{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T09:42:30Z","timestamp":1779183750920,"version":"3.51.4"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2011,2,4]],"date-time":"2011-02-04T00:00:00Z","timestamp":1296777600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0016770","type":"journal-article","created":{"date-parts":[[2011,2,4]],"date-time":"2011-02-04T22:19:05Z","timestamp":1296857945000},"page":"e16770","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Endogenous Retinoic Acid Activity in Principal Cells and Intercalated Cells of Mouse Collecting Duct System"],"prefix":"10.1371","volume":"6","author":[{"given":"Yuen Fei","family":"Wong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey B.","family":"Kopp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Scambler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifusa","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra C.","family":"Rankin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelanjana","family":"Dutt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce M.","family":"Hendry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qihe","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2011,2,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1111\/j.1523-1755.2004.66002.x","article-title":"Retinoids in nephrology: promises and pitfalls.","volume":"66","author":"Q Xu","year":"2004","journal-title":"Kidney Int"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1096\/fasebj.10.9.8801176","article-title":"A decade of molecular biology of retinoic acid receptors.","volume":"10","author":"P Chambon","year":"1996","journal-title":"FASEB J"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.cell.2008.09.002","article-title":"Retinoic acid synthesis and signaling during early organogenesis.","volume":"134","author":"G Duester","year":"2008","journal-title":"Cell"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/aja.1000830303","article-title":"Malformations in the genito-urinary tract induced by maternal vitamin A deficiency in the rat.","volume":"83","author":"JG Wilson","year":"1948","journal-title":"Am J Anat"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1242\/dev.120.10.2749","article-title":"Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants.","volume":"120","author":"C Mendelsohn","year":"1994","journal-title":"Development"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/7788","article-title":"Embryonic retinoic acid synthesis is essential for early mouse post-implantation development.","volume":"21","author":"K Niederreither","year":"1999","journal-title":"Nat Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.1159\/000276587","article-title":"Kidneys of Alb\/TGF-beta1 transgenic mice are deficient in retinoic acid and exogenous retinoic acid shows dose-dependent toxicity.","volume":"114","author":"Q Xu","year":"2010","journal-title":"Nephron Exp Nephrol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1042\/BJ20041867","article-title":"Quantification of endogenous retinoic acid in limited biological samples by LC\/MS\/MS.","volume":"388","author":"MA Kane","year":"2005","journal-title":"Biochem J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1021\/ac702030f","article-title":"Quantitative profiling of endogenous retinoic acid in vivo and in vitro by tandem mass spectrometry.","volume":"80","author":"MA Kane","year":"2008","journal-title":"Anal Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0003-2697(02)00662-0","article-title":"Chromatographic analysis of endogenous retinoids in tissues and serum.","volume":"315","author":"CK Schmidt","year":"2003","journal-title":"Anal Biochem"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e11095","DOI":"10.1371\/journal.pone.0011095","article-title":"Altered retinoic acid metabolism in diabetic mouse kidney identified by <sup>18<\/sup>O isotopic labeling and 2D mass spectrometry.","volume":"5","author":"JM Starkey","year":"2010","journal-title":"PLoS One"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1177\/002215549804600906","article-title":"Changing patterns of renal retinal dehydrogenase expression parallel nephron development in the rat.","volume":"46","author":"PV Bhat","year":"1998","journal-title":"J Histochem Cytochem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0925-4773(01)00561-5","article-title":"Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse.","volume":"110","author":"K Niederreither","year":"2002","journal-title":"Mech Dev"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"9856","DOI":"10.1074\/jbc.M211417200","article-title":"Mouse retinal dehydrogenase 4 (RALDH4), molecular cloning, cellular expression, and activity in 9-cis-retinoic acid biosynthesis in intact cells.","volume":"278","author":"M Lin","year":"2003","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1101\/gad.5.8.1333","article-title":"Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis.","volume":"5","author":"J Rossant","year":"1991","journal-title":"Genes Dev"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1242\/dev.040287","article-title":"Non-cell-autonomous retinoid signaling is crucial for renal development.","volume":"137","author":"C Rosselot","year":"2010","journal-title":"Development"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1177\/002215540205001015","article-title":"Effects of different fixatives on beta-galactosidase activity.","volume":"50","author":"W Ma","year":"2002","journal-title":"J Histochem Cytochem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s00418-008-0454-3","article-title":"Use of dual section mRNA in situ hybridisation\/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney.","volume":"130","author":"K Georgas","year":"2008","journal-title":"Histochem Cell Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1038\/sj.ki.5001851","article-title":"The connecting tubule is the main site of the furosemide-induced urinary acidification by the vacuolar H+-ATPase.","volume":"70","author":"J Kovacikova","year":"2006","journal-title":"Kidney Int"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0378-1119(03)00790-X","article-title":"Molecular cloning and characterization of Atp6v1b1, the murine vacuolar H+ -ATPase B1-subunit.","volume":"318","author":"KE Finberg","year":"2003","journal-title":"Gene"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.cell.2007.02.050","article-title":"Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors.","volume":"129","author":"TT Schug","year":"2007","journal-title":"Cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/83792","article-title":"Vitamin A controls epithelial\/mesenchymal interactions through Ret expression.","volume":"27","author":"E Batourina","year":"2001","journal-title":"Nat Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1681\/ASN.V133668","article-title":"Midkine is involved in kidney development and in its regulation by retinoids.","volume":"13","author":"J Vilar","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"F987","DOI":"10.1152\/ajprenal.00098.2007","article-title":"LGL1, a novel branching morphogen in developing kidney, is induced by retinoic acid.","volume":"293","author":"J Quinlan","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"F1845","DOI":"10.1152\/ajprenal.90355.2008","article-title":"Retinoic acid-dependent activation of the polycystic kidney disease-1 (PKD1) promoter.","volume":"295","author":"MR Islam","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1073\/pnas.0813002106","article-title":"Systems-level analysis of cell-specific AQP2 gene expression in renal collecting duct.","volume":"106","author":"MJ Yu","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/jn\/102.10.1255","article-title":"Vitamin A deficiency and urinary calcium excretion in rats.","volume":"102","author":"M Zile","year":"1972","journal-title":"J Nutr"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0009-8981(97)00198-8","article-title":"Vitamin A and urolithiasis.","volume":"269","author":"F Grases","year":"1998","journal-title":"Clin Chim Acta"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1001\/jama.1935.02760150008002","article-title":"Production and solution of urinary calculi.","volume":"104","author":"C Higgins","year":"1935","journal-title":"J Am Med Assoc"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/jn\/135.4.695","article-title":"Vitamin A deficiency alters the structure and collagen IV composition of rat renal basement membranes.","volume":"135","author":"MP Marin","year":"2005","journal-title":"J Nutr"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF00338069","article-title":"Alterations in cytokeratin expression precede histological changes in epithelia of vitamin A-deficient rats.","volume":"268","author":"MJ Gijbels","year":"1992","journal-title":"Cell Tissue Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s004670100606","article-title":"Could the effective mechanisms of retinoids on nephrogenesis be also operative on the amelioration of injury in acquired renal lesions?","volume":"16","author":"S Kavukcu","year":"2001","journal-title":"Pediatr Nephrol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/ndt\/16.3.441","article-title":"Potential role of retinoids in the therapy of renal disease.","volume":"16","author":"J Wagner","year":"2001","journal-title":"Nephrol Dial Transplant"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"33642","DOI":"10.1074\/jbc.M109.011668","article-title":"Comparative expression profiling reveals an essential role for raldh2 in epimorphic regeneration.","volume":"284","author":"LK Mathew","year":"2009","journal-title":"J Biol Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1681\/ASN.2009080851","article-title":"Inhibition of histone deacetylase expands the renal progenitor cell population.","volume":"21","author":"ED de Groh","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"F458","DOI":"10.1152\/ajprenal.00173.2003","article-title":"The renal retinoid system: time-dependent activation in experimental glomerulonephritis.","volume":"286","author":"S Liebler","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1097\/01.ASN.0000057857.66268.8F","article-title":"Retinoids regulate the repairing process of the podocytes in puromycin aminonucleoside-induced nephrotic rats.","volume":"14","author":"A Suzuki","year":"2003","journal-title":"J Am Soc Nephrol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0016770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T15:20:33Z","timestamp":1637248833000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0016770"}},"subtitle":[],"editor":[{"given":"Jean-Claude","family":"Dussaule","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2011,2,4]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,2,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0016770","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,4]]}}}