{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:32:46Z","timestamp":1791228766110,"version":"4.1.0"},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2011,3,25]],"date-time":"2011-03-25T00:00:00Z","timestamp":1301011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0017985","type":"journal-article","created":{"date-parts":[[2011,3,25]],"date-time":"2011-03-25T20:53:05Z","timestamp":1301086385000},"page":"e17985","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":54,"title":["Amyotrophic Lateral Sclerosis Is Associated with Hypolipidemia at the Presymptomatic Stage in Mice"],"prefix":"10.1371","volume":"6","author":[{"given":"Sung-Min","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heejaung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee-Eun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Seok","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Joon","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Woo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,3,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuron.2006.09.018","article-title":"ALS: a disease of motor neurons and their nonneuronal neighbors.","volume":"52","author":"S Boill\u00e9e","year":"2006","journal-title":"Neuron"},{"key":"ref2","first-page":"163","article-title":"Natural history of amyotrophic lateral sclerosis: quantification of symptoms, signs, strength, and function.","volume":"68","author":"BR Brooks","year":"1995","journal-title":"Adv Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1212\/01.wnl.0000172911.39167.b6","article-title":"Prevalence and patterns of cognitive impairment in sporadic ALS.","volume":"65","author":"GM Ringholz","year":"2005","journal-title":"Neurology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1136\/jnnp.2006.111195","article-title":"Relation between cognitive dysfunction and reduced vital capacity in amyotrophic lateral sclerosis.","volume":"78","author":"SM Kim","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1126\/science.1123511","article-title":"Onset and progression in inherited ALS determined by motor neurons and microglia.","volume":"312","author":"S Boill\u00e9e","year":"2006","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/17482960802295192","article-title":"High metabolic level in patients with familial ALS.","volume":"10","author":"B Funalot","year":"2009","journal-title":"Amyotrophic Lateral Scler"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1194\/jlr.M700017-JLR200","article-title":"Increased peripheral lipid clearance in an animal model of amyotrophic lateral sclerosis.","volume":"48","author":"A Fergani","year":"2007","journal-title":"J Lipid Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"11159","DOI":"10.1073\/pnas.0402026101","article-title":"Evidence for defective energy homeostasis in amyotrophic lateral sclerosis: benefit of a high-energy diet in a transgenic mice.","volume":"101","author":"L Dupuis","year":"2004","journal-title":"PNAS"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1212\/01.wnl.0000285080.70324.27","article-title":"Dyslipidemia is a protective factor in amyotrophic lateral sclerosis.","volume":"70","author":"L Dupuis","year":"2008","journal-title":"Neurology"},{"issue":"20","key":"ref10","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1212\/WNL.0b013e3181c1df1e","article-title":"Lower serum lipid levels are related to respiratory impairment in patients with ALS.","volume":"73","author":"A Chi\u00f2","year":"2009","journal-title":"Neurology"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.biopha.2005.03.003","article-title":"The metabolic hypothesis in amyotrophic lateral sclerosis: insights from mutant Cu\/Zn-superoxide dismutase mice.","volume":"59","author":"JL Gonzalez de Aguilar","year":"2005","journal-title":"Biomed Pharmacother"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1212\/WNL.58.7.1112","article-title":"APOE: a potential marker of disease progression in ALS.","volume":"58","author":"L Lacomblez","year":"2002","journal-title":"Neurology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.8209258","article-title":"Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation.","author":"ME Gurney","year":"1994","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.neulet.2006.11.058","article-title":"Pyruvate slows disease progression in a G93A SOD1 mutant transgenic mouse.","volume":"413","author":"JH Park","year":"2007","journal-title":"Neurosci Lett"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1073\/pnas.93.7.3155","article-title":"Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions.","volume":"93","author":"PH Tu","year":"1996","journal-title":"PNAS"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"20606","DOI":"10.1073\/pnas.0707906105","article-title":"Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice.","volume":"104","author":"D Kieran","year":"2007","journal-title":"PNAS"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1038\/oby.2007.238","article-title":"C57BL\/6J and A\/J mice fed a high-fat diet delineate components of metabolic syndrome.","volume":"15","author":"C Gallou-Kabani","year":"2007","journal-title":"Obesity"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/ajcn\/74.3.328","article-title":"Factors correlated with hypermetabolism in patients with ALS.","volume":"74","author":"JC Desport","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1007\/s00415-009-5100-z","article-title":"Hypermetabolism in ALS patients: an early and persistent phenomenon.","volume":"256","author":"C Bouteloup","year":"2009","journal-title":"J Neurol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1073\/pnas.0500634102","article-title":"Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice.","volume":"102","author":"S Andersson","year":"2005","journal-title":"PNAS"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jns.2007.10.024","article-title":"Effects of estrogen on lifespan and motor functions in female hSOD1 G93A transgenic mice.","volume":"268","author":"CI Choi","year":"2008","journal-title":"J Neurol Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1002\/ana.21543","article-title":"Current hypotheses for the underlying biology of amyotrophic lateral sclerosis.","volume":"65","author":"JD Rothstein","year":"2009","journal-title":"Ann Neurol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0017985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T12:52:32Z","timestamp":1560084752000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0017985"}},"subtitle":[],"editor":[{"given":"Masato","family":"Asanuma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,3,25]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,3,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0017985","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,25]]}}}