{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:21:27Z","timestamp":1792693287707,"version":"4.5.0"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2011,3,10]],"date-time":"2011-03-10T00:00:00Z","timestamp":1299715200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0017376","type":"journal-article","created":{"date-parts":[[2011,3,10]],"date-time":"2011-03-10T21:56:00Z","timestamp":1299794160000},"page":"e17376","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Therapy with Sodium Stibogluconate in Stearylamine-Bearing Liposomes Confers Cure against SSG-Resistant Leishmania donovani in BALB\/c Mice"],"prefix":"10.1371","volume":"6","author":[{"given":"Jayeeta","family":"Roychoudhury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roma","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,3,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.cimid.2004.03.004","article-title":"Leishmaniasis: current situation and new perspectives.","volume":"27","author":"P Desjeux","year":"2004","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"9375","DOI":"10.1073\/pnas.0703678104","article-title":"Evolutionary and geographical history of the Leishmania donovani complex with a revision of current taxonomy.","volume":"104","author":"J Lukes","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.pt.2003.09.008","article-title":"Leishmaniasis\u2013current chemotherapy and recent advances in the search for novel drugs.","volume":"19","author":"SL Croft","year":"2003","journal-title":"Trends Parasitol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1128\/CMR.19.1.111-126.2006","article-title":"Drug resistance in leishmaniasis.","volume":"19","author":"SL Croft","year":"2006","journal-title":"Clin Microbiol Rev"},{"key":"ref5","article-title":"Drug resistance in visceral leishmaniasis.","volume":"2010","author":"HC Maltezou","year":"2010"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S1473-3099(05)70296-6","article-title":"Treatment options for visceral leishmaniasis: a systematic review of clinical studies done in India, 1980-2004.","volume":"5","author":"PL Olliaro","year":"2005","journal-title":"Lancet Infect Dis"},{"key":"ref7","first-page":"345","article-title":"Visceral leishmaniasis - current therapeutic modalities.","volume":"123","author":"S Sundar","year":"2006","journal-title":"Indian J Med Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0035-9203(90)90263-E","article-title":"Treatment of visceral leishmaniasis in Kenya by aminosidine alone or combined with sodium stibogluconate.","volume":"84","author":"CN Chunge","year":"1990","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4269\/ajtmh.2007.77.89","article-title":"Treatment of kala-azar in southern Sudan using a 17-day regimen of sodium stibogluconate combined with paromomycin: a retrospective comparison with 30-day sodium stibogluconate monotherapy.","volume":"77","author":"Y Melaku","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1086\/591972","article-title":"New treatment approach in Indian visceral leishmaniasis: single-dose liposomal amphotericin B followed by short-course oral miltefosine.","volume":"47","author":"S Sundar","year":"2008","journal-title":"Clin Infect Dis"},{"key":"ref11","first-page":"197","article-title":"Liposomal amphotericin B and rHuGM-CSF for treatment of visceral leishmaniasis in AIDS.","volume":"12","author":"A Mastroianni","year":"2004","journal-title":"Infez Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1097\/QCO.0b013e32833fca9d","article-title":"Drug combinations for visceral leishmaniasis.","volume":"23","author":"PL Olliaro","year":"2010","journal-title":"Curr Opin Infect Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.exppara.2006.02.015","article-title":"Leishmania donovani: effect of verapamil on in vitro susceptibility of promastigote and amastigote stages of Indian clinical isolates to sodium stibogluconate.","volume":"114","author":"R Valiathan","year":"2006","journal-title":"Exp Parasitol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1128\/AAC.47.5.1529-1535.2003","article-title":"The in vivo susceptibility of Leishmania donovani to sodium stibogluconate is drug specific and can be reversed by inhibiting glutathione biosynthesis.","volume":"47","author":"KC Carter","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1128\/AAC.01233-08","article-title":"In vitro susceptibility of field isolates of Leishmania donovani to Miltefosine and amphotericin B: correlation with sodium antimony gluconate susceptibility and implications for treatment in areas of endemicity.","volume":"53","author":"D Kumar","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref16","first-page":"86","article-title":"Functionality of drug efflux pumps in antimonial resistant Leishmania donovani field isolates.","volume":"46","author":"G Mandal","year":"2009","journal-title":"Indian J Biochem Biophys"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.3390\/molecules14072317","article-title":"Pentavalent antimonials: new perspectives for old drugs.","volume":"14","author":"F Frezard","year":"2009","journal-title":"Molecules"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2174\/156720105774370177","article-title":"Targeted drug delivery to macrophages in parasitic infections.","volume":"2","author":"M Owais","year":"2005","journal-title":"Curr Drug Deliv"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1073\/pnas.75.6.2959","article-title":"Therapy of leishmaniasis: superior efficacies of liposome-encapsulated drugs.","volume":"75","author":"CR Alving","year":"1978","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/0024-3205(78)90270-9","article-title":"Improved therapy of experimental leishmaniasis by use of a liposome-encapsulated antimonial drug.","volume":"22","author":"CR Alving","year":"1978","journal-title":"Life Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/j.2042-7158.1986.tb04623.x","article-title":"Non-ionic surfactant vesicles, niosomes, as a delivery system for the anti-leishmanial drug, sodium stibogluconate.","volume":"38","author":"AJ Baillie","year":"1986","journal-title":"J Pharm Pharmacol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/0035-9203(77)90155-9","article-title":"The use of Pentostam liposomes in the chemotherapy of experimental leishmaniasis.","volume":"71","author":"CD Black","year":"1977","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.2042-7158.1989.tb06399.x","article-title":"Visceral leishmaniasis: drug carrier system characteristics and the ability to clear parasites from the liver, spleen and bone marrow in Leishmania donovani infected BALB\/c mice.","volume":"41","author":"KC Carter","year":"1989","journal-title":"J Pharm Pharmacol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.2042-7158.1988.tb05210.x","article-title":"Vesicular systems (niosomes and liposomes) for delivery of sodium stibogluconate in experimental murine visceral leishmaniasis.","volume":"40","author":"CA Hunter","year":"1988","journal-title":"J Pharm Pharmacol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/272055a0","article-title":"Antileishmanial activity of antimonials entrapped in liposomes.","volume":"272","author":"RR New","year":"1978","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1128\/AAC.45.12.3555-3559.2001","article-title":"Efficacies of vesicular and free sodium stibogluconate formulations against clinical isolates of Leishmania donovani.","volume":"45","author":"KC Carter","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1645\/0022-3395(2001)087[0188:LAOSBL]2.0.CO;2","article-title":"Leishmanicidal activity of stearylamine-bearing liposomes in vitro.","volume":"87","author":"F Afrin","year":"2001","journal-title":"J Parasitol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1128\/AAC.44.6.1739-1742.2000","article-title":"Antileishmanial activities of stearylamine-bearing liposomes.","volume":"44","author":"T Dey","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1128\/AAC.48.9.3591-3593.2004","article-title":"Combination therapy using sodium antimony gluconate in stearylamine-bearing liposomes against established and chronic Leishmania donovani infection in BALB\/c Mice.","volume":"48","author":"S Pal","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/jac\/dkm396","article-title":"Stearylamine-bearing cationic liposomes kill Leishmania parasites through surface exposed negatively charged phosphatidylserine.","volume":"61","author":"A Banerjee","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.4049\/jimmunol.181.2.1386","article-title":"Complete cure of experimental visceral leishmaniasis with amphotericin B in stearylamine-bearing cationic liposomes involves down-regulation of IL-10 and favorable T cell responses.","volume":"181","author":"A Banerjee","year":"2008","journal-title":"J Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S1368-7646(03)00082-7","article-title":"Liposome-based approaches to overcome anticancer drug resistance.","volume":"6","author":"C Mamot","year":"2003","journal-title":"Drug Resist Updat"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/BF02705047","article-title":"Studies on stibanate unresponsive isolates of Leishmania donovani.","volume":"27","author":"A Bhattacharyya","year":"2002","journal-title":"J Biosci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/10717540902937562","article-title":"Liposome composition is important for retention of liposomal rhodamine in P-glycoprotein-overexpressing cancer cells.","volume":"16","author":"DI Kang","year":"2009","journal-title":"Drug Deliv"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1023\/A:1020440229102","article-title":"Design and characterization of liposomes containing long-chain N-acylPEs for brain delivery: penetration of liposomes incorporating GM1 into the rat brain.","volume":"19","author":"M Mora","year":"2002","journal-title":"Pharm Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"24717","DOI":"10.1074\/jbc.M201961200","article-title":"Increase in cytosolic Ca2+ levels through the activation of non-selective cation channels induced by oxidative stress causes mitochondrial depolarization leading to apoptosis-like death in Leishmania donovani promastigotes.","volume":"277","author":"SB Mukherjee","year":"2002","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/abio.1993.1223","article-title":"Antimony quantification in Leishmania by electrothermal atomic absorption spectroscopy.","volume":"211","author":"WL Roberts","year":"1993","journal-title":"Anal Biochem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1124\/dmd.31.11.1296","article-title":"Induction of ABCC3 (MRP3) by pregnane X receptor activators.","volume":"31","author":"S Teng","year":"2003","journal-title":"Drug Metab Dispos"},{"key":"ref39","first-page":"80","article-title":"Resistance to the Khartoum strain of Leishmania donovani. Rice Inst. Pamphlet.","volume":"45","author":"Stauber","year":"1956"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"6697","DOI":"10.1128\/IAI.70.12.6697-6706.2002","article-title":"Characterization of Leishmania donovani antigens encapsulated in liposomes that induce protective immunity in BALB\/c mice.","volume":"70","author":"F Afrin","year":"2002","journal-title":"Infect Immun"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.4049\/jimmunol.141.7.2407","article-title":"Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.","volume":"141","author":"AH Ding","year":"1988","journal-title":"J Immunol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.4049\/jimmunol.179.8.5592","article-title":"IL-10- and TGF-beta-mediated susceptibility in kala-azar and post-kala-azar dermal leishmaniasis: the significance of amphotericin B in the control of Leishmania donovani infection in India.","volume":"179","author":"S Saha","year":"2007","journal-title":"J Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0065-2776(08)60536-2","article-title":"Mechanism and regulation of immunoglobulin isotype switching.","volume":"54","author":"RL Coffman","year":"1993","journal-title":"Adv Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.4049\/jimmunol.174.8.4916","article-title":"Prevention of relapse after chemotherapy in a chronic intracellular infection: mechanisms in experimental visceral leishmaniasis.","volume":"174","author":"HW Murray","year":"2005","journal-title":"J Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1128\/IAI.42.2.702-707.1983","article-title":"Cell-mediated immune response in Indian kala-azar and post-kala-azar dermal leishmaniasis.","volume":"42","author":"JP Haldar","year":"1983","journal-title":"Infect Immun"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1002\/1521-4141(200010)30:10<2935::AID-IMMU2935>3.0.CO;2-Q","article-title":"Endogenous IL-4 is necessary for effective drug therapy against visceral leishmaniasis.","volume":"30","author":"J Alexander","year":"2000","journal-title":"Eur J Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"7160","DOI":"10.4049\/jimmunol.174.11.7160","article-title":"Kinetoplastid membrane protein-11 DNA vaccination induces complete protection against both pentavalent antimonial-sensitive and -resistant strains of Leishmania donovani that correlates with inducible nitric oxide synthase activity and IL-4 generation: evidence for mixed Th1- and Th2-like responses in visceral leishmaniasis.","volume":"174","author":"R Basu","year":"2005","journal-title":"J Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1172\/JCI116570","article-title":"Interleukin 10 production correlates with pathology in human Leishmania donovani infections.","volume":"92","author":"HW Ghalib","year":"1993","journal-title":"J Clin Invest"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1002\/1521-4141(2001010)31:10<2848::AID-IMMU2848>3.0.CO;2-T","article-title":"IL-10 mediates susceptibility to Leishmania donovani infection.","volume":"31","author":"ML Murphy","year":"2001","journal-title":"Eur J Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.4049\/jimmunol.171.7.3705","article-title":"The role of interleukin-10 in susceptibility of BALB\/c mice to infection with Leishmania mexicana and Leishmania amazonensis.","volume":"171","author":"UM Padigel","year":"2003","journal-title":"J Immunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"17123","DOI":"10.1073\/pnas.0904955106","article-title":"A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome.","volume":"106","author":"D Ranatunga","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.4049\/jimmunol.180.6.4090","article-title":"IL-10 and TGF-beta control the establishment of persistent and transmissible infections produced by Leishmania tropica in C57BL\/6 mice.","volume":"180","author":"CF Anderson","year":"2008","journal-title":"J Immunol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"974","DOI":"10.4049\/jimmunol.162.2.974","article-title":"Anti-TGF-beta treatment promotes rapid healing of Leishmania major infection in mice by enhancing in vivo nitric oxide production.","volume":"162","author":"J Li","year":"1999","journal-title":"J Immunol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1126\/science.1636092","article-title":"Transforming growth factor-beta in leishmanial infection: a parasite escape mechanism.","volume":"257","author":"M Barral-Netto","year":"1992","journal-title":"Science"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1006\/bbrc.1997.7749","article-title":"Positively charged liposome functions as an efficient immunoadjuvant in inducing immune responses to soluble proteins.","volume":"240","author":"T Nakanishi","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1099\/jmm.0.46841-0","article-title":"Molecular mechanisms of antimony resistance in Leishmania.","volume":"56","author":"Ashutosh","year":"2007","journal-title":"J Med Microbiol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0005-2736(95)00121-I","article-title":"The cationic lipid stearylamine reduces the permeability of the cationic drugs verapamil and prochlorperazine to lipid bilayers: implications for drug delivery.","volume":"1238","author":"MS Webb","year":"1995","journal-title":"Biochim Biophys Acta"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/1097-0215(20000715)87:2<172::AID-IJC3>3.0.CO;2-K","article-title":"Differential expression of sphingolipids in MRP1 overexpressing HT29 cells.","volume":"87","author":"JW Kok","year":"2000","journal-title":"Int J Cancer"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1172\/JCI114009","article-title":"Requirement for T cells and effect of lymphokines in successful chemotherapy for an intracellular infection. Experimental visceral leishmaniasis.","volume":"83","author":"HW Murray","year":"1989","journal-title":"J Clin Invest"},{"key":"ref60","article-title":"Combination therapy with paromomycin associated stearylamine-bearing liposomes cures experimental visceral leishmaniasis through Th-1 biased immunomodulation.","author":"A Banerjee","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1128\/AAC.50.5.1788-1797.2006","article-title":"Sodium antimony gluconate induces generation of reactive oxygen species and nitric oxide via phosphoinositide 3-kinase and mitogen-activated protein kinase activation in Leishmania donovani-infected macrophages.","volume":"50","author":"J Mookerjee Basu","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"e1000907","DOI":"10.1371\/journal.ppat.1000907","article-title":"Leishmania donovani isolates with antimony-resistant but not -sensitive phenotype inhibit sodium antimony gluconate-induced dendritic cell activation.","volume":"6","author":"AK Haldar","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1189\/jlb.0405181","article-title":"Cationic liposomes induce apoptosis through p38 MAP kinase-caspase-8-Bid pathway in macrophage-like RAW264.7 cells.","volume":"79","author":"S Iwaoka","year":"2006","journal-title":"J Leukoc Biol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nm1045","article-title":"Reciprocal CD40 signals through p38MAPK and ERK-1\/2 induce counteracting immune responses.","volume":"10","author":"RK Mathur","year":"2004","journal-title":"Nat Med"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1365-2249.2008.03741.x","article-title":"Leishmania donovani infection down-regulates TLR2-stimulated IL-12p40 and activates IL-10 in cells of macrophage\/monocytic lineage by modulating MAPK pathways through a contact-dependent mechanism.","volume":"154","author":"D Chandra","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"6403","DOI":"10.4049\/jimmunol.163.12.6403","article-title":"Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase.","volume":"163","author":"GJ Feng","year":"1999","journal-title":"J Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0017376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T03:24:23Z","timestamp":1712287463000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0017376"}},"subtitle":[],"editor":[{"given":"Erika","family":"Braga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,3,10]]},"references-count":66,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,3,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0017376","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,10]]}}}