{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:59:28Z","timestamp":1789390768446,"version":"build-2803163510"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2010,12,9]],"date-time":"2010-12-09T00:00:00Z","timestamp":1291852800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0015277","type":"journal-article","created":{"date-parts":[[2010,12,21]],"date-time":"2010-12-21T16:26:58Z","timestamp":1292948818000},"page":"e15277","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["High Frequency of Endothelial Colony Forming Cells Marks a Non-Active Myeloproliferative Neoplasm with High Risk of Splanchnic Vein Thrombosis"],"prefix":"10.1371","volume":"5","author":[{"given":"Vittorio","family":"Rosti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Bonetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Bergamaschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Campanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Guglielmelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Maestri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Magrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Massa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Tinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Viarengo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Villani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Primignani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro M.","family":"Vannucchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Frassoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Barosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the AGIMM Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,12,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3322\/caac.20009","article-title":"Advances in understanding and management of myeloproliferative neoplasms.","volume":"59","author":"AM Vannucchi","year":"2009","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1182\/blood.V6.4.372.372","article-title":"Some speculations on the myeloproliferative syndromes.","volume":"6","author":"W Dameshek","year":"1951","journal-title":"Blood"},{"key":"ref3","first-page":"40","article-title":"WHO Classification of Tumours of Haemopoietic and Lymphoid Tissues.","author":"SH Swerdlow","year":"2008"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1182\/blood.V96.10.3374","article-title":"Evaluation and clinical correlations of bone marrow angiogenesis in myelofibrosis with myeloid metaplasia.","volume":"96","author":"RA Mesa","year":"2000","journal-title":"Blood"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1182\/blood.V98.12.3249","article-title":"Diagnostic and clinical relevance of the number of circulating CD34(+) cells in myelofibrosis with myeloid metaplasia.","volume":"98","author":"G Barosi","year":"2001","journal-title":"Blood"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.bcmd.2007.01.003","article-title":"The expression of CXCR4 is down-regulated on the CD34+ cells of patients with myelofibrosis with myeloid metaplasia.","volume":"38","author":"G Barosi","year":"2007","journal-title":"Blood Cells Mol Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1182\/blood-2005-09-3826","article-title":"Relation between JAK2 (V617F) mutation status, granulocyte activation, and constitutive mobilization of CD34+ cells into peripheral blood in myeloproliferative disorders.","volume":"107","author":"F Passamonti","year":"2006","journal-title":"Blood"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1182\/blood-2007-07-099184","article-title":"JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis.","volume":"110","author":"G Barosi","year":"2007","journal-title":"Blood"},{"key":"ref9","first-page":"1465","article-title":"Hematopoietic and endothelial progenitor cell trafficking in patients with myeloproliferative diseases.","volume":"91","author":"E Oppliger Leibundgut","year":"2006","journal-title":"Haematologica"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"5688","DOI":"10.1200\/JCO.2005.09.021","article-title":"Circulating CD34+, CD133+, and vascular endothelial growth factor receptor 2-positive endothelial progenitor cells in myelofibrosis with myeloid metaplasia.","volume":"23","author":"M Massa","year":"2005","journal-title":"J Clin Oncol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.bcmd.2008.06.008","article-title":"Circulating angiogenic monocyte progenitor cells are reduced in JAK2V617F high allele burden myeloproliferative disorders.","volume":"41","author":"S Sozer","year":"2008","journal-title":"Blood Cells Mol Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1634\/stemcells.2005-0072","article-title":"Blood monocytes mimic endothelial progenitor cells.","volume":"24","author":"E Rohde","year":"2006","journal-title":"Stem Cells"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.exphem.2007.04.002","article-title":"Human CD34+AC133+VEGFR-2+ cells are not endothelial progenitor cells but distinct, primitive hematopoietic progenitors.","volume":"35","author":"J Case","year":"2007","journal-title":"Exp Hematol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1182\/blood-2004-04-1396","article-title":"Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood.","volume":"2004;104","author":"DA Ingram","year":"2004","journal-title":"Blood"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1182\/blood-2006-08-043471","article-title":"Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem\/progenitor cell principals.","volume":"109","author":"MC Yoder","year":"2007","journal-title":"Blood"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1046\/j.1365-2141.1999.01262.x","article-title":"The Italian Consensus Conference on Diagnostic Criteria for Myelofibrosis with Myeloid Metaplasia.","volume":"104","author":"G Barosi","year":"1999","journal-title":"Br J Haematol"},{"key":"ref17","article-title":"Pathology and genetics of tumours of haematopoietic and lymphoid tissues.","author":"ES Jaffe","year":"2001"},{"key":"ref18","first-page":"1128","article-title":"European consensus on grading bone marrow fibrosis and assessment of cellularity.","volume":"90","author":"J Thiele","year":"2005","journal-title":"Haematologica"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(05)74230-6","article-title":"Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders.","volume":"365","author":"EJ Baxter","year":"2005","journal-title":"Lancet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e270","DOI":"10.1371\/journal.pmed.0030270","article-title":"MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.","volume":"3","author":"Y Pikman","year":"2006","journal-title":"PLoS Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1056\/NEJMoa065202","article-title":"JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis.","volume":"356","author":"LM Scott","year":"2007","journal-title":"N Engl J Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1046\/j.1365-2141.1998.00867.x","article-title":"Unbalanced X-chromosome inactivation in haemopoietic cells from normal women.","volume":"102","author":"L Tonon","year":"1998","journal-title":"Br J Haematol"},{"key":"ref23","article-title":"The design and analysis of clinical experiments.","author":"JL Fleiss","year":"1986"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1182\/blood-2009-09-245837","article-title":"A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment).","volume":"115","author":"F Passamonti","year":"2010","journal-title":"Blood"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1002\/1097-0142(19911115)68:10<2310::AID-CNCR2820681034>3.0.CO;2-2","article-title":"An atypical myeloproliferative disorder with high thrombotic risk and slow disease progression.","volume":"68","author":"G Barosi","year":"1991","journal-title":"Cancer"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/j.1538-7836.2007.02424.x","article-title":"Incidence of the JAK2 V617F mutation among patients with splanchnic or cerebral venous thrombosis and without overt chronic myeloproliferative disorders.","volume":"5","author":"V De Stefano","year":"2007","journal-title":"J Thromb Haemost"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1002\/hep.21435","article-title":"Role of the JAK2 mutation in the diagnosis of chronic myeloproliferative disorders in splanchnic vein thrombosis.","volume":"44","author":"M Primignani","year":"2006","journal-title":"Hepatology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1159\/000221962","article-title":"JAK2 V617F-positive latent essential thrombocythemia and splanchnic vein thrombosis: the role of bone marrow biopsy for the diagnosis of myeloproliferative disease.","volume":"121","author":"A Allegra","year":"2009","journal-title":"Acta Haematol"},{"key":"ref29","first-page":"981","article-title":"In vitro colony culture and chromosomal studies in hepatic and portal vein thrombosis\u2014possible evidence of an occult myeloproliferative state.","volume":"76","author":"A Pagliuca","year":"1990","journal-title":"Q J Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1111\/j.1365-2036.2010.04299.x","article-title":"The prevalence of the activating JAK2 tyrosine kinase mutation in chronic porto-splenomesenteric venous thrombosis.","volume":"31","author":"DW Orr","year":"2020","journal-title":"Aliment Pharmacol Ther"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0015277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T18:09:00Z","timestamp":1592158140000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0015277"}},"subtitle":[],"editor":[{"given":"Syed A.","family":"Aziz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,12,9]]},"references-count":30,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2010,12,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0015277","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,9]]}}}