{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:30:58Z","timestamp":1791052258156,"version":"4.1.0"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0013779","type":"journal-article","created":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T19:37:44Z","timestamp":1288640264000},"page":"e13779","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":187,"title":["The Regulation of miRNA-211 Expression and Its Role in Melanoma Cell Invasiveness"],"prefix":"10.1371","volume":"5","author":[{"given":"Joseph","family":"Mazar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"DeYoung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Khaitan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Meister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvin","family":"Almodovar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Goydos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Animesh","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjan J.","family":"Perera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,11,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1111\/j.1468-3083.2007.02475.x","article-title":"Systemic therapy of disseminated malignant melanoma: an evidence-based overview of the state-of-the-art in daily routine.","volume":"21","author":"D Nashan","year":"2007","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/978-0-387-77574-6_13","article-title":"UV damage and DNA repair in malignant melanoma and nonmelanoma skin cancer.","volume":"624","author":"K Rass","year":"2008","journal-title":"Adv Exp Med Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"d765","DOI":"10.2741\/matsumur","article-title":"Molecular mechanisms of photocarcinogenesis.","volume":"7","author":"Y Matsumura","year":"2002","journal-title":"Front Biosci"},{"key":"ref4","first-page":"d1024","article-title":"UV damage, DNA repair and skin carcinogenesis.","volume":"7","author":"JE Cleaver","year":"2002","journal-title":"Front Biosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1011-1344(01)00199-3","article-title":"UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer.","volume":"63","author":"FR de Gruijl","year":"2001","journal-title":"J Photochem Photobiol B"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"d538","DOI":"10.2741\/A211","article-title":"Mechanisms of induction of skin cancer by UV radiation.","volume":"2","author":"H Soehnge","year":"1997","journal-title":"Front Biosci"},{"key":"ref7","first-page":"5336","article-title":"Low frequency of p16\/CDKN2A methylation in sporadic melanoma: comparative approaches for methylation analysis of primary tumors.","volume":"57","author":"ML Gonzalgo","year":"1997","journal-title":"Cancer Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.1038\/sj.onc.1203891","article-title":"Aberrant p27Kip1 promoter methylation in malignant melanoma.","volume":"19","author":"J Worm","year":"2000","journal-title":"Oncogene"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.1038\/sj.onc.1207647","article-title":"Genetic and epigenetic alterations of the APC gene in malignant melanoma.","volume":"23","author":"J Worm","year":"2004","journal-title":"Oncogene"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1038\/sj.onc.1207505","article-title":"Profiling epigenetic inactivation of tumor suppressor genes in tumors and plasma from cutaneous melanoma patients.","volume":"23","author":"DS Hoon","year":"2004","journal-title":"Oncogene"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/ijc.11376","article-title":"ASC\/TMS1, a caspase-1 activating adaptor, is downregulated by aberrant methylation in human melanoma.","volume":"107","author":"X Guan","year":"2003","journal-title":"Int J Cancer"},{"key":"ref12","first-page":"1045","article-title":"Involvement of p16 and PTCH in pathogenesis of melanoma and basal cell carcinoma.","volume":"34","author":"M Cretnik","year":"2009","journal-title":"Int J Oncol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1093\/carcin\/bgn243","article-title":"Modulation of basal and squamous cell carcinoma by endogenous estrogen in mouse models of skin cancer.","volume":"30","author":"M Mancuso","year":"2009","journal-title":"Carcinogenesis"},{"key":"ref14","first-page":"349","article-title":"Early-onset of sporadic basal-cell carcinoma: germline mutations in the TP53, PTCH, and XPD genes.","volume":"26","author":"EB Suarez-Martinez","year":"2007","journal-title":"P R Health Sci J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/j.1468-3083.2007.02574.x","article-title":"Photoprotection of bacterial-derived melanin against ultraviolet A-induced cell death and its potential application as an active sunscreen.","volume":"22","author":"J Geng","year":"2008","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1038\/sj.onc.1206448","article-title":"Gene-expression profiling in human cutaneous melanoma.","volume":"22","author":"KM Carr","year":"2003","journal-title":"Oncogene"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S1535-6108(02)00161-7","article-title":"Focus on melanoma.","volume":"2","author":"AN Houghton","year":"2002","journal-title":"Cancer Cell"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/ng.356","article-title":"Braf(V600E) cooperates with Pten loss to induce metastatic melanoma.","volume":"41","author":"D Dankort","year":"2009","journal-title":"Nat Genet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1158\/0008-5472.CAN-05-3589","article-title":"Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase\/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression.","volume":"66","author":"ZJ Liu","year":"2006","journal-title":"Cancer Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/modpathol.3800526","article-title":"Evidence for differential expression of Notch receptors and their ligands in melanocytic nevi and cutaneous malignant melanoma.","volume":"19","author":"D Massi","year":"2006","journal-title":"Mod Pathol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1056\/NEJMoa050092","article-title":"Distinct sets of genetic alterations in melanoma.","volume":"353","author":"JA Curtin","year":"2005","journal-title":"N Engl J Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nature07567","article-title":"Efficient tumour formation by single human melanoma cells.","volume":"456","author":"E Quintana","year":"2008","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10555-009-9188-5","article-title":"MicroRNA function in cancer: oncogene or a tumor suppressor?","volume":"28","author":"SK Shenouda","year":"2009","journal-title":"Cancer Metastasis Rev"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/cdd.2009.69","article-title":"miR-15a and miR-16-1 in cancer: discovery, function and future perspectives.","volume":"17","author":"RI Aqeilan","year":"2010","journal-title":"Cell Death Differ"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1469-185X.2008.00061.x","article-title":"The roles of microRNA in cancer and apoptosis.","volume":"84","author":"N Lynam-Lennon","year":"2009","journal-title":"Biol Rev Camb Philos Soc"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1111\/j.1582-4934.2008.00483.x","article-title":"Regulation of microRNA processing in development, differentiation and cancer.","volume":"12","author":"TD Schmittgen","year":"2008","journal-title":"J Cell Mol Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1007\/s10529-008-9800-8","article-title":"Complementary analysis of microRNA and mRNA expression during phorbol 12-myristate 13-acetate (TPA)-induced differentiation of HL-60 cells.","volume":"30","author":"A Chen","year":"2008","journal-title":"Biotechnol Lett"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.bbrc.2008.12.152","article-title":"MicroRNA-dependent regulation of cKit in cutaneous melanoma.","volume":"379","author":"O Igoucheva","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1126\/science.1169628","article-title":"RNA Pol II accumulates at promoters of growth genes during developmental arrest.","volume":"324","author":"LR Baugh","year":"2009","journal-title":"Science"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1158\/0008-5472.CAN-07-2538","article-title":"The promyelocytic leukemia zinc finger-microRNA-221\/-222 pathway controls melanoma progression through multiple oncogenic mechanisms.","volume":"68","author":"F Felicetti","year":"2008","journal-title":"Cancer Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/cr.2008.45","article-title":"MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth.","volume":"18","author":"J Schultz","year":"2008","journal-title":"Cell Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1158\/0008-5472.CAN-07-2912","article-title":"MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines.","volume":"68","author":"LT Bemis","year":"2008","journal-title":"Cancer Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1056\/NEJMp058190","article-title":"MicroRNAs as oncogenes and tumor suppressors.","volume":"353","author":"CZ Chen","year":"2005","journal-title":"N Engl J Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"6170","DOI":"10.1038\/sj.onc.1209911","article-title":"MicroRNAs and the hallmarks of cancer.","volume":"25","author":"T Dalmay","year":"2006","journal-title":"Oncogene"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrc1840","article-title":"Oncomirs - microRNAs with a role in cancer.","volume":"6","author":"A Esquela-Kerscher","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2165\/00063030-200721020-00004","article-title":"MicroRNAs in the search for understanding human diseases.","volume":"21","author":"RJ Perera","year":"2007","journal-title":"BioDrugs"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"6188","DOI":"10.1038\/sj.onc.1209913","article-title":"A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes.","volume":"25","author":"OA Kent","year":"2006","journal-title":"Oncogene"},{"key":"ref38","article-title":"microRNAs as oncogenes and tumor suppressors.","author":"B Zhang","year":"2006","journal-title":"Dev Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.gde.2005.12.005","article-title":"MicroRNAs as oncogenes.","volume":"16","author":"SM Hammond","year":"2006","journal-title":"Curr Opin Genet Dev"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"5270","DOI":"10.1158\/0008-5472.CAN-04-0731","article-title":"Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas.","volume":"64","author":"K Hoek","year":"2004","journal-title":"Cancer Res"},{"key":"ref41","article-title":"miRNA Expression Profiling in Melanocytes and Melanoma Cell Lines Reveals miRNAs Associated with Formation and Progression of Malignant Melanoma.","author":"DW Mueller","year":"2009","journal-title":"J Invest Dermatol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1586\/14737140.8.11.1759","article-title":"MicroRNA-221 and -222 pathway controls melanoma progression.","volume":"8","author":"F Felicetti","year":"2008","journal-title":"Expert Rev Anticancer Ther"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1073\/pnas.0808263106","article-title":"Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor.","volume":"106","author":"MF Segura","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1479-5876-8-27","article-title":"Microrna profiling analysis of differences between the melanoma of young adults and older adults.","volume":"8","author":"DM Jukic","year":"2010","journal-title":"J Transl Med"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0898-6568(02)00049-9","article-title":"Expression of plasma membrane calcium pump isoform mRNAs in breast cancer cell lines.","volume":"14","author":"WJ Lee","year":"2002","journal-title":"Cell Signal"},{"key":"ref46","first-page":"3819","article-title":"N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells.","volume":"61","author":"G Li","year":"2001","journal-title":"Cancer Res"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"4386","DOI":"10.1091\/mbc.E05-03-0186","article-title":"Transendothelial migration of melanoma cells involves N-cadherin-mediated adhesion and activation of the beta-catenin signaling pathway.","volume":"16","author":"J Qi","year":"2005","journal-title":"Mol Biol Cell"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00401-006-0190-5","article-title":"Ependymoma gene expression profiles associated with histological subtype, proliferation, and patient survival.","volume":"113","author":"I Lukashova-v Zangen","year":"2007","journal-title":"Acta Neuropathol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1038\/sj.onc.1210036","article-title":"KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer.","volume":"26","author":"M Bloch","year":"2007","journal-title":"Oncogene"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1113\/jphysiol.2005.096818","article-title":"Ca2+-activated K+ channels in human melanoma cells are up-regulated by hypoxia involving hypoxia-inducible factor-1alpha and the von Hippel-Lindau protein.","volume":"571","author":"N Tajima","year":"2006","journal-title":"J Physiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/glia.20364","article-title":"Expression and function of calcium-activated potassium channels in human glioma cells.","volume":"54","author":"AK Weaver","year":"2006","journal-title":"Glia"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1016\/j.ejca.2007.08.025","article-title":"MEIS and PBX homeobox proteins in ovarian cancer.","volume":"43","author":"AP Crijns","year":"2007","journal-title":"Eur J Cancer"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0304-3835(03)00087-9","article-title":"The role of the MEIS homeobox genes in neuroblastoma.","volume":"197","author":"D Geerts","year":"2003","journal-title":"Cancer Lett"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"26518","DOI":"10.1074\/jbc.M803337200","article-title":"Cell surface proteomics identifies molecules functionally linked to tumor cell intravasation.","volume":"283","author":"EM Conn","year":"2008","journal-title":"J Biol Chem"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1074\/jbc.M803997200","article-title":"Integrin alpha6beta4 controls the expression of genes associated with cell motility, invasion, and metastasis, including S100A4\/metastasin.","volume":"284","author":"M Chen","year":"2009","journal-title":"J Biol Chem"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"222001","DOI":"10.1103\/PhysRevLett.97.222001","article-title":"Observation of a new Ds meson decaying to DK at a mass of 2.86 GeV\/c2.","volume":"97","author":"B Aubert","year":"2006","journal-title":"Phys Rev Lett"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/01.cmr.0000215037.23188.58","article-title":"Analysis of gene expression profiles in melanoma cells with acquired resistance against antineoplastic drugs.","volume":"16","author":"B Gyorffy","year":"2006","journal-title":"Melanoma Res"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1158\/0008-5472.CAN-03-2440","article-title":"Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma.","volume":"64","author":"AJ Miller","year":"2004","journal-title":"Cancer Res"},{"key":"ref59","first-page":"192","article-title":"A new in vitro assay for quantitating tumor cell invasion.","volume":"9","author":"LA Repesh","year":"1989","journal-title":"Invasion Metastasis"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.ccr.2004.05.015","article-title":"A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen.","volume":"5","author":"X-J Ma","year":"2004","journal-title":"Cancer Cell"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1200\/JCO.2001.19.2.568","article-title":"Melastatin expression and prognosis in cutaneous malignant melanoma.","volume":"19","author":"LM Duncan","year":"2001","journal-title":"J Clin Oncol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"ra21","DOI":"10.1126\/scisignal.2000146","article-title":"TRPM1 forms ion channels associated with melanin content in melanocytes.","volume":"2","author":"E Oancea","year":"2009","journal-title":"Sci Signal"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2009.06.034","article-title":"Identification of selective inhibitors of cancer stem cells by high-throughput screening.","volume":"138","author":"PB Gupta","year":"2009","journal-title":"Cell"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1158\/0008-5472.CAN-06-2698","article-title":"Characterization of microRNA expression levels and their biological correlates in human cancer cell lines.","volume":"67","author":"A Gaur","year":"2007","journal-title":"Cancer Res"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"e179","DOI":"10.1093\/nar\/gni178","article-title":"Real-time quantification of microRNAs by stem-loop RT-PCR.","volume":"33","author":"C Chen","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref66","first-page":"149","article-title":"Statistical methods for identifying differentially expressed genes in DNA microarrays.","volume":"224","author":"JD Storey","year":"2003","journal-title":"Methods Mol Biol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies.","volume":"100","author":"JD Storey","year":"2003","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0013779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T17:38:07Z","timestamp":1589045887000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0013779"}},"subtitle":[],"editor":[{"given":"Venugopalan","family":"Cheriyath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,11,1]]},"references-count":67,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2010,11,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0013779","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,1]]}}}