{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T16:40:39Z","timestamp":1771605639087,"version":"3.50.1"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2010,12,6]],"date-time":"2010-12-06T00:00:00Z","timestamp":1291593600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0015253","type":"journal-article","created":{"date-parts":[[2010,12,6]],"date-time":"2010-12-06T21:43:59Z","timestamp":1291671839000},"page":"e15253","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Arginase Activities and Global Arginine Bioavailability in Wild-Type and ApoE-Deficient Mice: Responses to High Fat and High Cholesterol Diets"],"prefix":"10.1371","volume":"5","author":[{"given":"Aaron","family":"Erdely","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Kepka-Lenhart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Salmen-Muniz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"Hulderman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kashon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petia P.","family":"Simeonova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidney M.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2010,12,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3360001","article-title":"Arginine metabolism: nitric oxide and beyond.","volume":"336(Pt 1)","author":"G Wu","year":"1998","journal-title":"Biochem J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/j.1440-1681.2007.04638.x","article-title":"Arginase: a critical regulator of nitric oxide synthesis and vascular function.","volume":"34","author":"W Durante","year":"2007","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1191\/1358863x05vm601oa","article-title":"Arginine metabolism in vascular biology and disease.","volume":"10","author":"SM Morris Jr","year":"2005","journal-title":"Vasc Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s12272-009-1801-1","article-title":"Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases.","volume":"32","author":"C Napoli","year":"2009","journal-title":"Arch Pharm Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s11906-006-0041-8","article-title":"Endothelial arginase: a new target in atherosclerosis.","volume":"8","author":"Z Yang","year":"2006","journal-title":"Curr Hypertens Rep"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9150(01)00717-1","article-title":"Vascular effects of dietary L-arginine supplementation.","volume":"162","author":"RB Preli","year":"2002","journal-title":"Atherosclerosis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1006\/bbrc.2000.3169","article-title":"Regulation of nitric oxide production by arginine metabolic enzymes.","volume":"275","author":"M Mori","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"ref8","first-page":"E740","article-title":"Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells.","volume":"275","author":"SM Morris Jr","year":"1998","journal-title":"Am J Physiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"C248","DOI":"10.1152\/ajpcell.2000.279.1.C248","article-title":"IL-4 and IL-13 upregulate arginase I expression by cAMP and JAK\/STAT6 pathways in vascular smooth muscle cells.","volume":"279","author":"LH Wei","year":"2000","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1161\/01.CIR.0000092948.04444.C7","article-title":"Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels.","volume":"108","author":"DE Berkowitz","year":"2003","journal-title":"Circulation"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1097\/01.hjh.0000166837.78559.93","article-title":"Arginase inhibition reduces endothelial dysfunction and blood pressure rising in spontaneously hypertensive rats.","volume":"23","author":"C Demougeot","year":"2005","journal-title":"J Hypertens"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1096\/fj.03-0115fje","article-title":"Ischemia-reperfusion selectively impairs nitric oxide-mediated dilation in coronary arterioles: counteracting role of arginase.","volume":"17","author":"TW Hein","year":"2003","journal-title":"Faseb J"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"R1057","DOI":"10.1152\/ajpregu.00758.2004","article-title":"Arginase inhibition restores arteriolar endothelial function in Dahl rats with salt-induced hypertension.","volume":"288","author":"FK Johnson","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1161\/CIRCRESAHA.107.157727","article-title":"Inducible NO synthase dependent S-nitrosylation and activation of arginase1 contribute to age-related endothelial dysfunction.","volume":"101","author":"L Santhanam","year":"2007","journal-title":"Circ Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1161\/01.HYP.0000198543.34502.d7","article-title":"Knockdown of arginase I restores NO signaling in the vasculature of old rats.","volume":"47","author":"AR White","year":"2006","journal-title":"Hypertension"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1161\/01.HYP.0000146907.82869.f2","article-title":"Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles.","volume":"44","author":"C Zhang","year":"2004","journal-title":"Hypertension"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"30154","DOI":"10.1074\/jbc.272.48.30154","article-title":"Lysophosphatidylcholine regulates cationic amino acid transport and metabolism in vascular smooth muscle cells. Role in polyamine biosynthesis.","volume":"272","author":"W Durante","year":"1997","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1161\/01.CIR.103.8.1121","article-title":"Transforming growth factor-beta(1) stimulates L-arginine transport and metabolism in vascular smooth muscle cells: role in polyamine and collagen synthesis.","volume":"103","author":"W Durante","year":"2001","journal-title":"Circulation"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"9260","DOI":"10.1073\/pnas.161294898","article-title":"Elevated arginase I expression in rat aortic smooth muscle cells increases cell proliferation.","volume":"98","author":"LH Wei","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1161\/01.ATV.14.1.133","article-title":"ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.","volume":"14","author":"Y Nakashima","year":"1994","journal-title":"Arterioscler Thromb"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0021-9150(87)90202-4","article-title":"Quantitative assessment of atherosclerotic lesions in mice.","volume":"68","author":"B Paigen","year":"1987","journal-title":"Atherosclerosis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1161\/01.ATV.0000201071.49029.17","article-title":"Diet and murine atherosclerosis.","volume":"26","author":"GS Getz","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1001\/jama.294.1.81","article-title":"Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease.","volume":"294","author":"CR Morris","year":"2005","journal-title":"JAMA"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1016\/j.jacc.2009.02.036","article-title":"Diminished global arginine bioavailability and increased arginine catabolism as metabolic profile of increased cardiovascular risk.","volume":"53","author":"WH Tang","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1189\/jlb.0607390","article-title":"Atherogenic diet-induced hepatitis is partially dependent on murine TLR4.","volume":"83","author":"MS Desai","year":"2008","journal-title":"J Leukoc Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1172\/JCI116495","article-title":"Genetic control of inflammatory gene induction and NF-kappa B-like transcription factor activation in response to an atherogenic diet in mice.","volume":"91","author":"F Liao","year":"1993","journal-title":"J Clin Invest"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1152\/physiolgenomics.90350.2008","article-title":"Effects of atherogenic diet on hepatic gene expression across mouse strains.","volume":"39","author":"KR Shockley","year":"2009","journal-title":"Physiol Genomics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"42774","DOI":"10.1074\/jbc.M306022200","article-title":"Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression.","volume":"278","author":"L Vergnes","year":"2003","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11010-005-2997-0","article-title":"Feeding apolipoprotein E-knockout mice with cholesterol and fat enriched diets may be a model of non-alcoholic steatohepatitis.","volume":"268","author":"M Tous","year":"2005","journal-title":"Mol Cell Biochem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ejphar.2008.01.045","article-title":"Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice.","volume":"584","author":"S Zheng","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev.nu.12.070192.000501","article-title":"Regulation of enzymes of urea and arginine synthesis.","volume":"12","author":"SM Morris Jr","year":"1992","journal-title":"Annu Rev Nutr"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0003-9861(87)90455-3","article-title":"Regulation of mRNA levels for five urea cycle enzymes in rat liver by diet, cyclic AMP, and glucocorticoids.","volume":"256","author":"SM Morris Jr","year":"1987","journal-title":"Arch Biochem Biophys"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0021-9258(18)93943-8","article-title":"Adaptive characteristics of urea cycle enzymes in the rat.","volume":"237","author":"RT Schimke","year":"1962","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1161\/CIRCRESAHA.107.169573","article-title":"Endothelial arginase II: a novel target for the treatment of atherosclerosis.","volume":"102","author":"S Ryoo","year":"2008","journal-title":"Circ Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0009-8981(97)00226-X","article-title":"Liver-type arginase in serum during and after liver transplantation: a novel index in monitoring conditions of the liver graft and its clinical significance.","volume":"271","author":"M Ikemoto","year":"1998","journal-title":"Clin Chim Acta"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1093\/clinchem\/47.5.946","article-title":"Liver-type arginase is a highly sensitive marker for hepatocellular damage in rats.","volume":"47","author":"M Ikemoto","year":"2001","journal-title":"Clin Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"G512","DOI":"10.1152\/ajpgi.00227.2006","article-title":"Liver I\/R injury is improved by the arginase inhibitor, N(omega)-hydroxy-nor-L-arginine (nor-NOHA).","volume":"292","author":"KM Reid","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1097\/00007890-199403150-00006","article-title":"L-Arginine deficiency after liver transplantation as an effect of arginase efflux from the graft. Influence on nitric oxide metabolism.","volume":"57","author":"E Roth","year":"1994","journal-title":"Transplantation"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1289\/ehp.9688","article-title":"Cardiovascular effects of pulmonary exposure to single-wall carbon nanotubes.","volume":"115","author":"Z Li","year":"2007","journal-title":"Environ Health Perspect"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1172\/JCI117460","article-title":"Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption.","volume":"94","author":"SH Zhang","year":"1994","journal-title":"J Clin Invest"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1073\/pnas.012587699","article-title":"The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL\/6 and apoE-knockout mice.","volume":"99","author":"CW Joyce","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"32197","DOI":"10.1074\/jbc.M605237200","article-title":"The arginase II gene is an anti-inflammatory target of liver X receptor in macrophages.","volume":"281","author":"C Marathe","year":"2006","journal-title":"J Biol Chem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1093\/jn\/131.10.2606","article-title":"Novel tocotrienols of rice bran inhibit atherosclerotic lesions in C57BL\/6 ApoE-deficient mice.","volume":"131","author":"AA Qureshi","year":"2001","journal-title":"J Nutr"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"502","DOI":"10.3945\/jn.108.100032","article-title":"Osteoclastogenesis by bone marrow-derived macrophages is enhanced in obese mice.","volume":"139","author":"TW Kyung","year":"2009","journal-title":"J Nutr"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"L534","DOI":"10.1152\/ajplung.00326.2005","article-title":"Inhibition of phosphodiesterase 4 amplifies cytokine-dependent induction of arginase in macrophages.","volume":"290","author":"A Erdely","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1128\/MCB.21.3.811-813.2001","article-title":"Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II gene.","volume":"21","author":"O Shi","year":"2001","journal-title":"Mol Cell Biol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0015253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T19:39:28Z","timestamp":1636918768000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0015253"}},"subtitle":[],"editor":[{"given":"Maria A.","family":"Deli","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2010,12,6]]},"references-count":47,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2010,12,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0015253","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,6]]}}}