{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T04:30:44Z","timestamp":1723264244359},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2011,3,10]],"date-time":"2011-03-10T00:00:00Z","timestamp":1299715200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0017809","type":"journal-article","created":{"date-parts":[[2011,3,10]],"date-time":"2011-03-10T21:59:46Z","timestamp":1299794386000},"page":"e17809","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Epstein\u2013Barr Virus (EBV) Rta-Mediated EBV and Kaposi's Sarcoma-Associated Herpesvirus Lytic Reactivations in 293 Cells"],"prefix":"10.1371","volume":"6","author":[{"given":"Yen-Ju","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan-Hua","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Lian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Chieh","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Ping","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen-Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Fang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2011,3,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1056\/NEJM200011093431904","article-title":"Mucosal shedding of human herpesvirus 8 in men.","volume":"343","author":"J Pauk","year":"2000","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1056\/NEJM198405103101905","article-title":"Epstein-Barr virus replication in oropharyngeal epithelial cells.","volume":"310","author":"JW Sixbey","year":"1984","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jaci.2005.05.038","article-title":"EBV the prototypical human tumor virus\u2013just how bad is it?","volume":"116","author":"DA Thorley-Lawson","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/ijc.22727","article-title":"Epstein-Barr virus B95.8 produced in 293 cells shows marked tropism for differentiated primary epithelial cells and reveals interindividual variation in susceptibility to viral infection.","volume":"121","author":"R Feederle","year":"2007","journal-title":"Int J Cancer"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"13769","DOI":"10.1128\/JVI.79.21.13769-13777.2005","article-title":"Activation of Kaposi's sarcoma-associated herpesvirus lytic gene expression during epithelial differentiation.","volume":"79","author":"AS Johnson","year":"2005","journal-title":"J Virol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1128\/JVI.65.6.2868-2874.1991","article-title":"Differentiation-associated expression of the Epstein-Barr virus BZLF1 transactivator protein in oral hairy leukoplakia.","volume":"65","author":"LS Young","year":"1991","journal-title":"J Virol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"13566","DOI":"10.1128\/JVI.01055-07","article-title":"Plasma cell-specific transcription factor XBP-1s binds to and transactivates the Epstein-Barr virus BZLF1 promoter.","volume":"81","author":"CC Sun","year":"2007","journal-title":"J Virol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"13578","DOI":"10.1128\/JVI.01663-07","article-title":"X box binding protein XBP-1s transactivates the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency.","volume":"81","author":"SJ Wilson","year":"2007","journal-title":"J Virol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1007\/s00018-007-7271-z","article-title":"Cell fate determination during G1 phase progression.","volume":"64","author":"VA Blomen","year":"2007","journal-title":"Cell Mol Life Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.4161\/cc.7.20.6853","article-title":"Underlying principles of cell fate determination during G1 phase of the mammalian cell cycle.","volume":"7","author":"B Pfeuty","year":"2008","journal-title":"Cell Cycle"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1196\/annals.1395.039","article-title":"The differentiation-associated linker histone, H1.0, during the in vitro aging and senescence of human diploid fibroblasts.","volume":"1100","author":"KE Sekeri-Pataryas","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/S0047-6374(02)00102-1","article-title":"Replicative senescence and senescence-like state induced in cancer-derived cells.","volume":"123","author":"ES Hwang","year":"2002","journal-title":"Mech Ageing Dev"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0092-8674(00)81902-9","article-title":"Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.","volume":"88","author":"M Serrano","year":"1997","journal-title":"Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nrc2772","article-title":"Senescence in tumours: evidence from mice and humans.","volume":"10","author":"M Collado","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1056\/NEJMra062285","article-title":"Oncogene-induced cell senescence\u2013halting on the road to cancer.","volume":"355","author":"WJ Mooi","year":"2006","journal-title":"N Engl J Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"13028","DOI":"10.1073\/pnas.0701953104","article-title":"Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation.","volume":"104","author":"CH Wu","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nature07260","article-title":"Modelling Myc inhibition as a cancer therapy.","volume":"455","author":"L Soucek","year":"2008","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.1128\/JVI.75.10.4475-4481.2001","article-title":"Herpesvirus lytic replication and the cell cycle: arresting new developments.","volume":"75","author":"EK Flemington","year":"2001","journal-title":"J Virol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1128\/JVI.75.5.2400-2410.2001","article-title":"Activators of the Epstein-Barr virus lytic program concomitantly induce apoptosis, but lytic gene expression protects from cell death.","volume":"75","author":"GJ Inman","year":"2001","journal-title":"J Virol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1128\/JVI.77.2.851-861.2003","article-title":"Reactivation of lytic replication from B cells latently infected with Epstein-Barr virus occurs with high S-phase cyclin-dependent kinase activity while inhibiting cellular DNA replication.","volume":"77","author":"A Kudoh","year":"2003","journal-title":"J Virol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"8245","DOI":"10.1128\/JVI.73.10.8245-8255.1999","article-title":"Perturbation of cell cycle progression and cellular gene expression as a function of herpes simplex virus ICP0.","volume":"73","author":"WE Hobbs 2nd","year":"1999","journal-title":"J Virol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"12135","DOI":"10.1128\/JVI.76.23.12135-12148.2002","article-title":"Cell cycle arrest by human cytomegalovirus 86-kDa IE2 protein resembles premature senescence.","volume":"76","author":"E Noris","year":"2002","journal-title":"J Virol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"7978","DOI":"10.1128\/JVI.72.10.7978-7984.1998","article-title":"The Epstein-Barr virus Rta protein activates lytic cycle genes and can disrupt latency in B lymphocytes.","volume":"72","author":"T Ragoczy","year":"1998","journal-title":"J Virol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"9194","DOI":"10.1073\/pnas.93.17.9194","article-title":"Epstein-Barr viral latency is disrupted by the immediate-early BRLF1 protein through a cell-specific mechanism.","volume":"93","author":"S Zalani","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"10866","DOI":"10.1073\/pnas.95.18.10866","article-title":"A viral gene that activates lytic cycle expression of Kaposi's sarcoma- associated herpesvirus.","volume":"95","author":"R Sun","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"9348","DOI":"10.1128\/JVI.73.11.9348-9361.1999","article-title":"Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells.","volume":"73","author":"DM Lukac","year":"1999","journal-title":"J Virol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4161\/cc.8.1.7411","article-title":"The Epstein-Barr virus replication and transcription activator, Rta\/BRLF1, induces cellular senescence in epithelial cells.","volume":"8","author":"YL Chen","year":"2009","journal-title":"Cell Cycle"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"11913","DOI":"10.1128\/JVI.01100-08","article-title":"Epstein-Barr virus BGLF4 kinase induces disassembly of the nuclear lamina to facilitate virion production.","volume":"82","author":"CP Lee","year":"2008","journal-title":"J Virol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.virol.2004.03.049","article-title":"Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expression.","volume":"325","author":"J Vieira","year":"2004","journal-title":"Virology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/jcp.20750","article-title":"Cell senescence: hypertrophic arrest beyond the restriction point.","volume":"209","author":"MV Blagosklonny","year":"2006","journal-title":"J Cell Physiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.4161\/cc.7.21.6919","article-title":"Growth stimulation leads to cellular senescence when the cell cycle is blocked.","volume":"7","author":"ZN Demidenko","year":"2008","journal-title":"Cell Cycle"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"11778","DOI":"10.1128\/JVI.78.21.11778-11785.2004","article-title":"The C-mer gene is induced by Epstein-Barr virus immediate-early protein BRLF1.","volume":"78","author":"Y Li","year":"2004","journal-title":"J Virol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1128\/JVI.78.8.4197-4206.2004","article-title":"Fatty acid synthase expression is induced by the Epstein-Barr virus immediate-early protein BRLF1 and is required for lytic viral gene expression.","volume":"78","author":"Y Li","year":"2004","journal-title":"J Virol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.","volume":"4","author":"W Huang da","year":"2009","journal-title":"Nat Protoc"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"W741","DOI":"10.1093\/nar\/gki475","article-title":"WebGestalt: an integrated system for exploring gene sets in various biological contexts.","volume":"33","author":"B Zhang","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrm2233","article-title":"Cellular senescence: when bad things happen to good cells.","volume":"8","author":"J Campisi","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref37","article-title":"Myc is required for the maintenance of Kaposi's sarcoma-associated herpesvirus latency.","author":"X Li","year":"2010","journal-title":"J Virol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"9635","DOI":"10.1128\/JVI.79.15.9635-9650.2005","article-title":"Marked variation in response of consensus binding elements for the Rta protein of Epstein-Barr virus.","volume":"79","author":"LW Chen","year":"2005","journal-title":"J Virol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1093\/nar\/22.7.1172","article-title":"Characterization of the DNA-binding site repertoire for the Epstein-Barr virus transcription factor R.","volume":"22","author":"H Gruffat","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1476-4598-8-53","article-title":"14-3-3sigma gene silencing during melanoma progression and its role in cell cycle control and cellular senescence.","volume":"8","author":"J Schultz","year":"2009","journal-title":"Mol Cancer"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1002\/j.1460-2075.1996.tb00635.x","article-title":"The Epstein-Barr virus bZIP transcription factor Zta causes G0\/G1 cell cycle arrest through induction of cyclin-dependent kinase inhibitors.","volume":"15","author":"C Cayrol","year":"1996","journal-title":"Embo J"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"9652","DOI":"10.1128\/JVI.77.17.9652-9661.2003","article-title":"Cell cycle regulation by Kaposi's sarcoma-associated herpesvirus K-bZIP: direct interaction with cyclin-CDK2 and induction of G1 growth arrest.","volume":"77","author":"Y Izumiya","year":"2003","journal-title":"J Virol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1128\/JVI.75.10.4482-4489.2001","article-title":"Cell cycle analysis of Epstein-Barr virus-infected cells following treatment with lytic cycle-inducing agents.","volume":"75","author":"A Rodriguez","year":"2001","journal-title":"J Virol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1128\/JVI.77.2.1481-1500.2003","article-title":"CCAAT\/enhancer binding protein alpha interacts with ZTA and mediates ZTA-induced p21(CIP-1) accumulation and G(1) cell cycle arrest during the Epstein-Barr virus lytic cycle.","volume":"77","author":"FY Wu","year":"2003","journal-title":"J Virol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"10683","DOI":"10.1073\/pnas.162352299","article-title":"Lytic replication-associated protein (RAP) encoded by Kaposi sarcoma-associated herpesvirus causes p21CIP-1-mediated G1 cell cycle arrest through CCAAT\/enhancer-binding protein-alpha.","volume":"99","author":"FY Wu","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/j.molimm.2010.02.017","article-title":"Transactivators Zta and Rta of Epstein-Barr virus promote G0\/G1 to S transition in Raji cells: a novel relationship between lytic virus and cell cycle.","volume":"47","author":"Q Guo","year":"2010","journal-title":"Mol Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"6540","DOI":"10.1128\/JVI.73.8.6540-6550.1999","article-title":"The Epstein-Barr virus protein BRLF1 activates S phase entry through E2F1 induction.","volume":"73","author":"JJ Swenson","year":"1999","journal-title":"J Virol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"8043","DOI":"10.1128\/JVI.72.10.8043-8051.1998","article-title":"The Epstein-Barr virus immediate-early gene product, BRLF1, interacts with the retinoblastoma protein during the viral lytic cycle.","volume":"72","author":"VL Zacny","year":"1998","journal-title":"J Virol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1056\/NEJM198512193132502","article-title":"Replication of Epstein-Barr virus within the epithelial cells of oral \u201chairy\u201d leukoplakia, an AIDS-associated lesion.","volume":"313","author":"JS Greenspan","year":"1985","journal-title":"N Engl J Med"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e1000496","DOI":"10.1371\/journal.ppat.1000496","article-title":"The dynamics of EBV shedding implicate a central role for epithelial cells in amplifying viral output.","volume":"5","author":"V Hadinoto","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"5762","DOI":"10.1093\/emboj\/19.21.5762","article-title":"Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways.","volume":"19","author":"SI Wells","year":"2000","journal-title":"Embo J"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1158\/0008-5472.CAN-03-3739","article-title":"Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cells.","volume":"64","author":"A Psyrri","year":"2004","journal-title":"Cancer Res"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"7093","DOI":"10.1073\/pnas.1232309100","article-title":"Transcriptome signature of irreversible senescence in human papillomavirus-positive cervical cancer cells.","volume":"100","author":"SI Wells","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1073\/pnas.0911948107","article-title":"AP-1 homolog BZLF1 of Epstein-Barr virus has two essential functions dependent on the epigenetic state of the viral genome.","volume":"107","author":"M Kalla","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"6623","DOI":"10.1038\/onc.2008.258","article-title":"C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells.","volume":"27","author":"D Zhuang","year":"2008","journal-title":"Oncogene"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"10451","DOI":"10.1128\/JVI.00804-07","article-title":"The Kaposi's sarcoma-associated herpesvirus LANA protein stabilizes and activates c-Myc.","volume":"81","author":"J Liu","year":"2007","journal-title":"J Virol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1128\/JVI.02241-08","article-title":"The human cytomegalovirus UL112-113 locus can activate the full Kaposi's sarcoma-associated herpesvirus lytic replication cycle.","volume":"83","author":"R Wells","year":"2009","journal-title":"J Virol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0140-6736(05)60199-7","article-title":"Activation of HHV-8 by HIV-1 tat.","volume":"349","author":"W Harrington Jr","year":"1997","journal-title":"Lancet"},{"key":"ref59","first-page":"716","article-title":"Characterization of seven newly established nasopharyngeal carcinoma cell lines.","volume":"68","author":"CT Lin","year":"1993","journal-title":"Lab Invest"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"9628","DOI":"10.1128\/JVI.00622-06","article-title":"Antibodies to gp350\/220 enhance the ability of Epstein-Barr virus to infect epithelial cells.","volume":"80","author":"SM Turk","year":"2006","journal-title":"J Virol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0017809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T07:44:32Z","timestamp":1592379872000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0017809"}},"subtitle":[],"editor":[{"given":"Micah","family":"Luftig","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2011,3,10]]},"references-count":60,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,3,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0017809","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,10]]}}}