{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:00:27Z","timestamp":1791108027884,"version":"4.1.0"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2011,3,3]],"date-time":"2011-03-03T00:00:00Z","timestamp":1299110400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0017161","type":"journal-article","created":{"date-parts":[[2011,3,3]],"date-time":"2011-03-03T21:58:32Z","timestamp":1299189512000},"page":"e17161","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Large Zinc Finger Protein ZAS3 Is a Critical Modulator of Osteoclastogenesis"],"prefix":"10.1371","volume":"6","author":[{"given":"Shujun","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Madiai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin V.","family":"Hackshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl E.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Carl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Huschart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Karanfilov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Litsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Hickey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Marcucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarandeep","family":"Huja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Caligiuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai-Chu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,3,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3727\/000000002783992479","article-title":"ZAS: C<sub>2<\/sub>H<sub>2<\/sub> zinc finger proteins involved in growth and development.","volume":"10","author":"LC Wu","year":"2002","journal-title":"Gene Expr"},{"key":"ref2","first-page":"233","article-title":"ZAS zinc finger proteins: the other kappa-B-binding protein family.","author":"CE Allen","year":"2004"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"5067","DOI":"10.1093\/nar\/21.22.5067","article-title":"Molecular cloning of a zinc finger protein which binds to the heptamer of the signal sequence for V(D)J recombination.","volume":"21","author":"LC Wu","year":"1993","journal-title":"Nucleic Acids Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1074\/jbc.275.2.913","article-title":"The kappa B and V(D)J Recombination Signal Sequence Binding Protein KRC Regulates Transcription of the Mouse Metastasis-associated Gene S100A4\/mts1.","volume":"275","author":"I Hjelmsoe","year":"2000","journal-title":"J Biol Chem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1101\/gad.4.1.29","article-title":"A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence.","volume":"4","author":"CM Fan","year":"1990","journal-title":"Genes Dev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"18710","DOI":"10.1074\/jbc.M500859200","article-title":"Mint represses transactivation of the type II collagen gene enhancer through interaction with alpha A-crystallin-binding protein 1.","volume":"280","author":"X Yang","year":"2005","journal-title":"J Biol Chem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3736","DOI":"10.1128\/MCB.19.5.3736","article-title":"Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain.","volume":"19","author":"U Dorflinger","year":"1999","journal-title":"Mol Cell Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5679","DOI":"10.1093\/nar\/22.25.5679","article-title":"Cloning and characterization of a c-myc intron binding protein (MIBP1).","volume":"22","author":"R Makino","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.devcel.2006.02.016","article-title":"Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins.","volume":"10","author":"W Jin","year":"2006","journal-title":"Dev Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/ncb1885","article-title":"TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3.","volume":"11","author":"A Shukla","year":"2009","journal-title":"Nat Cell Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cellsig.2010.08.009","article-title":"ZAS3 accentuates transforming growth factor beta signaling in epithelial cells.","volume":"23","author":"AJ Yakovich","year":"2011","journal-title":"Cell Signal"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1097-2765(01)00434-8","article-title":"A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2.","volume":"9","author":"M Oukka","year":"2002","journal-title":"Mol Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1084\/jem.20030421","article-title":"Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells.","volume":"199","author":"M Oukka","year":"2004","journal-title":"J Exp Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1126\/science.1126313","article-title":"Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3.","volume":"312","author":"DC Jones","year":"2006","journal-title":"Science"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3727\/105221607783417574","article-title":"Disruption of ZAS3 in mice alters NF-kappaB and AP-1 DNA binding and T-cell development.","volume":"14","author":"CE Allen","year":"2007","journal-title":"Gene Expr"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"12907","DOI":"10.1074\/jbc.M611203200","article-title":"Lack of schnurri-2 expression associates with reduced bone remodeling and osteopenia.","volume":"282","author":"Y Saita","year":"2007","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"8254","DOI":"10.1073\/pnas.1003727107","article-title":"Uncoupling of growth plate maturation and bone formation in mice lacking both Schnurri-2 and Schnurri-3.","volume":"107","author":"DC Jones","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1242\/jcs.00082","article-title":"JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms.","volume":"115","author":"JP David","year":"2002","journal-title":"J Cell Sci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1172\/JCI200419657","article-title":"Critical roles of c-Jun signaling in regulation of NFAT family and sRANKL-regulated osteoclast differentiation.","volume":"114","author":"F Ikeda","year":"2004","journal-title":"J Clin Invest"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1146\/annurev.pathmechdis.3.121806.151431","article-title":"The osteoclast: friend or foe?","volume":"3","author":"DV Novack","year":"2008","journal-title":"Annu Rev Pathol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"31155","DOI":"10.1074\/jbc.M001229200","article-title":"Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (sRANKL).","volume":"275","author":"M Matsumoto","year":"2000","journal-title":"J Biol Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0883-5403(94)90086-8","article-title":"Bone strength and histomorphometry of the distal femur.","volume":"9","author":"Y Nakabayashi","year":"1994","journal-title":"J Arthroplasty"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1128\/MCB.01839-06","article-title":"Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitors.","volume":"27","author":"R Hu","year":"2007","journal-title":"Mol Cell Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1101\/gad.13.8.1015","article-title":"TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.","volume":"13","author":"MA Lomaga","year":"1999","journal-title":"Genes Dev"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature00888","article-title":"Distinct molecular mechanism for initiating TRAF6 signalling.","volume":"418","author":"H Ye","year":"2002","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1210\/edrv.20.3.0367","article-title":"Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families.","volume":"20","author":"T Suda","year":"1999","journal-title":"Endocr Rev"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"6453","DOI":"10.1242\/dev.00863","article-title":"The Caenorhabditis elegans schnurri homolog sma-9 mediates stage- and cell type-specific responses to DBL-1 BMP-related signaling.","volume":"130","author":"J Liang","year":"2003","journal-title":"Development"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1006\/dbio.2000.9901","article-title":"The zinc finger protein schnurri acts as a Smad partner in mediating the transcriptional response to decapentaplegic.","volume":"227","author":"H Dai","year":"2000","journal-title":"Dev Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1146\/annurev-genom-082908-150158","article-title":"Signaling pathways in human skeletal dysplasias.","volume":"11","author":"D Baldridge","year":"2010","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1084\/jem.20051150","article-title":"Autoamplification of NFATc1 expression determines its essential role in bone homeostasis.","volume":"202","author":"M Asagiri","year":"2005","journal-title":"J Exp Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1534-5807(02)00369-6","article-title":"Induction and activation of the transcription factor NFATc1 (NFAT2) integrate sRANKL signaling in terminal differentiation of osteoclasts.","volume":"3","author":"H Takayanagi","year":"2002","journal-title":"Dev Cell"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"13984","DOI":"10.1074\/jbc.M213067200","article-title":"The calcineurin\/NFAT signaling pathway regulates osteoclastogenesis in RAW 264.7 cells.","volume":"279","author":"H Hirotani","year":"2004","journal-title":"J Biol Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ccr.2010.03.008","article-title":"Sp1\/NFkappaB\/HDAC\/miR-29b regulatory network in KIT-driven myeloid leukemia.","volume":"17","author":"S Liu","year":"2010","journal-title":"Cancer Cell"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2202-7-4","article-title":"Reciprocal regulation of nuclear factor kappa B and its inhibitor ZAS3 after peripheral nerve injury.","volume":"7","author":"LC Wu","year":"2006","journal-title":"BMC Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1182\/blood-2007-08-110171","article-title":"Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1\/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia.","volume":"111","author":"S Liu","year":"2008","journal-title":"Blood"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"12301","DOI":"10.1073\/pnas.2133048100","article-title":"Inhibition of NF-kappaB by ZAS3, a zinc-finger protein that also binds to the kappaB motif.","volume":"100","author":"JW Hong","year":"2003","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0017161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T23:29:49Z","timestamp":1588980589000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0017161"}},"subtitle":[],"editor":[{"given":"Eliana","family":"Abdelhay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,3,3]]},"references-count":36,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,3,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0017161","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,3]]}}}