{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:56:59Z","timestamp":1778752619605,"version":"3.51.4"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2010,12,28]],"date-time":"2010-12-28T00:00:00Z","timestamp":1293494400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0015525","type":"journal-article","created":{"date-parts":[[2010,12,28]],"date-time":"2010-12-28T21:36:27Z","timestamp":1293572187000},"page":"e15525","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Bcr\/Abl Interferes with the Fanconi Anemia\/BRCA Pathway: Implications in the Chromosomal Instability of Chronic Myeloid Leukemia Cells"],"prefix":"10.1371","volume":"5","author":[{"given":"Antonio","family":"Valeri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Eugenia","family":"Alonso-Ferrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"R\u00edo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Roser","family":"Pujol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"Casado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariana","family":"Jacome","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xabier","family":"Agirre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jos\u00e9","family":"Calasanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Hanenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Surrall\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Prosper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Albella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan A.","family":"Bueren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2010,12,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/306277a0","article-title":"Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia.","volume":"306","author":"CR Bartram","year":"1983","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0092-8674(84)90077-1","article-title":"Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22.","volume":"36","author":"J Groffen","year":"1984","journal-title":"Cell"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1126\/science.2408149","article-title":"Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.","volume":"247","author":"TG Lugo","year":"1990","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1182\/blood-2008-03-144790","article-title":"Molecular biology of bcr-abl1-positive chronic myeloid leukemia.","volume":"113","author":"A Quintas-Cardama","year":"2009","journal-title":"Blood"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1126\/science.2406902","article-title":"Induction of chronic myelogenous leukemia in mice by the P210bcr\/abl gene of the Philadelphia chromosome.","volume":"247","author":"GQ Daley","year":"1990","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrc2147","article-title":"Chronic myeloid leukaemia as a model of disease evolution in human cancer.","volume":"7","author":"JV Melo","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"ref7","article-title":"BCR-ABL: a multi-faceted promoter of DNA mutation in chronic myelogeneous leukemia.","author":"BA Burke","year":"2010","journal-title":"Leukemia Epub ahead of print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"24273","DOI":"10.1074\/jbc.M002094200","article-title":"The BCR\/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells.","volume":"275","author":"M Sattler","year":"2000","journal-title":"J Biol Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1182\/blood-2004-05-1941","article-title":"BCR\/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks.","volume":"104","author":"MO Nowicki","year":"2004","journal-title":"Blood"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/leu.2008.308","article-title":"BCR\/ABL induces chromosomal instability after genotoxic stress and alters the cell death threshold.","volume":"23","author":"J Dierov","year":"2009","journal-title":"Leukemia"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1182\/blood-2005-07-2815","article-title":"BCR\/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance.","volume":"108","author":"M Koptyra","year":"2006","journal-title":"Blood"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1038\/leu.2008.78","article-title":"BCR\/ABL promotes accumulation of chromosomal aberrations induced by oxidative and genotoxic stress.","volume":"22","author":"M Koptyra","year":"2008","journal-title":"Leukemia"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1182\/blood.V97.7.2084","article-title":"BCR-ABL down-regulates the DNA repair protein DNA-PKcs.","volume":"97","author":"E Deutsch","year":"2001","journal-title":"Blood"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S1097-2765(00)80202-6","article-title":"Brca1 controls homology-directed DNA repair.","volume":"4","author":"ME Moynahan","year":"1999","journal-title":"Mol Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.1182\/blood-2002-10-3011","article-title":"Down-regulation of BRCA1 in BCR-ABL-expressing hematopoietic cells.","volume":"101","author":"E Deutsch","year":"2003","journal-title":"Blood"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"6884","DOI":"10.1158\/0008-5472.CAN-08-1101","article-title":"BCR\/ABL and other kinases from chronic myeloproliferative disorders stimulate single-strand annealing, an unfaithful DNA double-strand break repair.","volume":"68","author":"K Cramer","year":"2008","journal-title":"Cancer Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1182\/blood-2008-07-172148","article-title":"BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair.","volume":"114","author":"MS Fernandes","year":"2009","journal-title":"Blood"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev-genet-102108-134222","article-title":"How the Fanconi Anemia Pathway Guards the Genome.","volume":"43","author":"GL Moldovan","year":"2009","journal-title":"Annu Rev Genet"},{"key":"ref19","first-page":"3","article-title":"The Fanconi anemia pathway of genomic maintenance.","volume":"28","author":"M Levitus","year":"2006","journal-title":"Cell Oncol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.molcel.2008.10.009","article-title":"Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways.","volume":"32","author":"MA Cohn","year":"2008","journal-title":"Mol Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1084\/jem.191.6.977","article-title":"Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL.","volume":"191","author":"M Horita","year":"2000","journal-title":"J Exp Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/j.1365-2141.2008.07221.x","article-title":"BCR-ABL1-induced expression of HSPA8 promotes cell survival in chronic myeloid leukaemia.","volume":"142","author":"ES Jose-Eneriz","year":"2008","journal-title":"Br J Haematol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1089\/hum.2006.17.245","article-title":"A simplified approach to improve the efficiency and safety of ex vivo hematopoietic gene therapy in fanconi anemia patients.","volume":"17","author":"A Jacome","year":"2006","journal-title":"Hum Gene Ther"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1136\/jmg.2006.044719","article-title":"A comprehensive strategy for the subtyping of Fanconi Anemia patients: conclusions from the Spanish Fanconi Anemia research network.","volume":"44","author":"JA Casado","year":"2007","journal-title":"J Med Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1182\/blood-2002-01-0278","article-title":"S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51.","volume":"100","author":"T Taniguchi","year":"2002","journal-title":"Blood"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1182\/blood.V85.8.2233.bloodjournal8582233","article-title":"Comparative evaluation of diepoxybutane sensitivity and cell cycle blockage in the diagnosis of Fanconi anemia.","volume":"85","author":"H Seyschab","year":"1995","journal-title":"Blood"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1097-2765(01)00173-3","article-title":"Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.","volume":"7","author":"I Garcia-Higuera","year":"2001","journal-title":"Mol Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S1097-2765(03)00281-8","article-title":"BRCA1-independent ubiquitination of FANCD2.","volume":"12","author":"CJ Vandenberg","year":"2003","journal-title":"Mol Cell"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1038\/sj.emboj.7601574","article-title":"Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability.","volume":"26","author":"M Bogliolo","year":"2007","journal-title":"Embo J"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"32274","DOI":"10.1074\/jbc.274.45.32274","article-title":"Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase\/AKT in breast cancer cells.","volume":"274","author":"S Altiok","year":"1999","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"8457","DOI":"10.1128\/MCB.24.19.8457-8466.2004","article-title":"BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number.","volume":"24","author":"LM Starita","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/sj.leu.2403779","article-title":"Centrosome aberrations in chronic myeloid leukemia correlate with stage of disease and chromosomal instability.","volume":"19","author":"M Giehl","year":"2005","journal-title":"Leukemia"},{"key":"ref33","first-page":"1179","article-title":"BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death.","volume":"83","author":"A McGahon","year":"1994","journal-title":"Blood"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1182\/blood.V86.3.1148.1148","article-title":"BCR-ABL-mediated inhibition of apoptosis with delay of G2\/M transition after DNA damage: a mechanism of resistance to multiple anticancer agents.","volume":"86","author":"A Bedi","year":"1995","journal-title":"Blood"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1128\/MCB.20.4.1179-1186.2000","article-title":"The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf.","volume":"20","author":"MS Neshat","year":"2000","journal-title":"Mol Cell Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/nm852","article-title":"Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors.","volume":"9","author":"T Taniguchi","year":"2003","journal-title":"Nat Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1158\/0008-5472.CAN-04-0245","article-title":"Promoter hypermethylation of FANCF: disruption of Fanconi Anemia-BRCA pathway in cervical cancer.","volume":"64","author":"G Narayan","year":"2004","journal-title":"Cancer Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/sj.leu.2403280","article-title":"Deletion and reduced expression of the Fanconi anemia FANCA gene in sporadic acute myeloid leukemia.","volume":"18","author":"MD Tischkowitz","year":"2004","journal-title":"Leukemia"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0002-9440(10)63329-9","article-title":"Functional defects in the fanconi anemia pathway in pancreatic cancer cells.","volume":"165","author":"MS van der Heijden","year":"2004","journal-title":"Am J Pathol"},{"key":"ref40","first-page":"299","article-title":"Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia.","volume":"30","author":"CJ Hess","year":"2008","journal-title":"Cell Oncol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.canlet.2005.07.038","article-title":"Disruption of the Fanconi anemia\/BRCA pathway in sporadic cancer.","volume":"232","author":"A Lyakhovich","year":"2006","journal-title":"Cancer Lett"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1182\/blood.V99.9.3197","article-title":"Modulation of p210(BCR-ABL) activity in transduced primary human hematopoietic cells controls lineage programming.","volume":"99","author":"Y Chalandon","year":"2002","journal-title":"Blood"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1182\/blood.V97.8.2406","article-title":"A model of human p210(bcr\/ABL)-mediated chronic myelogenous leukemia by transduction of primary normal human CD34(+) cells with a BCR\/ABL-containing retroviral vector.","volume":"97","author":"RC Zhao","year":"2001","journal-title":"Blood"},{"key":"ref44","first-page":"112","article-title":"Monoubiquitination of the Fanconi Anemia D2 (FANCD2) Protein Regulates the Transforming Potential of BCR\/ABL.","volume":"112","author":"M Koptyra","year":"2008","journal-title":"Blood (ASH Annual Meeting Abstracts)"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S1097-2765(00)80466-9","article-title":"Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells.","volume":"3","author":"X Xu","year":"1999","journal-title":"Mol Cell"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1128\/MCB.11.2.1107","article-title":"Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants.","volume":"11","author":"L Varticovski","year":"1991","journal-title":"Mol Cell Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"9404","DOI":"10.1158\/0008-5472.CAN-08-0861","article-title":"AKT1 inhibits homologous recombination by inducing cytoplasmic retention of BRCA1 and RAD51.","volume":"68","author":"I Plo","year":"2008","journal-title":"Cancer Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"23790","DOI":"10.1074\/jbc.M110.104372","article-title":"Akt activation emulates Chk1 inhibition and Bcl2 overexpression and abrogates G2 cell cycle checkpoint by inhibiting BRCA1 foci.","volume":"285","author":"I Tonic","year":"2010","journal-title":"J Biol Chem"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.canlet.2004.12.028","article-title":"Centrosome amplification, chromosome instability and cancer development.","volume":"230","author":"K Fukasawa","year":"2005","journal-title":"Cancer Lett"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/261494a0","article-title":"Susceptibility of Fanconi&apos;s anaemia fibroblasts to chromosome damage by carcinogens.","volume":"261","author":"AD Auerbach","year":"1976","journal-title":"Nature"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/sj.onc.1201490","article-title":"BCR-ABL activates pathways mediating cytokine independence and protection against apoptosis in murine hematopoietic cells in a dose-dependent manner.","volume":"16","author":"N Cambier","year":"1998","journal-title":"Oncogene"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.1073\/pnas.0731871100","article-title":"Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factor.","volume":"100","author":"S Ghaffari","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1182\/blood-2004-02-0749","article-title":"Identification of mcl-1 as a BCR\/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides.","volume":"105","author":"KJ Aichberger","year":"2005","journal-title":"Blood"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0015525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T01:56:12Z","timestamp":1592186172000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0015525"}},"subtitle":[],"editor":[{"given":"Sue","family":"Cotterill","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2010,12,28]]},"references-count":53,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2010,12,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0015525","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,28]]}}}