{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:40:15Z","timestamp":1780584015859,"version":"3.54.1"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2011,2,8]],"date-time":"2011-02-08T00:00:00Z","timestamp":1297123200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0016775","type":"journal-article","created":{"date-parts":[[2011,2,8]],"date-time":"2011-02-08T17:03:49Z","timestamp":1297184629000},"page":"e16775","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":56,"title":["Human Stiff-Person Syndrome IgG Induces Anxious Behavior in Rats"],"prefix":"10.1371","volume":"6","author":[{"given":"Christian","family":"Geis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Weishaupt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Gr\u00fcnewald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Wultsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Reif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Gerlach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Dirkx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Solimena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Perani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Heckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus V.","family":"Toyka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Folli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,2,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF00868343","article-title":"Stiff man syndrome: clinical and laboratory findings in eight patients.","volume":"241","author":"HM Meinck","year":"1994","journal-title":"J Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1136\/jnnp.74.4.462","article-title":"Specific phobia is a frequent non-motor feature in stiff man syndrome.","volume":"74","author":"P Henningsen","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1212\/WNL.55.10.1531","article-title":"The clinical spectrum of anti-GAD antibody-positive patients with stiff-person syndrome.","volume":"55","author":"MC Dalakas","year":"2000","journal-title":"Neurology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/mds.10279","article-title":"Stiff man syndrome and related conditions.","volume":"17","author":"HM Meinck","year":"2002","journal-title":"Mov Disord"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1212\/WNL.51.1.85","article-title":"Physiologic studies of spinal inhibitory circuits in patients with stiff-person syndrome.","volume":"51","author":"MK Floeter","year":"1998","journal-title":"Neurology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s11910-008-0009-y","article-title":"Advances in the pathogenesis and treatment of patients with stiff person syndrome.","volume":"8","author":"MC Dalakas","year":"2008","journal-title":"Curr Neurol Neurosci Rep"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1212\/01.WNL.0000163984.71993.FE","article-title":"A neuropsychological assessment of phobias in patients with stiff person syndrome.","volume":"64","author":"R Ameli","year":"2005","journal-title":"Neurology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0033-3182(98)71379-9","article-title":"Stiff-man syndrome. Results of interviews and psychologic testing.","volume":"39","author":"JL Black","year":"1998","journal-title":"Psychosomatics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1017\/S1092852900021805","article-title":"Stiff-person syndrome: autoimmunity and the central nervous system.","volume":"6","author":"BB Murinson","year":"2001","journal-title":"CNS Spectr"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/12146","article-title":"Anxiety: at the intersection of genes and experience.","volume":"2","author":"SG Anagnostaras","year":"1999","journal-title":"Nat Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/12207","article-title":"Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues.","volume":"2","author":"F Crestani","year":"1999","journal-title":"Nat Neurosci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/da.20262","article-title":"Role of GABA in anxiety and depression.","volume":"24","author":"AV Kalueff","year":"2007","journal-title":"Depress Anxiety"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00726-006-0415-x","article-title":"Mechanisms regulating GABAergic inhibitory transmission in the basolateral amygdala: implications for epilepsy and anxiety disorders.","volume":"32","author":"V Aroniadou-Anderjaska","year":"2007","journal-title":"Amino Acids"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1192\/bjp.179.5.390","article-title":"New insights into the role of the GABA(A)-benzodiazepine receptor in psychiatric disorder.","volume":"179","author":"DJ Nutt","year":"2001","journal-title":"Br J Psychiatry"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1101\/lm.705408","article-title":"Critical role of the 65-kDa isoform of glutamic acid decarboxylase in consolidation and generalization of Pavlovian fear memory.","volume":"15","author":"JR Bergado-Acosta","year":"2008","journal-title":"Learn Mem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1126\/science.1085818","article-title":"Amygdalar and hippocampal theta rhythm synchronization during fear memory retrieval.","volume":"301","author":"T Seidenbecher","year":"2003","journal-title":"Science"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1001\/archneur.61.6.902","article-title":"Anti-glutamic acid decarboxylase antibodies in the serum and cerebrospinal fluid of patients with stiff-person syndrome: correlation with clinical severity.","volume":"61","author":"G Rakocevic","year":"2004","journal-title":"Arch Neurol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1056\/NEJM199005313222202","article-title":"Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome.","volume":"322","author":"M Solimena","year":"1990","journal-title":"N Engl J Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1056\/NEJM198804213181602","article-title":"Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type I diabetes mellitus.","volume":"318","author":"M Solimena","year":"1988","journal-title":"N Engl J Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1002\/mds.21441","article-title":"PET evidence of central GABAergic changes in stiff-person syndrome.","volume":"22","author":"D Perani","year":"2007","journal-title":"Mov Disord"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/ana.21123","article-title":"Effects of anti-glutamic acid decarboxylase antibodies associated with neurological diseases.","volume":"61","author":"MU Manto","year":"2007","journal-title":"Ann Neurol"},{"key":"ref22","article-title":"Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition.","author":"C Geis","year":"2010","journal-title":"Brain 2010"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/S0140-6736(05)66376-3","article-title":"Paraneoplastic stiff-person syndrome: passive transfer to rats by means of IgG antibodies to amphiphysin.","volume":"365","author":"C Sommer","year":"2005","journal-title":"Lancet"},{"key":"ref24","first-page":"970","article-title":"Brain gamma-aminobutyric acid changes in stiff-person syndrome.","volume":"62","author":"LM Levy","year":"2005","journal-title":"Arch Neurol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1001\/archpsyc.55.8.715","article-title":"Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study.","volume":"55","author":"AL Malizia","year":"1998","journal-title":"Arch Gen Psychiatry"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1073\/pnas.96.4.1698","article-title":"Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.","volume":"96","author":"SF Kash","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1113\/jphysiol.1963.sp007205","article-title":"Pharmacological Studies on Presynaptic Inhibition.","volume":"168","author":"JC Eccles","year":"1963","journal-title":"J Physiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1093\/brain\/awl245","article-title":"Autoimmunity to GABAA-receptor-associated protein in stiff-person syndrome.","volume":"129","author":"R Raju","year":"2006","journal-title":"Brain"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1006\/bbrc.1999.2038","article-title":"A novel method for expression and large-scale production of human brain l-glutamate decarboxylase.","volume":"267","author":"KM Davis","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1474-4422(09)70324-2","article-title":"Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen.","volume":"9","author":"E Lancaster","year":"2010","journal-title":"Lancet Neurol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/S1474-4422(10)70137-X","article-title":"Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series.","volume":"9","author":"M Lai","year":"2010","journal-title":"Lancet Neurol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1093\/brain\/awq213","article-title":"Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia.","volume":"133","author":"SR Irani","year":"2010","journal-title":"Brain"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1093\/brain\/awq113","article-title":"N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes.","volume":"133","author":"SR Irani","year":"2010","journal-title":"Brain"},{"key":"ref34","first-page":"189","article-title":"Statistical parametric maps in functional imaging: a general linear approach.","author":"HA Friston KJ","year":"1995","journal-title":"Hum Brain Mapp"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/0031-9384(76)90029-9","article-title":"Chronic catheterization of the spinal subarachnoid space.","volume":"17","author":"TL Yaksh","year":"1976","journal-title":"Physiol Behav"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1006\/exnr.1993.1017","article-title":"Methods to assess the development and recovery of locomotor function after spinal cord injury in rats.","volume":"119","author":"E Kunkel-Bagden","year":"1993","journal-title":"Exp Neurol"},{"key":"ref37","first-page":"69","article-title":"Behavioural and expressional phenotyping of nitric oxide synthase-I knockdown animals.","author":"T Wultsch","year":"2007"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.expneurol.2005.08.018","article-title":"Effect of spinal cord injury severity on alterations of the H-reflex.","volume":"196","author":"JK Lee","year":"2005","journal-title":"Exp Neurol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1113\/jphysiol.1938.sp003603","article-title":"The interpretation of potential changes in the spinal cord.","volume":"92","author":"DH Barron","year":"1938","journal-title":"J Physiol"},{"key":"ref40","first-page":"20","article-title":"Presynaptic inhibition in the vertebrate central nervous system.","volume":"63","author":"RF Schmidt","year":"1971","journal-title":"Ergeb Physiol"},{"key":"ref41","article-title":"The Rat Brain in Stereotaxic Coordinates.","author":"G Paxinos","year":"1998"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/cdd.2008.1","article-title":"Essential role for Stat5 in the neurotrophic but not in the neuroprotective effect of erythropoietin.","volume":"15","author":"N Byts","year":"2008","journal-title":"Cell Death Differ"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1126\/science.1140621","article-title":"A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis.","volume":"316","author":"SM Ferguson","year":"2007","journal-title":"Science"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1073\/pnas.0712171105","article-title":"Cell- and stimulus-dependent heterogeneity of synaptic vesicle endocytic recycling mechanisms revealed by studies of dynamin 1-null neurons.","volume":"105","author":"M Hayashi","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0006-8993(96)00915-8","article-title":"A post mortem study on neurochemical markers of dopaminergic, GABA-ergic and glutamatergic neurons in basal ganglia-thalamocortical circuits in Parkinson syndrome.","volume":"741","author":"M Gerlach","year":"1996","journal-title":"Brain Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0016775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T14:20:36Z","timestamp":1540304436000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0016775"}},"subtitle":[],"editor":[{"given":"Sven","family":"Meuth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,2,8]]},"references-count":45,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,2,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0016775","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,8]]}}}