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Blutt","year":"1997","journal-title":"Endocrinology"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1210\/me.2003-0412","article-title":"1 alpha,25-dihydroxyvitamin D3 transrepresses retinoic acid transcriptional activity via vitamin D receptor in myeloid cells.","volume":"18","author":"JN Bastie","year":"2004","journal-title":"Mol Endocrinol"},{"key":"ref77","first-page":"205","article-title":"Mechanistic interrelationships between two superfamilies: the steroid\/retinoid receptors and transforming growth factor-beta.","volume":"14","author":"AB Roberts","year":"1992","journal-title":"Cancer Surv"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"142","DOI":"10.4161\/cam.1.3.5062","article-title":"TGFbeta and retinoic acid intersect in immune-regulation.","volume":"1","author":"D Mucida","year":"2007","journal-title":"Cell Adh 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Pendaries","year":"2003","journal-title":"Oncogene"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1165\/ajrcmb.12.3.7873195","article-title":"Retinoic acid inhibition of transforming growth factor-beta-induced collagen production by human lung fibroblasts.","volume":"12","author":"CA Redlich","year":"1995","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1091\/mbc.1.1.87","article-title":"Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis.","volume":"1","author":"AB Glick","year":"1989","journal-title":"Cell Regul"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1006\/viro.2000.0282","article-title":"Retinoic acid resistance at late stages of human papillomavirus type 16-mediated transformation of human keratinocytes arises despite intact retinoid signaling and is due to a loss of sensitivity to transforming growth factor-beta.","volume":"270","author":"DR Borger","year":"2000","journal-title":"Virology"},{"key":"ref85","first-page":"495","article-title":"Effects of endogenously activated transforming growth factor-beta on growth and differentiation of retinoic acid-treated HL-60 cells.","volume":"56","author":"I Nunes","year":"1996","journal-title":"Cancer Res"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/(SICI)1097-4652(199601)166:1<231::AID-JCP24>3.0.CO;2-G","article-title":"Induction of transforming growth factor-beta autocrine activity by all-trans-retinoic acid and 1 alpha,25-dihydroxyvitamin D3 in NRP-152 rat prostatic epithelial cells.","volume":"166","author":"D Danielpour","year":"1996","journal-title":"J Cell Physiol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0014-5793(97)00673-X","article-title":"9,13-di-cis-Retinoic acid induces the production of tPA and activation of latent TGF-beta via RAR alpha in a human liver stellate cell line, LI90.","volume":"411","author":"S Imai","year":"1997","journal-title":"FEBS Lett"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/jcp.1041550213","article-title":"Mechanism of retinoid-induced activation of latent transforming growth factor-beta in bovine endothelial cells.","volume":"155","author":"S Kojima","year":"1993","journal-title":"J Cell Physiol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/sj.onc.1206100","article-title":"Fusion proteins of retinoid receptors antagonize TGF-beta-induced growth inhibition of lung epithelial cells.","volume":"22","author":"P La","year":"2003","journal-title":"Oncogene"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1182\/blood-2002-05-1549","article-title":"Levels of phospho-Smad2\/3 are sensors of the interplay between effects of TGF-beta and retinoic acid on monocytic and granulocytic differentiation of HL-60 cells.","volume":"101","author":"Z Cao","year":"2003","journal-title":"Blood"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.critrevonc.2004.08.009","article-title":"Treatment concepts of acute promyelocytic leukemia.","volume":"56","author":"E Lengfelder","year":"2005","journal-title":"Crit Rev Oncol Hematol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1529-8019.2006.00084.x","article-title":"Update in retinoid therapy of acne.","volume":"19","author":"A Thielitz","year":"2006","journal-title":"Dermatol Ther"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2165\/11319020-000000000-00000","article-title":"Neuromuscular adverse effects associated with systemic retinoid dermatotherapy: monitoring and treatment algorithm for clinicians.","volume":"33","author":"E Chroni","year":"2010","journal-title":"Drug Saf"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1517\/14656566.9.8.1363","article-title":"Systemic retinoids in chemoprevention of non-melanoma skin cancer.","volume":"9","author":"M Lens","year":"2008","journal-title":"Expert Opin Pharmacother"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1200\/JCO.1997.15.2.790","article-title":"Initial clinical trial of a selective retinoid X receptor ligand, LGD1069.","volume":"15","author":"VA Miller","year":"1997","journal-title":"J Clin Oncol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0889-8588(03)00107-2","article-title":"Topical and systemic retinoid therapy for cutaneous T-cell lymphoma.","volume":"17","author":"W Kempf","year":"2003","journal-title":"Hematol Oncol Clin North Am"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1396-0296.2003.01644.x","article-title":"Retinoids: therapeutic applications and 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