{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:43:42Z","timestamp":1773251022103,"version":"3.50.1"},"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2010,12,13]],"date-time":"2010-12-13T00:00:00Z","timestamp":1292198400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0014301","type":"journal-article","created":{"date-parts":[[2010,12,14]],"date-time":"2010-12-14T14:31:07Z","timestamp":1292337067000},"page":"e14301","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Chromatin Remodeling Pathways in Smooth Muscle Cell Differentiation, and Evidence for an Integral Role for p300"],"prefix":"10.1371","volume":"5","author":[{"given":"Joshua M.","family":"Spin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Quertermous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip S.","family":"Tsao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2010,12,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2014an inflammatory disease.","volume":"340","author":"R Ross","year":"1999","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1152\/physrev.1995.75.3.487","article-title":"Regulation of differentiation of vascular smooth muscle cells.","volume":"75","author":"GK Owens","year":"1995","journal-title":"Physiol Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1152\/physrev.00041.2003","article-title":"Molecular regulation of vascular smooth muscle cell differentiation in development and disease.","volume":"84","author":"GK Owens","year":"2004","journal-title":"Physiol Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1172\/JCI26505","article-title":"Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo.","volume":"116","author":"OG McDonald","year":"2006","journal-title":"J Clin Invest"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1161\/01.RES.0000266448.30370.a0","article-title":"Programming smooth muscle plasticity with chromatin dynamics.","volume":"100","author":"OG McDonald","year":"2007","journal-title":"Circ Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0955-0674(03)00013-9","article-title":"Histone and chromatin cross-talk.","volume":"15","author":"W Fischle","year":"2003","journal-title":"Curr Opin Cell Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/35073047","article-title":"Protein modules that manipulate histone tails for chromatin regulation.","volume":"2","author":"R Marmorstein","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0092-8674(04)00044-3","article-title":"The nucleosome: from genomic organization to genomic regulation.","volume":"116","author":"S Khorasanizadeh","year":"2004","journal-title":"Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1073\/pnas.51.5.786","article-title":"Acetylation and Methylation of Histones and Their Possible Role in the Regulation of Rna Synthesis.","volume":"51","author":"VG Allfrey","year":"1964","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/bies.950140103","article-title":"Reversible histone modifications and the chromosome cell cycle.","volume":"14","author":"EM Bradbury","year":"1992","journal-title":"Bioessays"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/nar\/27.3.711","article-title":"Chromatin disruption and modification.","volume":"27","author":"AP Wolffe","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0092-8674(00)00118-5","article-title":"Signaling to chromatin through histone modifications.","volume":"103","author":"P Cheung","year":"2000","journal-title":"Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/47412","article-title":"The language of covalent histone modifications.","volume":"403","author":"BD Strahl","year":"2000","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1101\/gad.14.13.1553","article-title":"CBP\/p300 in cell growth, transformation, and development.","volume":"14","author":"RH Goodman","year":"2000","journal-title":"Genes Dev"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0955-0674(02)00389-7","article-title":"Signaling chromatin to make muscle.","volume":"14","author":"TA McKinsey","year":"2002","journal-title":"Curr Opin Cell Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"6816","DOI":"10.1093\/emboj\/20.23.6816","article-title":"CBP\/p300 and muscle differentiation: no HAT, no muscle.","volume":"20","author":"A Polesskaya","year":"2001","journal-title":"Embo J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1101\/gad.10.19.2478","article-title":"Interaction and functional collaboration of p300\/CBP and bHLH proteins in muscle and B-cell differentiation.","volume":"10","author":"R Eckner","year":"1996","journal-title":"Genes Dev"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"24390","DOI":"10.1074\/jbc.M202490200","article-title":"The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism.","volume":"277","author":"YS Dai","year":"2002","journal-title":"J Biol Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"8643","DOI":"10.1128\/MCB.20.23.8643-8654.2000","article-title":"Proteasome-mediated degradation of the coactivator p300 impairs cardiac transcription.","volume":"20","author":"C Poizat","year":"2000","journal-title":"Mol Cell Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1161\/hh1101.091339","article-title":"Recruitment of serum response factor and hyperacetylation of histones at smooth muscle-specific regulatory regions during differentiation of a novel P19-derived in vitro smooth muscle differentiation system.","volume":"88","author":"I Manabe","year":"2001","journal-title":"Circ Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1161\/01.RES.0000016504.08608.B9","article-title":"Histone acetylation and recruitment of serum responsive factor and CREB-binding protein onto SM22 promoter during SM22 gene expression.","volume":"90","author":"P Qiu","year":"2002","journal-title":"Circ Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0968-0004(99)01537-6","article-title":"SAP - a putative DNA-binding motif involved in chromosomal organization.","volume":"25","author":"L Aravind","year":"2000","journal-title":"Trends Biochem Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1128\/MCB.25.1.364-376.2005","article-title":"Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin.","volume":"25","author":"D Cao","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"25330","DOI":"10.1074\/jbc.M000828200","article-title":"A p300 protein as a coactivator of GATA-6 in the transcription of the smooth muscle-myosin heavy chain gene.","volume":"275","author":"H Wada","year":"2000","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"6204","DOI":"10.1074\/jbc.M409506200","article-title":"Cell cycle-mediated regulation of smooth muscle alpha-actin gene transcription in fibroblasts and vascular smooth muscle cells involves multiple adenovirus E1A-interacting cofactors.","volume":"280","author":"SX Wang","year":"2005","journal-title":"J Biol Chem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1152\/physiolgenomics.00148.2004","article-title":"Transcriptional profiling of in vitro smooth muscle cell differentiation identifies specific patterns of gene and pathway activation.","volume":"19","author":"JM Spin","year":"2004","journal-title":"Physiol Genomics"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"11295","DOI":"10.1073\/pnas.94.21.11295","article-title":"A histone deacetylase inhibitor potentiates retinoid receptor action in embryonal carcinoma cells.","volume":"94","author":"S Minucci","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0076-6879(03)76013-3","article-title":"Histone deacetylase inhibitors: assays to assess effectiveness in vitro and in vivo.","volume":"376","author":"VM Richon","year":"2004","journal-title":"Methods Enzymol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"17182","DOI":"10.1021\/ja0558544","article-title":"Synthesis and evaluation of a potent and selective cell-permeable p300 histone acetyltransferase inhibitor.","volume":"127","author":"Y Zheng","year":"2005","journal-title":"J Am Chem Soc"},{"key":"ref30","first-page":"36","article-title":"Image Processing with ImageJ.","volume":"11","author":"MD Abramoff","year":"2004","journal-title":"Biophotonics International"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1186\/gb-2003-4-4-r28","article-title":"GoMiner: a resource for biological interpretation of genomic and proteomic data.","volume":"4","author":"BR Zeeberg","year":"2003","journal-title":"Genome Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","article-title":"DAVID: Database for Annotation, Visualization, and Integrated Discovery.","volume":"4","author":"G Dennis Jr","year":"2003","journal-title":"Genome Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"10264","DOI":"10.1074\/jbc.M408748200","article-title":"SIRT1 deacetylation and repression of p300 involves lysine residues 1020\/1024 within the cell cycle regulatory domain 1.","volume":"280","author":"T Bouras","year":"2005","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S1097-2765(03)00226-0","article-title":"Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state.","volume":"12","author":"M Fulco","year":"2003","journal-title":"Mol Cell"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S1097-2765(00)80452-9","article-title":"HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF.","volume":"5","author":"OD Lau","year":"2000","journal-title":"Mol Cell"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1016\/j.bmc.2004.03.070","article-title":"Bisubstrate analogue structure-activity relationships for p300 histone acetyltransferase inhibitors.","volume":"12","author":"V Sagar","year":"2004","journal-title":"Bioorg Med Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0076-6879(03)76012-1","article-title":"Selective HAT inhibitors as mechanistic tools for protein acetylation.","volume":"376","author":"Y Zheng","year":"2004","journal-title":"Methods Enzymol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/01.RES.0000197782.21444.8f","article-title":"Control of cardiac growth by histone acetylation\/deacetylation.","volume":"98","author":"J Backs","year":"2006","journal-title":"Circ Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1161\/CIRCRESAHA.107.164178","article-title":"The histone demethylase, Jmjd1a, interacts with the myocardin factors to regulate SMC differentiation marker gene expression.","volume":"101","author":"K Lockman","year":"2007","journal-title":"Circ Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/35065132","article-title":"Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.","volume":"410","author":"M Lachner","year":"2001","journal-title":"Nature"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/35065138","article-title":"Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.","volume":"410","author":"AJ Bannister","year":"2001","journal-title":"Nature"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1126\/science.1060781","article-title":"Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor.","volume":"293","author":"H Wang","year":"2001","journal-title":"Science"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1006\/geno.1997.5190","article-title":"Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2).","volume":"48","author":"HS Scott","year":"1998","journal-title":"Genomics"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"28624","DOI":"10.1074\/jbc.M201053200","article-title":"Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.","volume":"277","author":"C Qi","year":"2002","journal-title":"J Biol Chem"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/nature04431","article-title":"The Polycomb group protein EZH2 directly controls DNA methylation.","volume":"439","author":"E Vire","year":"2006","journal-title":"Nature"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1749-6632.2003.tb05964.x","article-title":"Histone deacetylases: unique players in shaping the epigenetic histone code.","volume":"983","author":"S Thiagalingam","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1096\/fj.04-2303fje","article-title":"Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility.","volume":"19","author":"D Waltregny","year":"2005","journal-title":"Faseb J"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0959-437X(00)00224-0","article-title":"Control of muscle development by dueling HATs and HDACs.","volume":"11","author":"TA McKinsey","year":"2001","journal-title":"Curr Opin Genet Dev"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"183","DOI":"10.5551\/jat.13.183","article-title":"Trichostatin A, an inhibitor of histone deacetylase, inhibits smooth muscle cell proliferation via induction of p21(WAF1).","volume":"13","author":"H Okamoto","year":"2006","journal-title":"J Atheroscler Thromb"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.bbrc.2006.07.009","article-title":"Dynamic changes in chromatin acetylation and the expression of histone acetyltransferases and histone deacetylases regulate the SM22alpha transcription in response to Smad3-mediated TGFbeta1 signaling.","volume":"348","author":"P Qiu","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"31016","DOI":"10.1074\/jbc.272.49.31016","article-title":"The CREB-binding protein (CBP) cooperates with the serum response factor for transactivation of the c-fos serum response element.","volume":"272","author":"S Ramirez","year":"1997","journal-title":"J Biol Chem"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/383099a0","article-title":"Role of CBP\/P300 in nuclear receptor signalling.","volume":"383","author":"D Chakravarti","year":"1996","journal-title":"Nature"},{"key":"ref53","first-page":"487","article-title":"Developmentally regulated expression of the transcriptional cofactors\/histone acetyltransferases CBP and p300 during mouse embryogenesis.","volume":"43","author":"A Partanen","year":"1999","journal-title":"Int J Dev Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0092-8674(00)81165-4","article-title":"Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300.","volume":"93","author":"TP Yao","year":"1998","journal-title":"Cell"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"13505","DOI":"10.1074\/jbc.R000025200","article-title":"CREB-binding protein and p300 in transcriptional regulation.","volume":"276","author":"N Vo","year":"2001","journal-title":"J Biol Chem"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1101\/gad.1393106","article-title":"MOZ is essential for maintenance of hematopoietic stem cells.","volume":"20","author":"T Katsumoto","year":"2006","journal-title":"Genes Dev"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.bcp.2004.03.045","article-title":"CBP and p300: HATs for different occasions.","volume":"68","author":"E Kalkhoven","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0006-291X(03)00266-3","article-title":"CBP\/p300 induction is required for retinoic acid sensitivity in human mammary cells.","volume":"302","author":"EC Dietze","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/24190","article-title":"Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A.","volume":"396","author":"S Ait-Si-Ali","year":"1998","journal-title":"Nature"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/30538","article-title":"Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation.","volume":"393","author":"H Kawasaki","year":"1998","journal-title":"Nature"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"39509","DOI":"10.1074\/jbc.M307123200","article-title":"Concomitant increase of histone acetyltransferase activity and degradation of p300 during retinoic acid-induced differentiation of F9 cells.","volume":"278","author":"F Brouillard","year":"2003","journal-title":"J Biol Chem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0014301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T11:39:51Z","timestamp":1636976391000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0014301"}},"subtitle":[],"editor":[{"given":"Joanna Mary","family":"Bridger","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2010,12,13]]},"references-count":61,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2010,12,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0014301","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,13]]}}}