{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:28:27Z","timestamp":1791106107006,"version":"4.1.0"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2011,3,31]],"date-time":"2011-03-31T00:00:00Z","timestamp":1301529600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0018336","type":"journal-article","created":{"date-parts":[[2011,3,31]],"date-time":"2011-03-31T21:00:44Z","timestamp":1301605244000},"page":"e18336","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":45,"title":["Altered Dopamine and Serotonin Metabolism in Motorically Asymptomatic R6\/2 Mice"],"prefix":"10.1371","volume":"6","author":[{"given":"Fanny","family":"Mochel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Durant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Durr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Schiffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,3,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington&apos;s disease chromosomes.","volume":"72","year":"1993","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/306234a0","article-title":"A polymorphic DNA marker genetically linked to Huntington&apos;s disease.","volume":"306","author":"JF Gusella","year":"1983","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.biopsych.2006.11.034","article-title":"Psychiatric symptoms in Huntington&apos;s disease before diagnosis: the predict-HD study.","volume":"62","author":"K Duff","year":"2007","journal-title":"Biol Psychiatry"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.neuropsychologia.2009.10.016","article-title":"Irritability in pre-clinical Huntington&apos;s disease.","volume":"48","author":"S Kloppel","year":"2010","journal-title":"Neuropsychologia"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1046\/j.1471-4159.2002.00804.x","article-title":"The role of dopamine in motor symptoms in the R6\/2 transgenic mouse model of Huntington&apos;s disease.","volume":"81","author":"MA Hickey","year":"2002","journal-title":"J Neurochem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/brain\/awl332","article-title":"The fate of striatal dopaminergic neurons in Parkinson&apos;s disease and Huntington&apos;s chorea.","volume":"130","author":"P Huot","year":"2007","journal-title":"Brain"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0014-2999(83)90009-2","article-title":"Dopamine D-1 and D-2 receptors in Huntington&apos;s disease.","volume":"88","author":"A Cross","year":"1983","journal-title":"Eur J Pharmacol"},{"issue":"Pt 7","key":"ref8","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1093\/brain\/121.7.1343","article-title":"The relationship between striatal dopamine receptor binding and cognitive performance in Huntington&apos;s disease.","volume":"121","author":"AD Lawrence","year":"1998","journal-title":"Brain"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1212\/01.wnl.0000176071.08694.cc","article-title":"Striatal dopamine D2 receptors, metabolism, and volume in preclinical Huntington disease.","volume":"65","author":"JC van Oostrom","year":"2005","journal-title":"Neurology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"9723","DOI":"10.1523\/JNEUROSCI.3044-08.2008","article-title":"Dysregulation of gene expression in primary neuron models of Huntington&apos;s disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry.","volume":"28","author":"H Runne","year":"2008","journal-title":"J Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11940-000-0007-0","article-title":"Huntington&apos;s Disease.","volume":"2","author":"BA Haskins","year":"2000","journal-title":"Curr Treat Options Neurol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1212\/WNL.53.7.1605","article-title":"Long-lasting improvement following (-)-OSU6162 in a patient with Huntington&apos;s disease.","volume":"53","author":"J Tedroff","year":"1999","journal-title":"Neurology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1046\/j.1471-4159.1999.721773.x","article-title":"Brain neurotransmitter deficits in mice transgenic for the Huntington&apos;s disease mutation.","volume":"72","author":"GP Reynolds","year":"1999","journal-title":"J Neurochem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0014-2999(93)90073-Q","article-title":"Reduced levels of 5-HT3 receptor recognition sites in the putamen of patients with Huntington&apos;s disease.","volume":"242","author":"LJ Steward","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"ref15","first-page":"425","article-title":"Postmortem instability of dopamine and its metabolites in rat striatum and limbic forebrain.","volume":"50","author":"B Karolewicz","year":"1998","journal-title":"Pol J Pharmacol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"8857","DOI":"10.1073\/pnas.0701681104","article-title":"Deletion of PrBP\/delta impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments.","volume":"104","author":"H Zhang","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jneumeth.2003.12.006","article-title":"Focused microwave irradiation of the brain preserves in vivo protein phosphorylation: comparison with other methods of sacrifice and analysis of multiple phosphoproteins.","volume":"135","author":"JP O'Callaghan","year":"2004","journal-title":"J Neurosci Methods"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1073\/pnas.0610779104","article-title":"The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington&apos;s and prion diseases.","volume":"104","author":"AD Steele","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.bbr.2008.10.043","article-title":"Differential effects of exogenous and endogenous estrogen on anxiety as measured by elevated T-maze in relation to the serotonergic system.","volume":"198","author":"J Pandaranandaka","year":"2009","journal-title":"Behav Brain Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"6055","DOI":"10.1523\/JNEUROSCI.0032-08.2008","article-title":"Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression.","volume":"28","author":"RM Hines","year":"2008","journal-title":"J Neurosci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jneumeth.2004.10.001","article-title":"The grooming analysis algorithm discriminates between different levels of anxiety in rats: potential utility for neurobehavioural stress research.","volume":"143","author":"AV Kalueff","year":"2005","journal-title":"J Neurosci Methods"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.expneurol.2008.05.017","article-title":"Aberrant connectivity of lateral prefrontal networks in presymptomatic Huntington&apos;s disease.","volume":"213","author":"RC Wolf","year":"2008","journal-title":"Exp Neurol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1136\/jnnp.40.6.581","article-title":"Biochemical aspects of Huntington&apos;s chorea.","volume":"40","author":"T Caraceni","year":"1977","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1136\/jnnp.44.3.258","article-title":"Homovanilic acid in Huntington&apos;s disease and Sydenham&apos;s chorea.","volume":"44","author":"L Cunha","year":"1981","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1001\/archpsyc.1986.01800020071009","article-title":"Neurochemistry of dopamine in Huntington&apos;s dementia and normal aging.","volume":"43","author":"SM Stahl","year":"1986","journal-title":"Arch Gen Psychiatry"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bbr.2009.04.034","article-title":"Detection of early behavioral markers of Huntington&apos;s disease in R6\/2 mice employing an automated social home cage.","volume":"203","author":"O Rudenko","year":"2009","journal-title":"Behav Brain Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1046\/j.1471-4159.2003.01704.x","article-title":"Mice transgenic for exon 1 of Huntington&apos;s disease: properties of cholinergic and dopaminergic pre-synaptic function in the striatum.","volume":"85","author":"JM Vetter","year":"2003","journal-title":"J Neurochem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1111\/j.1471-4159.2007.04908.x","article-title":"Catecholamine exocytosis is diminished in R6\/2 Huntington&apos;s disease model mice.","volume":"103","author":"MA Johnson","year":"2007","journal-title":"J Neurochem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/j.1471-4159.2009.06501.x","article-title":"Dysregulation of intracellular dopamine stores revealed in the R6\/2 mouse striatum.","volume":"112","author":"AN Ortiz","year":"2010","journal-title":"J Neurochem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1093\/brain\/awm217","article-title":"Thalamic metabolism and symptom onset in preclinical Huntington&apos;s disease.","volume":"130","author":"A Feigin","year":"2007","journal-title":"Brain"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1471-4159.1987.tb04106.x","article-title":"Time course of adaptations in dopamine biosynthesis, metabolism, and release following nigrostriatal lesions: implications for behavioral recovery from brain injury.","volume":"48","author":"CA Altar","year":"1987","journal-title":"J Neurochem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/hmg\/ddn385","article-title":"Altered serotonin receptor expression is associated with depression-related behavior in the R6\/1 transgenic mouse model of Huntington&apos;s disease.","volume":"18","author":"TY Pang","year":"2009","journal-title":"Hum Mol Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.expneurol.2007.10.015","article-title":"The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6\/2 Huntington&apos;s disease mouse model.","volume":"210","author":"Q Peng","year":"2008","journal-title":"Exp Neurol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.nbd.2008.01.015","article-title":"Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington&apos;s disease.","volume":"30","author":"W Duan","year":"2008","journal-title":"Neurobiol Dis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0079-6123(08)00928-X","article-title":"Serotonin\/dopamine interaction in memory formation.","volume":"172","author":"I Gonzalez-Burgos","year":"2008","journal-title":"Prog Brain Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0165-0270(95)00119-0","article-title":"Brain regional levels of adenosine and adenosine nucleotides in rats killed by high-energy focused microwave irradiation.","volume":"64","author":"SM Delaney","year":"1996","journal-title":"J Neurosci Methods"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0018336","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T20:24:59Z","timestamp":1540239899000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0018336"}},"subtitle":[],"editor":[{"given":"David","family":"Rubinsztein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,3,31]]},"references-count":36,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,3,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0018336","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,31]]}}}