{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:28:43Z","timestamp":1791044923736,"version":"4.1.0"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2011,1,19]],"date-time":"2011-01-19T00:00:00Z","timestamp":1295395200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0014557","type":"journal-article","created":{"date-parts":[[2011,1,19]],"date-time":"2011-01-19T20:24:32Z","timestamp":1295468672000},"page":"e14557","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["Time Course of Gene Expression Profiling in the Liver of Experimental Mice Infected with Echinococcus multilocularis"],"prefix":"10.1371","volume":"6","author":[{"given":"Renyong","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"L\u00fc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanshan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Mantion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lysiane","family":"Richert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique A.","family":"Vuitton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,1,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3748\/wjg.v12.i4.509","article-title":"Molecular therapy for hepatic injury and fibrosis: where are we?","volume":"12","author":"CC Prosser","year":"2006","journal-title":"World J Gastroenterol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jss.2005.12.011","article-title":"Prometheus' challenge: molecular, cellular and systemic aspects of liver regeneration.","volume":"134","author":"PS Pahlavan","year":"2006","journal-title":"J Surg Res"},{"key":"ref3","first-page":"100","article-title":"Cirrhosis\u2014can we reverse hepatic fibrosis?","author":"P Tangkijvanich","year":"2002"},{"key":"ref4","first-page":"319","article-title":"The role of the liver in the response to LPS: experimental and clinical findings.","volume":"8","author":"E Jirillo","year":"2002","journal-title":"J Endotoxin Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"D520","DOI":"10.2741\/A447","article-title":"NF-kappa B, liposomes and pathogenesis of hepatic injury and fibrosis.","volume":"4","author":"J Wu","year":"1999","journal-title":"Front Biosci"},{"key":"ref6","article-title":"Infectious, non-viral, diseases of the liver.","author":"D Vuitton","year":"1999"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/00001432-200310000-00010","article-title":"Echinococcus multilocularis.","volume":"16","author":"P Craig","year":"2003","journal-title":"Curr Opin Infect Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1365-2249.1990.tb05457.x","article-title":"Cellular immunity in experimental Echinococcus multilocularis infection. II. Sequential and comparative phenotypic study of the periparasitic mononuclear cells in resistant and sensitive mice.","volume":"82","author":"S Bresson-Hadni","year":"1990","journal-title":"Clin Exp Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s004360050466","article-title":"Echinococcus multilocularis: relationship between susceptibility\/resistance and liver fibrogenesis in experimental mice.","volume":"84","author":"S Guerret","year":"1998","journal-title":"Parasitol Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S0140-6736(03)14573-4","article-title":"Echinococcosis.","volume":"362","author":"DP McManus","year":"2003","journal-title":"Lancet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.vetpar.2005.03.034","article-title":"Experimental alveolar echinococcosis in pigs, lesion development and serological follow up.","volume":"130","author":"P Deplazes","year":"2005","journal-title":"Vet Parasitol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0001-706X(02)00230-9","article-title":"The ambiguous role of immunity in echinococcosis: protection of the host or of the parasite?","volume":"85","author":"DA Vuitton","year":"2003","journal-title":"Acta Trop"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1079\/JOH200188","article-title":"Effect of Echinococcus multilocularis on the origin of acetyl-coA entering the tricarboxylic acid cycle in host liver.","volume":"76","author":"C Kepron","year":"2002","journal-title":"J Helminthol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0020-7519(94)00086-4","article-title":"Echinococcus multilocularis protoscoleces and hepatic cell activity in vitro.","volume":"25","author":"C Gabrion","year":"1995","journal-title":"Int J Parasitol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.3748\/wjg.15.2116","article-title":"Components of the mitogen-activated protein kinase cascade are activated in hepatic cells by Echinococcus multilocularis metacestode.","volume":"15","author":"RY Lin","year":"2009","journal-title":"World J Gastroenterol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1269\/jrr.07078","article-title":"Gene expression profiles in mouse liver cells after exposure to different types of radiation.","volume":"49","author":"MH Roudkenar","year":"2008","journal-title":"J Radiat Res (Tokyo)"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/aps.2009.22","article-title":"Gene expression profiles of human liver cells mediated by hepatitis B virus X protein.","volume":"30","author":"WY Zhang","year":"2009","journal-title":"Acta Pharmacol Sin"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00428-002-0617-x","article-title":"Genes involved in hepatocellular carcinoma: deregulation in cell cycling and apoptosis.","volume":"440","author":"A Tannapfel","year":"2002","journal-title":"Virchows Arch"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1053\/gast.2001.22468","article-title":"Differential gene expression between chronic hepatitis B and C hepatic lesion.","volume":"120","author":"M Honda","year":"2001","journal-title":"Gastroenterology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.yexmp.2007.10.001","article-title":"Increased severity of alcoholic liver injury in female verses male rats: a microarray analysis.","volume":"84","author":"MR Sharma","year":"2008","journal-title":"Exp Mol Pathol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e9779","DOI":"10.1371\/journal.pone.0009779","article-title":"Hepatic gene expression profile in mice perorally infected with Echinococcus multilocularis eggs.","volume":"5","author":"B Gottstein","year":"2010","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s12038-007-0059-3","article-title":"Heat shock genes - integrating cell survival and death.","volume":"32","author":"R Arya","year":"2007","journal-title":"J Biosci"},{"issue":"Suppl 3","key":"ref23","doi-asserted-by":"crossref","first-page":"iii65","DOI":"10.1136\/ard.2006.058495","article-title":"Heat shock proteins induce T cell regulation of chronic inflammation.","volume":"65","author":"F Hauet-Broere","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1086\/586709","article-title":"Expression of major histocompatibility complex class I chain-related molecule A, NKG2D, and transforming growth factor-beta in the liver of humans with alveolar echinococcosis: new actors in the tolerance to parasites?","volume":"197","author":"S Zhang","year":"2008","journal-title":"J Infect Dis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1046\/j.1365-3024.2003.00617.x","article-title":"Molecular and immunological characterization of the C-terminal region of a new Echinococcus granulosus Heat Shock Protein 70.","volume":"25","author":"E Ortona","year":"2003","journal-title":"Parasite Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1194\/jlr.M200296-JLR200","article-title":"Alkylacylglycerolipid domain of GPI molecules of Leishmania is responsible for inhibition of PKC-mediated c-fos expression.","volume":"44","author":"M Chawla","year":"2003","journal-title":"J Lipid Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.vetimm.2005.02.004","article-title":"Understanding bovine trypanosomiasis and trypanotolerance: the promise of functional genomics.","volume":"105","author":"EW Hill","year":"2005","journal-title":"Vet Immunol Immunopathol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1269\/jrr.06057","article-title":"Oxidative stress induced lipocalin 2 gene expression: addressing its expression under the harmful conditions.","volume":"48","author":"MH Roudkenar","year":"2007","journal-title":"J Radiat Res (Tokyo)"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S1097-2765(02)00710-4","article-title":"An iron delivery pathway mediated by a lipocalin.","volume":"10","author":"J Yang","year":"2002","journal-title":"Mol Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1126\/science.1061075","article-title":"Induction of apoptosis by a secreted lipocalin that is transcriptionally regulated by IL-3 deprivation.","volume":"293","author":"LR Devireddy","year":"2001","journal-title":"Science"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/ijc.20376","article-title":"Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis.","volume":"112","author":"E Missiaglia","year":"2004","journal-title":"Int J Cancer"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/intimm\/dxl123","article-title":"Pathological role of Toll-like receptor signaling in cerebral malaria.","volume":"19","author":"C Coban","year":"2007","journal-title":"Int Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1373\/clinchem.2006.075614","article-title":"Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans.","volume":"53","author":"Y Wang","year":"2007","journal-title":"Clin Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0928-8244(03)00112-3","article-title":"The acute phase protein serum amyloid A primes neutrophils.","volume":"38","author":"E Hatanaka","year":"2003","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/0962935031000134897","article-title":"mRNA expression and release of interleukin-8 induced by serum amyloid A in neutrophils and monocytes.","volume":"12","author":"FP Ribeiro","year":"2003","journal-title":"Mediators Inflamm"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1046\/j.1365-3083.1996.d01-26.x","article-title":"Both murine SAA1 and SAA2 yield AA amyloid in alveolar hydatid cyst-infected mice.","volume":"43","author":"AW Bell","year":"1996","journal-title":"Scand J Immunol"},{"key":"ref37","first-page":"313","article-title":"Pathogenesis of secondary amyloidosis in an alveolar hydatid cyst-mouse model: histopathology and immuno\/enzyme-histochemical analysis of splenic marginal zone cells during amyloidogenesis.","volume":"71","author":"T Du","year":"1990","journal-title":"J Exp Pathol (Oxford)"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/0014-4894(88)90080-X","article-title":"Echinococcus multilocularis: relationship between persistent inflammation, serum amyloid A protein response and amyloidosis in four mouse strains.","volume":"67","author":"Z Ali-Khan","year":"1988","journal-title":"Exp Parasitol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1111\/j.1440-1746.2008.05345.x","article-title":"Changing the pathogenetic roadmap of liver fibrosis? Where did it start; where will it go?","volume":"23","author":"OA Gressner","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF00927740","article-title":"Collagen immunotyping of the hepatic fibrosis in human alveolar echinococcosis.","volume":"72","author":"DA Vuitton","year":"1986","journal-title":"Z Parasitenkd"},{"key":"ref41","first-page":"397","article-title":"Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals.","volume":"12","author":"BA Ballif","year":"2001","journal-title":"Cell Growth Differ"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1126\/science.7973727","article-title":"Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.","volume":"266","author":"ML Smith","year":"1994","journal-title":"Science"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1749-6632.1992.tb38657.x","article-title":"Genotoxic-stress-response genes and growth-arrest genes. gadd, MyD, and other genes induced by treatments eliciting growth arrest.","volume":"663","author":"AJ Fornace Jr","year":"1992","journal-title":"Ann N Y Acad Sci"},{"key":"ref44","first-page":"461","article-title":"Cellular localisations of interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha mRNA in a parasitic granulomatous disease of the liver, alveolar echinococcosis.","volume":"5","author":"S Bresson-Hadni","year":"1994","journal-title":"Eur Cytokine Netw"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-5793(87)80865-7","article-title":"Cyclin (PCNA, auxiliary protein of DNA polymerase delta) is a central component of the pathway(s) leading to DNA replication and cell division.","volume":"220","author":"JE Celis","year":"1987","journal-title":"FEBS Lett"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1172\/JCI200316712","article-title":"Massive hepatic apoptosis associated with TGF-beta1 activation after Fas ligand treatment of IGF binding protein-1-deficient mice.","volume":"111","author":"JI Leu","year":"2003","journal-title":"J Clin Invest"},{"key":"ref47","first-page":"37","article-title":"Identification and inhibition of the ICE\/CED-3 protease necessary for mammalian apoptosis Nature","volume":"376","author":"DW Nicholson","year":"1995"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1002\/hep.22237","article-title":"Caspase activation is associated with spontaneous recovery from acute liver failure.","volume":"47","author":"X Volkmann","year":"2008","journal-title":"Hepatology"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1046\/j.1365-2249.2000.01150.x","article-title":"Trypanosoma cruzi-induced immunosuppression: B cells undergo spontaneous apoptosis and lipopolysaccharide (LPS) arrests their proliferation during acute infection.","volume":"119","author":"E Zuniga","year":"2000","journal-title":"Clin Exp Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1189\/jlb.0702353","article-title":"Interleukin-4 biases differentiation of B cells from Trypanosoma cruzi-infected mice and restrains their fratricide: role of Fas ligand down-regulation and MHC class II-transactivator up-regulation.","volume":"73","author":"EV Acosta Rodriguez","year":"2003","journal-title":"J Leukoc Biol"},{"key":"ref51","first-page":"245","article-title":"The role of Fas system [Fas-FasL] as an inducer of apoptosis in cutaneous leishmaniasis: a combined human and experimental study.","volume":"31","author":"SI el-Kowrany","year":"2001","journal-title":"J Egypt Soc Parasitol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"902","DOI":"10.4049\/jimmunol.167.2.902","article-title":"IFN-gamma overproduction and high level apoptosis are associated with high but not low virulence Toxoplasma gondii infection.","volume":"167","author":"LC Gavrilescu","year":"2001","journal-title":"J Immunol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1080\/00034983.2001.11813699","article-title":"Trypanosoma brucei infection induces apoptosis and up-regulates neuroleukin expression in the Cerebellum.","volume":"95","author":"JK Stiles","year":"2001","journal-title":"Ann Trop Med Parasitol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"34329","DOI":"10.1074\/jbc.M201344200","article-title":"Skin-stage schistosomula of Schistosoma mansoni produce an apoptosis inducing factor that can cause apoptosis of T cells.","volume":"277","author":"L Chen","year":"2002","journal-title":"J Biol Chem"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.expneurol.2006.02.011","article-title":"Neuronal apoptosis, metallothionein expression and proinflammatory responses during cerebral malaria in mice.","volume":"200","author":"L Wiese","year":"2006","journal-title":"Exp Neurol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0192-0561(94)90094-9","article-title":"Factors involved in the down-regulation of cytochrome P450 during Listeria monocytogenes infection.","volume":"16","author":"SG Armstrong","year":"1994","journal-title":"Int J Immunopharmacol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1124\/dmd.105.007393","article-title":"Hepatic and renal cytochrome p450 gene regulation during Citrobacter rodentium infection in wild-type and toll-like receptor 4 mutant mice.","volume":"34","author":"TA Richardson","year":"2006","journal-title":"Drug Metab Dispos"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.exppara.2006.01.013","article-title":"Plasmodium berghei (ANKA): infection induces CYP2A5 and 2E1 while depressing other CYP isoforms in the mouse liver.","volume":"113","author":"AC De-Oliveira","year":"2006","journal-title":"Exp Parasitol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbrc.2003.09.227","article-title":"Mechanism of impairment of cytochrome P450-dependent metabolism in hamster liver during leishmaniasis.","volume":"312","author":"TB Samanta","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0006-2952(94)90235-6","article-title":"Contribution of hepatic cytochrome P450 systems to the generation of reactive oxygen species.","volume":"48","author":"SC Bondy","year":"1994","journal-title":"Biochem Pharmacol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.3109\/03602539709002246","article-title":"Regulation of cytochromes P450 during inflammation and infection.","volume":"29","author":"ET Morgan","year":"1997","journal-title":"Drug Metab Rev"},{"key":"ref62","first-page":"207","article-title":"Regulation of cytochrome P450 by inflammatory mediators: why and how?","volume":"29","author":"ET Morgan","year":"2001","journal-title":"Drug Metab Dispos"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1046\/j.1472-8206.2003.00171.x","article-title":"Albendazole for the treatment of echinococcosis.","volume":"17","author":"J Horton","year":"2003","journal-title":"Fundam Clin Pharmacol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"46835","DOI":"10.1074\/jbc.M409340200","article-title":"Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes.","volume":"279","author":"DL Brasaemle","year":"2004","journal-title":"J Biol Chem"},{"key":"ref65","first-page":"1047","article-title":"Echinococcosis of the liver.","volume":"2007","author":"S Bresson-Hadni"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1007\/BF01951932","article-title":"Experimental alveolar echinococcosis. Suitability of a murine model of intrahepatic infection by Echinococcus multilocularis for immunological studies.","volume":"40","author":"M Liance","year":"1984","journal-title":"Experientia"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"D258","DOI":"10.1093\/nar\/gkh036","article-title":"The Gene Ontology (GO) database and informatics resource.","volume":"32","author":"MA Harris","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.","volume":"4","author":"W Huang da","year":"2009","journal-title":"Nat Protoc"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1093\/bioinformatics\/bti430","article-title":"Automated genome annotation and pathway identification using the KEGG Orthology (KO) as a controlled vocabulary.","volume":"21","author":"X Mao","year":"2005","journal-title":"Bioinformatics"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0014557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T23:15:34Z","timestamp":1740870934000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0014557"}},"subtitle":[],"editor":[{"given":"I. King","family":"Jordan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,1,19]]},"references-count":69,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,1,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0014557","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,19]]}}}