{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:22:01Z","timestamp":1791267721836,"version":"4.1.0"},"reference-count":84,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2011,2,28]],"date-time":"2011-02-28T00:00:00Z","timestamp":1298851200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0016849","type":"journal-article","created":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T20:18:06Z","timestamp":1299010686000},"page":"e16849","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":46,"title":["Enhanced Fear Expression in a Psychopathological Mouse Model of Trait Anxiety: Pharmacological Interventions"],"prefix":"10.1371","volume":"6","author":[{"given":"Simone B.","family":"Sartori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Hauschild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Bunck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Gaburro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Landgraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Singewald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,2,28]]},"reference":[{"key":"ref1","first-page":"213","article-title":"The role of the amygdala in conditioned and unconditioned fear and anxiety.","author":"A Davis","year":"2000"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1314.001","article-title":"Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders.","volume":"1032","author":"BS McEwen","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication.","volume":"62","author":"RC Kessler","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1001\/archpsyc.1995.03950240066012","article-title":"Posttraumatic stress disorder in the National Comorbidity Survey.","volume":"52","author":"RC Kessler","year":"1995","journal-title":"Arch Gen Psychiatry"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1521\/psyc.67.4.391.56572","article-title":"Understanding heterogeneous effects of trauma exposure: relevance to postmortem studies of PTSD.","volume":"67","author":"R Yehuda","year":"2004","journal-title":"Psychiatry"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1176\/appi.ajp.2009.09071074","article-title":"How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD.","volume":"167","author":"T Jovanovic","year":"2010","journal-title":"Am J Psychiatry"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.actpsy.2007.11.007","article-title":"The relevance of recent developments in classical conditioning to understanding the etiology and maintenance of anxiety disorders.","volume":"127","author":"S Mineka","year":"2008","journal-title":"Acta Psychol (Amst)"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.janxdis.2003.09.001","article-title":"The relationship between trait vulnerability and anxiety and depressive diagnoses at long-term follow-up of Generalized Anxiety Disorder.","volume":"18","author":"JA Chambers","year":"2004","journal-title":"J Anxiety Disord"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.tins.2009.02.004","article-title":"From high anxiety trait to depression: a neurocognitive hypothesis.","volume":"32","author":"C Sandi","year":"2009","journal-title":"Trends Neurosci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/jts.20261","article-title":"Individual differences in fear: isolating fear reactivity and fear recovery phenotypes.","volume":"20","author":"DE Bush","year":"2007","journal-title":"J Trauma Stress"},{"key":"ref11","first-page":"27","article-title":"The Roman High- and Low-Avoidance rat strains differ in fear-potentiated startle and classical aversive conditioning.","volume":"21","author":"R Lopez-Aumatell","year":"2009","journal-title":"Psicothema"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bbr.2009.03.024","article-title":"Unlearned anxiety predicts learned fear: a comparison among heterogeneous rats and the Roman rat strains.","volume":"202","author":"R Lopez-Aumatell","year":"2009","journal-title":"Behav Brain Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1601-183X.2007.00306.x","article-title":"Selection for contextual fear conditioning affects anxiety-like behaviors and gene expression.","volume":"6","author":"CA Ponder","year":"2007","journal-title":"Genes Brain Behav"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1101\/gr.203402. Article published online before print in March 2002","article-title":"A quantitative trait locus influencing anxiety in the laboratory rat.","volume":"12","author":"A Fernandez-Teruel","year":"2002","journal-title":"Genome Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1097\/FBP.0b013e32830c368c","article-title":"Genetic relationship between anxiety-related and fear-related behaviors in BXD recombinant inbred mice.","volume":"20","author":"JL Brigman","year":"2009","journal-title":"Behav Pharmacol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00335-002-3059-5","article-title":"Fine scale mapping of a genetic locus for conditioned fear.","volume":"14","author":"CJ Talbot","year":"2003","journal-title":"Mamm Genome"},{"key":"ref17","first-page":"13","article-title":"Neurobiology of posttraumatic stress disorder.","volume":"14","author":"C Heim","year":"2009","journal-title":"CNS Spectr"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0301-0082(03)00087-X","article-title":"The neurobiology and control of anxious states.","volume":"70","author":"MJ Millan","year":"2003","journal-title":"Prog Neurobiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0149-7634(99)00016-0","article-title":"The neuroanatomical and neurochemical basis of conditioned fear.","volume":"23","author":"M Fendt","year":"1999","journal-title":"Neurosci Biobehav Rev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00426027","article-title":"Diazepam and flurazepam: effects on conditioned fear as measured with the potentiated startle paradigm.","volume":"62","author":"M Davis","year":"1979","journal-title":"Psychopharmacology (Berl)"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/sj.npp.1300079","article-title":"GABA-A and 5-HT1A receptor agonists block expression of fear-potentiated startle in mice.","volume":"28","author":"VB Risbrough","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.euroneuro.2004.10.004","article-title":"Pharmacological dissociation of moderate and high contextual fear as assessed by freezing behavior and fear-potentiated startle.","volume":"15","author":"JM Santos","year":"2005","journal-title":"Eur Neuropsychopharmacol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1523\/JNEUROSCI.0115-05.2005","article-title":"Identification of glyoxalase-I as a protein marker in a mouse model of extremes in trait anxiety.","volume":"25","author":"SA Kromer","year":"2005","journal-title":"J Neurosci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"9030","DOI":"10.1523\/JNEUROSCI.1651-08.2008","article-title":"Dissociable roles for the hippocampus and the amygdala in human cued versus context fear conditioning.","volume":"28","author":"A Marschner","year":"2008","journal-title":"J Neurosci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1111\/j.1460-9568.2008.06485.x","article-title":"Pavlovian fear conditioning as a behavioral assay for hippocampus and amygdala function: cautions and caveats.","volume":"28","author":"S Maren","year":"2008","journal-title":"Eur J Neurosci"},{"key":"ref26","article-title":"Conditioned Reflexes: An Investigation of the Physiological Activity of the Cerebral Cortex.","author":"IP Pavlov","year":"1927"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1037\/h0069608","article-title":"Conditioned emotional reactions.","volume":"3","author":"JB Watson","year":"1920","journal-title":"J Exp Psychol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.2174\/138161209788168074","article-title":"Tachykinin receptors as therapeutic targets in stress-related disorders.","volume":"15","author":"K Ebner","year":"2009","journal-title":"Curr Pharm Des"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1111\/j.1471-4159.2008.05596.x","article-title":"Modulation of basal and stress-induced amygdaloid substance P release by the potent and selective NK1 receptor antagonist L-822429.","volume":"106","author":"N Singewald","year":"2008","journal-title":"J Neurochem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1176\/appi.ajp.161.8.1488","article-title":"Low-dose cortisol for symptoms of posttraumatic stress disorder.","volume":"161","author":"A Aerni","year":"2004","journal-title":"Am J Psychiatry"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nrn2651","article-title":"Stress, memory and the amygdala.","volume":"10","author":"B Roozendaal","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"5585","DOI":"10.1073\/pnas.0509184103","article-title":"Glucocorticoids reduce phobic fear in humans.","volume":"103","author":"LM Soravia","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/75761","article-title":"Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.","volume":"3","author":"RM McKernan","year":"2000","journal-title":"Nat Neurosci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bbr.2005.08.009","article-title":"Rat ultrasonic vocalization in aversively motivated situations and the role of individual differences in anxiety-related behavior.","volume":"166","author":"A Borta","year":"2006","journal-title":"Behav Brain Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1111\/j.1460-9568.2008.06511.x","article-title":"Impaired extinction of learned fear in rats selectively bred for high anxiety\u2013evidence of altered neuronal processing in prefrontal-amygdala pathways.","volume":"28","author":"P Muigg","year":"2008","journal-title":"Eur J Neurosci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1017\/S0033291708003516","article-title":"Influence of trait anxiety on brain activity during the acquisition and extinction of aversive conditioning.","volume":"39","author":"J Barrett","year":"2009","journal-title":"Psychol Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0166-4328(02)00020-7","article-title":"Altered performance characteristics in cognitive tasks: comparison of the albino ICR and CD1 mouse strains.","volume":"133","author":"B Adams","year":"2002","journal-title":"Behav Brain Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1073\/pnas.0610059104","article-title":"Enhancement of learning and memory after activation of cerebral Rho GTPases.","volume":"104","author":"G Diana","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e5129","DOI":"10.1371\/journal.pone.0005129","article-title":"A hypomorphic vasopressin allele prevents anxiety-related behavior.","volume":"4","author":"M Bunck","year":"2009","journal-title":"PLoS One"},{"key":"ref40","article-title":"Introduction to Quantitative Genetics 4th Ed.","author":"DS Falconer","year":"1996"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1101\/lm.5.4.391","article-title":"Automated measurement of mouse freezing behavior and its use for quantitative trait locus analysis of contextual fear conditioning in (BALB\/cJ x C57BL\/6J)F2 mice.","volume":"5","author":"VS Valentinuzzi","year":"1998","journal-title":"Learn Mem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.brat.2004.10.007","article-title":"Classical fear conditioning in the anxiety disorders: a meta-analysis.","volume":"43","author":"S Lissek","year":"2005","journal-title":"Behav Res Ther"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/00008877-200605000-00003","article-title":"The effects of cannabinoids on contextual conditioned fear in CB1 knockout and CD1 mice.","volume":"17","author":"E Mikics","year":"2006","journal-title":"Behav Pharmacol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e5346","DOI":"10.1371\/journal.pone.0005346","article-title":"Differential stress-induced neuronal activation patterns in mouse lines selectively bred for high, normal or low anxiety.","volume":"4","author":"P Muigg","year":"2009","journal-title":"PLoS One"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1037\/1528-3542.6.2.180","article-title":"The role of attentional strategies in moderating links between acute pain induction and subsequent psychological stress: evidence for symptom-specific reactivity among patients with chronic pain versus healthy nonpatients.","volume":"6","author":"JW Burns","year":"2006","journal-title":"Emotion"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1385\/NI:4:1:51","article-title":"Imaging genomics applied to anxiety, stress response, and resiliency.","volume":"4","author":"K Xu","year":"2006","journal-title":"Neuroinformatics"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.neuro.23.1.155","article-title":"Emotion circuits in the brain.","volume":"23","author":"JE LeDoux","year":"2000","journal-title":"Annu Rev Neurosci"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/1073858403261077","article-title":"The amygdala and persistent pain.","volume":"10","author":"V Neugebauer","year":"2004","journal-title":"Neuroscientist"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/0005-7967(95)00012-M","article-title":"Anxiety sensitivity in patients with physically unexplained chronic back pain: a preliminary report.","volume":"33","author":"GJ Asmundson","year":"1995","journal-title":"Behav Res Ther"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.pain.2008.05.006","article-title":"Quantitative testing of pain perception in subjects with PTSD\u2013implications for the mechanism of the coexistence between PTSD and chronic pain.","volume":"138","author":"R Defrin","year":"2008","journal-title":"Pain"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1053\/eujp.2000.0210","article-title":"Investigating the effects of anxiety sensitivity and coping on the perception of cold pressor pain in healthy women.","volume":"5","author":"E Keogh","year":"2001","journal-title":"Eur J Pain"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.pain.2008.12.018","article-title":"Differentiation of pain ratings in combat-related posttraumatic stress disorder.","volume":"143","author":"A Kraus","year":"2009","journal-title":"Pain"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1001\/archpsyc.1990.01810180041007","article-title":"Naloxone-reversible analgesic response to combat-related stimuli in posttraumatic stress disorder. A pilot study.","volume":"47","author":"RK Pitman","year":"1990","journal-title":"Arch Gen Psychiatry"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"56","DOI":"10.55782\/ane-2010-1774","article-title":"The relationship between pain sensitivity and conditioned fear response in rats.","volume":"70","author":"M Lehner","year":"2010","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/BF00404119","article-title":"A new technique for the investigation of some analgesic drugs on a reflexive behavior in the rat.","volume":"2","author":"WO Evans","year":"1961","journal-title":"Psychopharmacologia"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.neulet.2009.08.031","article-title":"Effect of high trait anxiety on mechanical hypersensitivity in male rats.","volume":"464","author":"K Roeska","year":"2009","journal-title":"Neurosci Lett"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0166-4328(01)00471-5","article-title":"Circadian modulation of learning and memory in fear-conditioned mice.","volume":"133","author":"D Chaudhury","year":"2002","journal-title":"Behav Brain Res"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"14415","DOI":"10.1073\/pnas.2336172100","article-title":"Circadian modulation of long-term sensitization in Aplysia.","volume":"100","author":"RI Fernandez","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.194313","article-title":"Circadian rhythm of synaptic excitability in rat and monkey central nervous system.","volume":"197","author":"CA Barnes","year":"1977","journal-title":"Science"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/0748730405276352","article-title":"Circadian regulation of hippocampal long-term potentiation.","volume":"20","author":"D Chaudhury","year":"2005","journal-title":"J Biol Rhythms"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.janxdis.2009.10.011","article-title":"Enhancing exposure therapy for anxiety disorders with glucocorticoids: from basic mechanisms of emotional learning to clinical applications.","volume":"24","author":"D Bentz","year":"2010","journal-title":"J Anxiety Disord"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2174\/1568007033482841","article-title":"Anxioselective compounds acting at the GABA(A) receptor benzodiazepine binding site.","volume":"2","author":"JR Atack","year":"2003","journal-title":"Curr Drug Targets CNS Neurol Disord"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00726-006-0335-9","article-title":"The role of substance P in stress and anxiety responses.","volume":"31","author":"K Ebner","year":"2006","journal-title":"Amino Acids"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1517\/13543784.15.5.479","article-title":"NK1 receptor antagonists under investigation for the treatment of affective disorders.","volume":"15","author":"B Czeh","year":"2006","journal-title":"Expert Opin Investig Drugs"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.nlm.2006.09.007","article-title":"Reinstatement of episodic-like memory in rats by neurokinin-1 receptor antagonism.","volume":"87","author":"E Kart-Teke","year":"2007","journal-title":"Neurobiol Learn Mem"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1046\/j.1460-9568.2003.02542.x","article-title":"Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobe.","volume":"17","author":"DJ de Quervain","year":"2003","journal-title":"Eur J Neurosci"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/29542","article-title":"Stress and glucocorticoids impair retrieval of long-term spatial memory.","volume":"394","author":"DJ de Quervain","year":"1998","journal-title":"Nature"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/73873","article-title":"Acute cortisone administration impairs retrieval of long-term declarative memory in humans.","volume":"3","author":"DJ de Quervain","year":"2000","journal-title":"Nat Neurosci"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1073\/pnas.0337480100","article-title":"The hippocampus mediates glucocorticoid-induced impairment of spatial memory retrieval: dependence on the basolateral amygdala.","volume":"100","author":"B Roozendaal","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"8161","DOI":"10.1523\/JNEUROSCI.2574-04.2004","article-title":"Glucocorticoid effects on memory retrieval require concurrent noradrenergic activity in the hippocampus and basolateral amygdala.","volume":"24","author":"B Roozendaal","year":"2004","journal-title":"J Neurosci"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1196\/annals.1314.019","article-title":"Cortisol and memory retrieval in humans: influence of emotional valence.","volume":"1032","author":"OT Wolf","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.nlm.2003.10.001","article-title":"A systemically administered beta-adrenoceptor antagonist blocks corticosterone-induced impairment of contextual memory retrieval in rats.","volume":"81","author":"B Roozendaal","year":"2004","journal-title":"Neurobiol Learn Mem"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.yhbeh.2007.05.007","article-title":"The effects of acute corticosterone administration on anxiety, endogenous corticosterone, and c-Fos expression in the rat brain.","volume":"52","author":"A Skorzewska","year":"2007","journal-title":"Horm Behav"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.pbb.2006.10.001","article-title":"The effects of acute and chronic administration of corticosterone on rat behavior in two models of fear responses, plasma corticosterone concentration, and c-Fos expression in the brain structures.","volume":"85","author":"A Skorzewska","year":"2006","journal-title":"Pharmacol Biochem Behav"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0166-4328(03)00216-X","article-title":"Corticosterone facilitates retention of contextually conditioned fear and increases CRH mRNA expression in the amygdala.","volume":"149","author":"BL Thompson","year":"2004","journal-title":"Behav Brain Res"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"5573","DOI":"10.1073\/pnas.0705615105","article-title":"Acute corticosterone treatment is sufficient to induce anxiety and amygdaloid dendritic hypertrophy.","volume":"105","author":"R Mitra","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref77"},{"key":"ref78"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1152\/physrev.00037.2009","article-title":"Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fear.","volume":"90","author":"HC Pape","year":"2010","journal-title":"Physiol Rev"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1749-6632.2003.tb07074.x","article-title":"Genes and mechanisms in the amygdala involved in the formation of fear memory.","volume":"985","author":"HC Pape","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1101\/lm.886208","article-title":"Role of L-type Ca2+ channel isoforms in the extinction of conditioned fear.","volume":"15","author":"P Busquet","year":"2008","journal-title":"Learn Mem"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1037\/h0027676","article-title":"Passive and active reactions to fear-eliciting stimuli.","volume":"68","author":"RJ Blanchard","year":"1969","journal-title":"J Comp Physiol Psychol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF03001163","article-title":"Conditioned and unconditional components of post-shock freezing.","volume":"15","author":"MS Fanselow","year":"1980","journal-title":"Pavlov J Biol Sci"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/npp.2008.142","article-title":"Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone.","volume":"34","author":"W Wittmann","year":"2009","journal-title":"Neuropsychopharmacology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0016849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T16:45:30Z","timestamp":1712249130000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0016849"}},"subtitle":[],"editor":[{"given":"Abraham","family":"Palmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,2,28]]},"references-count":84,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,2,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0016849","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,28]]}}}