{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:39:50Z","timestamp":1791121190468,"version":"4.1.0"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2010,11,15]],"date-time":"2010-11-15T00:00:00Z","timestamp":1289779200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0015451","type":"journal-article","created":{"date-parts":[[2010,11,15]],"date-time":"2010-11-15T15:19:27Z","timestamp":1289834367000},"page":"e15451","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":77,"title":["Matrix Rigidity Induces Osteolytic Gene Expression of Metastatic Breast Cancer Cells"],"prefix":"10.1371","volume":"5","author":[{"given":"Nazanin S.","family":"Ruppender","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa R.","family":"Merkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. John","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory R.","family":"Mundy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Sterling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Guelcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,11,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1172\/JCI118947","article-title":"Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis.","volume":"98","author":"T Guise","year":"1996","journal-title":"J Clin Invest"},{"key":"ref2","first-page":"7710","article-title":"Immunohistochemical localization of parathyroid hormone-related protein in human breast cancer.","volume":"50","author":"J Southby","year":"1990","journal-title":"Cancer Res"},{"key":"ref3","first-page":"3059061","article-title":"Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites.","volume":"51","author":"GJ Powell","year":"1991","journal-title":"Cancer Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"7548","DOI":"10.1158\/0008-5472.CAN-06-0452","article-title":"The hedgehog signaling molecule Gli2 induces parathyroid hormone-related peptide expression and osteolysis in metastatic human breast cancer cells.","volume":"66","author":"JA Sterling","year":"2006","journal-title":"Cancer Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1172\/JCI3523","article-title":"TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development.","volume":"103","author":"JJ Yin","year":"1999","journal-title":"J Clin Invest"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1152\/physrev.1996.76.1.127","article-title":"Defining the roles of parathyroid hormone-related protein in normal physiology.","volume":"76","author":"WM Philbrick","year":"1996","journal-title":"Physiol Rev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1210\/endo.134.5.8156926","article-title":"Mechanical stimuli induce vascular parathyroid hormone-related protein gene expression in vivo and in vitro.","volume":"134","author":"CJ Pirola","year":"1994","journal-title":"Endocrinology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5326","DOI":"10.1073\/pnas.89.12.5326","article-title":"Parathyroid hormone-related protein in the rat urinary bladder: a smooth muscle relaxant produced locally in response to mechanical stretch.","volume":"89","author":"M Yamamoto","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ccr.2005.08.010","article-title":"Tensional homeostasis and the malignant phenotype.","volume":"8","author":"MJ Paszek","year":"2005","journal-title":"Cancer Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10911-004-1404-x","article-title":"The tension mounts: mechanics meets morphogenesis and malignancy.","volume":"9","author":"MJ Paszek","year":"2004","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrc2544","article-title":"A tense situation: forcing tumour progression.","volume":"9","author":"DT Butcher","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"8742","DOI":"10.1158\/0008-5472.CAN-09-1541","article-title":"Inhibition of rho-associated kinase signaling prevents breast cancer metastasis to human bone.","volume":"69","author":"S Liu","year":"2009","journal-title":"Cancer Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1529\/biophysj.105.060723","article-title":"Computational Model for Cell Migration in Three-Dimensional Matrices.","volume":"89","author":"MH Zaman","year":"2005","journal-title":"Biophys J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"10889","DOI":"10.1073\/pnas.0604460103","article-title":"Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis.","volume":"103","author":"MH Zaman","year":"2006","journal-title":"PNAS"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.cub.2008.07.090","article-title":"Extracellular matrix rigidity promotes invadopodia activity.","volume":"18","author":"NR Alexander","year":"2008","journal-title":"Curr Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/jcp.20974","article-title":"The Regulation of Osteogenesis by ECM Rigidity in MC3T3-E1 Cells Requires MAPK Activation.","volume":"211","author":"CB Khatiwala","year":"2006","journal-title":"J Cellular Physiology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","article-title":"Matrix Elasticity Directs Stem Cell Lineage Specification.","volume":"126","author":"AJ Engler","year":"2006","journal-title":"Cell"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.biomaterials.2007.12.046","article-title":"Synthesis, mechanical properties, biocompatibility, and biodegradation of polyurethane networks from lysine polyisocyanates.","volume":"29","author":"SA Guelcher","year":"2008","journal-title":"Biomaterials"},{"key":"ref19","article-title":"Biodegradable polyurethanes: synthesis and applications in regenerative medicine.","author":"S Guelcher","year":"2008","journal-title":"Tissue Eng"},{"key":"ref20","first-page":"40","article-title":"The combined effect of tumor-produced parathyroid hormone-related protein and transforming growth factor-alpha enhance hypercalcemia in vivo and bone resorption in vitro.","volume":"77","author":"TA Guise","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1158\/0008-5472.CAN-06-3950","article-title":"Stable overexpression of Smad7 in human melanoma cells impairs bone metastasis.","volume":"67","author":"D Javelaud","year":"2007","journal-title":"Cancer Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1007\/s11095-008-9618-z","article-title":"Injectable biodegradable polyurethane scaffolds with release of platelet-derived growth factor for tissue repair and regeneration.","volume":"25","author":"A Hafeman","year":"2008","journal-title":"Pharm Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1529\/biophysj.108.133199","article-title":"Dependence of invadopodia function on collagen fiber spacing and crosslinking: computational modeling and experimental evidence.","volume":"95","author":"H Enderling","year":"2008","journal-title":"Biophys J"},{"key":"ref24","article-title":"Introduction to Physical Polymer Science","author":"LH Sperling","year":"2001"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1529\/biophysj.104.050682","article-title":"Molecularly engineered PEG hydrogels: a novel model system for proteolytically mediated cell migration.","volume":"89","author":"GP Raeber","year":"2005","journal-title":"Biophys J"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"24571","DOI":"10.1074\/jbc.M202561200","article-title":"Transforming growth factor-beta stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways.","volume":"277","author":"SM Kakonen","year":"2002","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10555-008-9170-7","article-title":"Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion.","volume":"28","author":"S Narumiya","year":"2009","journal-title":"Cancer Metastasis Rev"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/5587","article-title":"An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.","volume":"5","author":"K Itoh","year":"1999","journal-title":"Nat Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1535-6108(03)00132-6","article-title":"A multigenic program mediating breast cancer metastasis to bone.","volume":"3","author":"Y Kang","year":"2003","journal-title":"Cancer Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e6361","DOI":"10.1371\/journal.pone.0006361","article-title":"Differential matrix rigidity response in breast cancer cell lines correlates with the tissue tropism.","volume":"4","author":"A Kostic","year":"2009","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10911-004-1404-x","article-title":"The tension mounts: mechanics meets morphogenesis and malignancy.","volume":"9","author":"MJ Paszek","year":"2004","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.cub.2008.07.090","article-title":"Extracellular Matrix Rigidity Promotes Invadopodia Activity.","volume":"18","author":"NR Alexander","year":"2008","journal-title":"Curr Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","article-title":"Matrix elasticity directs stem cell lineage specification.","volume":"126","author":"AJ Engler","year":"2006","journal-title":"Cell"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1006\/excr.1996.3405","article-title":"Fibronectin distribution in human bone marrow stroma: matrix assembly and tumor cell adhesion via alpha5 beta1 integrin.","volume":"230","author":"D Van der Velde-Zimmermann","year":"1997","journal-title":"Exp Cell Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s00223-002-2123-1","article-title":"The longitudinal Young&apos;s modulus of cortical bone in the midshaft of human femur and its correlation with CT scanning data.","volume":"74","author":"M Cuppone","year":"2004","journal-title":"Calcif Tissue Int"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1111\/j.1742-4658.2007.05823.x","article-title":"Biomechanical properties of native basement membranes.","volume":"274","author":"J Candiello","year":"2007","journal-title":"FEBS Journal"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1126\/science.1116995","article-title":"Tissue cells feel and respond to the stiffness of their substrate.","volume":"310","author":"DE Discher","year":"2005","journal-title":"Science"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/cncr.10709","article-title":"Plasma osteopontin: associations with survival and metastasis to bone in men with hormone-refractory prostate carcinoma.","volume":"95","author":"SJ Hotte","year":"2002","journal-title":"Cancer"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"23455","DOI":"10.1016\/S0021-9258(18)35857-5","article-title":"Stretch-induced parathyroid hormone-related peptide gene expression in the rat uterus.","volume":"267","author":"AG Daifotis","year":"1992","journal-title":"J Biol Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1073\/pnas.87.18.6969","article-title":"Intrauterine occupancy controls expression of the parathyroid hormone-related peptide gene in preterm rat myometrium.","volume":"87","author":"MA Thiede","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1126\/science.3175653","article-title":"Expression of a calcium-mobilizing parathyroid hormone-like peptide in lactating mammary tissue.","volume":"242","author":"MA Thiede","year":"1988","journal-title":"Science"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"663","DOI":"10.2147\/VHRM.S4711","article-title":"RhoA\/Rho-kinase signaling: a therapeutic target in pulmonary hypertension.","volume":"5","author":"SA Barman","year":"2009","journal-title":"Vasc Health Risk Manag"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e1000250","DOI":"10.1371\/journal.pcbi.1000250","article-title":"Identification of mechanosensitive genes during embryonic bone formation.","volume":"4","author":"NC Nowlan","year":"2008","journal-title":"Plos Computational Biology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1177\/154405910408300516","article-title":"Indian hedgehog: a mechanotransduction mediator in condylar cartilage.","volume":"83","author":"GH Tang","year":"2004","journal-title":"J Dent Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.yexcr.2003.10.021","article-title":"Impaired endochondral bone development and osteopenia in Gli2-deficient mice.","volume":"294","author":"D Miao","year":"2004","journal-title":"Exp Cell Res"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1101\/gad.1038103","article-title":"Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development.","volume":"17","author":"P Mill","year":"2003","journal-title":"Genes Dev"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"12426","DOI":"10.1074\/jbc.M707117200","article-title":"GLI2-specific transcriptional activation of the bone morphogenetic protein\/activin antagonist follistatin in human epidermal cells.","volume":"283","author":"T Eichberger","year":"2008","journal-title":"J Biol Chem"},{"key":"ref48","article-title":"(Submitted) TGF-\u03b2 promotion of Gli2 induced PTHrP expression is independent of canonical Hedgehog signaling.","author":"RW Johnson","journal-title":"Cancer Res"},{"key":"ref49","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.200704042","article-title":"Myofibroblast contraction activates latent TGF-1 from the extracellular matrix.","volume":"179","author":"PJ Wipff","year":"2007","journal-title":"J Cell Biol"},{"key":"ref50","doi-asserted-by":"crossref","DOI":"10.1126\/stke.110pe13","article-title":"Matrix elasticity, cytoskeletal tension, and TGF-beta: the insoluble and soluble meet.","volume":"1","author":"RG Wells","year":"2008","journal-title":"Science Signaling"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1161\/CIRCRESAHA.108.179465","article-title":"Endothelial cells provide feedback control for vascular remodeling through a mechanosensitive autocrine TGF-beta signaling pathway.","volume":"103","author":"AB Baker","year":"2008","journal-title":"Circ Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1172\/JCI117787","article-title":"Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production. Modulation by potassium channel blockade.","volume":"95","author":"M Ohno","year":"1995","journal-title":"J Clin Invest"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1365-2362.2004.01302.x","article-title":"Mechanical stretch induces TGF-beta synthesis in hepatic stellate cells.","volume":"34","author":"R Sakata","year":"2004","journal-title":"Eur J Clin Invest"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.devcel.2010.07.018","article-title":"Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing.","volume":"19","author":"SW Moore","year":"2010","journal-title":"Dev Cell"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0015451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T10:32:08Z","timestamp":1636799528000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0015451"}},"subtitle":[],"editor":[{"given":"Syed A.","family":"Aziz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,11,15]]},"references-count":54,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2010,11,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0015451","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,15]]}}}