{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:29:09Z","timestamp":1791286149014,"version":"4.1.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0015723","type":"journal-article","created":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T21:37:42Z","timestamp":1294436262000},"page":"e15723","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":75,"title":["Macrophage Activation and Differentiation Signals Regulate Schlafen-4 Gene Expression: Evidence for Schlafen-4 as a Modulator of Myelopoiesis"],"prefix":"10.1371","volume":"6","author":[{"given":"Wendy J.","family":"van Zuylen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Garceau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Idris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Schroder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine M.","family":"Irvine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E.","family":"Lattin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry A.","family":"Ovchinnikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Perkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Hertzog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katryn J.","family":"Stacey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Kellie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Hume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Sweet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cell.2008.01.025","article-title":"Hematopoiesis: an evolving paradigm for stem cell biology.","volume":"132","author":"SH Orkin","year":"2008","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.coi.2005.11.008","article-title":"The mononuclear phagocyte system.","volume":"18","author":"DA Hume","year":"2006","journal-title":"Curr Opin Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.dci.2003.09.010","article-title":"Regulation of myeloid development and function by colony stimulating factors.","volume":"28","author":"DR Barreda","year":"2004","journal-title":"Dev Comp Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"13453","DOI":"10.1073\/pnas.2230460100","article-title":"Critical roles for IFN-beta in lymphoid development, myelopoiesis, and tumor development: Links to tumour necrosis factor alpha.","volume":"100","author":"R Deonarain","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S1074-7613(00)80663-9","article-title":"Schlafen, a new family of growth regulatory genes that affect thymocyte development.","volume":"9","author":"DA Schwarz","year":"1998","journal-title":"Immunity"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1093\/intimm\/dxh155","article-title":"Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif.","volume":"16","author":"P Geserick","year":"2004","journal-title":"International Immunology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2009.07.006","article-title":"Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence.","volume":"447","author":"O Bustos","year":"2009","journal-title":"Gene"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"4936","DOI":"10.1073\/pnas.0401133101","article-title":"Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals.","volume":"101","author":"YH Huang","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1189\/jlb.0609410","article-title":"Characterization of Schlafen-3 expression in effector and regulatory T cells.","volume":"87","author":"T Condamine","year":"2010","journal-title":"J Leukoc Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1128\/MCB.24.2.741-756.2004","article-title":"Molecular signatures of self-renewal, differentiation, and lineage choice in multipotential hemopoietic progenitor cells in vitro.","volume":"24","author":"L Bruno","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1128\/IAI.74.5.2787-2802.2006","article-title":"Influence of Slc11a1 on the outcome of Salmonella enterica serovar Enteritidis infection in mice is associated with Th polarization.","volume":"74","author":"J Caron","year":"2006","journal-title":"Infect Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1128\/IAI.73.1.532-545.2005","article-title":"Central role of toll-like receptor 4 signaling and host defense in experimental pneumonia caused by Gram-negative bacteria.","volume":"73","author":"JR Schurr","year":"2005","journal-title":"Infect Immun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/ni.1847","article-title":"An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.","volume":"11","author":"M Berger","year":"2010","journal-title":"Nat Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"25051","DOI":"10.1074\/jbc.M109.030445","article-title":"Role of Schlafen 2 (SLFN2) in the generation of interferon alpha-induced growth inhibitory responses.","volume":"284","author":"E Katsoulidis","year":"2009","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"30723","DOI":"10.1074\/jbc.M500435200","article-title":"Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1.","volume":"280","author":"G Brady","year":"2005","journal-title":"J Biol Chem"},{"key":"ref16","article-title":"Functional clustering and lineage markers: Insights into cellular differentiation and gene function from large-scale microarray studies of purified primary cell populations.","author":"DA Hume","year":"2010","journal-title":"Genomics"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/ar86","article-title":"Macrophages in rheumatoid arthritis.","volume":"2","author":"RW Kinne","year":"2000","journal-title":"Arthritis Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/ng1789","article-title":"Genome-wide analysis of mammalian promoter architecture and evolution.","volume":"38","author":"P Carninci","year":"2006","journal-title":"Nature Genetics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"15319","DOI":"10.1074\/jbc.R700009200","article-title":"Toll-like receptors and Type I interferons.","volume":"282","author":"S Uematsu","year":"2007","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.imbio.2006.05.007","article-title":"Signal integration between IFNgamma and TLR signalling pathways in macrophages.","volume":"211","author":"K Schroder","year":"2006","journal-title":"Immunobiology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/ni1308","article-title":"MyD88-mediated stabilization of interferon-gamma-induced cytokine and chemokine mRNA.","volume":"7","author":"D Sun","year":"2006","journal-title":"Nat Immunol"},{"key":"ref22","article-title":"HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA.","author":"TL Roberts","year":"2009","journal-title":"Science"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.4049\/jimmunol.156.7.2553","article-title":"Endogenous ifn-alpha beta suppresses colony-stimulating factor (csf-1)-1 stimulated macrophage DNA synthesis and mediates inhibitory effects of lipopolysaccharide and tnf-alpha.","volume":"156","author":"JA Hamilton","year":"1996","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1189\/jlb.0807585","article-title":"Expression of Gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r-Gal4VP16\/UAS-ECFP double-transgenic mice.","volume":"83","author":"DA Ovchinnikov","year":"2008","journal-title":"J Leukoc Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1189\/jlb.0809557","article-title":"A conserved distal segment of the mouse CSF-1 receptor promoter is required for maximal expression of a reporter gene in macrophages and osteoclasts of transgenic mice.","volume":"87","author":"DA Ovchinnikov","year":"2010","journal-title":"J Leukoc Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/jcp.1041220305","article-title":"Lineage specific receptors used to identify a growth factor for developmentally early hemopoietic cells: assay of hemopoietin-2.","volume":"122","author":"SH Bartelmez","year":"1985","journal-title":"J Cell Physiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1365-2141.1990.tb02556.x","article-title":"The Effects of Interleukin 3 (Il-3) on Cells Responsive to Macrophage Colony-Stimulating Factor (Csf-1) in Liquid Murine Bone-Marrow Culture.","volume":"74","author":"FN Breen","year":"1990","journal-title":"British Journal of Haematology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"G955","DOI":"10.1152\/ajpgi.90726.2008","article-title":"Schlafen 3, a novel gene, regulates colonic mucosal growth during aging.","volume":"296","author":"BB Patel","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.bbrc.2009.08.094","article-title":"Schlafen-3: a novel regulator of intestinal differentiation.","volume":"388","author":"VB Patel","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bbrc.2008.03.032","article-title":"Subcellular localization of the Schlafen protein family.","volume":"370","author":"B Neumann","year":"2008","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3412","DOI":"10.1182\/blood-2007-11-122028","article-title":"High-resolution whole genome tiling path array cgh analysis of cd34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival.","volume":"112","author":"D Starczynowski","year":"2008","journal-title":"Blood"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1146\/annurev.bi.56.070187.003455","article-title":"Interferons and their actions.","volume":"56","author":"S Pestka","year":"1987","journal-title":"Annu Rev Biochem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/nm1303","article-title":"CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection.","volume":"11","author":"JW Tyner","year":"2005","journal-title":"Nat Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jneuroim.2005.01.017","article-title":"Restraint stress alters lung gene expression in an experimental influenza A viral infection.","volume":"162","author":"A Engler","year":"2005","journal-title":"J Neuroimmunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1099\/vir.0.82748-0","article-title":"Camelpox virus encodes a schlafen-like protein that affects orthopoxvirus virulence.","volume":"88","author":"C Gubser","year":"2007","journal-title":"J Gen Virol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1189\/jlb.1204710","article-title":"Inflammation suppressor genes: please switch out all the lights.","volume":"78","author":"CA Wells","year":"2005","journal-title":"Journal of Leukocyte Biology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"R100","DOI":"10.1186\/ar1985","article-title":"Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis.","volume":"8","author":"N Fujikado","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1096\/fj.06-5848fje","article-title":"A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations.","volume":"20","author":"KM Irvine","year":"2006","journal-title":"Faseb J"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1189\/jlb.0808497","article-title":"Colony-stimulating factor-1 (csf-1) delivers a proatherogenic signal to human macrophages.","volume":"85","author":"KM Irvine","year":"2009","journal-title":"J Leukoc Biol"},{"key":"ref40","first-page":"67","article-title":"Involvement of Ets, rel and Sp1-like proteins in lipopolysaccharide-mediated activation of the HIV-1 LTR in macrophages.","volume":"48","author":"MJ Sweet","year":"1998","journal-title":"J Inflamm"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1136\/ard.56.6.364","article-title":"Granulocyte-macrophage colony stimulating factor exacerbates collagen induced arthritis in mice.","volume":"56","author":"IK Campbell","year":"1997","journal-title":"Annals of the Rheumatic Diseases"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"9784","DOI":"10.1073\/pnas.89.20.9784","article-title":"Antitumor Necrosis Factor Ameliorates Joint Disease in Murine Collagen-Induced Arthritis.","volume":"89","author":"RO Williams","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.4049\/jimmunol.181.2.1232","article-title":"Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo.","volume":"181","author":"MK Chang","year":"2008","journal-title":"J Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0015723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T19:52:08Z","timestamp":1685908328000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0015723"}},"subtitle":[],"editor":[{"given":"Lisa Ng Fong","family":"Poh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,1,7]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,1,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0015723","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,7]]}}}