{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T10:00:24Z","timestamp":1769680824839,"version":"3.49.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2010,11,24]],"date-time":"2010-11-24T00:00:00Z","timestamp":1290556800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0015008","type":"journal-article","created":{"date-parts":[[2010,11,24]],"date-time":"2010-11-24T21:33:22Z","timestamp":1290634402000},"page":"e15008","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Functional Identification of Neuroprotective Molecules"],"prefix":"10.1371","volume":"5","author":[{"given":"Cheng","family":"Dai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiwu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ted M.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valina L.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2010,11,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrn1927","article-title":"Cerebral preconditioning and ischaemic tolerance.","volume":"7","author":"JM Gidday","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.2741\/3297","article-title":"Parthanatos, a messenger of death.","volume":"14","author":"KK David","year":"2009","journal-title":"Front Biosci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.expneurol.2009.03.020","article-title":"Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos.","volume":"218","author":"Y Wang","year":"2009","journal-title":"Exp Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0092-8674(00)80785-0","article-title":"Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes.","volume":"97","author":"D Fambrough","year":"1999","journal-title":"Cell"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1126\/science.283.5398.83","article-title":"The transcriptional program in the response of human fibroblasts to serum.","volume":"283","author":"VR Iyer","year":"1999","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"12684","DOI":"10.1073\/pnas.220431297","article-title":"RaSH, a rapid subtraction hybridization approach for identifying and cloning differentially expressed genes.","volume":"97","author":"H Jiang","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1126\/science.1354393","article-title":"Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction.","volume":"257","author":"P Liang","year":"1992","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1126\/science.270.5235.467","article-title":"Quantitative monitoring of gene expression patterns with a complementary DNA microarray.","volume":"270","author":"M Schena","year":"1995","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1126\/science.270.5235.484","article-title":"Serial analysis of gene expression.","volume":"270","author":"VE Velculescu","year":"1995","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1523\/JNEUROSCI.18-03-01009.1998","article-title":"Bcl-xL is an antiapoptotic regulator for postnatal CNS neurons.","volume":"18","author":"AS Parsadanian","year":"1998","journal-title":"J Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"7591","DOI":"10.1074\/jbc.M207232200","article-title":"Calmodulin mediates brain-derived neurotrophic factor cell survival signaling upstream of Akt kinase in embryonic neocortical neurons.","volume":"278","author":"A Cheng","year":"2003","journal-title":"J Biol Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1042\/BJ20061817","article-title":"Connective tissue growth factor (CTGF) promotes activated mesangial cell survival via up-regulation of mitogen-activated protein kinase phosphatase-1 (MKP-1).","volume":"406","author":"N Wahab","year":"2007","journal-title":"Biochem J"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/sj.cdd.4401078","article-title":"Elongation factor-1 alpha is a selective regulator of growth factor withdrawal and ER stress-induced apoptosis.","volume":"9","author":"S Talapatra","year":"2002","journal-title":"Cell Death Differ"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1042\/BST0371293","article-title":"eEF1A2 and neuronal degeneration.","volume":"37","author":"CM Abbott","year":"2009","journal-title":"Biochem Soc Trans"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1073\/pnas.0611609104","article-title":"Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor.","volume":"104","author":"Y Huang","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","article-title":"Reduced expression of plasma membrane calcium ATPase 2 and collapsin response mediator protein 1 promotes death of spinal cord neurons.","author":"MP Kurnellas","year":"2010","journal-title":"Cell Death Differ"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1038\/jcbfm.2008.65","article-title":"Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke.","volume":"28","author":"J Liauw","year":"2008","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.","volume":"443","author":"MT Lin","year":"2006","journal-title":"Nature"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gad.1376506","article-title":"Necrotic death as a cell fate.","volume":"20","author":"WX Zong","year":"2006","journal-title":"Genes Dev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/ng758","article-title":"Mutations in a newly identified GTPase gene cause autosomal dominant hereditary spastic paraplegia.","volume":"29","author":"X Zhao","year":"2001","journal-title":"Nat Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cell.2006.12.017","article-title":"Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans.","volume":"128","author":"DA Keays","year":"2007","journal-title":"Cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/72829","article-title":"A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation.","volume":"24","author":"R Zemni","year":"2000","journal-title":"Nat Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1042\/BJ20082422","article-title":"Lateral organization of membrane proteins: tetraspanins spin their web.","volume":"420","author":"S Charrin","year":"2009","journal-title":"Biochem J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1126\/science.287.5458.1660","article-title":"Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein.","volume":"287","author":"N Lezcano","year":"2000","journal-title":"Science"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1242\/jcs.037051","article-title":"EHD3 regulates early-endosome-to-Golgi transport and preserves Golgi morphology.","volume":"122","author":"N Naslavsky","year":"2009","journal-title":"J Cell Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/ng.268","article-title":"The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation.","volume":"41","author":"J Wang","year":"2009","journal-title":"Nat Genet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"11296","DOI":"10.1016\/S0021-9258(18)82124-X","article-title":"Cloning and characterization of a putative Ca2+\/H+ antiporter gene from Escherichia coli upon functional complementation of Na+\/H+ antiporter-deficient strains by the overexpressed gene.","volume":"268","author":"DM Ivey","year":"1993","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"7335","DOI":"10.1074\/jbc.M211684200","article-title":"Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade.","volume":"278","author":"YA Moon","year":"2003","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1523\/JNEUROSCI.18-06-02040.1998","article-title":"Manganese superoxide dismutase protects nNOS neurons from NMDA and nitric oxide-mediated neurotoxicity.","volume":"18","author":"M Gonzalez-Zulueta","year":"1998","journal-title":"J Neurosci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1073\/pnas.97.1.436","article-title":"Requirement for nitric oxide activation of p21(ras)\/extracellular regulated kinase in neuronal ischemic preconditioning.","volume":"97","author":"M Gonzalez-Zulueta","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0076-6879(00)25451-7","article-title":"Expression of Rho GTPases using retroviral vectors.","volume":"325","author":"F Michiels","year":"2000","journal-title":"Methods Enzymol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/geno.1999.6087","article-title":"EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins.","volume":"63","author":"U Pohl","year":"2000","journal-title":"Genomics"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0015008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T03:10:06Z","timestamp":1636859406000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0015008"}},"subtitle":[],"editor":[{"given":"Maria A.","family":"Deli","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2010,11,24]]},"references-count":32,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2010,11,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0015008","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,24]]}}}