{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T04:53:07Z","timestamp":1770267187134,"version":"3.49.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2011,1,27]],"date-time":"2011-01-27T00:00:00Z","timestamp":1296086400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0016269","type":"journal-article","created":{"date-parts":[[2011,1,27]],"date-time":"2011-01-27T22:02:33Z","timestamp":1296165753000},"page":"e16269","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Prostaglandin E2 Reverses Aberrant Production of an Inflammatory Chemokine by Microglia from Sandhoff Disease Model Mice through the cAMP-PKA Pathway"],"prefix":"10.1371","volume":"6","author":[{"given":"Eri","family":"Kawashita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Toyoshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Matsuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohji","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2011,1,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0925-4439(99)00074-5","article-title":"Biochemical consequences of mutations causing the GM2 gangliosidoses.","volume":"1455","author":"DJ Mahuran","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"ref2","first-page":"3827","article-title":"The Metabolic and Molecular Basis of Inherited Disease:","author":"RA Gravel","year":"2001"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev.neuro.22.1.219","article-title":"Microglia as mediators of inflammatory and degenerative diseases.","volume":"22","author":"F Gonz\u00e1lez-Scarano","year":"1999","journal-title":"Annu Rev Neurosci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/emm.2006.40","article-title":"Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease.","volume":"38","author":"YS Kim","year":"2006","journal-title":"Exp Mol Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ng1095-170","article-title":"Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism.","volume":"11","author":"K Sango","year":"1995","journal-title":"Nat Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1093\/hmg\/6.11.1879","article-title":"Apoptotic cell death in mouse models of GM2 gangliosidosis and observations on human Tay-Sachs and Sandhoff diseases.","volume":"6","author":"JQ Huang","year":"1997","journal-title":"Hum Mol Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"10954","DOI":"10.1073\/pnas.97.20.10954","article-title":"Microglial activation precedes acute neurodegeneration in Sandhoff disease and is suppressed by bone marrow transplantation.","volume":"97","author":"R Wada","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1093\/hmg\/11.11.1343","article-title":"Molecular pathophysiology in Tay-Sachs and Sandhoff diseases as revealed by gene expression profiling.","volume":"11","author":"R Myerowitz","year":"2002","journal-title":"Hum Mol Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1093\/brain\/awg089","article-title":"Central nervous system inflammation is a hallmark of pathogenesis in mouse models of GM1 and GM2 gangliosidosis.","volume":"126","author":"M Jeyakumar","year":"2003","journal-title":"Brain"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1111\/j.1471-4159.2005.02986.x","article-title":"Specific induction of macrophage inflammatory protein-1alpha in glial cells of Sandhoff disease model mice associated with accumulation of N-acetylhexosaminyl glycoconjugates.","volume":"92","author":"D Tsuji","year":"2005","journal-title":"J Neurochem"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/j.1471-4159.2009.06041.x","article-title":"Abnormal production of macrophage inflammatory protein-1alpha by microglial cell lines derived from neonatal brains of Sandhoff disease model mice.","volume":"109","author":"E Kawashita","year":"2009","journal-title":"J Neurochem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"8425","DOI":"10.1073\/pnas.0400625101","article-title":"Deletion of macrophage-inflammatory protein 1 alpha retards neurodegeneration in Sandhoff disease mice.","volume":"101","author":"YP Wu","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev.bi.55.070186.000441","article-title":"Arachidonic acid metabolism.","volume":"55","author":"P Needleman","year":"1986","journal-title":"Annu Rev Biochem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S1471-4906(01)02154-8","article-title":"Prostaglandins as modulators of immunity.","volume":"23","author":"SG Harris","year":"2002","journal-title":"Trends Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"11613","DOI":"10.1074\/jbc.R600038200","article-title":"Prostaglandin E receptors.","volume":"282","author":"Y Sugimoto","year":"2007","journal-title":"J Biol Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1742-2094-4-2","article-title":"Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein.","volume":"4","author":"J Jin","year":"2007","journal-title":"J Neuroinflammation"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/ana.21437","article-title":"The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis.","volume":"64","author":"X Liang","year":"2008","journal-title":"Ann Neurol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1046\/j.1471-4159.1999.0720565.x","article-title":"Prostaglandin E receptor subtypes in cultured rat microglia and their role in reducing lipopolysaccharide-induced interleukin-1beta production.","volume":"72","author":"AO Caggiano","year":"1999","journal-title":"J Neurochem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1523\/JNEUROSCI.4485-03.2004","article-title":"Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia.","volume":"24","author":"L McCullough","year":"2004","journal-title":"J Neurosci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.neulet.2008.04.054","article-title":"Misoprostol, an anti-ulcer agent and PGE2 receptor agonist, protects against cerebral ischemia.","volume":"438","author":"J Li","year":"2008","journal-title":"Neurosci Lett"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"44147","DOI":"10.1074\/jbc.M204810200","article-title":"Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor.","volume":"277","author":"K Takayama","year":"2002","journal-title":"J Biol Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1189\/jlb.0303116","article-title":"Prostaglandin E2 inhibits production of the inflammatory chemokines CCL3 and CCL4 in dendritic cells.","volume":"74","author":"H Jing","year":"2003","journal-title":"J Leukoc Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/24884","article-title":"Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.","volume":"396","author":"J de Rooij","year":"1998","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.tibs.2006.10.002","article-title":"Epac proteins: multi-purpose cAMP targets.","volume":"31","author":"JL Bos","year":"2006","journal-title":"Trends Biochem Sci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/ncb874","article-title":"A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.","volume":"4","author":"JM Enserink","year":"2002","journal-title":"Nat Cell Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"35394","DOI":"10.1074\/jbc.M302179200","article-title":"cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension.","volume":"278","author":"AE Christensen","year":"2003","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"55176","DOI":"10.1074\/jbc.M409816200","article-title":"A novel signaling pathway mediates the inhibition of CCL3\/4 expression by prostaglandin E2.","volume":"279","author":"H Jing","year":"2004","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"6388","DOI":"10.1073\/pnas.96.11.6388","article-title":"Delayed symptom onset and increased life expectancy in Sandhoff disease mice treated with N-butyldeoxynojirimycin.","volume":"96","author":"M Jeyakumar","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","article-title":"Substrate deprivation therapy in juvenile Sandhoff disease.","author":"SB Wortmann","year":"2009","journal-title":"J Inherit Metab Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1172\/JCI2127","article-title":"Bone marrow transplantation prolongs life span and ameliorates neurologic manifestations in Sandhoff disease mice.","volume":"101","author":"F Norflus","year":"1998","journal-title":"J Clin Invest"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"10954","DOI":"10.1073\/pnas.97.20.10954","article-title":"Microglial activation precedes acute neurodegeneration in Sandhoff disease and is suppressed by bone marrow transplantation.","volume":"97","author":"R Wada","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nm1548","article-title":"Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease.","volume":"13","author":"JP Lee","year":"2007","journal-title":"Nat Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1038\/mt.2010.113","article-title":"Introduction of an N-glycan sequon into HEXA enhances human beta-hexosaminidase cellular uptake in a model of Sandhoff disease.","volume":"18","author":"K Matsuoka","year":"2010","journal-title":"Mol Ther"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0016269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T21:12:34Z","timestamp":1588972354000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0016269"}},"subtitle":[],"editor":[{"given":"Mel","family":"Feany","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2011,1,27]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,1,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0016269","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,27]]}}}