{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:40:06Z","timestamp":1791214806355,"version":"4.1.0"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2011,3,7]],"date-time":"2011-03-07T00:00:00Z","timestamp":1299456000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0017793","type":"journal-article","created":{"date-parts":[[2011,3,7]],"date-time":"2011-03-07T22:00:24Z","timestamp":1299535224000},"page":"e17793","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":121,"title":["Copy Number Variation in Patients with Disorders of Sex Development Due to 46,XY Gonadal Dysgenesis"],"prefix":"10.1371","volume":"6","author":[{"given":"Stefan","family":"White","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ohnesorg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Notini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Roeszler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Hewitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hinda","family":"Daggag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Turbitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Gustin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"van den Bergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Miles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Western","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Arboleda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Bengtsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Speed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hutson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garry","family":"Warne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Harley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Koopman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Vilain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,3,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00009.2006","article-title":"Sex determination and gonadal development in mammals.","volume":"87","author":"D Wilhelm","year":"2007","journal-title":"Physiol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e488","DOI":"10.1542\/peds.2006-0738","article-title":"Consensus statement on management of intersex disorders. International Consensus Conference on Intersex.","volume":"118","author":"PA Lee","year":"2006","journal-title":"Pediatrics"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"612","DOI":"10.5694\/j.1326-5377.2009.tb02586.x","article-title":"Disorders of sex development: current understanding and continuing controversy.","volume":"190","author":"GL Warne","year":"2009","journal-title":"Med J Aust"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/(SICI)1098-1004(1997)9:5<388::AID-HUMU2>3.0.CO;2-0","article-title":"Mutations in SRY and SOX9: testis-determining genes.","volume":"9","author":"FJ Cameron","year":"1997","journal-title":"Hum Mutat"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/nrg1903","article-title":"The makings of maleness: towards an integrated view of male sexual development.","volume":"7","author":"D Wilhelm","year":"2006","journal-title":"Nat Rev Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/35799","article-title":"Dax1 antagonizes Sry action in mammalian sex determination.","volume":"391","author":"A Swain","year":"1998","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0092-8674(94)90211-9","article-title":"A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation.","volume":"77","author":"X Luo","year":"1994","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1086\/320125","article-title":"Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans.","volume":"68","author":"BK Jordan","year":"2001","journal-title":"Am J Hum Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1210\/jc.2004-0863","article-title":"Mutations in the desert hedgehog (DHH) gene in patients with 46,XY complete pure gonadal dysgenesis.","volume":"89","author":"P Canto","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.ajhg.2010.11.003","article-title":"Mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis determination.","volume":"87","author":"A Pearlman","year":"2010","journal-title":"Am J Hum Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1590\/S0100-879X2004000100020","article-title":"Mutations in the SRY, DAX1, SF1 and WNT4 genes in Brazilian sex-reversed patients.","volume":"37","author":"S Domenice","year":"2004","journal-title":"Braz J Med Biol Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ydbio.2005.09.008","article-title":"Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development.","volume":"287","author":"S Nef","year":"2005","journal-title":"Developmental Biology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/hmg\/ddi463","article-title":"Expression profiling of purified mouse gonadal somatic cells during the critical time window of sex determination reveals novel candidate genes for human sexual dysgenesis syndromes.","volume":"15","author":"A Beverdam","year":"2006","journal-title":"Hum Mol Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/nature06944","article-title":"Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer.","volume":"453","author":"R Sekido","year":"2008","journal-title":"Nature"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/346240a0","article-title":"A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif.","volume":"346","author":"AH Sinclair","year":"1990","journal-title":"Nature"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/ng1407","article-title":"Mutations in a new member of the chromodomain gene family cause CHARGE syndrome.","volume":"36","author":"LE Vissers","year":"2004","journal-title":"Nat Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1086\/507567","article-title":"Peters Plus syndrome is caused by mutations in B3GALTL, a putative glycosyltransferase.","volume":"79","author":"SA Lesnik Oberstein","year":"2006","journal-title":"Am J Hum Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/ajmg.a.31631","article-title":"Recurrent SOX9 deletion campomelic dysplasia due to somatic mosaicism in the father.","volume":"143","author":"M Smyk","year":"2007","journal-title":"Am J Med Genet A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1210\/jc.2007-0505","article-title":"Isolated 46,XY gonadal dysgenesis in two sisters caused by a Xp21.2 interstitial duplication containing the DAX1 gene.","volume":"92","author":"M Barbaro","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e15392","DOI":"10.1371\/journal.pone.0015392","article-title":"Identification of de novo copy number variants associated with human disorders of sexual development.","volume":"5","author":"M Tannour-Louet","year":"2010","journal-title":"PLoS One"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1093\/humrep\/deq167","article-title":"Array-CGH analysis in patients with syndromic and non-syndromic XY gonadal dysgenesis: evaluation of array CGH as diagnostic tool and search for new candidate loci.","volume":"25","author":"S Ledig","year":"2010","journal-title":"Hum Reprod"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1093\/bioinformatics\/btp371","article-title":"A single-array preprocessing method for estimating full-resolution raw copy numbers from all Affymetrix genotyping arrays including GenomeWideSNP 5 &amp; 6.","volume":"25","author":"H Bengtsson","year":"2009","journal-title":"Bioinformatics"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/bioinformatics\/btn016","article-title":"Estimation and assessment of raw copy numbers at the single locus level.","volume":"24","author":"H Bengtsson","year":"2008","journal-title":"Bioinformatics"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1093\/nar\/gnf056","article-title":"Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification.","volume":"30","author":"JP Schouten","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/humu.20054","article-title":"Two-color multiplex ligation-dependent probe amplification: detecting genomic rearrangements in hereditary multiple exostoses.","volume":"24","author":"SJ White","year":"2004","journal-title":"Hum Mutat"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0091-679X(04)75032-3","article-title":"Detecting copy number changes in genomic DNA: MAPH and MLPA.","volume":"75","author":"SJ White","year":"2004","journal-title":"Methods Cell Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/hmg\/8.4.691","article-title":"Structural and functional characterization of the mouse Sox9 promoter: implications for campomelic dysplasia.","volume":"8","author":"Y Kanai","year":"1999","journal-title":"Hum Mol Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1002\/mrd.20889","article-title":"Characteristics of testicular dysgenesis syndrome and decreased expression of SRY and SOX9 in Frasier syndrome.","volume":"75","author":"V Schumacher","year":"2008","journal-title":"Mol Reprod Dev"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1634\/stemcells.2007-0622","article-title":"Dynamic Regulation of Mitotic Arrest in Fetal Male Germ Cells.","volume":"26","author":"PS Western","year":"2008","journal-title":"Stem Cells"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/humu.20843","article-title":"Emerging themes and new challenges in defining the role of structural variation in human disease.","volume":"30","author":"AJ Sharp","year":"2009","journal-title":"Hum Mutat"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/ng1416","article-title":"Detection of large-scale variation in the human genome.","volume":"36","author":"AJ Iafrate","year":"2004","journal-title":"Nat Genet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1399-0004.2008.00980.x","article-title":"Gene dosage imbalances in patients with 46,XY gonadal DSD detected by an in-house-designed synthetic probe set for multiplex ligation-dependent probe amplification analysis.","volume":"73","author":"M Barbaro","year":"2008","journal-title":"Clin Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ng0496-404","article-title":"Mouse Dax1 expression is consistent with a role in sex determination as well as in adrenal and hypothalamus function.","volume":"12","author":"A Swain","year":"1996","journal-title":"Nat Genet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1242\/dev.01890","article-title":"Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells.","volume":"132","author":"GJ Bouma","year":"2005","journal-title":"Development"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/ng1141","article-title":"Dax1 is required for testis determination.","volume":"34","author":"JJ Meeks","year":"2003","journal-title":"Nat Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.tem.2004.02.002","article-title":"Sex determination: a \u2018window\u2019 of DAX1 activity.","volume":"15","author":"LM Ludbrook","year":"2004","journal-title":"Trends Endocrinol Metab"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/ng0195-15","article-title":"The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos.","volume":"9","author":"E Wright","year":"1995","journal-title":"Nat Genet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/90046","article-title":"Sox9 induces testis development in XX transgenic mice.","volume":"28","author":"VP Vidal","year":"2001","journal-title":"Nat Genet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/(SICI)1096-8628(19991203)87:4<349::AID-AJMG13>3.0.CO;2-N","article-title":"Autosomal XX sex reversal caused by duplication of SOX9.","volume":"87","author":"B Huang","year":"1999","journal-title":"Am J Med Genet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1086\/429254","article-title":"Fine mapping of chromosome 17 translocation breakpoints &gt; or = 900 Kb upstream of SOX9 in acampomelic campomelic dysplasia and a mild, familial skeletal dysplasia.","volume":"76","author":"KL Hill-Harfe","year":"2005","journal-title":"Am J Hum Genet"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1086\/429252","article-title":"Position effects due to chromosome breakpoints that map approximately 900 Kb upstream and approximately 1.3 Mb downstream of SOX9 in two patients with campomelic dysplasia.","volume":"76","author":"GV Velagaleti","year":"2005","journal-title":"Am J Hum Genet"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1136\/jmg.2003.013185","article-title":"Screening of the 1 Mb SOX9 5\u2032 control region by array CGH identifies a large deletion in a case of campomelic dysplasia with XY sex reversal.","volume":"41","author":"R Pop","year":"2004","journal-title":"J Med Genet"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1086\/302455","article-title":"Campomelic dysplasia translocation breakpoints are scattered over 1 Mb proximal to SOX9: evidence for an extended control region.","volume":"65","author":"D Pfeifer","year":"1999","journal-title":"Am J Hum Genet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"10649","DOI":"10.1073\/pnas.95.18.10649","article-title":"Deletion of long-range regulatory elements upstream of SOX9 causes campomelic dysplasia.","volume":"95","author":"VM Wunderle","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/372525a0","article-title":"Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene.","volume":"372","author":"JW Foster","year":"1994","journal-title":"Nature"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/0092-8674(94)90041-8","article-title":"Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9.","volume":"79","author":"T Wagner","year":"1994","journal-title":"Cell"},{"key":"ref47","first-page":"1028","article-title":"Mutations in SOX9, the gene responsible for Campomelic dysplasia and autosomal sex reversal.","volume":"57","author":"C Kwok","year":"1995","journal-title":"Am J Hum Genet"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1002\/ajmg.a.32830","article-title":"Familial acampomelic form of campomelic dysplasia caused by a 960 kb deletion upstream of SOX9.","volume":"149A","author":"C Lecointre","year":"2009","journal-title":"Am J Med Genet A"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/ng.329","article-title":"Highly conserved non-coding elements on either side of SOX9 associated with Pierre Robin sequence.","volume":"41","author":"S Benko","year":"2009","journal-title":"Nat Genet"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/82652","article-title":"A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse.","volume":"26","author":"CE Bishop","year":"2000","journal-title":"Nat Genet"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1093\/hmg\/ddh141","article-title":"Long-range activation of Sox9 in Odd Sex (Ods) mice.","volume":"13","author":"Y Qin","year":"2004","journal-title":"Hum Mol Genet"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1159\/000320142","article-title":"Mutations of the SRY-Responsive Enhancer of SOX9 Are Uncommon in XY Gonadal Dysgenesis.","volume":"4","author":"I Georg","year":"2010","journal-title":"Sex Dev"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ydbio.2005.11.013","article-title":"Long-range upstream and downstream enhancers control distinct subsets of the complex spatiotemporal Sox9 expression pattern.","volume":"291","author":"S Bagheri-Fam","year":"2006","journal-title":"Dev Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/geno.2001.6648","article-title":"Comparative genomics of the SOX9 region in human and Fugu rubripes: conservation of short regulatory sequence elements within large intergenic regions.","volume":"78","author":"S Bagheri-Fam","year":"2001","journal-title":"Genomics"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"14994","DOI":"10.1073\/pnas.0701677104","article-title":"Correct dosage of Fog2 and Gata4 transcription factors is critical for fetal testis development in mice.","volume":"104","author":"GJ Bouma","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1471-2199-9-44","article-title":"A GATA4\/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation.","volume":"9","author":"Y Miyamoto","year":"2008","journal-title":"BMC Mol Biol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1172\/JCI42580","article-title":"Identification of SOX3 as an XX male sex reversal gene in mice and humans.","volume":"121","author":"E Sutton","year":"2011","journal-title":"J Clin Invest"},{"issue":"4","key":"ref58","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1073\/pnas.1010257108","article-title":"Loss-of-function mutation in GATA4 causes anomalies of human testicular development.","volume":"108","author":"D Lourenco","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.mod.2008.03.001","article-title":"A functional screen for genes involved in Xenopus pronephros development.","volume":"125","author":"J Kyuno","year":"2008","journal-title":"Mech Dev"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/ng.120","article-title":"Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.","volume":"40","author":"E Zeggini","year":"2008","journal-title":"Nat Genet"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature07829","article-title":"Histone modifications at human enhancers reflect global cell-type-specific gene expression.","volume":"459","author":"ND Heintzman","year":"2009","journal-title":"Nature"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1101\/gr.4074106","article-title":"Genome-wide mapping of DNase hypersensitive sites using massively parallel signature sequencing (MPSS).","volume":"16","author":"GE Crawford","year":"2006","journal-title":"Genome Res"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1186\/1471-2164-10-412","article-title":"Rapid high-throughput analysis of DNaseI hypersensitive sites using a modified MLPA approach.","volume":"10","author":"T Ohnesorg","year":"2009","journal-title":"BMC Genomics"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0017793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T05:16:07Z","timestamp":1592370967000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0017793"}},"subtitle":[],"editor":[{"given":"Laszlo","family":"Orban","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,3,7]]},"references-count":63,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,3,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0017793","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,7]]}}}