{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:53:04Z","timestamp":1790851984595,"version":"4.1.0"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T00:00:00Z","timestamp":1302134400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0018303","type":"journal-article","created":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T20:51:38Z","timestamp":1302209498000},"page":"e18303","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Brain Abnormalities and Glioma-Like Lesions in Mice Overexpressing the Long Isoform of PDGF-A in Astrocytic Cells"],"prefix":"10.1371","volume":"6","author":[{"given":"Inga","family":"Nazarenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Hedr\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Sj\u00f6din","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abiel","family":"Orrego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Andrae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gijs B.","family":"Afink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Nist\u00e9r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael S.","family":"Lindstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,4,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1101\/gad.1653708","article-title":"Role of platelet-derived growth factors in physiology and medicine.","volume":"22","author":"J Andrae","year":"2008","journal-title":"Genes Dev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cytogfr.2004.03.007","article-title":"The PDGF family: four gene products form five dimeric isoforms.","volume":"15","author":"L Fredriksson","year":"2004","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1152\/physrev.1999.79.4.1283","article-title":"Mechanism of action and in vivo role of platelet-derived growth factor.","volume":"79","author":"CH Heldin","year":"1999","journal-title":"Physiol Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S0021-9258(17)42200-9","article-title":"Characterization of the retention motif in the C-terminal part of the long splice form of platelet-derived growth factor A-chain.","volume":"269","author":"M Andersson","year":"1994","journal-title":"J Biol Chem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1128\/MCB.8.2.571","article-title":"Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins.","volume":"8","author":"F Rorsman","year":"1988","journal-title":"Mol Cell Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1006\/abbi.2001.2707","article-title":"New members of the platelet-derived growth factor family of mitogens.","volume":"398","author":"CH Heldin","year":"2002","journal-title":"Arch Biochem Biophys"},{"key":"ref7","first-page":"925","article-title":"Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14.","volume":"8","author":"D Maglione","year":"1993","journal-title":"Oncogene"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/344299a0","article-title":"Analogous alternative splicing.","volume":"344","author":"C Betsholtz","year":"1990","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1126\/science.3413486","article-title":"Platelet-derived growth factor A chain is maternally encoded in Xenopus embryos.","volume":"241","author":"M Mercola","year":"1988","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3109\/08977199209046928","article-title":"Platelet-derived growth factor (PDGF) A-chain mRNA heterogeneity generated by the use of alternative promoters and alternative polyadenylation sites.","volume":"7","author":"F Rorsman","year":"1992","journal-title":"Growth Factors"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/320695a0","article-title":"cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines.","volume":"320","author":"C Betsholtz","year":"1986","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/328621a0","article-title":"Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain.","volume":"328","author":"T Collins","year":"1987","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1128\/MCB.9.7.3148","article-title":"Alternative splicing of the platelet-derived growth factor A-chain transcript occurs in normal as well as tumor cells and is conserved among mammalian species.","volume":"9","author":"B Matoskova","year":"1989","journal-title":"Mol Cell Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"6051","DOI":"10.1128\/MCB.10.11.6051","article-title":"Alternatively spliced platelet-derived growth factor A-chain transcripts are not tumor specific but encode normal cellular proteins.","volume":"10","author":"RM Young","year":"1990","journal-title":"Mol Cell Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0896-6273(00)80244-5","article-title":"PDGF mediates a neuron-astrocyte interaction in the developing retina.","volume":"17","author":"M Fruttiger","year":"1996","journal-title":"Neuron"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0896-6273(00)80469-9","article-title":"Oligodendrocyte population dynamics and the role of PDGF in vivo.","volume":"20","author":"AR Calver","year":"1998","journal-title":"Neuron"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cytogfr.2004.03.005","article-title":"Insight into the physiological functions of PDGF through genetic studies in mice.","volume":"15","author":"C Betsholtz","year":"2004","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0092-8674(00)81270-2","article-title":"PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis.","volume":"85","author":"H Bostrom","year":"1996","journal-title":"Cell"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/333560a0","article-title":"Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte\/type-2 astrocyte progenitor cell.","volume":"333","author":"M Noble","year":"1988","journal-title":"Nature"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/333562a0","article-title":"Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture.","volume":"333","author":"MC Raff","year":"1988","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0092-8674(88)90392-3","article-title":"A role for platelet-derived growth factor in normal gliogenesis in the central nervous system.","volume":"53","author":"WD Richardson","year":"1988","journal-title":"Cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1242\/dev.126.3.457","article-title":"Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice.","volume":"126","author":"M Fruttiger","year":"1999","journal-title":"Development"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0925-4773(01)00460-9","article-title":"A 1.8 kb GFAP-promoter fragment is active in specific regions of the embryonic CNS.","volume":"107","author":"J Andrae","year":"2001","journal-title":"Mech Dev"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.jocn.2007.04.009","article-title":"Biology of the subventricular zone in relation to gliomagenesis.","volume":"14","author":"K Barami","year":"2007","journal-title":"J Clin Neurosci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(00)80783-7","article-title":"Subventricular zone astrocytes are neural stem cells in the adult mammalian brain.","volume":"97","author":"F Doetsch","year":"1999","journal-title":"Cell"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00441-007-0461-z","article-title":"Cells in the astroglial lineage are neural stem cells.","volume":"331","author":"RA Ihrie","year":"2008","journal-title":"Cell Tissue Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.ceb.2006.09.008","article-title":"Neural stem cells in mammalian development.","volume":"18","author":"FT Merkle","year":"2006","journal-title":"Curr Opin Cell Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/glia.20837","article-title":"GFAP promoter driven transgenic expression of PDGFB in the mouse brain leads to glioblastoma in a Trp53 null background.","volume":"57","author":"SM Hede","year":"2009","journal-title":"Glia"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.1073\/pnas.91.10.4303","article-title":"Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.","volume":"91","author":"P Mountford","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0925-4773(97)00190-1","article-title":"Specific expression in mouse mesoderm- and neural crest-derived tissues of a human PDGFRA promoter\/lacZ transgene.","volume":"70","author":"XQ Zhang","year":"1998","journal-title":"Mech Dev"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neuron.2006.06.012","article-title":"PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling.","volume":"51","author":"EL Jackson","year":"2006","journal-title":"Neuron"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1242\/dev.115.4.1045","article-title":"Platelet-derived growth factor-A and its receptor are expressed in separate, but adjacent cell layers of the mouse embryo.","volume":"115","author":"A Orr-Urtreger","year":"1992","journal-title":"Development"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1002\/j.1460-2075.1989.tb03472.x","article-title":"PDGF A chain homodimers drive proliferation of bipotential (O-2A) glial progenitor cells in the developing rat optic nerve.","volume":"8","author":"N Pringle","year":"1989","journal-title":"EMBO J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0092-8674(91)90222-K","article-title":"PDGF A-chain gene is expressed by mammalian neurons during development and in maturity.","volume":"64","author":"HJ Yeh","year":"1991","journal-title":"Cell"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1517\/14712598.4.8.1191","article-title":"The choroid plexus: function, pathology and therapeutic potential of its transplantation.","volume":"4","author":"DF Emerich","year":"2004","journal-title":"Expert Opin Biol Ther"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1750-3639.2004.tb00070.x","article-title":"Insights into the pathogenesis of hydrocephalus from transgenic and experimental animal models.","volume":"14","author":"L Crews","year":"2004","journal-title":"Brain Pathol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/ddrr.94","article-title":"Neuropathology and structural changes in hydrocephalus.","volume":"16","author":"MR Del Bigio","journal-title":"Dev Disabil Res Rev"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1016\/j.yexcr.2010.07.009","article-title":"Enlarged lateral ventricles and aberrant behavior in mice overexpressing PDGF-B in embryonic neural stem cells.","volume":"316","author":"M Niklasson","year":"2010","journal-title":"Exp Cell Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1091\/mbc.2.7.503","article-title":"Identification of a cell retention signal in the B-chain of platelet-derived growth factor and in the long splice version of the A-chain.","volume":"2","author":"A Ostman","year":"1991","journal-title":"Cell Regul"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1126\/science.2648568","article-title":"Glial cell diversification in the rat optic nerve.","volume":"243","author":"MC Raff","year":"1989","journal-title":"Science"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/303390a0","article-title":"A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium.","volume":"303","author":"MC Raff","year":"1983","journal-title":"Nature"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000111186","article-title":"Origins of spinal cord oligodendrocytes: possible developmental and evolutionary relationships with motor neurons.","volume":"19","author":"WD Richardson","year":"1997","journal-title":"Dev Neurosci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1242\/dev.105.3.595","article-title":"PDGF receptors on cells of the oligodendrocyte-type-2 astrocyte (O-2A) cell lineage.","volume":"105","author":"IK Hart","year":"1989","journal-title":"Development"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.mcn.2003.10.014","article-title":"Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination.","volume":"25","author":"RH Woodruff","year":"2004","journal-title":"Mol Cell Neurosci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1523\/JNEUROSCI.21-10-03483.2001","article-title":"Immature neurons from CNS stem cells proliferate in response to platelet-derived growth factor.","volume":"21","author":"A Erlandsson","year":"2001","journal-title":"J Neurosci"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1101\/gad.903001","article-title":"PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo.","volume":"15","author":"C Dai","year":"2001","journal-title":"Genes Dev"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1750-3639.2009.00335.x","article-title":"Recent insights into PDGF-Induced gliomagenesis.","volume":"20","author":"F Calzolari","year":"2010","journal-title":"Brain Pathol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1159\/000114541","article-title":"Characterization of adult neural stem cells and their relation to brain tumors.","volume":"188","author":"EL Jackson","year":"2008","journal-title":"Cells Tissues Organs"},{"key":"ref49","first-page":"5275","article-title":"Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus.","volume":"58","author":"L Uhrbom","year":"1998","journal-title":"Cancer Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1535-6108(02)00029-6","article-title":"Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation.","volume":"1","author":"A Xiao","year":"2002","journal-title":"Cancer Cell"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0018303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T08:24:42Z","timestamp":1637483082000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0018303"}},"subtitle":[],"editor":[{"given":"Maria G.","family":"Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,4,7]]},"references-count":50,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,4,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0018303","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,7]]}}}