{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:48:50Z","timestamp":1791017330659,"version":"4.1.0"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T00:00:00Z","timestamp":1296432000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0015752","type":"journal-article","created":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T21:54:18Z","timestamp":1296510858000},"page":"e15752","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":64,"title":["Executive Decision-Making in the Domestic Sheep"],"prefix":"10.1371","volume":"6","author":[{"given":"A. Jennifer","family":"Morton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Avanzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,1,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nature06975","article-title":"Towards a transgenic model of Huntington's disease in a non-human primate.","volume":"453","author":"SH Yang","year":"2008","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1093\/hmg\/ddq063","article-title":"An ovine transgenic Huntington's disease model.","volume":"19","author":"JC Jacobsen","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/jmcb\/mjp009","article-title":"Transgenic primate research paves the path to a better animal model: are we a step closer to curing inherited human genetic disorders?","volume":"1","author":"AW Chan","year":"2009","journal-title":"J Mol Cell Biol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1359\/jbmr.080516","article-title":"Review of nonprimate, large animal models for osteoporosis research.","volume":"23","author":"S Reinwald","year":"2008","journal-title":"J Bone Miner Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/08037050903576767","article-title":"Characterization of cardiac remodeling in a large animal "one-kidney, one-clip" hypertensive model.","volume":"19","author":"DH Lau","year":"2010","journal-title":"Blood Press"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/MOH.0b013e32833cd4bd","article-title":"Preclinical and clinical progress in hemophilia gene therapy.","volume":"17","author":"J M\u00e1trai","year":"2010","journal-title":"Curr Opin Hematol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"11787","DOI":"10.1073\/pnas.1006951107","article-title":"Mapping of cerebral oxidative metabolism with MRI.","volume":"107","author":"EA Mellon","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"E61","DOI":"10.2527\/jas.2009-2359","article-title":"Developmental programming: the concept, large animal models, and the key role of uteroplacental vascular development.","volume":"88","author":"LP Reynolds","year":"2010","journal-title":"J Anim Sci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/35102669","article-title":"Sheep don't forget a face.","volume":"414","author":"KM Kendrick","year":"2001","journal-title":"Nature"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/0028-3932(91)90063-E","article-title":"Extra-dimensional versus intra-dimensional set-shifting performance following frontal lobe excisions, temporal lobe excisions of amygdalo-hippocampectomy in man.","volume":"29","author":"AM Owen","year":"1991","journal-title":"Neuropsychologia"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0278-2626(03)00284-7","article-title":"The neuropsychology of ventral prefrontal cortex: decision-making and reversal learning.","volume":"55","author":"L Clark","year":"2004","journal-title":"Brain Cogn"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.conb.2010.01.007","article-title":"Learning and cognitive flexibility: frontostriatal function and monoaminergic modulation.","volume":"20","author":"AA Kehagia","year":"2010","journal-title":"Curr Opin Neurobiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1093\/brain\/121.7.1329","article-title":"Evidence for specific cognitive deficits in preclinical Huntington's disease.","volume":"121","author":"AD Lawrence","year":"1998","journal-title":"Brain"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1093\/brain\/119.5.1633","article-title":"Executive and mnemonic functions in early Huntington's disease.","volume":"119","author":"AD Lawrence","year":"1996","journal-title":"Brain"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1111\/j.1460-9568.2004.03586.x","article-title":"Attention and executive function deficits in chronic low-dose MPTP-treated non-human primates.","volume":"20","author":"E Decamp","year":"2004","journal-title":"Eur J Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0197-4580(02)00054-4","article-title":"Impairment in abstraction and set shifting in aged rhesus monkeys.","volume":"24","author":"TL Moore","year":"2003","journal-title":"Neurobiol Aging"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1037\/a0014723","article-title":"Effects on executive function following damage to the prefrontal cortex in the rhesus monkey (Macaca mulatta).","volume":"123","author":"TL Moore","year":"2009","journal-title":"Behav Neurosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1523\/JNEUROSCI.3690-04.2005","article-title":"Prefrontal serotonin depletion affects reversal learning but not attentional set shifting.","volume":"25","author":"HF Clarke","year":"2005","journal-title":"J Neurosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/cercor\/bhj120","article-title":"Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific.","volume":"17","author":"HF Clarke","year":"2007","journal-title":"Cereb Cortex"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1037\/0735-7044.110.5.872","article-title":"Primate analogue of the Wisconsin Card Sorting Test: effects of excitotoxic lesions in the prefrontal cortex of the marmoset.","volume":"110","author":"R Dias","year":"1996","journal-title":"Behav Neurosci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/380069a0","article-title":"Dissociation in prefrontal cortex of affective and attentional shifts.","volume":"380","author":"R Dias","year":"1996","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1037\/h0025762","article-title":"A methodological analysis of shift paradigms in human discrimination learning.","volume":"69","author":"NJ Slamecka","year":"1968","journal-title":"Psychol Bull"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0306-4522(92)90241-S","article-title":"A specific form of cognitive rigidity following excitotoxic lesions of the basal forebrain in marmosets.","volume":"47","author":"AC Roberts","year":"1992","journal-title":"Neuroscience"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"9285","DOI":"10.1523\/JNEUROSCI.17-23-09285.1997","article-title":"Dissociable forms of inhibitory control within prefrontal cortex with an analog of the Wisconsin Card Sort Test: restriction to novel situations and independence from "on-line" processing.","volume":"17","author":"R Dias","year":"1997","journal-title":"J Neurosci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1523\/JNEUROSCI.20-11-04320.2000","article-title":"Medial prefrontal cortex mediates perceptual attentional set shifting in the rat.","volume":"20","author":"JM Birrell","year":"2000","journal-title":"J Neurosci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/cercor\/11.11.1015","article-title":"Differential effects of 6-OHDA lesions of the frontal cortex and caudate nucleus on the ability to acquire an attentional set.","volume":"11","author":"HS Crofts","year":"2001","journal-title":"Cereb Cortex"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1162\/jocn.2003.15.5.629","article-title":"Task-set switching deficits in early-stage Huntington's disease: implications for basal ganglia function.","volume":"15","author":"AR Aron","year":"2003","journal-title":"J Cog Neurosci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1523\/JNEUROSCI.4312-03.2004","article-title":"Differential responses in human striatum and prefrontal cortex to changes in object and rule relevance.","volume":"24","author":"R Cools","year":"2004","journal-title":"J Neurosci"},{"key":"ref29","article-title":"Conditioning and Associative learning.","author":"NJ Mackintosh","year":"1983"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nmeth1006-767","article-title":"Measuring cognitive deficits in disabled mice using an automated interactive touchscreen system.","volume":"3","author":"AJ Morton","year":"2006","journal-title":"Nat Methods"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1037\/0735-7044.119.3.839","article-title":"Discrimination of multidimensional visual stimuli by mice: intra- and extradimensional shifts.","volume":"119","author":"JL Brigman","year":"2005","journal-title":"Behav Neurosci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.bbr.2007.08.035","article-title":"Lesions of the basal forebrain impair reversal learning but not shifting of attentional set in rats.","volume":"187","author":"DS Tait","year":"2008","journal-title":"Behav Brain Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1111\/j.1460-9568.2007.05612.x","article-title":"Lesions of the dorsal noradrenergic bundle impair attentional set-shifting in the rat.","volume":"25","author":"DS Tait","year":"2007","journal-title":"Eur J Neurosci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jneumeth.2009.09.014","article-title":"Chronic infusion of PCP via osmotic mini-pumps: a new rodent model of cognitive deficit in schizophrenia characterized by impaired attentional set-shifting (ID\/ED) performance.","volume":"85","author":"CS Pedersen","year":"2009","journal-title":"J Neurosci Meth"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bbr.2010.01.043","article-title":"One week of exposure to intermittent hypoxia impairs attentional set-shifting in rats.","volume":"210","author":"JG McCoy","year":"2010","journal-title":"Behav Brain Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0166-4328(01)00391-6","article-title":"Attentional set-shifting in mice: modification of a rat paradigm, and evidence for strain-dependent variation.","volume":"132","author":"G Colacicco","year":"2002","journal-title":"Behav Brain Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"11124","DOI":"10.1523\/JNEUROSCI.2820-08.2008","article-title":"Double dissociation of the effects of medial and orbital prefrontal cortical lesions on attentional and affective shifts in mice.","volume":"28","author":"GB Bissonette","year":"2008","journal-title":"J Neurosci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bbr.2006.06.002","article-title":"Animal neuropsychology: validation of the Intra-Dimensional Extra-Dimensional set shifting task for mice.","volume":"173","author":"JP Garner","year":"2006","journal-title":"Behav Brain Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1017\/S0033291700033523","article-title":"Neuropsychological evidence for frontostriatal dysfunction in schizophrenia.","volume":"25","author":"R Elliott","year":"1995","journal-title":"Psychol Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1192\/bjp.181.43.s38","article-title":"Executive dysfunction in first-episode schizophrenia and relationship to duration of untreated psychosis: the West London Study.","volume":"181","author":"E Joyce","year":"2002","journal-title":"Br J Psychiatry"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.biopsych.2008.05.009","article-title":"Set-shifting ability and schizophrenia: a marker of clinical illness or an intermediate phenotype?","volume":"64","author":"AE Ceaser","year":"2008","journal-title":"Biol Psychiatry"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1017\/S0033291709991255","article-title":"The neuropsychology of the schizo-obsessive subtype of schizophrenia: a new analysis.","volume":"40","author":"DD Patel","year":"2010","journal-title":"Psychol Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/S0028-3932(01)00150-6","article-title":"Relationship between attentional performance and corpus callosum morphometry in patients with Alzheimer's disease.","volume":"40","author":"AA Dorion","year":"2002","journal-title":"Neuropsychologia"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1136\/jnnp.57.1.79","article-title":"Cognitive deficits in progressive supranuclear palsy, Parkinson's disease, and multiple system atrophy in tests sensitive to frontal lobe dysfunction.","volume":"57","author":"TW Robbins","year":"1994","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/0028-3932(89)90128-0","article-title":"Impaired extra-dimensional shift performance in medicated and unmedicated Parkinson's disease: evidence for a specific attentional dysfunction.","volume":"27","author":"JJ Downes","year":"1989","journal-title":"Neuropsychologia"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/brain\/116.5.1159","article-title":"Contrasting mechanisms of impaired attentional set-shifting in patients with frontal lobe damage or Parkinson's disease.","volume":"116","author":"AM Owen","year":"1993","journal-title":"Brain"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0028-3932(98)00049-9","article-title":"Mechanisms underlying attentional set-shifting in Parkinson's disease.","volume":"37","author":"J Gauntlett-Gilbert","year":"1999","journal-title":"Neuropsychologia"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1162\/089892900561931","article-title":"Contrasting cortical and subcortical activations produced by attentional-set shifting and reversal learning in humans.","volume":"12","author":"Rogers","year":"2000","journal-title":"J Cogn Neurosci"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.neuroimage.2004.12.054","article-title":"Dissociation of neural systems mediating shifts in behavioural response and cognitive set.","volume":"25","author":"KM Shafritz","year":"2005","journal-title":"Neuroimage"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.neubiorev.2004.09.006","article-title":"Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates.","volume":"28","author":"JW Dalley","year":"2004","journal-title":"Neurosci Biobehav Rev"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.applanim.2005.06.001","article-title":"Development of a maze test and its application to assess spatial learning and memory in Merino sheep.","volume":"96","author":"C Lee","year":"2006","journal-title":"Appl Animal Behav Sci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.conb.2009.01.002","article-title":"How good is the macaque monkey model of the human brain?","volume":"19","author":"R Passingham","year":"2009","journal-title":"Curr Opinion Neurobiol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0304-3762(80)90133-9","article-title":"Behavioral responses to short-term social isolation in sheep and goats.","volume":"6","author":"EO Price","year":"1980","journal-title":"Applied Animal Ethology"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.physbeh.2007.03.016","article-title":"A critical review of fear tests used on cattle, pigs, sheep, poultry and horses.","volume":"92","author":"BA Forkman","year":"2007","journal-title":"Physiol Beh"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.physbeh.2009.05.017","article-title":"Physiological expression of emotional reactions in sheep.","volume":"98","author":"N Reefmann","year":"2009","journal-title":"Physiol Behav"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.physbeh.2007.02.003","article-title":"Assessment of positive emotions in animals to improve their welfare.","volume":"92","author":"A Boissy","year":"2007","journal-title":"Physiol Beh"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0015752","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T07:11:33Z","timestamp":1559977893000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0015752"}},"subtitle":[],"editor":[{"given":"Georges","family":"Chapouthier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,1,31]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,1,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0015752","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,31]]}}}