{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:51:14Z","timestamp":1792569074408,"version":"4.5.0"},"reference-count":98,"publisher":"Public Library of Science (PLoS)","issue":"1","content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0016260","type":"journal-article","created":{"date-parts":[[2011,1,20]],"date-time":"2011-01-20T21:51:54Z","timestamp":1295560314000},"page":"e16260","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Genetic Analysis of Hedgehog Signaling in Ventral Body Wall Development and the Onset of Omphalocele Formation"],"prefix":"10.1371","volume":"6","author":[{"given":"Daisuke","family":"Matsumaru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuma","family":"Haraguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Miyagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Motoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Nakagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frits","family":"Meijlink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,1,20]]},"reference":[{"key":"ref1","article-title":"The atlas of mouse development.","author":"MH Kaufman","year":"1992"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1002\/bies.20137","article-title":"Finally, a sense of closure? Animal models of human ventral body wall defects.","volume":"26","author":"S Brewer","year":"2004","journal-title":"Bioessays"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1101\/gad.11.23.3128","article-title":"Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes.","volume":"11","author":"J Eggenschwiler","year":"1997","journal-title":"Genes Dev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1046\/j.1469-0705.1995.06040256.x","article-title":"Fetal midgut herniation into the umbilical cord: improved definition of ventral abdominal anomaly with the use of transvaginal sonography.","volume":"6","author":"R Achiron","year":"1995","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/pd.2008","article-title":"Prenatal and postnatal management of omphalocele.","volume":"28","author":"S Mann","year":"2008","journal-title":"Prenat Diagn"},{"key":"ref6","first-page":"626","article-title":"Langman&apos;s medical embryology.","author":"T Sadler","year":"2006"},{"key":"ref7","article-title":"Omphalocele and Gastroschisis.","author":"JG Glasser","year":"2009"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/00008480-200208000-00023","article-title":"Abdominal wall defects.","volume":"14","author":"T Weber","year":"2002","journal-title":"Curr Opin Pediatr"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1053\/j.sempedsurg.2010.03.006","article-title":"The embryologic origin of ventral body wall defects.","volume":"19","author":"T Sadler","year":"2010","journal-title":"Semin Pediatr Surg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1083\/jcb.144.5.857","article-title":"Calreticulin is essential for cardiac development.","volume":"144","author":"N Mesaeli","year":"1999","journal-title":"J Cell Biol"},{"key":"ref11","first-page":"xxi, 1633","article-title":"Avery&apos;s diseases of the newborn.","author":"HW Taeusch","year":"2005"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1002\/dvdy.20823","article-title":"A new serine\/threonine protein kinase, Omphk1, essential to ventral body wall formation.","volume":"235","author":"M Hirano","year":"2006","journal-title":"Dev Dyn"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0022-3468(86)80360-8","article-title":"Omphalocele: a 25-year experience.","volume":"21","author":"S Yazbeck","year":"1986","journal-title":"J Pediatr Surg"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.cupe.2006.03.005","article-title":"Abdominal wall defects.","volume":"16","author":"G Aspelund","year":"2006","journal-title":"Current Paediatrics"},{"key":"ref15","article-title":"Atlas of Congenital Anomalies of the External Genitalia; Perovic, V. S, editors.","author":"SV Perovic","year":"1999"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00268-002-6746-1","article-title":"Abdominal wall defects.","volume":"27","author":"J Langer","year":"2003","journal-title":"World J Surg"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/bdra.20557","article-title":"Bladder exstrophy-epispadias complex.","volume":"85","author":"M Ludwig","year":"2009","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.gde.2009.08.004","article-title":"New horizons at the caudal embryos: coordinated urogenital\/reproductive organ formation by growth factor signaling.","volume":"19","author":"K Suzuki","year":"2009","journal-title":"Curr Opin Genet Dev"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/ajmg.1211","article-title":"Exstrophy of the cloaca and the OEIS complex: one and the same.","volume":"99","author":"J Carey","year":"2001","journal-title":"Am J Med Genet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/ajmg.10084","article-title":"OEIS complex, VATER, and the ongoing difficulties in terminology and delineation.","volume":"107","author":"A Bohring","year":"2002","journal-title":"Am J Med Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1046\/j.1469-0705.1999.13030207.x","article-title":"Congenital hernia of the abdominal wall: a differential diagnosis of fetal abdominal wall defects.","volume":"13","author":"H Stepan","year":"1999","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/45803","article-title":"Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis.","volume":"401","author":"C Lin","year":"1999","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"5749","DOI":"10.1242\/dev.126.24.5749","article-title":"Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism.","volume":"126","author":"K Kitamura","year":"1999","journal-title":"Development"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"13714","DOI":"10.1073\/pnas.95.23.13714","article-title":"AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice.","volume":"95","author":"T Nottoli","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00429-002-0273-6","article-title":"Tgfbeta2 \u2212\/\u2212 Tgfbeta3 \u2212\/\u2212 double knockout mice display severe midline fusion defects and early embryonic lethality.","volume":"206","author":"N Dunker","year":"2002","journal-title":"Anat Embryol (Berl)"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.bbrc.2007.06.049","article-title":"Deficient Alk3-mediated BMP signaling causes prenatal omphalocele-like defect.","volume":"360","author":"J Sun","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1242\/dev.02368","article-title":"Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity.","volume":"133","author":"D Goldman","year":"2006","journal-title":"Development"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/ar.a.20180","article-title":"Ventral abdominal wall dysmorphogenesis of Msx1\/Msx2 double-mutant mice.","volume":"284","author":"H Ogi","year":"2005","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ydbio.2003.11.021","article-title":"Loss of AP-2alpha impacts multiple aspects of ventral body wall development and closure.","volume":"267","author":"S Brewer","year":"2004","journal-title":"Dev Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/381235a0","article-title":"Transcription factor AP-2 essential for cranial closure and craniofacial development.","volume":"381","author":"H Schorle","year":"1996","journal-title":"Nature"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/381238a0","article-title":"Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2.","volume":"381","author":"J Zhang","year":"1996","journal-title":"Nature"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/45797","article-title":"Function of Rieger syndrome gene in left-right asymmetry and craniofacial development.","volume":"401","author":"M Lu","year":"1999","journal-title":"Nature"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1242\/dev.126.20.4643","article-title":"Dosage requirement of Pitx2 for development of multiple organs.","volume":"126","author":"P Gage","year":"1999","journal-title":"Development"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1101\/gad.1693608","article-title":"Hedgehog: functions and mechanisms.","volume":"22","author":"M Varjosalo","year":"2008","journal-title":"Genes Dev"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/0092-8674(93)90626-2","article-title":"Sonic hedgehog mediates the polarizing activity of the ZPA.","volume":"75","author":"R Riddle","year":"1993","journal-title":"Cell"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.devcel.2008.11.010","article-title":"Hedgehog signaling in development and cancer.","volume":"15","author":"J Jiang","year":"2008","journal-title":"Dev Cell"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.gde.2006.06.013","article-title":"Mechanistic insight into how Shh patterns the vertebrate limb.","volume":"16","author":"E McGlinn","year":"2006","journal-title":"Curr Opin Genet Dev"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.devcel.2008.01.008","article-title":"Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud.","volume":"14","author":"J Zhu","year":"2008","journal-title":"Dev Cell"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nrg2681","article-title":"Vertebrate limb bud development: moving towards integrative analysis of organogenesis.","volume":"10","author":"R Zeller","year":"2009","journal-title":"Nat Rev Genet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1126\/science.1075620","article-title":"Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.","volume":"298","author":"P te Welscher","year":"2002","journal-title":"Science"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nature01033","article-title":"Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity.","volume":"418","author":"Y Litingtung","year":"2002","journal-title":"Nature"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1242\/dev.126.20.4431","article-title":"Mouse patched1 controls body size determination and limb patterning.","volume":"126","author":"L Milenkovic","year":"1999","journal-title":"Development"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1242\/dev.037507","article-title":"Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb.","volume":"136","author":"N Butterfield","year":"2009","journal-title":"Development"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e155","DOI":"10.1093\/nar\/gni146","article-title":"An ES cell system for rapid, spatial and temporal analysis of gene function in vitro and in vivo.","volume":"33","author":"J Mao","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ydbio.2008.11.009","article-title":"Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development.","volume":"326","author":"Y Pan","year":"2009","journal-title":"Dev Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ydbio.2006.03.013","article-title":"BMP receptor type IA in limb bud mesenchyme regulates distal outgrowth and patterning.","volume":"295","author":"DA Ovchinnikov","year":"2006","journal-title":"Dev Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1242\/dev.01877","article-title":"Analysis of Msx1; Msx2 double mutants reveals multiple roles for Msx genes in limb development.","volume":"132","author":"Y Lallemand","year":"2005","journal-title":"Development"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1093\/hmg\/ddq060","article-title":"AP-2alpha knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis.","volume":"19","author":"E Bassett","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.ydbio.2009.02.017","article-title":"A SHH-independent regulation of Gli3 is a significant determinant of anteroposterior patterning of the limb bud.","volume":"328","author":"P Hill","year":"2009","journal-title":"Dev Biol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ng0393-241","article-title":"A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene.","volume":"3","author":"CC Hui","year":"1993","journal-title":"Nat Genet"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1053\/jpsu.2001.20722","article-title":"Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway.","volume":"36","author":"P Kim","year":"2001","journal-title":"J Pediatr Surg"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1387\/ijdb.051984lp","article-title":"Genetic interaction of Gli3 and Alx4 during limb development.","volume":"49","author":"L Panman","year":"2005","journal-title":"Int J Dev Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.1242\/dev.124.20.3999","article-title":"Polydactyly and ectopic ZPA formation in Alx-4 mutant mice.","volume":"124","author":"S Qu","year":"1997","journal-title":"Development"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1242\/dev.125.14.2711","article-title":"Mutations in mouse Aristaless-like4 cause Strong&apos;s luxoid polydactyly.","volume":"125","author":"S Qu","year":"1998","journal-title":"Development"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1242\/dev.125.22.4417","article-title":"The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development.","volume":"125","author":"M Takahashi","year":"1998","journal-title":"Development"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.ydbio.2005.06.017","article-title":"Function and regulation of Alx4 in limb development: complex genetic interactions with Gli3 and Shh.","volume":"285","author":"S Kuijper","year":"2005","journal-title":"Dev Biol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1006\/dbio.1996.8457","article-title":"Multigenic control of the localization of the zone of polarizing activity in limb morphogenesis in the mouse.","volume":"182","author":"H Masuya","year":"1997","journal-title":"Dev Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1242\/dev.01735","article-title":"Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes.","volume":"132","author":"S Kuijper","year":"2005","journal-title":"Development"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/383407a0","article-title":"Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.","volume":"383","author":"C Chiang","year":"1996","journal-title":"Nature"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.cell.2004.07.023","article-title":"Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning.","volume":"118","author":"S Ahn","year":"2004","journal-title":"Cell"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cell.2004.07.024","article-title":"Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities.","volume":"118","author":"B Harfe","year":"2004","journal-title":"Cell"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain.","volume":"21","author":"P Soriano","year":"1999","journal-title":"Nat Genet"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1006\/dbio.2002.0597","article-title":"Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation\/inactivation in the mouse.","volume":"244","author":"S Hayashi","year":"2002","journal-title":"Dev Biol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"10171","DOI":"10.1158\/0008-5472.CAN-06-0657","article-title":"A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway.","volume":"66","author":"J Mao","year":"2006","journal-title":"Cancer Res"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1242\/dev.02736","article-title":"Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling.","volume":"134","author":"R Haraguchi","year":"2007","journal-title":"Development"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1242\/dev.124.7.1313","article-title":"A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro.","volume":"124","author":"H Sasaki","year":"1997","journal-title":"Development"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/S0960-9822(07)00562-3","article-title":"Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase.","volume":"8","author":"PS Danielian","year":"1998","journal-title":"Curr Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1006\/bbrc.1997.7124","article-title":"Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains.","volume":"237","author":"R Feil","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"10887","DOI":"10.1073\/pnas.93.20.10887","article-title":"Ligand-activated site-specific recombination in mice.","volume":"93","author":"R Feil","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1242\/dev.039438","article-title":"Dosage-dependent hedgehog signals integrated with Wnt\/beta-catenin signaling regulate external genitalia formation as an appendicular program.","volume":"136","author":"S Miyagawa","year":"2009","journal-title":"Development"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1210\/me.2008-0478","article-title":"Genetic interactions of the androgen and Wnt\/beta-catenin pathways for the masculinization of external genitalia.","volume":"23","author":"S Miyagawa","year":"2009","journal-title":"Mol Endocrinol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature03994","article-title":"In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog.","volume":"437","author":"S Ahn","year":"2005","journal-title":"Nature"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1101\/gad.1190304","article-title":"Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia.","volume":"18","author":"J Jeong","year":"2004","journal-title":"Genes Dev"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1242\/dev.128.21.4241","article-title":"Unique functions of Sonic hedgehog signaling during external genitalia development.","volume":"128","author":"R Haraguchi","year":"2001","journal-title":"Development"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1242\/dev.021295","article-title":"Embryonic hair follicle fate change by augmented {beta}-catenin through Shh and Bmp signaling.","volume":"136","author":"K Suzuki","year":"2009","journal-title":"Development"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/jmor.10785","article-title":"4D-analysis of early pelvic girdle development in the mouse (Mus musculus).","volume":"271","author":"C Pomikal","year":"2010","journal-title":"J Morphol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.1093\/nar\/27.22.4324","article-title":"Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases.","volume":"27","author":"A Indra","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/jcb.10656","article-title":"Analysis of SOX10 mutations identified in Waardenburg-Hirschsprung patients: Differential effects on target gene regulation.","volume":"90","author":"KK Chan","year":"2003","journal-title":"J Cell Biochem"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/dvdy.20347","article-title":"Hoxb3 vagal neural crest-specific enhancer element for controlling enteric nervous system development.","volume":"233","author":"K Chan","year":"2005","journal-title":"Dev Dyn"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1741-4520.2007.00143.x","article-title":"Fetal jaw movement affects development of articular disk in the temporomandibular joint.","volume":"47","author":"H Habib","year":"2007","journal-title":"Congenit Anom (Kyoto)"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/ajmg.a.31578","article-title":"Development of gastroschisis: review of hypotheses, a novel hypothesis, and implications for research.","volume":"143","author":"M Feldkamp","year":"2007","journal-title":"Am J Med Genet A"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/ajmg.c.30179","article-title":"Animal models of ventral body wall closure defects: a personal perspective on gastroschisis.","volume":"148C","author":"T Williams","year":"2008","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1053\/j.gastro.2009.05.002","article-title":"Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning.","volume":"137","author":"A Kolterud","year":"2009","journal-title":"Gastroenterology"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"8143","DOI":"10.1074\/jbc.274.12.8143","article-title":"Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3.","volume":"274","author":"P Dai","year":"1999","journal-title":"J Biol Chem"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1242\/dev.129.20.4753","article-title":"Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway.","volume":"129","author":"C Bai","year":"2002","journal-title":"Development"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/ajmg.a.30329","article-title":"Mutations in PITX2 may contribute to cases of omphalocele and VATER-like syndromes.","volume":"130A","author":"L Katz","year":"2004","journal-title":"Am J Med Genet A"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.modgep.2006.11.004","article-title":"Expression pattern of the homeodomain transcription factor Pitx2 during muscle development.","volume":"7","author":"H Shih","year":"2007","journal-title":"Gene Expr Patterns"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)01084-X","article-title":"Identification of a Wnt\/Dvl\/beta-Catenin \u2014&gt; Pitx2 pathway mediating cell-type-specific proliferation during development.","volume":"111","author":"C Kioussi","year":"2002","journal-title":"Cell"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"11129","DOI":"10.1074\/jbc.M109.087429","article-title":"Pitx2-dependent occupancy by histone deacetylases is associated with T-box gene regulation in mammalian abdominal tissue.","volume":"285","author":"T Hilton","year":"2010","journal-title":"J Biol Chem"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1542\/peds.110.6.1193","article-title":"Growth and metabolic consequences of bladder augmentation in children with myelomeningocele and bladder exstrophy.","volume":"110","author":"G Mingin","year":"2002","journal-title":"Pediatrics"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1750-1172-4-23","article-title":"The exstrophy-epispadias complex.","volume":"4","author":"A Ebert","year":"2009","journal-title":"Orphanet J Rare Dis"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2106\/00004623-199502000-00003","article-title":"The anatomy of the pelvis in the exstrophy complex.","volume":"77","author":"P Sponseller","year":"1995","journal-title":"J Bone Joint Surg Am"},{"key":"ref93","first-page":"xv, 799","article-title":"Abdomen and superficial structures.","author":"DM Kawamura","year":"1997"},{"key":"ref94","first-page":"x, 1059","article-title":"Clinical anatomy for medical students.","author":"RS Snell","year":"1992"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF00317946","article-title":"On the origin and development of the ventrolateral abdominal muscles in the avian embryo. An experimental and ultrastructural study.","volume":"166","author":"B Christ","year":"1983","journal-title":"Anat Embryol (Berl)"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s00441-007-0556-6","article-title":"Avian pelvis originates from lateral plate mesoderm and its development requires signals from both ectoderm and paraxial mesoderm.","volume":"331","author":"Y Malashichev","year":"2008","journal-title":"Cell Tissue Res"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1093\/hmg\/ddq030","article-title":"A primary cilia-dependent etiology for midline facial disorders.","volume":"19","author":"S Brugmann","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref98","article-title":"Polydactyly of the Foot.","author":"C Novick","year":"2009"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0016260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T19:38:16Z","timestamp":1637177896000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0016260"}},"subtitle":[],"editor":[{"given":"Mai Har","family":"Sham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,1,20]]},"references-count":98,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,1,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0016260","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,20]]}}}