{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:25:37Z","timestamp":1791303937650,"version":"4.1.0"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2010,11,12]],"date-time":"2010-11-12T00:00:00Z","timestamp":1289520000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0015460","type":"journal-article","created":{"date-parts":[[2010,11,12]],"date-time":"2010-11-12T21:00:33Z","timestamp":1289595633000},"page":"e15460","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":162,"title":["Automated High-Content Live Animal Drug Screening Using C. elegans Expressing the Aggregation Prone Serpin \u03b11-antitrypsin Z"],"prefix":"10.1371","volume":"5","author":[{"given":"Sager J.","family":"Gosai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Hyeok","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cliff J.","family":"Luke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia S.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale E.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Kovatch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong Ying","family":"Shun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Lazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Perlmutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary A.","family":"Silverman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Pak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,11,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nrd3050","article-title":"Protein aggregation diseases: pathogenicity and therapeutic perspectives.","volume":"9","author":"A Aguzzi","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1096\/fj.07-099671","article-title":"Molecular and cellular aspects of protein misfolding and disease.","volume":"22","author":"E Herczenik","year":"2008","journal-title":"FASEB J"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jmb.2009.11.015","article-title":"Molecular mechanisms of rhodopsin retinitis pigmentosa and the efficacy of pharmacological rescue.","volume":"395","author":"MP Krebs","year":"2010","journal-title":"J Mol Biol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/BST0330321","article-title":"Molecular mousetraps and the serpinopathies.","volume":"33","author":"DA Lomas","year":"2005","journal-title":"Biochem Soc Trans"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"545","DOI":"10.5858\/134.4.545","article-title":"Amyloidosis-where are we now and where are we heading?","volume":"134","author":"MM Picken","year":"2010","journal-title":"Arch Pathol Lab Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1126\/science.1141448","article-title":"Adapting proteostasis for disease intervention.","volume":"319","author":"WE Balch","year":"2008","journal-title":"Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1126\/science.1124646","article-title":"Opposing activities protect against age-onset proteotoxicity.","volume":"313","author":"E Cohen","year":"2006","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/cbic.200900666","article-title":"Strategies for the inhibition of protein aggregation in human diseases.","volume":"11","author":"M Bartolini","year":"2010","journal-title":"Chembiochem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1001\/archneurol.2010.40","article-title":"Clearance of mutant proteins as a therapeutic target in neurodegenerative diseases.","volume":"67","author":"D Krainc","year":"2010","journal-title":"Arch Neurol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1126\/science.1190354","article-title":"An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis.","volume":"329","author":"T Hidvegi","year":"2010","journal-title":"Science"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.exger.2006.06.059","article-title":"C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer&apos;s disease.","volume":"41","author":"CD Link","year":"2006","journal-title":"Exp Gerontol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.drudis.2009.09.004","article-title":"HTS and hit finding in academia - from chemical genomics to drug discovery.","volume":"14","author":"JA Frearson","year":"2009","journal-title":"Drug Discov Today"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.coph.2009.08.004","article-title":"Novel trends in high-throughput screening.","volume":"9","author":"LM Mayr","year":"2009","journal-title":"Curr Opin Pharmacol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nrd1086","article-title":"Hit and lead generation: beyond high-throughput screening.","volume":"2","author":"KH Bleicher","year":"2003","journal-title":"Nat Rev Drug Discov"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/90761","article-title":"ADMET\u2013turning chemicals into drugs.","volume":"19","author":"J Hodgson","year":"2001","journal-title":"Nat Biotechnol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1021\/jm701122q","article-title":"Generation of a set of simple, interpretable ADMET rules of thumb.","volume":"51","author":"MP Gleeson","year":"2008","journal-title":"J Med Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"5906","DOI":"10.1016\/j.bmc.2009.07.002","article-title":"ADMET rules of thumb II: A comparison of the effects of common substituents on a range of ADMET parameters.","volume":"17","author":"P Gleeson","year":"2009","journal-title":"Bioorg Med Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0076-6879(06)14031-8","article-title":"Systems cell biology based on high-content screening.","volume":"414","author":"KA Giuliano","year":"2006","journal-title":"Methods Enzymol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.drudis.2006.08.015","article-title":"High-content screening moves to the front of the line.","volume":"11","author":"SA Haney","year":"2006","journal-title":"Drug Discov Today"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S1359-6446(01)02140-7","article-title":"Cellular platforms for HTS: three case studies.","volume":"7","author":"PA Johnston","year":"2002","journal-title":"Drug Discov Today"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1089\/adt.2008.186","article-title":"Cdc25B dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library.","volume":"7","author":"PA Johnston","year":"2009","journal-title":"Assay Drug Dev Technol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1089\/adt.2007.101","article-title":"HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus.","volume":"5","author":"PA Johnston","year":"2007","journal-title":"Assay Drug Dev Technol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1089\/adt.2008.151","article-title":"Development of a 384-well colorimetric assay to quantify hydrogen peroxide generated by the redox cycling of compounds in the presence of reducing agents.","volume":"6","author":"PA Johnston","year":"2008","journal-title":"Assay Drug Dev Technol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0076-6879(06)14022-7","article-title":"Development and implementation of three mitogen-activated protein kinase (MAPK) signaling pathway imaging assays to provide MAPK module selectivity profiling for kinase inhibitors: MK2-EGFP translocation, c-Jun, and ERK activation.","volume":"414","author":"D Nickischer","year":"2006","journal-title":"Methods Enzymol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0076-6879(06)14023-9","article-title":"Assay development and case history of a 32K-biased library high-content MK2-EGFP translocation screen to identify p38 mitogen-activated protein kinase inhibitors on the ArrayScan 3.1 imaging platform.","volume":"414","author":"OJ Trask Jr","year":"2006","journal-title":"Methods Enzymol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0076-6879(06)14021-5","article-title":"Generation and characterization of a stable MK2-EGFP cell line and subsequent development of a high-content imaging assay on the Cellomics ArrayScan platform to screen for p38 mitogen-activated protein kinase inhibitors.","volume":"414","author":"RG Williams","year":"2006","journal-title":"Methods Enzymol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/35038557","article-title":"Chemical genetics: ligand-based discovery of gene function.","volume":"1","author":"BR Stockwell","year":"2000","journal-title":"Nat Rev Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1371\/journal.ppat.0030018","article-title":"Antifungal chemical compounds identified using a C. elegans pathogenicity assay.","volume":"3","author":"J Breger","year":"2007","journal-title":"PLoS Pathog"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nature04657","article-title":"A small-molecule screen in C. elegans yields a new calcium channel antagonist.","volume":"441","author":"TC Kwok","year":"2006","journal-title":"Nature"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/nchembio.190","article-title":"Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages.","volume":"5","author":"G Molina","year":"2009","journal-title":"Nat Chem Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1021\/cb900084v","article-title":"High-throughput screen for novel antimicrobials using a whole animal infection model.","volume":"4","author":"TI Moy","year":"2009","journal-title":"ACS Chem Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/nature05883","article-title":"Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.","volume":"447","author":"TE North","year":"2007","journal-title":"Nature"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nature05991","article-title":"An antidepressant that extends lifespan in adult Caenorhabditis elegans.","volume":"450","author":"M Petrascheck","year":"2007","journal-title":"Nature"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1126\/science.1183090","article-title":"Zebrafish behavioral profiling links drugs to biological targets and rest\/wake regulation.","volume":"327","author":"J Rihel","year":"2010","journal-title":"Science"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"11386","DOI":"10.1158\/0008-5472.CAN-07-3126","article-title":"Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish.","volume":"67","author":"TC Tran","year":"2007","journal-title":"Cancer Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nchembio.2007.54","article-title":"Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism.","volume":"4","author":"PB Yu","year":"2008","journal-title":"Nat Chem Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/biot.200600176","article-title":"Caenorhabditis elegans: a versatile platform for drug discovery.","volume":"1","author":"M Artal-Sanz","year":"2006","journal-title":"Biotechnol J"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.bbadis.2008.04.003","article-title":"Caenorhabditis elegans as a model for lysosomal storage disorders.","volume":"1782","author":"G de Voer","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrd2031","article-title":"Finding function in novel targets: C. elegans as a model organism.","volume":"5","author":"T Kaletta","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1203\/PDR.0b013e31819009b0","article-title":"Modeling molecular and cellular aspects of human disease using the nematode Caenorhabditis elegans.","volume":"65","author":"GA Silverman","year":"2009","journal-title":"Pediatr Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0076-6879(06)14025-2","article-title":"High-content screening: emerging hardware and software technologies.","volume":"414","author":"S Lee","year":"2006","journal-title":"Methods Enzymol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"10417","DOI":"10.1073\/pnas.152161099","article-title":"The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans.","volume":"99","author":"JF Morley","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nrm1660","article-title":"Autophagy in metazoans: cell survival in the land of plenty.","volume":"6","author":"JJ Lum","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1126\/science.1087782","article-title":"Autophagy genes are essential for dauer development and life-span extension in C. elegans.","volume":"301","author":"A Melendez","year":"2003","journal-title":"Science"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1101\/gad.1573107","article-title":"Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation.","volume":"21","author":"C Kang","year":"2007","journal-title":"Genes Dev"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/349588a0","article-title":"The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration.","volume":"349","author":"M Driscoll","year":"1991","journal-title":"Nature"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"41976","DOI":"10.1074\/jbc.M510732200","article-title":"Temperature-sensitive mutant of the Caenorhabditis elegans neurotoxic MEC-4(d) DEG\/ENaC channel identifies a site required for trafficking or surface maintenance.","volume":"280","author":"DC Royal","year":"2005","journal-title":"J Biol Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.cell.2007.07.013","article-title":"An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury.","volume":"130","author":"CJ Luke","year":"2007","journal-title":"Cell"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0891-5849(03)00328-9","article-title":"An automated high-throughput assay for survival of the nematode Caenorhabditis elegans.","volume":"35","author":"MS Gill","year":"2003","journal-title":"Free Radic Biol Med"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"44657","DOI":"10.1074\/jbc.M307351200","article-title":"A reduction in intestinal cell pHi due to loss of the Caenorhabditis elegans Na+\/H+ exchanger NHX-2 increases life span.","volume":"278","author":"K Nehrke","year":"2003","journal-title":"J Biol Chem"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1172\/JCI0216787","article-title":"Liver injury in alpha1-antitrypsin deficiency: an aggregated protein induces mitochondrial injury.","volume":"110","author":"DH Perlmutter","year":"2002","journal-title":"Journal of Clinical Investigation"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/108705719900400206","article-title":"A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays.","volume":"4","author":"JH Zhang","year":"1999","journal-title":"J Biomol Screen"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1476-5381.2010.00725.x","article-title":"High-throughput screening and small animal models, where are we?","volume":"160","author":"J Giacomotto","year":"2010","journal-title":"Br J Pharmacol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1472-6750-3-19","article-title":"Chemically defined medium and Caenorhabditis elegans.","volume":"3","author":"NJ Szewczyk","year":"2003","journal-title":"BMC Biotechnol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1177\/1087057103261038","article-title":"Screening for presenilin inhibitors using the free-living nematode, Caenorhabditis elegans.","volume":"9","author":"BR Ellerbrock","year":"2004","journal-title":"J Biomol Screen"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"e7025","DOI":"10.1371\/journal.pone.0007025","article-title":"Identification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assay.","volume":"4","author":"I Okoli","year":"2009","journal-title":"PLoS One"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nchembio.79","article-title":"Novel targets for Huntington&apos;s disease in an mTOR-independent autophagy pathway.","volume":"4","author":"A Williams","year":"2008","journal-title":"Nat Chem Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"19023","DOI":"10.1073\/pnas.0709695104","article-title":"Small molecule regulators of autophagy identified by an image-based high-throughput screen.","volume":"104","author":"L Zhang","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1074\/jbc.M509409200","article-title":"Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity.","volume":"281","author":"T Kamimoto","year":"2006","journal-title":"J Biol Chem"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"9368","DOI":"10.1073\/pnas.92.20.9368","article-title":"Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans.","volume":"92","author":"CD Link","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"9980","DOI":"10.1073\/pnas.1533448100","article-title":"Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy.","volume":"100","author":"BC Kraemer","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1046\/j.1471-4159.2003.01809.x","article-title":"Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein.","volume":"86","author":"M Lakso","year":"2003","journal-title":"J Neurochem"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1073\/pnas.96.1.179","article-title":"Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron.","volume":"96","author":"PW Faber","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1093\/hmg\/10.19.2013","article-title":"Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic Caenorhabditis elegans.","volume":"10","author":"T Oeda","year":"2001","journal-title":"Hum Mol Genet"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"29036","DOI":"10.1074\/jbc.M203200200","article-title":"The NHX family of Na+-H+ exchangers in Caenorhabditis elegans.","volume":"277","author":"K Nehrke","year":"2002","journal-title":"J Biol Chem"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1089\/adt.2007.066","article-title":"Development and implementation of a 384-well homogeneous fluorescence intensity high-throughput screening assay to identify mitogen-activated protein kinase phosphatase-1 dual-specificity protein phosphatase inhibitors.","volume":"5","author":"PA Johnston","year":"2007","journal-title":"Assay Drug Dev Technol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1177\/1087057103258285","article-title":"Improved statistical methods for hit selection in high-throughput screening.","volume":"8","author":"C Brideau","year":"2003","journal-title":"J Biomol Screen"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nbt1186","article-title":"Statistical practice in high-throughput screening data analysis.","volume":"24","author":"N Malo","year":"2006","journal-title":"Nat Biotechnol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/75406","article-title":"Short-lived green fluorescent proteins for quantifying ubiquitin\/proteasome-dependent proteolysis in living cells.","volume":"18","author":"NP Dantuma","year":"2000","journal-title":"Nat Biotechnol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0015460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T13:39:50Z","timestamp":1636810790000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0015460"}},"subtitle":[],"editor":[{"given":"Anne C.","family":"Hart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,11,12]]},"references-count":69,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2010,11,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0015460","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,12]]}}}