{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:26:20Z","timestamp":1784874380496,"version":"3.55.0"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T00:00:00Z","timestamp":1297296000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0017081","type":"journal-article","created":{"date-parts":[[2011,2,11]],"date-time":"2011-02-11T00:14:49Z","timestamp":1297383289000},"page":"e17081","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Extra-Visual Functional and Structural Connection Abnormalities in Leber's Hereditary Optic Neuropathy"],"prefix":"10.1371","volume":"6","author":[{"given":"Maria A.","family":"Rocca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Valsasina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Pagani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Bianchi-Marzoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Milesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Falini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Comi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Filippi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,2,10]]},"reference":[{"key":"ref1","first-page":"1147","article-title":"A new mtDNA mutation associated with Leber hereditary optic neuroretinopathy.","volume":"48","author":"K Huoponen","year":"1991","journal-title":"Am J Hum Genet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S0002-9394(14)76784-4","article-title":"The clinical characteristics of pedigrees of Leber&apos;s hereditary optic neuropathy with the 11778 mutation.","volume":"111","author":"NJ Newman","year":"1991","journal-title":"Am J Ophthalmol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.3201231","article-title":"Mitochondrial DNA mutation associated with Leber&apos;s hereditary optic neuropathy.","volume":"242","author":"DC Wallace","year":"1988","journal-title":"Science"},{"key":"ref4","first-page":"223","article-title":"Leber&apos;s hereditary optic neuropathy differentially affects smaller axons in the optic nerve.","volume":"98","author":"AA Sadun","year":"2000","journal-title":"Trans Am Ophthalmol Soc"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1001\/archopht.1992.01080230077025","article-title":"Leber&apos;s hereditary optic neuropathy. Clinical manifestations of the 3460 mutation.","volume":"110","author":"DR Johns","year":"1992","journal-title":"Arch Ophthalmol"},{"key":"ref6","first-page":"1218","article-title":"A variant of Leber hereditary optic neuropathy characterized by recovery of vision and by an unusual mitochondrial genetic etiology.","volume":"51","author":"D Mackey","year":"1992","journal-title":"Am J Hum Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1093\/brain\/awl039","article-title":"Selective magnetization transfer ratio decrease in the visual cortex following optic neuritis.","volume":"129","author":"B Audoin","year":"2006","journal-title":"Brain"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/hbm.20101","article-title":"Optic radiation changes after optic neuritis detected by tractography-based group mapping.","volume":"25","author":"O Ciccarelli","year":"2005","journal-title":"Hum Brain Mapp"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S1350-9462(03)00026-0","article-title":"Effects of retinal ganglion cell loss on magno-, parvo-, koniocellular pathways in the lateral geniculate nucleus and visual cortex in glaucoma.","volume":"22","author":"YH Yucel","year":"2003","journal-title":"Prog Retin Eye Res"},{"key":"ref10","first-page":"1291","article-title":"MR changes in the calcarine area resulting from retinal degeneration.","volume":"18","author":"M Kitajima","year":"1997","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1111\/j.1460-9568.2005.04433.x","article-title":"Retinal abnormalities in human albinism translate into a reduction of grey matter in the occipital cortex.","volume":"22","author":"EA von dem Hagen","year":"2005","journal-title":"Eur J Neurosci"},{"issue":"Pt 4","key":"ref12","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/brain\/115.4.979","article-title":"Occurrence of a multiple sclerosis-like illness in women who have a Leber&apos;s hereditary optic neuropathy mitochondrial DNA mutation.","volume":"115","author":"AE Harding","year":"1992","journal-title":"Brain"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1136\/jnnp.59.2.160","article-title":"Leber&apos;s \u201cplus\u201d: neurological abnormalities in patients with Leber&apos;s hereditary optic neuropathy.","volume":"59","author":"EK Nikoskelainen","year":"1995","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1212\/WNL.41.8.1211","article-title":"Leber&apos;s hereditary optic neuropathy: genetic, biochemical, and phosphorus magnetic resonance spectroscopy study in an Italian family.","volume":"41","author":"P Cortelli","year":"1991","journal-title":"Neurology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1212\/WNL.45.7.1364","article-title":"Defective brain and muscle energy metabolism shown by in vivo 31P magnetic resonance spectroscopy in nonaffected carriers of 11778 mtDNA mutation.","volume":"45","author":"B Barbiroli","year":"1995","journal-title":"Neurology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1136\/jnnp.72.6.805","article-title":"Phosphorus MR spectroscopy shows a tissue specific in vivo distribution of biochemical expression of the G3460A mutation in Leber&apos;s hereditary optic neuropathy.","volume":"72","author":"R Lodi","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1136\/jnnp.70.4.444","article-title":"Magnetic resonance imaging, magnetisation transfer imaging, and diffusion weighted imaging correlates of optic nerve, brain, and cervical cord damage in Leber&apos;s hereditary optic neuropathy.","volume":"70","author":"M Inglese","year":"2001","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1093\/cercor\/bhm207","article-title":"Reduced resting-state brain activity in the \u201cdefault network\u201d in normal aging.","volume":"18","author":"JS Damoiseaux","year":"2008","journal-title":"Cereb Cortex"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"13848","DOI":"10.1073\/pnas.0601417103","article-title":"Consistent resting-state networks across healthy subjects.","volume":"103","author":"JS Damoiseaux","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1098\/rstb.2005.1634","article-title":"Investigations into resting-state connectivity using independent component analysis.","volume":"360","author":"CF Beckmann","year":"2005","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"13040","DOI":"10.1073\/pnas.0905267106","article-title":"Correspondence of the brain&apos;s functional architecture during activation and rest.","volume":"106","author":"SM Smith","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"368406","DOI":"10.1155\/2008\/368406","article-title":"Connectivity-based parcellation of the cortical mantle using q-ball diffusion imaging.","volume":"2008","author":"M Perrin","year":"2008","journal-title":"Int J Biomed Imaging"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"13335","DOI":"10.1073\/pnas.0403743101","article-title":"Changes in connectivity profiles define functionally distinct regions in human medial frontal cortex.","volume":"101","author":"H Johansen-Berg","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nn1075","article-title":"Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging.","volume":"6","author":"TE Behrens","year":"2003","journal-title":"Nat Neurosci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.neuroimage.2004.12.034","article-title":"A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data.","volume":"25","author":"SB Eickhoff","year":"2005","journal-title":"Neuroimage"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/hbm.20109","article-title":"Voxel-based analysis of MRI detects abnormal visual cortex in children and adults with amblyopia.","volume":"25","author":"JD Mendola","year":"2005","journal-title":"Hum Brain Mapp"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1093\/brain\/awp119","article-title":"Changes in cortical grey matter density associated with long-standing retinal visual field defects.","volume":"132","author":"CC Boucard","year":"2009","journal-title":"Brain"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0006-8993(96)01352-2","article-title":"Brain energy metabolism in early blind subjects: neural activity in the visual cortex.","volume":"750","author":"AG De Volder","year":"1997","journal-title":"Brain Res"},{"key":"ref29","article-title":"Evidence for retro-chiasmatic tissue loss in Leber&apos;s hereditary optic neuropathy.","author":"V Barcella","year":"2010","journal-title":"Hum Brain Mapp"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/00001756-200002280-00024","article-title":"Brain functional reorganization in early blind humans revealed by auditory event-related potentials.","volume":"11","author":"C Leclerc","year":"2000","journal-title":"Neuroreport"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.neuroimage.2005.11.036","article-title":"Auditory motion perception activates visual motion areas in early blind subjects.","volume":"31","author":"C Poirier","year":"2006","journal-title":"Neuroimage"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1093\/brain\/awm121","article-title":"Whole brain functional connectivity in the early blind.","volume":"130","author":"Y Liu","year":"2007","journal-title":"Brain"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/hbm.1048","article-title":"A method for making group inferences from functional MRI data using independent component analysis.","volume":"14","author":"VD Calhoun","year":"2001","journal-title":"Hum Brain Mapp"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0387-7604(00)00185-6","article-title":"Neurological bases of behavioral development in infancy.","volume":"22","author":"N Herschkowitz","year":"2000","journal-title":"Brain Dev"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1055\/s-2007-973720","article-title":"Neurobiological bases of behavioral development in the first year.","volume":"28","author":"N Herschkowitz","year":"1997","journal-title":"Neuropediatrics"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1136\/bjo.2009.165571","article-title":"Genome-wide expression profile of LHON patients with the 11778 mutation.","volume":"94","author":"KK Abu-Amero","year":"2010","journal-title":"Br J Ophthalmol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/hbm.20504","article-title":"Structural and functional MRI correlates of Stroop control in benign MS.","volume":"30","author":"MA Rocca","year":"2009","journal-title":"Hum Brain Mapp"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1162\/neco.1995.7.6.1129","article-title":"An information-maximization approach to blind separation and blind deconvolution.","volume":"7","author":"AJ Bell","year":"1995","journal-title":"Neural Comput"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.neuroimage.2004.03.027","article-title":"Validating the independent components of neuroimaging time series via clustering and visualization.","volume":"22","author":"J Himberg","year":"2004","journal-title":"Neuroimage"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e1794","DOI":"10.1371\/journal.pone.0001794","article-title":"Modulation of brain resting-state networks by sad mood induction.","volume":"3","author":"BJ Harrison","year":"2008","journal-title":"PLoS ONE"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1212\/WNL.0b013e3181d9ed91","article-title":"Default-mode network dysfunction and cognitive impairment in progressive MS.","volume":"74","author":"MA Rocca","year":"2010","journal-title":"Neurology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1093\/brain\/awq058","article-title":"Resting state networks change in clinically isolated syndrome.","volume":"133","author":"SD Roosendaal","year":"2010","journal-title":"Brain"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1002\/mrm.1910360620","article-title":"Correction for distortion of echo-planar images used to calculate the apparent diffusion coefficient.","volume":"36","author":"JC Haselgrove","year":"1996","journal-title":"Magn Reson Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1006\/nimg.2000.0715","article-title":"Human primary auditory cortex: cytoarchitectonic subdivisions and mapping into a spatial reference system.","volume":"13","author":"P Morosan","year":"2001","journal-title":"Neuroimage"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hbm.10062","article-title":"Fast robust automated brain extraction.","volume":"17","author":"SM Smith","year":"2002","journal-title":"Hum Brain Mapp"},{"key":"ref46","doi-asserted-by":"crossref","DOI":"10.1002\/9780470316801","article-title":"Finding Groups in Data: An Introduction to Cluster Analysis.","author":"L Kaufman","year":"1990"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0377-0427(87)90125-7","article-title":"Silhouettes: a graphical aid to the interpretation and validation of cluster analysis.","volume":"20","author":"PJ Rousseeuw","year":"1986","journal-title":"J Comp and Applied Mathematics"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0017081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T22:53:19Z","timestamp":1539989599000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0017081"}},"subtitle":[],"editor":[{"given":"Yi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,2,10]]},"references-count":47,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,2,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0017081","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,10]]}}}