{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:32:23Z","timestamp":1787851943308,"version":"build-2784847793"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2011,4,29]],"date-time":"2011-04-29T00:00:00Z","timestamp":1304035200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0018368","type":"journal-article","created":{"date-parts":[[2011,4,29]],"date-time":"2011-04-29T17:24:03Z","timestamp":1304097843000},"page":"e18368","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Effect of Anandamide on Uterine Nitric Oxide Synthase Activity Depends on the Presence of the Blastocyst"],"prefix":"10.1371","volume":"6","author":[{"given":"Micaela S.","family":"Sordelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimena S.","family":"Beltrame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Burdet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Zotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Pardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximiliano","family":"Cella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Franchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Laura","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,4,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/S0140-6736(00)02108-5","article-title":"Prediction of pregnancy loss.","volume":"355","author":"CJ Lockwood","year":"2000","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1093\/humrep\/del075","article-title":"The European IVF-monitoring programme (EIM) for the European Society of Human Reproduction and Embryology (ESHRE) Assisted reproductive technology in Europe, 2002. Results generated from European registers by ESHRE.","volume":"21","author":"AN Andersen","year":"2006","journal-title":"Hum Reprod"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1146\/annurev.ph.57.030195.003423","article-title":"Nitric oxide synthases: properties and catalytic mechanism.","volume":"57","author":"OW Griffith","year":"1995","journal-title":"Annu Rev Physiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/molehr\/5.5.467","article-title":"Nitric oxide synthase distribution during implantation in the mouse.","volume":"5","author":"TL Purcell","year":"1999","journal-title":"Mol Hum Reprod"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1071\/R97005","article-title":"Nitric oxide synthase regulation during embryonic implantation.","volume":"9","author":"V Novaro","year":"1997","journal-title":"Reprod Fertil Dev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1071\/RD99044","article-title":"Optimal levels of nitric oxide are crucial for implantation in mice.","volume":"11","author":"H Ota","year":"1999","journal-title":"Reprod Fertil Dev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1126\/science.1470919","article-title":"Isolation and structure of a brain constituent that binds to the cannabinoid receptor.","volume":"258","author":"WA Devane","year":"1992","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/S0140-6736(98)05021-1","article-title":"Adverse effects of cannabis.","volume":"352","author":"W Hall","year":"1998","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nm0104-19","article-title":"THC: moderation during implantation.","volume":"10","author":"D Piomelli","year":"2004","journal-title":"Nat Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/346561a0","article-title":"Structure of a cannabinoid receptor and functional expression of the cloned cDNA.","volume":"346","author":"LA Matsuda","year":"1990","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/365061a0","article-title":"Molecular characterization of a peripheral receptor for cannabinoids.","volume":"365","author":"S Munro","year":"1993","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"20523","DOI":"10.1074\/jbc.M100679200","article-title":"Dysregulated cannabinoid signalling disrupts uterine receptivity for embryo implantation.","volume":"276","author":"BC Paria","year":"2001","journal-title":"J Biol Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"14914","DOI":"10.1073\/pnas.2436379100","article-title":"Differential G proteincoupled cannabinoid receptor signalling by anandamide directs blastocyst activation for implantation.","volume":"100","author":"H Wang","year":"2003","journal-title":"Proc Nat Acad Sci USA"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"23429","DOI":"10.1074\/jbc.C500168200","article-title":"N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation.","volume":"280","author":"Y Guo","year":"2005","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/(SICI)1098-2795(199610)45:2<183::AID-MRD11>3.0.CO;2-2","article-title":"The uterus is a potential site for anandamide synthesis and hydrolysis: differential profiles of anandamide synthase and hydrolase activities in the mouse uterus during the periimplantation period.","volume":"45","author":"BC Paria","year":"1996","journal-title":"Mol Reprod Dev"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1472-6483(10)60258-1","article-title":"17\u03b2-estradiol and progesterone regulate anandamide synthesis in the rat uterus.","volume":"18","author":"ML Ribeiro","year":"2009","journal-title":"Reprod Biomed Online"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.neuropharm.2004.07.030","article-title":"Cannabinoid physiology and pharmacology: 30 years of progress.","volume":"47","author":"AC Howlett","year":"2004","journal-title":"Neuropharmacology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.lfs.2005.05.055","article-title":"Cannabinoid signalling.","volume":"78","author":"DG Demuth","year":"2006","journal-title":"Life Sci"},{"key":"ref19","first-page":"RA63","article-title":"Endocannabinoids as autoregulatory signalling molecules: coupling to nitric oxide and a possible association with the relaxation response.","volume":"9","author":"GB Stefano","year":"2003","journal-title":"Med Sci Monit"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/S1472-6483(10)60033-8","article-title":"Anandamide regulates lipopolysaccharide-induced nitric oxide synthesis and tissue damage in the murine uterus.","volume":"18","author":"CA Vercelli","year":"2009","journal-title":"Reprod Biomed Online"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.placenta.2009.04.003","article-title":"Endocannabinoid system and nitric oxide are involved in the deleterious effects of lipopolysaccharide on murine decidua.","volume":"30","author":"CA Vercelli","year":"2009","journal-title":"Placenta"},{"key":"ref22","first-page":"233","article-title":"Mechanism of the luteolytic action of prostaglandin F-2 alpha in the rat.","volume":"37","author":"M Lahav","year":"1989","journal-title":"J Reprod Fertil"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"9030","DOI":"10.1073\/pnas.86.22.9030","article-title":"Nitric oxide mediates glutamate linked enhancement of cGMP levels in the cerebellum.","volume":"86","author":"DS Bredt","year":"1989","journal-title":"Proc Nat Acad Sci USA"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.","volume":"72","author":"M Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/sj.bjp.0703094","article-title":"Comparison of novel cannabinoid partial agonists and SR141716Ai n the guinea-pig small intestine.","volume":"129","author":"AA Coutts","year":"2000","journal-title":"Br J Pharmacol"},{"key":"ref27","first-page":"582","article-title":"SR 144528, an antagonist for the peripheral cannabinoid receptor that behaves as an inverse agonist.","volume":"288","author":"M Portier","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"ref28","first-page":"243","article-title":"The biodisposition and metabolism of anandamide in mice.","volume":"282","author":"KA Willoughby","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0009-3084(02)00158-5","article-title":"N-Acylethanolamines in human reproductive fluids.","volume":"121","author":"H Schuel","year":"2002","journal-title":"Chem Phys Lipids"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/0024-3205(95)00174-5","article-title":"Biochemical and pharmacological characterisation of SR141716A, the first potent and selective brain cannabinoid receptor antagonist.","volume":"56","author":"M Rinaldi-Carmona","year":"1995","journal-title":"Life Sci"},{"key":"ref31","first-page":"644","article-title":"SR 144528, the First Potent and Selective Antagonist of the CB2 Cannabinoid Receptor.","volume":"284","author":"M Rinaldi-Carmona","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1046\/j.1432-1033.2002.03078.x","article-title":"Presence and regulation of the endocannabinoid system in human dendritic cells.","volume":"269","author":"I Matias","year":"2002","journal-title":"Eur J Biochem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1530\/rep.0.1210403","article-title":"Nitric oxide synthases in pregnant rat uterus.","volume":"121","author":"M Farina","year":"2001","journal-title":"Reproduction"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1006\/niox.2000.0286","article-title":"Increased appearance of inducible nitric oxide synthase in the uterus and embryo at implantation.","volume":"4","author":"D Saxena","year":"2000","journal-title":"Nitric Oxide"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/288373a0","article-title":"The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.","volume":"288","author":"RF Furchgott","year":"1980","journal-title":"Nature"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1071\/RD01036","article-title":"Regulation of metalloproteinases by nitric oxide in human trophoblast cells in culture.","volume":"13","author":"V Novaro","year":"2001","journal-title":"Reprod Fertil Dev"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.placenta.2008.05.003","article-title":"Dual effect of anandamide on rat placenta nitric oxide synthesis.","volume":"29","author":"M Cella","year":"2008","journal-title":"Placenta"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/sj.bjp.0707444","article-title":"CB2 receptors in reproduction.","volume":"153","author":"M Maccarrone","year":"2008","journal-title":"Br J Pharmacol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"359","DOI":"10.2174\/1381612033391784","article-title":"Nitric oxide and its role during pregnancy: from ovulation to delivery.","volume":"9","author":"H Maul","year":"2003","journal-title":"Curr Pharm Des"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4332","DOI":"10.1073\/pnas.92.10.4332","article-title":"Cannabinoid ligand\u2013receptor signalling in the mouse uterus.","volume":"92","author":"SK Das","year":"1995","journal-title":"Proc Nat Acad Sci USA"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0306-4522(97)00348-5","article-title":"Expression of the CB1 and CB2 receptor messenger RNAs during embryonic development in the rat.","volume":"82","author":"NE Buckley","year":"1998","journal-title":"Neuroscience"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.placenta.2009.05.012","article-title":"Anandamide-Induced Cell Death: Dual Effects in Primary Rat Decidual Cell Cultures.","volume":"30","author":"BM Fonseca","year":"2009","journal-title":"Placenta"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1477-7827-7-121","article-title":"Spatio-temporal expression patterns of anandamide-binding receptors in rat implantation sites: evidence for a role of the endocannabinoid system during the period of placental development.","volume":"7","author":"BM Fonseca","year":"2009","journal-title":"Reprod Biol Endocrinol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0018368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T14:08:14Z","timestamp":1540217294000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0018368"}},"subtitle":[],"editor":[{"given":"T. Mark","family":"Doherty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,4,29]]},"references-count":43,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,4,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0018368","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,29]]}}}