{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T01:18:35Z","timestamp":1768267115494,"version":"3.49.0"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2010,11,10]],"date-time":"2010-11-10T00:00:00Z","timestamp":1289347200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0013861","type":"journal-article","created":{"date-parts":[[2010,11,10]],"date-time":"2010-11-10T15:00:59Z","timestamp":1289401259000},"page":"e13861","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Levodopa-Induced Dyskinesia Is Associated with Increased Thyrotropin Releasing Hormone in the Dorsal Striatum of Hemi-Parkinsonian Rats"],"prefix":"10.1371","volume":"5","author":[{"given":"Ippolita","family":"Cantuti-Castelvetri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ledia F.","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine E.","family":"Keller-McGandy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren R.","family":"Kett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Landy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zane R.","family":"Hollingsworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esen","family":"Saka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill R.","family":"Crittenden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo A.","family":"Nillni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne B.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G.","family":"Standaert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann M.","family":"Graybiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2010,11,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/mds.21475","article-title":"Levodopa-induced dyskinesias.","volume":"22","author":"G Fabbrini","year":"2007","journal-title":"Mov Disord"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/S1471-1931(00)00031-8","article-title":"Levodopa motor complications in Parkinson&apos;s disease.","volume":"23","author":"JA Obeso","year":"2000","journal-title":"Trends Neurosci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1002\/ana.21481","article-title":"The basal ganglia in Parkinson&apos;s disease: current concepts and unexplained observations.","volume":"64","author":"JA Obeso","year":"2008","journal-title":"Ann Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/35086062","article-title":"Pathophysiology of levodopa-induced dyskinesia: potential for new therapies.","volume":"2","author":"E Bezard","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"S570","DOI":"10.1002\/mds.22019","article-title":"Molecular mechanisms underlying levodopa-induced dyskinesia.","volume":"23","author":"P Calabresi","year":"2008","journal-title":"Mov Disord"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF02743658","article-title":"Biochemical studies of the structure and function of the N-methyl-D-aspartate subtype of glutamate receptors.","volume":"19","author":"AW Dunah","year":"1999","journal-title":"Mol Neurobiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S560","DOI":"10.1002\/mds.22020","article-title":"Physiology of the normal and dopamine-depleted basal ganglia: insights into levodopa pharmacotherapy.","volume":"23","author":"AA Grace","year":"2008","journal-title":"Mov Disord"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1016\/S1471-1931(00)00027-6","article-title":"Levodopa-induced dyskinesias and dopamine-dependent stereotypies: a new hypothesis.","volume":"23","author":"AM Graybiel","year":"2000","journal-title":"Trends Neurosci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1073\/pnas.0812822106","article-title":"Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy.","volume":"106","author":"JR Crittenden","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","first-page":"599","article-title":"The biology of pro-thyrotropin-releasing hormone-derived peptides.","volume":"20","author":"EA Nillni","year":"1999","journal-title":"Endocr Rev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/mds.21279","article-title":"Autoimmune thyroid disease and segmental myoclonus.","volume":"22","author":"B Young","year":"2007","journal-title":"Mov Disord"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1002\/mds.20603","article-title":"Chorea associated with thyroxine replacement therapy.","volume":"20","author":"JD Isaacs","year":"2005","journal-title":"Mov Disord"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/mds.20119","article-title":"Bilateral chorea-ballism associated with hyperthyroidism.","volume":"19","author":"AJ Ristic","year":"2004","journal-title":"Mov Disord"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/mds.870130231","article-title":"Hyperthyroidism presenting as recurrent short paroxysmal kinesigenic dyskinesia.","volume":"13","author":"DJ Yen","year":"1998","journal-title":"Mov Disord"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000114600","article-title":"Parkinsonism and hyperthyroidism.","volume":"12","author":"S Lavy","year":"1974","journal-title":"Eur Neurol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S0140-6736(88)92677-3","article-title":"Parkinson&apos;s disease after antithyroid treatment.","volume":"2","author":"B Verges","year":"1988","journal-title":"Lancet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.parkreldis.2005.01.009","article-title":"Hyperthyroidism exaggerating parkinsonian tremor: a clinical lesson.","volume":"11","author":"HT Kim","year":"2005","journal-title":"Parkinsonism Relat Disord"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000092786","article-title":"Three in one: case report supporting different origins of essential and parkinsonian tremors.","volume":"55","author":"G Linazasoro","year":"2006","journal-title":"Eur Neurol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1136\/bmj.293.6538.38","article-title":"Resolution of dyskinesia and the \u201con-off\u201d phenomenon in thyrotoxic patients with Parkinson&apos;s disease after antithyroid treatment.","volume":"293","author":"TH Caradoc-Davies","year":"1986","journal-title":"Br Med J (Clin Res Ed)"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1046\/j.1471-4159.1995.65062462.x","article-title":"Pro-thyrotropin-releasing hormone processing by recombinant PC1.","volume":"65","author":"EA Nillni","year":"1995","journal-title":"J Neurochem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5651","DOI":"10.1210\/endo.137.12.8940396","article-title":"Identification of the thyrotropin-releasing hormone precursor, its processing products, and its coexpression with convertase 1 in primary cultures of hypothalamic neurons: anatomic distribution of PC1 and PC2.","volume":"137","author":"EA Nillni","year":"1996","journal-title":"Endocrinology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00726-001-0116-4","article-title":"Transcription factors involved in the pathogenesis of L-DOPA-induced dyskinesia in a rat model of Parkinson&apos;s disease.","volume":"23","author":"MA Cenci","year":"2002","journal-title":"Amino Acids"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1093\/brain\/awn085","article-title":"Sprouting of dopamine terminals and altered dopamine release and uptake in Parkinsonian dyskinaesia.","volume":"131","author":"J Lee","year":"2008","journal-title":"Brain"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bbr.2006.09.019","article-title":"The \u201cmotor complication syndrome\u201d in rats with 6-OHDA lesions treated chronically with L-DOPA: relation to dose and route of administration.","volume":"177","author":"HS Lindgren","year":"2007","journal-title":"Behav Brain Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/mds.21308","article-title":"Rat model of Parkinson&apos;s disease with bilateral motor abnormalities, reversible with levodopa, and dyskinesias.","volume":"22","author":"V Paille","year":"2007","journal-title":"Mov Disord"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1006\/nbdi.2002.0499","article-title":"L-DOPA-induced dyskinesia in the intrastriatal 6-hydroxydopamine model of parkinson&apos;s disease: relation to motor and cellular parameters of nigrostriatal function.","volume":"10","author":"C Winkler","year":"2002","journal-title":"Neurobiol Dis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1097\/01.jnen.0000190063.90440.69","article-title":"Alpha-Synuclein and Chaperones in Dementia With Lewy Bodies.","volume":"64","author":"I Cantuti-Castelvetri","year":"2005","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"19958","DOI":"10.1074\/jbc.272.32.19958","article-title":"Processing of prothyrotropin-releasing hormone by the family of prohormone convertases.","volume":"272","author":"P Schaner","year":"1997","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"22736","DOI":"10.1074\/jbc.271.37.22736","article-title":"Intracellular sites of prothyrotropin-releasing hormone processing.","volume":"271","author":"IP Cruz","year":"1996","journal-title":"J Biol Chem"},{"key":"ref30","first-page":"51","article-title":"Assays for the biosynthesis of thryotropin releasing hormone.","author":"EA Nillni","year":"1991"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1210\/endo.132.3.8440187","article-title":"Identification of the thyrotropin-releasing hormone-prohormone and its posttranslational processing in a transfected AtT20 tumoral cell line.","volume":"132","author":"EA Nillni","year":"1993","journal-title":"Endocrinology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1210\/endo.136.10.7664666","article-title":"Processing of prothyrotropin-releasing hormone (Pro-TRH) by bovine intermediate lobe secretory vesicle membrane PC1 and PC2 enzymes.","volume":"136","author":"TC Friedman","year":"1995","journal-title":"Endocrinology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1126\/science.3929378","article-title":"Immunohistochemical localization in the rat brain of the precursor for thyrotropin-releasing hormone.","volume":"229","author":"IM Jackson","year":"1985","journal-title":"Science"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1210\/endo-111-1-55","article-title":"Immunohistochemical localization of thyrotropin-releasing hormone in the rat hypothalamus and pituitary.","volume":"111","author":"RM Lechan","year":"1982","journal-title":"Endocrinology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1210\/endo-119-3-1210","article-title":"Immunolocalization of the thyrotropin-releasing hormone prohormone in the rat central nervous system.","volume":"119","author":"RM Lechan","year":"1986","journal-title":"Endocrinology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1126\/science.3079917","article-title":"Thyrotropin-releasing hormone precursor: characterization in rat brain.","volume":"231","author":"RM Lechan","year":"1986","journal-title":"Science"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/0006-8993(88)90342-3","article-title":"Post-translational processing of thyrotropin-releasing hormone precursor in rat brain: identification of 3 novel peptides derived from <italic>proTRH<\/italic>.","volume":"456","author":"P Wu","year":"1988","journal-title":"Brain Res"},{"key":"ref38","first-page":"337","article-title":"Detection and Purification of Thyrotropin-Releasing Hormone Precursor Peptides Using Antisera Generated Against Synthetic Peptides.","author":"P Wu","year":"1991"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2202-6-26","article-title":"Proliferation dynamics of germinative zone cells in the intact and excitotoxically lesioned postnatal rat brain.","volume":"6","author":"M Faiz","year":"2005","journal-title":"BMC Neurosci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainres.2004.10.043","article-title":"Grafts of adult subependymal zone neuronal progenitor cells rescue hemiparkinsonian behavioral decline.","volume":"1032","author":"RM Richardson","year":"2005","journal-title":"Brain Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1006\/nbdi.2000.0372","article-title":"Alterations in cortical and basal ganglia levels of opioid receptor binding in a rat model of l-DOPA-induced dyskinesia.","volume":"8","author":"PA Johansson","year":"2001","journal-title":"Neurobiol Dis"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0306-4522(01)00597-8","article-title":"Presence of Ras guanyl nucleotide-releasing protein in striosomes of the mature and developing rat.","volume":"111","author":"P Pierret","year":"2002","journal-title":"Neuroscience"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0306-4522(99)00294-8","article-title":"Changes in the regional and compartmental distribution of FosB- and JunB-like immunoreactivity induced in the dopamine-denervated rat striatum by acute or chronic L-dopa treatment.","volume":"94","author":"MA Cenci","year":"1999","journal-title":"Neuroscience"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.nbd.2004.07.005","article-title":"Transcriptome analysis in a rat model of L-DOPA-induced dyskinesia.","volume":"17","author":"C Konradi","year":"2004","journal-title":"Neurobiol Dis"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0006-8993(99)01231-7","article-title":"Compartmental changes in expression of c-Fos and FosB proteins in intact and dopamine-depleted striatum after chronic apomorphine treatment.","volume":"825","author":"E Saka","year":"1999","journal-title":"Brain Res"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1056\/NEJM198804073181402","article-title":"Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson&apos;s disease. Pathophysiologic and clinical implications.","volume":"318","author":"SJ Kish","year":"1988","journal-title":"N Engl J Med"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1471-4159.2008.05831.x","article-title":"L-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice.","volume":"108","author":"E Santini","year":"2009","journal-title":"J Neurochem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"5042","DOI":"10.1523\/JNEUROSCI.22-12-05042.2002","article-title":"D1 dopamine receptor supersensitivity in the dopamine-depleted striatum results from a switch in the regulation of ERK1\/2\/MAP kinase.","volume":"22","author":"CR Gerfen","year":"2002","journal-title":"J Neurosci"},{"key":"ref49","first-page":"S53","article-title":"Patterns of gene expression and behavior induced by chronic dopamine treatments.","volume":"47","author":"JJ Canales","year":"2000","journal-title":"Ann Neurol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/73949","article-title":"A measure of striatal function predicts motor stereotypy.","volume":"3","author":"JJ Canales","year":"2000","journal-title":"Nat Neurosci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1002\/mds.21732","article-title":"Compartmental loss of striatal medium spiny neurons in multiple system atrophy of parkinsonian type.","volume":"22","author":"K Sato","year":"2007","journal-title":"Mov Disord"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"12551","DOI":"10.1073\/pnas.0806065105","article-title":"Differential involvement of striosome and matrix dopamine systems in a transgenic model of dopa-responsive dystonia.","volume":"105","author":"K Sato","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/brain\/awl243","article-title":"Striosomes and mood dysfunction in Huntington&apos;s disease.","volume":"130","author":"LJ Tippett","year":"2007","journal-title":"Brain"},{"key":"ref54","first-page":"S122","article-title":"Striatal mechanisms and pathogenesis of parkinsonian signs and motor complications.","volume":"47","author":"TN Chase","year":"2000","journal-title":"Ann Neurol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"28ra28","DOI":"10.1126\/scitranslmed.3000664","article-title":"Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson&apos;s disease.","volume":"2","author":"MR Ahmed","year":"2010","journal-title":"Sci Transl Med"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.nbd.2010.05.001","article-title":"A mGluR5 antagonist under clinical development improves L-DOPA-induced dyskinesia in parkinsonian rats and monkeys.","volume":"39","author":"D Rylander","year":"2010","journal-title":"Neurobiol Dis"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0014-2999(91)90316-I","article-title":"Interactions between dopamine D1 and D2 receptors in the model of thyrotropin-releasing hormone (TRH)-induced behaviour in rabbits.","volume":"201","author":"P Popoli","year":"1991","journal-title":"Eur J Pharmacol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0014-2999(89)90523-2","article-title":"Effects of SCH 23390 on thyrotropin-releasing hormone-induced behaviour in rabbits.","volume":"173","author":"P Popoli","year":"1989","journal-title":"Eur J Pharmacol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0014-2999(95)00066-T","article-title":"YM-14673, a thyrotropin-releasing hormone analogue, injected into the nucleus accumbens and the striatum produces repetitive jaw movements in rats.","volume":"277","author":"Y Miwa","year":"1995","journal-title":"Eur J Pharmacol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0166-4328(93)90066-Y","article-title":"Adenosine receptor agonists inhibit TRH-induced behaviour in rabbits: evidence for a main role of striatal A2 receptors.","volume":"57","author":"P Popoli","year":"1993","journal-title":"Behav Brain Res"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0143-4179(91)90118-3","article-title":"The role of dopamine in regulation of thyrotropin-releasing hormone in the striatum and nucleus accumbens of the rat.","volume":"19","author":"E Przegalinski","year":"1991","journal-title":"Neuropeptides"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0143-4179(93)90044-B","article-title":"The role of dopamine receptors in the release of thyrotropin-releasing hormone from the rat striatum and nucleus accumbens: an in vitro study.","volume":"25","author":"E Przegalinski","year":"1993","journal-title":"Neuropeptides"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0143-4179(97)90056-1","article-title":"Effects of repeated cocaine administration on the thyrotropin-releasing hormone level and receptors in the rat brain.","volume":"31","author":"L Jaworska-Feil","year":"1997","journal-title":"Neuropeptides"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0006-8993(90)90049-H","article-title":"Systemic administration of thyrotropin-releasing hormone enhances striatal dopamine release in vivo.","volume":"536","author":"MR Kreutz","year":"1990","journal-title":"Brain Res"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/3327","article-title":"Real-time quantitative RT-PCR after laser-assisted cell picking.","volume":"4","author":"L Fink","year":"1998","journal-title":"Nat Med"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0006-8993(02)02244-8","article-title":"Expression and activity of antioxidants in the brain in progressive supranuclear palsy.","volume":"930","author":"I Cantuti-Castelvetri","year":"2002","journal-title":"Brain Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0013861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T01:26:39Z","timestamp":1559784399000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0013861"}},"subtitle":[],"editor":[{"given":"Mark R.","family":"Cookson","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2010,11,10]]},"references-count":67,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2010,11,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0013861","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,10]]}}}