{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:02:14Z","timestamp":1790326934904,"version":"4.1.0"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2010,12,16]],"date-time":"2010-12-16T00:00:00Z","timestamp":1292457600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0015567","type":"journal-article","created":{"date-parts":[[2010,12,16]],"date-time":"2010-12-16T20:53:53Z","timestamp":1292532833000},"page":"e15567","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["A Fluorescence Reporter Model Defines \u201cTip-DCs\u201d as the Cellular Source of Interferon \u03b2 in Murine Listeriosis"],"prefix":"10.1371","volume":"5","author":[{"given":"Philipp","family":"Dresing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Borkens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Kocur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Kropp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Scheu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,12,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nrmicro1413","article-title":"Listeria monocytogenes: a multifaceted model.","volume":"4","author":"M Hamon","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/nri1461","article-title":"Immune responses to Listeria monocytogenes.","volume":"4","author":"EG Pamer","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1371\/journal.ppat.0040006","article-title":"Distinct TLR- and NLR-mediated transcriptional responses to an intracellular pathogen.","volume":"4","author":"JH Leber","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"8219","DOI":"10.1128\/JVI.78.15.8219-8228.2004","article-title":"Characterization of the murine alpha interferon gene family.","volume":"78","author":"V van Pesch","year":"2004","journal-title":"J Virol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nri1684","article-title":"The yin and yang of type I interferon activity in bacterial infection.","volume":"5","author":"T Decker","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1084\/jem.20040976","article-title":"Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes.","volume":"200","author":"V Auerbuch","year":"2004","journal-title":"J Exp Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1084\/jem.20040769","article-title":"Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection.","volume":"200","author":"JA Carrero","year":"2004","journal-title":"J Exp Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1084\/jem.20040712","article-title":"Type I interferon production enhances susceptibility to Listeria monocytogenes infection.","volume":"200","author":"RM O'Connell","year":"2004","journal-title":"J Exp Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e1000355","DOI":"10.1371\/journal.ppat.1000355","article-title":"Characterization of the interferon-producing cell in mice infected with Listeria monocytogenes.","volume":"5","author":"S Stockinger","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.imbio.2008.07.020","article-title":"Novel functions of type I interferons revealed by infection studies with Listeria monocytogenes.","volume":"213","author":"S Stockinger","year":"2008","journal-title":"Immunobiology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1084\/jem.20091746","article-title":"Induction of IFN-alphabeta enables Listeria monocytogenes to suppress macrophage activation by IFN-gamma.","volume":"207","author":"M Rayamajhi","year":"2010","journal-title":"J Exp Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1126\/science.1178331","article-title":"Development of monocytes, macrophages, and dendritic cells.","volume":"327","author":"F Geissmann","year":"2010","journal-title":"Science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nri1733","article-title":"Monocyte and macrophage heterogeneity.","volume":"5","author":"S Gordon","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1126\/science.1142883","article-title":"Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior.","volume":"317","author":"C Auffray","year":"2007","journal-title":"Science"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/ni1340","article-title":"Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes.","volume":"7","author":"SH Naik","year":"2006","journal-title":"Nat Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1074-7613(03)00171-7","article-title":"TNF\/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection.","volume":"19","author":"NV Serbina","year":"2003","journal-title":"Immunity"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"20416","DOI":"10.1073\/pnas.0808537105","article-title":"Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo.","volume":"105","author":"S Scheu","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1074-7613(03)00174-2","article-title":"Blood monocytes consist of two principal subsets with distinct migratory properties.","volume":"19","author":"F Geissmann","year":"2003","journal-title":"Immunity"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/82763","article-title":"IL-6 switches the differentiation of monocytes from dendritic cells to macrophages.","volume":"1","author":"P Chomarat","year":"2000","journal-title":"Nat Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"13861","DOI":"10.1073\/pnas.202476699","article-title":"Innate recognition of bacteria by a macrophage cytosolic surveillance pathway.","volume":"99","author":"M O'Riordan","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.immuni.2008.06.013","article-title":"Bacterial entry to the splenic white pulp initiates antigen presentation to CD8+ T cells.","volume":"29","author":"T Aoshi","year":"2008","journal-title":"Immunity"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/eji.200526024","article-title":"Distinct in vivo dendritic cell activation by live versus killed Listeria monocytogenes.","volume":"35","author":"E Muraille","year":"2005","journal-title":"Eur J Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.immuni.2008.09.017","article-title":"Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells.","volume":"29","author":"SJ Kang","year":"2008","journal-title":"Immunity"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.4049\/jimmunol.0900460","article-title":"MyD88 and Type I interferon receptor-mediated chemokine induction and monocyte recruitment during Listeria monocytogenes infection.","volume":"183","author":"T Jia","year":"2009","journal-title":"J Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ni1309","article-title":"Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2.","volume":"7","author":"NV Serbina","year":"2006","journal-title":"Nat Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev.immunol.26.021607.090326","article-title":"Monocyte-mediated defense against microbial pathogens.","volume":"26","author":"NV Serbina","year":"2008","journal-title":"Annu Rev Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1128\/IAI.00443-06","article-title":"Essential role of CCL2 in clustering of splenic ERTR-9+ macrophages during infection of BALB\/c mice by Listeria monocytogenes.","volume":"75","author":"J Jablonska","year":"2007","journal-title":"Infect Immun"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity.","volume":"392","author":"J Banchereau","year":"1998","journal-title":"Nature"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0092-8674(01)00449-4","article-title":"Dendritic cells: specialized and regulated antigen processing machines.","volume":"106","author":"I Mellman","year":"2001","journal-title":"Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1034\/j.1600-0528.2002.017407.x","article-title":"Innate defenses in the liver during Listeria infection.","volume":"174","author":"LP Cousens","year":"2000","journal-title":"Immunol Rev"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.4049\/jimmunol.157.6.2514","article-title":"Bacteria in the bloodstream are trapped in the liver and killed by immigrating neutrophils.","volume":"157","author":"SH Gregory","year":"1996","journal-title":"J Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1371\/journal.pgen.0030152","article-title":"Irf3 polymorphism alters induction of interferon beta in response to Listeria monocytogenes infection.","volume":"3","author":"O Garifulin","year":"2007","journal-title":"PLoS Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.immunol.021908.132629","article-title":"The liver as a lymphoid organ.","volume":"27","author":"IN Crispe","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"6382","DOI":"10.4049\/jimmunol.168.12.6382","article-title":"Organ-specific CD4+ T cell response during Listeria monocytogenes infection.","volume":"168","author":"M Kursar","year":"2002","journal-title":"J Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1084\/jem.20081385","article-title":"CX3CR1+ CD115+ CD135+ common macrophage\/DC precursors and the role of CX3CR1 in their response to inflammation.","volume":"206","author":"C Auffray","year":"2009","journal-title":"J Exp Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"5829","DOI":"10.4049\/jimmunol.181.9.5829","article-title":"Macrophages as APC and the dendritic cell myth.","volume":"181","author":"DA Hume","year":"2008","journal-title":"J Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.4049\/jimmunol.1001205","article-title":"Route of antigen uptake differentially impacts presentation by dendritic cells and activated monocytes.","volume":"185","author":"AO Kamphorst","year":"2010","journal-title":"J Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1128\/IAI.69.2.1093-1100.2001","article-title":"Neural route of cerebral Listeria monocytogenes murine infection: role of immune response mechanisms in controlling bacterial neuroinvasion.","volume":"69","author":"Y Jin","year":"2001","journal-title":"Infect Immun"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0092-8674(95)90085-3","article-title":"Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase.","volume":"81","author":"JD MacMicking","year":"1995","journal-title":"Cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.4049\/jimmunol.143.9.2894","article-title":"Evidence that tumor necrosis factor has an important role in antibacterial resistance.","volume":"143","author":"EA Havell","year":"1989","journal-title":"J Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0092-8674(93)90134-C","article-title":"Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection.","volume":"73","author":"K Pfeffer","year":"1993","journal-title":"Cell"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/364798a0","article-title":"Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes.","volume":"364","author":"J Rothe","year":"1993","journal-title":"Nature"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.4049\/jimmunol.169.4.1665","article-title":"Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling.","volume":"169","author":"MA Freudenberg","year":"2002","journal-title":"J Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.4049\/jimmunol.178.5.3126","article-title":"Type I IFN signaling is crucial for host resistance against different species of pathogenic bacteria.","volume":"178","author":"G Mancuso","year":"2007","journal-title":"J Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.immuni.2006.08.007","article-title":"Type I interferons in host defense.","volume":"25","author":"DB Stetson","year":"2006","journal-title":"Immunity"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"522","DOI":"10.4049\/jimmunol.179.1.522","article-title":"The hypervirulent Mycobacterium tuberculosis strain HN878 induces a potent TH1 response followed by rapid down-regulation.","volume":"179","author":"D Ordway","year":"2007","journal-title":"J Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1172\/JCI40817","article-title":"Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte\/macrophage population.","volume":"120","author":"LR Antonelli","year":"2010","journal-title":"J Clin Invest"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"e1000722","DOI":"10.1371\/journal.ppat.1000722","article-title":"Type I interferon induction is detrimental during infection with the Whipple's disease bacterium, Tropheryma whipplei.","volume":"6","author":"K Al Moussawi","year":"2010","journal-title":"PLoS Pathog"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0015567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T03:04:26Z","timestamp":1712027066000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0015567"}},"subtitle":[],"editor":[{"given":"Mehrdad","family":"Matloubian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,12,16]]},"references-count":48,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2010,12,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0015567","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,16]]}}}