":"2004","journal-title":"J Clin Invest"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1172\/JCI28721","article-title":"Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration.","volume":"116","author":"F Mourkioti","year":"2006","journal-title":"J Clin Invest"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1096\/fj.06-7537com","article-title":"TNF-related weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokine.","volume":"21","author":"C Dogra","year":"2007","journal-title":"FASEB J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1096\/fasebj.12.10.871","article-title":"Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha.","volume":"12","author":"YP Li","year":"1998","journal-title":"FASEB J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1126\/science.289.5488.2363","article-title":"NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia.","volume":"289","author":"DC Guttridge","year":"2000","journal-title":"Science"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1096\/fj.00-0463","article-title":"Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-kappaB.","volume":"15","author":"RC Langen","year":"2001","journal-title":"FASEB J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1096\/fj.03-0251com","article-title":"Tumor necrosis factor-alpha inhibits myogenic differentiation through MyoD protein destabilization.","volume":"18","author":"RC Langen","year":"2004","journal-title":"FASEB J"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1093\/jnci\/89.23.1763","article-title":"Biology of cachexia.","volume":"89","author":"M Tisdale","year":"1997","journal-title":"J Natl Cancer Inst"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/0092-8674(93)90243-J","article-title":"Through thick and thin: Wasting, obesity, and TNF[alpha].","volume":"73","author":"BM Spiegelman","year":"1993","journal-title":"Cell"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1083\/jcb.200909117","article-title":"The TWEAK\u2013Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice.","volume":"188","author":"A Mittal","year":"2010","journal-title":"J Cell Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1065874","article-title":"Identification of ubiquitin ligases required for skeletal muscle atrophy.","volume":"294","author":"SC Bodine","year":"2001","journal-title":"Science"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"14440","DOI":"10.1073\/pnas.251541198","article-title":"Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy.","volume":"98","author":"MD Gomes","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1113\/jphysiol.2003.044701","article-title":"Global analysis of gene expression patterns during disuse atrophy in rat skeletal muscle.","volume":"551","author":"EJ Stevenson","year":"2003","journal-title":"J Physiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1152\/physiolgenomics.00249.2004","article-title":"Identification of a molecular signature of sarcopenia.","volume":"21","author":"PG Giresi","year":"2005","journal-title":"Physiol Genomics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e8760","DOI":"10.1371\/journal.pone.0008760","article-title":"Genomic profiling of messenger RNAs and microRNAs reveals potential mechanisms of TWEAK-induced skeletal muscle wasting in mice.","volume":"5","author":"SK Panguluri","year":"2010","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/0092-8674(83)90300-8","article-title":"Cytoplasmic activation of human nuclear genes in stable heterocaryons.","volume":"32","author":"HM Blau","year":"1983","journal-title":"Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1096\/fj.02-0759com","article-title":"TNF-alpha increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2\/E220k.","volume":"17","author":"YP Li","year":"2003","journal-title":"FASEB J"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1074\/jbc.M207129200","article-title":"Tumor necrosis factor-regulated biphasic activation of NF-kappa B is required for cytokine-induced loss of skeletal muscle gene products.","volume":"278","author":"KJ Ladner","year":"2003","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1074\/jbc.M805546200","article-title":"Tumor necrosis factor-related weak inducer of apoptosis augments matrix metalloproteinase-9 production (MMP-9) in skeletal muscle through the activation of nuclear factor-kappa B-inducing kinase and p38 mitogen-activated protein kinase: A potential role of MMP-9 in myopathy.","volume":"284","author":"H Li","year":"2008","journal-title":"J Biol Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1093\/hmg\/ddp191","article-title":"Matrix metalloproteinase-9 inhibition ameliorates pathogenesis and improves skeletal muscle regeneration in muscular dystrophy.","volume":"18","author":"H Li","year":"2009","journal-title":"Hum Mol Genet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/cvr\/cvn276","article-title":"Proapoptotic protein Siva binds to the muscle protein telethonin in cardiomyocytes during coxsackieviral infection.","volume":"81","author":"K Mihatsch","year":"2009","journal-title":"Cardiovasc Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0898-6568(01)00262-5","article-title":"TNF receptor subtype signalling: differences and cellular consequences.","volume":"14","author":"DJ MacEwan","year":"2002","journal-title":"Cell Signal"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.2741\/2881","article-title":"Tumor necrosis factor (TNF) biology and cell death.","volume":"13","author":"L Bertazza","year":"2008","journal-title":"Front Biosci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/gene.20160","article-title":"Tumor necrosis factor-alpha gene transfer induces cachexia and inhibits muscle regeneration.","volume":"43","author":"D Coletti","year":"2005","journal-title":"Genesis"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/emboj\/21.4.631","article-title":"TNFalpha inhibits skeletal myogenesis through a PW1-dependent pathway by recruitment of caspase pathways.","volume":"21","author":"D Coletti","year":"2002","journal-title":"EMBO J"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1196\/annals.1398.050","article-title":"Chemokine profile of different inflammatory myopathies reflects humoral versus cytotoxic immune responses.","volume":"1109","author":"B De Paepe","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.4049\/jimmunol.159.7.3595","article-title":"Chemokine networks in vivo: involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-alpha.","volume":"159","author":"PA Tessier","year":"1997","journal-title":"J Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/j.1476-5381.2009.00367.x","article-title":"A crucial role for TNF-alpha in mediating neutrophil influx induced by endogenously generated or exogenous chemokines, KC\/CXCL1 and LIX\/CXCL5.","volume":"158","author":"SM Vieira","year":"2009","journal-title":"Br J Pharmacol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"729","DOI":"10.3349\/ymj.2006.47.5.729","article-title":"Inflammatory Gene Expression Patterns Revealed by DNA Microarray Analysis in TNF-\u00ce\u00b1-treated SGBS Human Adipocytes.","volume":"47","author":"M-S Do","year":"2006","journal-title":"Yonsei Med J"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/00003677-200507000-00003","article-title":"Contraction-Induced Myokine Production and Release: Is Skeletal Muscle an Endocrine Organ?","volume":"33","author":"MA Febbraio","year":"2005","journal-title":"Exercise and Sport Sciences Reviews"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1258\/ebm.2009.009169","article-title":"Elevation of tumor necrosis factor-{alpha} induces the overproduction of postprandial intestinal apolipoprotein B48-containing very low-density lipoprotein particles: evidence for related gene expression of inflammatory, insulin and lipoprotein signaling in enterocytes.","volume":"235","author":"B Qin","year":"2010","journal-title":"Exp Biol Med"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1681\/ASN.2008060628","article-title":"IL-6 and serum amyloid A synergy mediates angiotensin II-induced muscle wasting.","volume":"20","author":"L Zhang","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.tig.2008.01.007","article-title":"MicroRNAs flex their muscles.","volume":"24","author":"E van Rooij","year":"2008","journal-title":"Trends Genet"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"10327","DOI":"10.1074\/jbc.M511131200","article-title":"Tumor necrosis factor-like weak inducer of apoptosis inhibits skeletal myogenesis through sustained activation of nuclear factor-kappaB and degradation of MyoD protein.","volume":"281","author":"C Dogra","year":"2006","journal-title":"J Biol Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"R1159","DOI":"10.1152\/ajpregu.00767.2006","article-title":"Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production.","volume":"293","author":"FL Muller","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.cmet.2008.09.002","article-title":"Skeletal muscle is a primary target of SOD1G93A-mediated toxicity.","volume":"8","author":"G Dobrowolny","year":"2008","journal-title":"Cell Metab"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.284.5415.770","article-title":"Notch signaling: cell fate control and signal integration in development.","volume":"284","author":"S Artavanis-Tsakonas","year":"1999","journal-title":"Science"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1083\/jcb.109.5.2427","article-title":"The notch gene product is a glycoprotein expressed on the cell surface of both epidermal and neuronal precursor cells during Drosophila development.","volume":"109","author":"KM Johansen","year":"1989","journal-title":"J Cell Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/19091","article-title":"Presenilin is required for activity and nuclear access of Notch in Drosophila.","volume":"398","author":"G Struhl","year":"1999","journal-title":"Nature"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"36801","DOI":"10.1074\/jbc.274.51.36801","article-title":"Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.","volume":"274","author":"WJ Ray","year":"1999","journal-title":"J Biol Chem"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1084\/jem.183.5.2025","article-title":"T cell leukemia-associated human Notch\/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells.","volume":"183","author":"E Guan","year":"1996","journal-title":"J Exp Med"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"289","DOI":"10.4049\/jimmunol.167.1.289","article-title":"Human Notch-1 inhibits NF-kappa B activity in the nucleus through a direct interaction involving a novel domain.","volume":"167","author":"J Wang","year":"2001","journal-title":"J Immunol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1126\/science.6262916","article-title":"Human muscle phosphoglycerate mutase deficiency: newly discovered metabolic myopathy.","volume":"212","author":"S DiMauro","year":"1981","journal-title":"Science"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.it.2004.03.008","article-title":"The two NF-kappaB activation pathways and their role in innate and adaptive immunity.","volume":"25","author":"G Bonizzi","year":"2004","journal-title":"Trends Immunol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1101\/gad.1228704","article-title":"Signaling to NF-kappaB.","volume":"18","author":"MS Hayden","year":"2004","journal-title":"Genes Dev"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.cell.2005.09.022","article-title":"TWEAK attenuates the transition from innate to adaptive immunity.","volume":"123","author":"H Maecker","year":"2005","journal-title":"Cell"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1038\/emboj.2010.60","article-title":"Mitochondrial fission and remodelling contributes to muscle atrophy.","volume":"29","author":"V Romanello","year":"2010","journal-title":"EMBO J"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00109-009-0550-4","article-title":"Therapeutic targeting of signaling pathways in muscular dystrophy.","volume":"88","author":"S Bhatnagar","year":"2010","journal-title":"J Mol Med"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"15000","DOI":"10.1074\/jbc.M608668200","article-title":"Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis.","volume":"282","author":"C Dogra","year":"2007","journal-title":"J Biol Chem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0013262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T19:58:45Z","timestamp":1685822325000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0013262"}},"subtitle":[],"editor":[{"given":"Neeraj","family":"Vij","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,10,12]]},"references-count":62,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2010,10,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0013262","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,12]]}}}