{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:47:53Z","timestamp":1758905273348},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2011,1,14]],"date-time":"2011-01-14T00:00:00Z","timestamp":1294963200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0014537","type":"journal-article","created":{"date-parts":[[2011,1,14]],"date-time":"2011-01-14T22:03:18Z","timestamp":1295042598000},"page":"e14537","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Changes in Corneal Basal Epithelial Phenotypes in an Altered Basement Membrane"],"prefix":"10.1371","volume":"6","author":[{"given":"I-Jong","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ray Jui-Fang","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lung-Kun","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan Yao-Nien","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fung-Rong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winston W. Y.","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2011,1,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/229560a0","article-title":"Role of the pericorneal papillary structure in renewal of corneal epithelium.","volume":"229","author":"M Davanger","year":"1971","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1073\/pnas.061032098","article-title":"p63 identifies keratinocyte stem cells.","volume":"98","author":"G Pellegrini","year":"2001","journal-title":"Proc Natl Acad Sci"},{"key":"ref3","first-page":"1533","article-title":"Comparison of limbal and peripheral human corneal epithelium in tissue culture.","volume":"29","author":"B Ebato","year":"1988","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/0092-8674(94)90383-2","article-title":"Location of stem cells of human hair follicles by clonal analysis.","volume":"76","author":"A Rochat","year":"1994","journal-title":"Cell"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1083\/jcb.145.4.769","article-title":"Location and clonal analysis of stem cell and their differentiated progeny in the human ocular surface.","volume":"145","author":"G Pellegrini","year":"1999","journal-title":"J Cell Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1242\/jcs.111.19.2867","article-title":"Strategies of epithelial repair: modulation of stem cell and transient amplifying cell proliferation.","volume":"111","author":"MS Lehrer","year":"1998","journal-title":"J Cell Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0092-8674(89)90958-6","article-title":"Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferative: implications on epithelial stem cells.","volume":"57","author":"G Cotsarelis","year":"1989","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0161-6420(89)32833-8","article-title":"Limbal autograft transplantation for ocular surface disorders.","volume":"96","author":"KR Kenyon","year":"1989","journal-title":"Ophthalmology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S0161-6420(90)32575-7","article-title":"Comparison of limbal and conjunctival autograft transplantation in corneal surface reconstruction in rabbits.","volume":"97","author":"RJ Tsai","year":"1990","journal-title":"Ophthalmology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/00003226-199409000-00003","article-title":"Human allograft limbal transplantation for corneal surface reconstruction.","volume":"13","author":"RJ Tsai","year":"1994","journal-title":"Cornea"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0092-8674(04)00255-7","article-title":"Socializing with the neighbors: stem cells and their niche.","volume":"116","author":"E Fuchs","year":"2004","journal-title":"Cell"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1126\/science.1110542","article-title":"Stem cells and their niches.","volume":"311","author":"KA Moore","year":"2006","journal-title":"Science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1146\/annurev.cellbio.21.012704.131525","article-title":"Stem cell niche:structure and function.","volume":"21","author":"L Li","year":"2005","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1126\/science.1110542","article-title":"Stem cells and their niches.","volume":"311","author":"KA Moore","year":"2006","journal-title":"Science"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.exer.2005.01.023","article-title":"Melanocytes in the corneal limbus interact with K19-positive basal epithelial cells.","volume":"81","author":"K Higa","year":"2005","journal-title":"Exp Eye Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/0002-9394(70)91637-5","article-title":"Melanocyte and Langerhans cell population of the cornea and limbus in the albino animal.","volume":"69","author":"JL Baum","year":"1970","journal-title":"Am J Ophthalmol"},{"key":"ref17","first-page":"220","article-title":"Lymphocytes and Langerhans cells in the normal human cornea.","volume":"26","author":"L Vantrappen","year":"1985","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref18","first-page":"155","article-title":"Limbal palisades of Vogt.","volume":"80","author":"MF Goldberg","year":"1982","journal-title":"Trans Am Ophthalmol Soc"},{"issue":"Pt 2","key":"ref19","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/eye.1989.21","article-title":"The epithelial basement membrane zone of the limbus.","volume":"3","author":"IK Gipson","year":"1989","journal-title":"Eye"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1136\/bjo.2004.049742","article-title":"Limbal epithelial crypts:a novel anatomical structure and a putative limbal stem cell niche.","volume":"89","author":"HS Dua","year":"2005","journal-title":"Br J Ophthalmol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1136\/bjo.2006.102640","article-title":"Morphological characteristics of the limbal epithelial crypt.","volume":"91","author":"VA Shanmuganathan","year":"2007","journal-title":"Br J Ophthalmol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1634\/stemcells.2006-0580","article-title":"Characterization of the limbal epithelial stem cell niche: Novel imaging techniques permit in vivo observation and targeted biopsy of limbal epithelial stem cells.","volume":"25","author":"AJ Shortt","year":"2007","journal-title":"STEM CELLS"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/sj.cr.7310137","article-title":"Niche regulation of corneal epithelial stem cell at the limbus.","volume":"17","author":"W Li","year":"2007","journal-title":"Cell Research"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1177\/43.4.7534781","article-title":"Localized distribution of alpha 9 integrin in the cornea and changes in expression duringcorneal epithelial cell differentiation.","volume":"43","author":"MA Stepp","year":"1995","journal-title":"J Histochem Cytochem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1634\/stemcells.2006-0167","article-title":"N-Cadherin is expressed by putative stem\/progenitor cells and melanocytes in the human limbal epithelial stem cell niche.","volume":"25","author":"R Hayashi","year":"2007","journal-title":"Stem Cells"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1046\/j.1432-0436.1997.6140251.x","article-title":"Stem cells of the corneal epithelium lack connexins and metabolite transfer capacity.","volume":"61","author":"M Matic","year":"1997","journal-title":"Differentiation"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/00003226-199605000-00010","article-title":"The immunohistochemical composition of the human corneal basement membrane.","volume":"15","author":"A Tuori","year":"1996","journal-title":"Cornea"},{"key":"ref28","first-page":"461","article-title":"Human corneal basement membrane heterogeneity: topographical differences in the expression of type IV collagen and laminin isoforms.","volume":"72","author":"AV Ljubimov","year":"1995","journal-title":"Lab Invest"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1098\/rstb.1998.0249","article-title":"Cellular and molecular partners involved in gut morphogenesis and differentiation.","volume":"353","author":"M Kedinger","year":"1998","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"15155","DOI":"10.1073\/pnas.95.26.15155","article-title":"Stem cell homing:rolling, crawling, and nesting.","volume":"95","author":"PJ Quesenberry","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/22214","article-title":"Signal transduction. Neither straight nor narrow.","volume":"400","author":"M Peifer","year":"1999","journal-title":"Nature"},{"key":"ref32","first-page":"439","article-title":"Effect of stromal inflammation on the outcome of limbal transplantation for corneal surface reconstruction.","volume":"14","author":"RJ Tsai","year":"1995","journal-title":"Cornea"},{"key":"ref33","first-page":"63","article-title":"Connexin 43 expression and proliferation of human limbal epithelium on intact and denuded amniotic membrane.","volume":"43","author":"M Grueterich","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1001\/archopht.120.6.783","article-title":"Human limbal progenitor cells expanded on intact amniotic membrane ex vivo.","volume":"120","author":"M Grueterich","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.survophthal.2003.08.003","article-title":"Ex vivo expansion of limbal epithelial stem cells: amniotic membrane serving as a stem cell niche.","volume":"48","author":"M Grueterich","year":"2003","journal-title":"Surv Ophthalmol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1056\/NEJM200007133430202","article-title":"Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells.","volume":"343","author":"RJ Tsai","year":"2000","journal-title":"N Engl J Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1097\/00003226-200111000-00018","article-title":"Epithelial plugs in radial keratotomy: the origin of incisional keratitis?","volume":"20","author":"J Bergmanson","year":"2001","journal-title":"Cornea"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/01.icl.0000189038.74139.4a","article-title":"In vivo confocal microscopy findings in keratoconus.","volume":"32","author":"OO Ucakhan","year":"2006","journal-title":"Eye Contact Lens"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1475-1313.2005.00278.x","article-title":"In vivo corneal confocal microscopy in keratoconus.","volume":"25","author":"JG Hollingsworth","year":"2005","journal-title":"Ophthalmic Physiol Opt"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1442-9071.2004.00805.x","article-title":"Morphological changes in keratoconus: pathology or pathogenesis.","volume":"32","author":"T Sherwin","year":"2004","journal-title":"Clin Experiment Ophthalmol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1242\/jcs.054791","article-title":"The growth-promoting effect of KGF on limbal epithelial cells is mediated by upregulation of DeltaNp63alpha through the p38 pathway.","volume":"122","author":"CC Cheng","year":"2009","journal-title":"J Cell Sci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1242\/dev.126.11.2409","article-title":"The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: a new view based on whole-mount labelling and lineage analysis.","volume":"126","author":"UB Jensen","year":"1999","journal-title":"Development"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"6622","DOI":"10.1093\/emboj\/17.22.6622","article-title":"Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival.","volume":"17","author":"L Moro","year":"1998","journal-title":"EMBO J"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1006\/exer.1998.0511","article-title":"Extracellular matrix changes in human corneas after radial keratotomy.","volume":"67","author":"AV Ljubimov","year":"1998","journal-title":"Exp Eye Res"},{"key":"ref45","first-page":"1442","article-title":"The X, Y, Z hypothesis of corneal epithelial maintenance.","volume":"24","author":"RA Thoft","year":"1983","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1006\/exer.1994.1152","article-title":"Effect of epidermal growth factor, hepatocyte growth factor, and keratinocyte growth factor, on proliferation, motility and differentiation of human corneal epithelial cells.","volume":"59","author":"SE Wilson","year":"1994","journal-title":"Exp Eye Res"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/jcp.1041630108","article-title":"Three patterns of cytokine expression potentially involved in epithelial-fibroblast interactions of human ocular surface.","volume":"163","author":"DQ Li","year":"1995","journal-title":"J Cell Physiol"},{"key":"ref48","first-page":"773","article-title":"A stem cell niche theory of intestinal crypt maintenance based on a study of somatic mutation in colonic mucosa.","volume":"141","author":"ED Williams","year":"1992","journal-title":"Am J Pathol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1126\/science.8456284","article-title":"Ultrastructural evidence for hair cell regeneration in the mammalian inner ear.","volume":"259","author":"A Forge","year":"1993","journal-title":"Science"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1242\/dev.121.8.2559","article-title":"PDGF-AA and its receptor influence early lung branching via an epithelial-mesenchymal interaction.","volume":"121","author":"P Souza","year":"1995","journal-title":"Development"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0925-4773(94)90050-7","article-title":"FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions.","volume":"45","author":"IJ Mason","year":"1994","journal-title":"Mech Dev"},{"key":"ref52","first-page":"201","article-title":"In vitro regulation of HGF-SF expression by epithelial-mesenchymal interactions.","volume":"65","author":"T Kamalati","year":"1993","journal-title":"EXS"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0014537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T12:45:09Z","timestamp":1637153109000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0014537"}},"subtitle":[],"editor":[{"given":"Che John","family":"Connon","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2011,1,14]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,1,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0014537","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,14]]}}}