{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:54:48Z","timestamp":1793109288190,"version":"4.5.0"},"reference-count":89,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2011,2,28]],"date-time":"2011-02-28T00:00:00Z","timestamp":1298851200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0017299","type":"journal-article","created":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T20:23:45Z","timestamp":1299011025000},"page":"e17299","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":161,"title":["Lipid Pathway Alterations in Parkinson's Disease Primary Visual Cortex"],"prefix":"10.1371","volume":"6","author":[{"given":"Danni","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Jenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghou","family":"Shui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Fun","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd W.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica R.","family":"Nealon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woojin S.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"McCann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus R.","family":"Wenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenda M.","family":"Halliday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Garner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,2,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2003.tb07458.x","article-title":"Description of Parkinson's disease as a clinical syndrome.","volume":"991","author":"S Fahn","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nm.2165","article-title":"Missing pieces in the Parkinson's disease puzzle.","volume":"16","author":"JA Obeso","year":"2010","journal-title":"Nat Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/S1474-4422(09)70238-8","article-title":"Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria.","volume":"8","author":"DW Dickson","year":"2009","journal-title":"Lancet Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1006\/exnr.2000.7527","article-title":"In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies.","volume":"166","author":"WP Gai","year":"2000","journal-title":"Exp Neurol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1093\/brain\/awh584","article-title":"Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease.","volume":"128","author":"GM Halliday","year":"2005","journal-title":"Brain"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson's disease.","volume":"24","author":"H Braak","year":"2003","journal-title":"Neurobiol Aging"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1749-6632.2009.05118.x","article-title":"The progression of pathology in Parkinson's disease.","volume":"1184","author":"GM Halliday","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S1353-8020(09)70769-2","article-title":"Neuropathology of non-motor features of Parkinson disease.","volume":"15","author":"DW Dickson","year":"2009","journal-title":"Parkinsonism Relat Disord"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/ana.21541","article-title":"A critical evaluation of the Braak staging scheme for Parkinson's disease.","volume":"64","author":"RE Burke","year":"2008","journal-title":"Ann Neurol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-008-0406-y","article-title":"A critical reappraisal of current staging of Lewy-related pathology in human brain.","volume":"116","author":"KA Jellinger","year":"2008","journal-title":"Acta Neuropathol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/mds.21956","article-title":"The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years.","volume":"23","author":"MA Hely","year":"2008","journal-title":"Mov Disord"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1136\/jnnp.70.6.727","article-title":"Visual hallucinations in Parkinson's disease: a review and phenomenological survey.","volume":"70","author":"J Barnes","year":"2001","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S1474-4422(05)70146-0","article-title":"Visual hallucinations in the diagnosis of idiopathic Parkinson's disease: a retrospective autopsy study.","volume":"4","author":"DR Williams","year":"2005","journal-title":"Lancet Neurol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1136\/jnnp.2007.124677","article-title":"Using the presence of visual hallucinations to differentiate Parkinson's disease from atypical parkinsonism.","volume":"79","author":"DR Williams","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1001\/archneurol.2010.166","article-title":"A 12-year population-based study of psychosis in Parkinson disease.","volume":"67","author":"EB Forsaa","year":"2010","journal-title":"Arch Neurol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nrneurol.2009.62","article-title":"Hallucinations in Parkinson disease.","volume":"5","author":"NJ Diederich","year":"2009","journal-title":"Nat Rev Neurol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"S748","DOI":"10.1002\/mds.22670","article-title":"MRI and cognitive impairment in Parkinson's disease.","volume":"24","author":"N Ibarretxe-Bilbao","year":"2009","journal-title":"Mov Disord"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/mds.22873","article-title":"Frontal and associative visual areas related to visual hallucinations in dementia with Lewy bodies and Parkinson's disease with dementia.","volume":"25","author":"C Sanchez-Castaneda","year":"2010","journal-title":"Mov Disord"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/j.1468-1331.2007.01768.x","article-title":"Cerebral atrophy in Parkinson's disease patients with visual hallucinations.","volume":"14","author":"B Ramirez-Ruiz","year":"2007","journal-title":"Eur J Neurol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1093\/brain\/awp223","article-title":"Impaired visual processing preceding image recognition in Parkinson's disease patients with visual hallucinations.","volume":"132","author":"AM Meppelink","year":"2009","journal-title":"Brain"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1002\/mds.22258","article-title":"Brain response to complex visual stimuli in Parkinson's patients with hallucinations: a functional magnetic resonance imaging study.","volume":"23","author":"B Ramirez-Ruiz","year":"2008","journal-title":"Mov Disord"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1176\/jnp.2006.18.3.402","article-title":"Preliminary FMRI evidence of visual system dysfunction in Parkinson's disease patients with visual hallucinations.","volume":"18","author":"S Holroyd","year":"2006","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0197-4580(94)90028-0","article-title":"Cortical glucose metabolism in Parkinson's disease without dementia.","volume":"15","author":"JL Eberling","year":"1994","journal-title":"Neurobiol Aging"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"Alpha-synuclein in Lewy bodies.","volume":"388","author":"MG Spillantini","year":"1997","journal-title":"Nature"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1471-4159.2006.04348.x","article-title":"Brain neutral lipids mass is increased in alpha-synuclein gene-ablated mice.","volume":"101","author":"G Barcelo-Coblijn","year":"2007","journal-title":"J Neurochem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1471-4159.2009.06290.x","article-title":"Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with alpha-synuclein genotype.","volume":"111","author":"I Rappley","year":"2009","journal-title":"J Neurochem"},{"key":"ref27","article-title":"Alpha-synuclein, lipids and Parkinson's disease.","author":"V Ruiperez","year":"2010","journal-title":"Prog Lipid Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/mds.870090115","article-title":"Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: an HPLC and ESR study.","volume":"9","author":"DT Dexter","year":"1994","journal-title":"Mov Disord"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1111\/j.1471-4159.2008.05254.x","article-title":"Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease.","volume":"105","author":"P Bar-On","year":"2008","journal-title":"J Neurochem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nchembio782","article-title":"Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization.","volume":"2","author":"DA Bosco","year":"2006","journal-title":"Nat Chem Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ymgme.2003.11.004","article-title":"Glucocerebrosidase mutations in subjects with parkinsonism.","volume":"81","author":"A Lwin","year":"2004","journal-title":"Mol Genet Metab"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1093\/brain\/awp044","article-title":"Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease.","volume":"132","author":"J Neumann","year":"2009","journal-title":"Brain"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nrd1776","article-title":"The emerging field of lipidomics.","volume":"4","author":"MR Wenk","year":"2005","journal-title":"Nat Rev Drug Discov"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e612","DOI":"10.1371\/journal.pone.0000612","article-title":"Neuronal conduction of excitation without action potentials based on ceramide production.","volume":"2","author":"C Fasano","year":"2007","journal-title":"PLoS ONE"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1038\/nn.2213","article-title":"Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease.","volume":"11","author":"RO Sanchez-Mejia","year":"2008","journal-title":"Nat Neurosci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e2630","DOI":"10.1371\/journal.pone.0002630","article-title":"Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism\u2013the GENOBIN study.","volume":"3","author":"U Schwab","year":"2008","journal-title":"PLoS ONE"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e6261","DOI":"10.1371\/journal.pone.0006261","article-title":"Top-down lipidomics reveals ether lipid deficiency in blood plasma of hypertensive patients.","volume":"4","author":"J Graessler","year":"2009","journal-title":"PLoS ONE"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e7735","DOI":"10.1371\/journal.pone.0007735","article-title":"A novel lipidomic strategy reveals plasma phospholipid signatures associated with respiratory disease severity in cystic fibrosis patients.","volume":"4","author":"IC Guerrera","year":"2009","journal-title":"PLoS ONE"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e11525","DOI":"10.1371\/journal.pone.0011525","article-title":"A combined transcriptomics and lipidomics analysis of subcutaneous, epididymal and mesenteric adipose tissue reveals marked functional differences.","volume":"5","author":"R Caesar","year":"2010","journal-title":"PLoS ONE"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.bbalip.2010.01.010","article-title":"Multi-dimensional mass spectrometry-based shotgun lipidomics and the altered lipids at the mild cognitive impairment stage of Alzheimer's disease.","volume":"1801","author":"X Han","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"ref41","article-title":"Lipidomics analysis reveals efficient storage of hepatic triacylglycerides enriched in unsaturated Fatty acids after one bout of exercise in mice.","volume":"5","author":"C Hu","year":"2010","journal-title":"PLoS ONE"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e11956","DOI":"10.1371\/journal.pone.0011956","article-title":"Characterization of substrate preference for Slc1p and Cst26p in Saccharomyces cerevisiae using lipidomic approaches and an LPAAT activity assay.","volume":"5","author":"G Shui","year":"2010","journal-title":"PLoS ONE"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00401-002-0529-5","article-title":"Consensus neuropathological diagnosis of common dementia syndromes: testing and standardising the use of multiple diagnostic criteria.","volume":"104","author":"G Halliday","year":"2002","journal-title":"Acta Neuropathol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neurobiolaging.2009.02.006","article-title":"Isoform-specific proteolysis of apolipoprotein-E in the brain.","volume":"32","author":"DA Elliott","year":"2011","journal-title":"Neurobiol Aging"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/brain\/awp282","article-title":"Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation.","volume":"133","author":"J Tong","year":"2010","journal-title":"Brain"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/o59-099","article-title":"A rapid method of total lipid extraction and purification.","volume":"37","author":"EG Bligh","year":"1959","journal-title":"Can J Biochem Physiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"11228","DOI":"10.1128\/JVI.00981-08","article-title":"Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides.","volume":"82","author":"R Chan","year":"2008","journal-title":"J Virol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1039\/b913353d","article-title":"Toward one step analysis of cellular lipidomes using liquid chromatography coupled with mass spectrometry: application to Saccharomyces cerevisiae and Schizosaccharomyces pombe lipidomics.","volume":"6","author":"G Shui","year":"2010","journal-title":"Mol Biosyst"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1158\/0008-5472.CAN-06-0077","article-title":"Emodin inhibits tumor cell adhesion through disruption of the membrane lipid Raft-associated integrin signaling pathway.","volume":"66","author":"Q Huang","year":"2006","journal-title":"Cancer Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.bbalip.2008.04.002","article-title":"Human lens lipids differ markedly from those of commonly used experimental animals.","volume":"1781","author":"JM Deeley","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1194\/jlr.M800601-JLR200","article-title":"Caveolin-1-dependent and -independent membrane domains.","volume":"50","author":"S Le Lay","year":"2009","journal-title":"J Lipid Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1073\/pnas.94.6.2339","article-title":"Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry.","volume":"94","author":"B Brugger","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1006\/abio.2001.5536","article-title":"Characterization and direct quantitation of ceramide molecular species from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry.","volume":"302","author":"X Han","year":"2002","journal-title":"Anal Biochem"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/j.1471-4159.2004.02975.x","article-title":"Dolichol is the major lipid component of human substantia nigra neuromelanin.","volume":"92","author":"H Fedorow","year":"2005","journal-title":"J Neurochem"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/j.1471-4159.2009.06031.x","article-title":"Apolipoprotein-D expression is increased during development and maturation of the human prefrontal cortex.","volume":"109","author":"WS Kim","year":"2009","journal-title":"J Neurochem"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/1467-9868.00346","article-title":"A direct approach to false discovery rates.","volume":"64","author":"J Storey","year":"2002","journal-title":"J R Stat Soc B"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0022-2275(20)39652-8","article-title":"Fatty Acid Composition of Human Brain Sphingomyelins: Normal Variation with Age and Changes during Myelin Disorders.","volume":"6","author":"S Staellberg-Stenhagen","year":"1965","journal-title":"J Lipid Res"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0047-6374(89)90021-3","article-title":"Buoyant density and lipid composition of purified myelin of aging human brain.","volume":"48","author":"A Stommel","year":"1989","journal-title":"Mech Ageing Dev"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1046\/j.1471-4159.1994.63051802.x","article-title":"Membrane lipids of adult human brain: lipid composition of frontal and temporal lobe in subjects of age 20 to 100 years.","volume":"63","author":"L Svennerholm","year":"1994","journal-title":"J Neurochem"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.mam.2009.02.005","article-title":"Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis.","volume":"30","author":"AJ Brown","year":"2009","journal-title":"Mol Aspects Med"},{"key":"ref61","first-page":"361","article-title":"Apolipoprotein D expression in substantia nigra of Parkinson disease.","volume":"21","author":"C Ordonez","year":"2006","journal-title":"Histol Histopathol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1097\/WNR.0b013e32831578b2","article-title":"Regulation of alpha-synuclein expression by liver X receptor ligands in vitro.","volume":"19","author":"D Cheng","year":"2008","journal-title":"Neuroreport"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1111\/j.1471-4159.2008.05736.x","article-title":"Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells.","volume":"107","author":"JP Rantham Prabhakara","year":"2008","journal-title":"J Neurochem"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1093\/brain\/awf251","article-title":"Clinical correlates of selective pathology in the amygdala of patients with Parkinson's disease.","volume":"125","author":"AJ Harding","year":"2002","journal-title":"Brain"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.1111\/j.1742-4658.2008.06709.x","article-title":"Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease.","volume":"275","author":"J Bras","year":"2008","journal-title":"FEBS J"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1002\/jnr.21268","article-title":"Interactions between neural membrane glycerophospholipid and sphingolipid mediators: a recipe for neural cell survival or suicide.","volume":"85","author":"AA Farooqui","year":"2007","journal-title":"J Neurosci Res"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1002\/ana.410320714","article-title":"Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease. The Royal Kings and Queens Parkinson's Disease Research Group.","volume":"32","author":"P Jenner","year":"1992","journal-title":"Ann Neurol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1749-6632.1996.tb39064.x","article-title":"Oxidative stress and Parkinson's disease.","volume":"786","author":"AD Owen","year":"1996","journal-title":"Ann N Y Acad Sci"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0197-0186(99)00157-6","article-title":"7alpha-Hydroperoxycholesterol causes CNS neuronal cell death.","volume":"36","author":"H Kolsch","year":"2000","journal-title":"Neurochem Int"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0006-8993(98)01274-8","article-title":"The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells.","volume":"818","author":"H Kolsch","year":"1999","journal-title":"Brain Res"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1073\/pnas.0711599105","article-title":"Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia.","volume":"105","author":"HJ Kim","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"14470","DOI":"10.1523\/JNEUROSCI.4823-07.2007","article-title":"Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse.","volume":"27","author":"JJ Repa","year":"2007","journal-title":"J Neurosci"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"13878","DOI":"10.1073\/pnas.172510899","article-title":"Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration.","volume":"99","author":"L Wang","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.stem.2009.08.019","article-title":"Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells.","volume":"5","author":"P Sacchetti","year":"2009","journal-title":"Cell Stem Cell"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.freeradbiomed.2009.11.026","article-title":"Oxidative damage in Parkinson disease: Measurement using accurate biomarkers.","volume":"48","author":"RC Seet","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1089\/ars.2008.2179","article-title":"Different patterns of oxidized lipid products in plasma and urine of dengue fever, stroke, and Parkinson's disease patients: cautions in the use of biomarkers of oxidative stress.","volume":"11","author":"CY Lee","year":"2009","journal-title":"Antioxid Redox Signal"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1194\/jlr.M500024-JLR200","article-title":"Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain.","volume":"46","author":"M Heverin","year":"2005","journal-title":"J Lipid Res"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1194\/jlr.M300320-JLR200","article-title":"Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease.","volume":"45","author":"M Heverin","year":"2004","journal-title":"J Lipid Res"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1196\/annals.1427.007","article-title":"Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease.","volume":"1147","author":"L Mosconi","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/ncpneuro0924","article-title":"Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis.","volume":"4","author":"C Henchcliffe","year":"2008","journal-title":"Nat Clin Pract Neurol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0306-4522(93)90175-F","article-title":"Glutathione peroxidase, glial cells and Parkinson's disease.","volume":"52","author":"P Damier","year":"1993","journal-title":"Neuroscience"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00401-008-0438-3","article-title":"Cellular glutathione peroxidase in human brain: cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson's disease and dementia with Lewy bodies.","volume":"117","author":"JH Power","year":"2009","journal-title":"Acta Neuropathol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0891-5849(89)90057-9","article-title":"Central nervous system trauma and stroke. II. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation.","volume":"6","author":"ED Hall","year":"1989","journal-title":"Free Radic Biol Med"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1089\/0897715041269632","article-title":"Lipid peroxidation early after brain injury.","volume":"21","author":"J Scholpp","year":"2004","journal-title":"J Neurotrauma"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1111\/j.1471-4159.2010.07055.x","article-title":"Mass-spectrometry based oxidative lipidomics and lipid imaging: applications in traumatic brain injury.","volume":"115","author":"LJ Sparvero","year":"2010","journal-title":"J Neurochem"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2009.12.080","article-title":"24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury.","volume":"1319","author":"CM Cartagena","year":"2010","journal-title":"Brain Res"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1136\/jnnp.69.2.172","article-title":"Hallucinations, delusions, and cognitive decline in Alzheimer's disease.","volume":"69","author":"RS Wilson","year":"2000","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1097\/WNR.0b013e32820049d3","article-title":"The physiological basis of visual hallucinations after damage to the primary visual cortex.","volume":"18","author":"EH De Haan","year":"2007","journal-title":"Neuroreport"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s11920-003-0042-0","article-title":"Psychotic disorder and traumatic brain injury.","volume":"5","author":"Q Zhang","year":"2003","journal-title":"Curr Psychiatry Rep"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0017299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T16:43:59Z","timestamp":1637340239000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0017299"}},"subtitle":[],"editor":[{"given":"Sergio","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,2,28]]},"references-count":89,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,2,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0017299","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,28]]}}}