{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:34:47Z","timestamp":1792737287685,"version":"4.5.0"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2011,3,24]],"date-time":"2011-03-24T00:00:00Z","timestamp":1300924800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0018153","type":"journal-article","created":{"date-parts":[[2011,3,24]],"date-time":"2011-03-24T21:01:31Z","timestamp":1301000491000},"page":"e18153","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Latent Stem Cell Population Is Retained in the Hippocampus of Transgenic Huntington's Disease Mice but Not Wild-Type Mice"],"prefix":"10.1371","volume":"6","author":[{"given":"Tara L.","family":"Walker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoff W.","family":"Turnbull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirinn W.","family":"Mackay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Hannan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry F.","family":"Bartlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,3,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/jnr.10670","article-title":"Enhanced neurogenesis following stroke.","volume":"73","author":"RJ Felling","year":"2003","journal-title":"J Neurosci Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.neuroscience.2004.04.061","article-title":"Neurogenesis in the striatum of the quinolinic acid lesion model of Huntington&apos;s disease.","volume":"127","author":"AS Tattersfield","year":"2004","journal-title":"Neuroscience"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"9023","DOI":"10.1073\/pnas.1532244100","article-title":"Increased cell proliferation and neurogenesis in the adult human Huntington&apos;s disease brain.","volume":"100","author":"MA Curtis","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.neuroscience.2004.12.051","article-title":"The distribution of progenitor cells in the subependymal layer of the lateral ventricle in the normal and Huntington&apos;s disease human brain.","volume":"132","author":"MA Curtis","year":"2005","journal-title":"Neuroscience"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.","volume":"87","author":"L Mangiarini","year":"1996","journal-title":"Cell"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/35008142","article-title":"Delaying the onset of Huntington&apos;s in mice.","volume":"404","author":"A van Dellen","year":"2000","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"8093","DOI":"10.1073\/pnas.110078997","article-title":"Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington&apos;s disease.","volume":"97","author":"M Turmaine","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1523\/JNEUROSCI.1658-03.2004","article-title":"Environmental enrichment rescues protein deficits in a mouse model of Huntington&apos;s disease, indicating a possible disease mechanism.","volume":"24","author":"TL Spires","year":"2004","journal-title":"J Neurosci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1523\/JNEUROSCI.4320-04.2005","article-title":"Deficits in experience-dependent cortical plasticity and sensory-discrimination learning in presymptomatic Huntington&apos;s disease mice.","volume":"25","author":"NK Mazarakis","year":"2005","journal-title":"J Neurosci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"11564","DOI":"10.1523\/JNEUROSCI.3796-05.2005","article-title":"Abnormalities of neurogenesis in the R6\/2 mouse model of Huntington&apos;s disease are attributable to the <italic>in vivo<\/italic> microenvironment.","volume":"25","author":"W Phillips","year":"2005","journal-title":"J Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1111\/j.1460-9568.2005.04365.x","article-title":"Cognitive disorders and neurogenesis deficits in Huntington&apos;s disease mice are rescued by fluoxetine.","volume":"22","author":"HE Grote","year":"2005","journal-title":"Eur J Neurosci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1097\/00001756-200404090-00014","article-title":"Decreased hippocampal cell proliferation in R6\/1 Huntington&apos;s mice.","volume":"15","author":"SE Lazic","year":"2004","journal-title":"Neuroreport"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"5240","DOI":"10.1523\/JNEUROSCI.0344-08.2008","article-title":"Latent stem and progenitor cells in the hippocampus are activated by neural excitation.","volume":"28","author":"TL Walker","year":"2008","journal-title":"J Neurosci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.neuroscience.2006.04.013","article-title":"Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington&apos;s disease transgenic mice.","volume":"141","author":"TY Pang","year":"2006","journal-title":"Neuroscience"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1523\/JNEUROSCI.5060-06.2007","article-title":"The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells.","volume":"27","author":"TL Walker","year":"2007","journal-title":"J Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"10815","DOI":"10.1523\/JNEUROSCI.3249-05.2005","article-title":"The adult mouse hippocampal progenitor is neurogenic but not a stem cell.","volume":"25","author":"ND Bull","year":"2005","journal-title":"J Neurosci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"10452","DOI":"10.1523\/JNEUROSCI.2850-06.2006","article-title":"A progressive and cell non-autonomous increase in striatal neural stem cells in the Huntington&apos;s disease R6\/2 mouse.","volume":"26","author":"CMC Batista","year":"2006","journal-title":"J Neurosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1097\/00001756-199512150-00010","article-title":"Age-related production of new granule cells in the adult dentate gyrus.","volume":"6","author":"T Seki","year":"1995","journal-title":"Neuroreport"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1523\/JNEUROSCI.16-06-02027.1996","article-title":"Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation.","volume":"16","author":"HG Kuhn","year":"1996","journal-title":"J Neurosci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1111\/j.1460-9568.2006.04715.x","article-title":"Neurogenesis in the R6\/1 transgenic mouse model of Huntington&apos;s disease: effects of environmental enrichment.","volume":"23","author":"SE Lazic","year":"2006","journal-title":"Eur J Neurosci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1523\/JNEUROSCI.3780-09.2010","article-title":"Norepinephrine directly activates adult hippocampal precursors via beta3-adrenergic receptors.","volume":"30","author":"DJ Jhaveri","year":"2010","journal-title":"J Neurosci"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0018153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T12:09:20Z","timestamp":1560082160000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0018153"}},"subtitle":[],"editor":[{"given":"Jialin","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,3,24]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,3,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0018153","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,24]]}}}