{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:43:06Z","timestamp":1790854986906,"version":"4.1.0"},"reference-count":113,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2011,4,29]],"date-time":"2011-04-29T00:00:00Z","timestamp":1304035200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0018685","type":"journal-article","created":{"date-parts":[[2011,4,29]],"date-time":"2011-04-29T21:24:46Z","timestamp":1304112286000},"page":"e18685","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":76,"title":["A Computational Model of the Ionic Currents, Ca2+ Dynamics and Action Potentials Underlying Contraction of Isolated Uterine Smooth Muscle"],"prefix":"10.1371","volume":"6","author":[{"given":"Wing-Chiu","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia Y.","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Karche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun V.","family":"Holden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henggui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Taggart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2011,4,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1152\/ajplegacy.1956.187.2.333","article-title":"Transmembrane potentials and contractility in the pregnant rat uterus.","volume":"187","author":"J Landa","year":"1956","journal-title":"Am J Physiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1152\/ajplegacy.1959.196.4.905","article-title":"Relationships between contraction and membrane electrical activity in the isolated uterus of the pregnant rat.","volume":"196","author":"JF Landa","year":"1959","journal-title":"Am J Physiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1113\/jphysiol.1963.sp007081","article-title":"Effects of ions and drugs on cell membrane activity and tension in the postpartum rat myometrium.","volume":"165","author":"IA Csapo","year":"1963","journal-title":"J Physiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.semcdb.2007.05.004","article-title":"Physiology and electrical activity of uterine contractions.","volume":"18","author":"RE Garfield","year":"2007","journal-title":"Semin Cell Dev Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.semcdb.2007.05.006","article-title":"Regulation of the uterine contractile apparatus and cytoskeleton.","volume":"18","author":"MJ Taggart","year":"2007","journal-title":"Semin Cell Dev Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology and causes of preterm birth.","volume":"371","author":"RL Goldenberg","year":"2008","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ejogrb.2005.04.015","article-title":"Outcomes of labours augmented with oxytocin.","volume":"124","author":"GJ Bugg","year":"2006","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"Pt 1","key":"ref8","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1469-7793.1999.229af.x","article-title":"Hyperpolarization and slowing of the rate of contraction in human uterus in pregnancy by prostaglandins E<sub>2<\/sub> and F<sub>2<italic>\u03b1<\/italic><\/sub>: Involvement of the Na<sup>+<\/sup> pump.","volume":"514","author":"HC Parkington","year":"1999","journal-title":"J Physiol"},{"key":"ref9","first-page":"523","article-title":"Cellular ionic mechanisms controlling uterine smooth muscle contraction: effects of gestational state.","author":"MJ Taggart","year":"2007"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1095\/biolreprod38.4.836","article-title":"Effects of tetraethylammonium and 4-aminopyridine on the plateau potential of circular myometrium from the pregnant rat.","volume":"38","author":"DW Wilde","year":"1988","journal-title":"Biol Reprod"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1139\/y99-046","article-title":"Augmentation and suppression of action potentials by estradiol in the myometrium of pregnant rat.","volume":"77","author":"Y Inoue","year":"1999","journal-title":"Can J Physiol Pharmacol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/j.1469-7793.1998.803bg.x","article-title":"Properties of voltage-activated [Ca<sup>2+<\/sup>]<sub>i<\/sub> transients in, single smooth muscle cells isolated from pregnant rat uterus.","volume":"511","author":"AV Shmigol","year":"1998","journal-title":"J Physiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1113\/jphysiol.2007.132126","article-title":"Characterization of the molecular and electrophysiological properties of the T-type calcium channel in human myometrium.","volume":"581","author":"AM Blanks","year":"2007","journal-title":"J Physiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF00240301","article-title":"Fast Na<sup>+<\/sup> channels and slow Ca<sup>2+<\/sup> current in smooth muscle from pregnant rat uterus.","volume":"114","author":"N Sperelakis","year":"1992","journal-title":"Mol Cell Biochem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s00424-003-1224-7","article-title":"Electrophysiological characterization and functional importance of calcium-activated chloride channel in rat uterine myocytes.","volume":"448","author":"K Jones","year":"2004","journal-title":"Pflugers Arch"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1098\/rspb.1993.0002","article-title":"Properties of large-conductance K<sup>+<\/sup> channels in human myometrium during pregnancy and labour.","volume":"251","author":"RN Khan","year":"1993","journal-title":"Proc Biol Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1085\/jgp.112.6.737","article-title":"Potassium currents in freshly dissociated uterine myocytes from nonpregnant and late-pregnant rats.","volume":"112","author":"SY Wang","year":"1998","journal-title":"J Gen Physiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/sj.bjp.0702685","article-title":"Calcium antagonistic properties of the cyclooxygenase-2 inhibitor nimesulide in human myometrial myocytes.","volume":"127","author":"GA Knock","year":"1999","journal-title":"Br J Pharmacol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1469-7793.1999.0769p.x","article-title":"Voltage-gated K<sup>+<\/sup> currents in freshly isolated myocytes of, the pregnant human myometrium.","volume":"518","author":"GA Knock","year":"1999","journal-title":"J Physiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ceca.2009.11.004","article-title":"Distribution, expression and functional effects of small conductance Ca-activated potassium (SK) channels in rat myometrium.","volume":"47","author":"K Noble","year":"2010","journal-title":"Cell Calcium"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1177\/1933719109355196","article-title":"Expression and distribution of Na, K-ATPase isoforms in the human uterus.","volume":"17","author":"RV Floyd","year":"2010","journal-title":"Reprod Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"C175","DOI":"10.1152\/ajpcell.1981.240.5.C175","article-title":"Na-Ca exchange in rat myometrium membrane vesicles highly enriched in plasma membranes.","volume":"240","author":"AK Grover","year":"1981","journal-title":"Am J Physiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/1471-2393-7-S1-S3","article-title":"Towards understanding the myometrial physiome: approaches for the construction of a virtual physiological uterus.","volume":"7","author":"MJ Taggart","year":"2007","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1152\/ajpcell.00478.2006","article-title":"Mathematical model of excitation-contraction in a uterine smooth muscle cell.","volume":"292","author":"L Bursztyn","year":"2007","journal-title":"Am J Physiol cell Physiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s11517-009-0433-4","article-title":"Mathematical modeling of electrical activity of uterine muscle cells.","volume":"47","author":"S Rihana","year":"2009","journal-title":"Med Biol Eng Comput"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1113\/jphysiol.1986.sp016275","article-title":"Inactivation of calcium channel current in rat uterine smooth muscle: evidence for calcium- and voltage-mediated mechanisms.","volume":"380","author":"K Jmari","year":"1986","journal-title":"J Physiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/BF00371121","article-title":"Electrophysiological properties of membrane currents in single myometrial, cells isolated from pregnant rats.","volume":"419","author":"H Miyoshi","year":"1991","journal-title":"Pflugers Arch"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/0002-9378(93)90006-5","article-title":"T-type and L-type calcium currents in freshly dispersed human uterine smooth muscle cells.","volume":"169","author":"RC Young","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1113\/jphysiol.1987.sp016779","article-title":"The calcium channel current of pregnant rat single myometrial cells, in short-term primary culture.","volume":"392","author":"T Amedee","year":"1987","journal-title":"J Physiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"C64","DOI":"10.1152\/ajpcell.1995.268.1.C64","article-title":"Effects of estrogens on Ca channels in myometrial cells isolated from pregnant rats.","volume":"268","author":"T Yamamoto","year":"1995","journal-title":"Am J Physiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/physrev.1994.74.2.365","article-title":"Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells.","volume":"74","author":"TF Mcdonald","year":"1994","journal-title":"Physiol Rev"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0014-2999(99)00353-2","article-title":"Estradiol inhibits Ca<sup>2+<\/sup> and K<sup>+<\/sup> channels in smooth muscle cells from pregnant rat myometrium.","volume":"376","author":"K Okabe","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1085\/jgp.110.5.565","article-title":"Sodium and calcium inward currents in freshly dissociated smooth myocytes of rat uterus.","volume":"110","author":"M Yoshino","year":"1997","journal-title":"J Gen Physiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"C658","DOI":"10.1152\/ajpcell.1991.260.3.C658","article-title":"Gestational change in Na<sup>+<\/sup> and Ca<sup>2+<\/sup> channel current densities, in rat myometrial smooth muscle cells.","volume":"260","author":"Y Inoue","year":"1991","journal-title":"Am J Physiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0005-2736(95)00191-3","article-title":"Inhibition of L-type calcium current by genistein, a tyrosine kinase inhibitor, in pregnant rat myometrial cells.","volume":"1240","author":"M Kusaka","year":"1995","journal-title":"Biochim Biophys Acta"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1007\/s004240050224","article-title":"Analysis of the time course of calcium-activated chloride \u2018tail\u2019 currents in rabbit portal vein smooth muscle cells.","volume":"432","author":"IA Greenwood","year":"1996","journal-title":"Pflugers Arch"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000061026","article-title":"Excitability in uterine smooth muscle.","volume":"27","author":"HC Parkington","year":"2001","journal-title":"Front Horm Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1095\/biolreprod51.5.993","article-title":"Changes in the expression of the L-type voltage-dependent calcium channel during pregnancy and parturition in the rat.","volume":"51","author":"JL Mershon","year":"1994","journal-title":"Biol Reprod"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"C1008","DOI":"10.1152\/ajpcell.1995.269.4.C1008","article-title":"Changes in transcripts encoding calcium channel subunits of rat myometrium during pregnancy.","volume":"269","author":"N Tezuka","year":"1995","journal-title":"Am J Physiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1159\/000082333","article-title":"Differential expression of L- and T-type calcium channels between, longitudinal and circular muscles of the rat myometrium during pregnancy.","volume":"59","author":"T Ohkubo","year":"2005","journal-title":"Gynecol Obstet Invest"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0304-4165(01)00234-3","article-title":"Tissue-specific regulation of Ca<sup>2+<\/sup> channel protein expression by sex hormones.","volume":"1569","author":"G Helguera","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"C408","DOI":"10.1152\/ajpcell.1989.257.2.C408","article-title":"Fast Na<sup>+<\/sup> and slow Ca<sup>2+<\/sup> channels in single uterine muscle cells from pregnant rats.","volume":"257","author":"Y Ohya","year":"1989","journal-title":"Am J Physiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1085\/jgp.114.2.185","article-title":"State-dependent inactivation of the alpha1G T-type calcium channel.","volume":"114","author":"JR Serrano","year":"1999","journal-title":"J Gen Physiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1113\/jphysiol.2003.054361","article-title":"Slow inactivation of the Cav3.1 isotype of T-type calcium channels.","volume":"555","author":"J Hering","year":"2003","journal-title":"J Physiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0014-2999(02)02487-1","article-title":"Effects of mibefradil on uterine contractility.","volume":"455","author":"KT Asokan","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"241","DOI":"10.4196\/kjpp.2009.13.3.241","article-title":"Role of T-type Ca channels in the spontaneous phasic contraction of pregnant rat uterine smooth muscle.","volume":"13","author":"SE Lee","year":"2009","journal-title":"Korean J Physiol Pharmacol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/0002-9378(90)91322-4","article-title":"Some electrical properties of human pregnant myometrium.","volume":"162","author":"Y Inoue","year":"1990","journal-title":"Am J Obstet Gynecol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/0306-3623(95)00006-M","article-title":"Identification of a hyperpolarization-activated inward current in uterine smooth muscle cells during pregnancy.","volume":"26","author":"H Satoh","year":"1995","journal-title":"Gen Pharmacol"},{"key":"ref49","first-page":"76","article-title":"Physiological significance of hyperpolarization-activated inward currents (ih) in smooth muscle cells from the circular layers of pregnant rat myometrium.","volume":"439","author":"K Okabe","year":"1999","journal-title":"Pflugers Arch"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1529\/biophysj.104.047449","article-title":"A mathematical treatment of integrated Ca dynamics within the ventricular myocyte.","volume":"87","author":"TR Shannon","year":"2004","journal-title":"Biophys J"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1095\/biolreprod64.5.1526","article-title":"Modulation of potassium current characteristics in human myometrial smooth muscle by 17beta-estradiol and progesterone.","volume":"64","author":"GA Knock","year":"2001","journal-title":"Biol Reprod"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1098\/rspb.1994.0049","article-title":"The influence of 17 beta-oestradiol on K<sup>+<\/sup> currents in smooth muscle cells isolated from immature rat uterus.","volume":"256","author":"SD Erulkar","year":"1994","journal-title":"Proc Biol Sci"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"C278","DOI":"10.1152\/ajpcell.1991.261.2.C278","article-title":"Potassium currents in freshly dispersed myometrial cells.","volume":"261","author":"E Piedras-Renteria","year":"1991","journal-title":"Am J Physiol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"C1049","DOI":"10.1152\/ajpcell.1992.263.5.C1049","article-title":"Ca<sup>2+<\/sup>-activated K<sup>+<\/sup> channels in pregnant rat myometrium: modulation by a beta-adrenergic agent.","volume":"263","author":"K Anwer","year":"1992","journal-title":"Am J Physiol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"C976","DOI":"10.1152\/ajpcell.1993.265.4.C976","article-title":"Calcium-activated K<sup>+<\/sup> channels as modulators of human myometrial contractile activity.","volume":"265","author":"K Anwer","year":"1993","journal-title":"Am J Physiol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/0002-9378(93)90513-I","article-title":"Characterization of large-conductance, calcium-activated potassium channels from human myometrium.","volume":"168","author":"GJ Perez","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0014-5793(99)01394-0","article-title":"Hormonal control of protein expression and mRNA levels of the MaxiK channel alpha subunit in myometrium.","volume":"460","author":"M Song","year":"1999","journal-title":"FEBS Lett"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"C1751","DOI":"10.1152\/ajpcell.2000.279.6.C1751","article-title":"BK(Ca) channel activation by membrane-associated cGMP kinase may contribute to uterine quiescence in pregnancy.","volume":"279","author":"XB Zhou","year":"2000","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1095\/biolreprod.102.010454","article-title":"Down-regulation of the alpha- and beta-subunits of the calcium-activated potassium channel in human myometrium with parturition.","volume":"68","author":"B Matharoo-Ball","year":"2003","journal-title":"Biol Reprod"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1477-7827-2-67","article-title":"Analysis of maxi-K alpha subunit splice variants in human myometrium.","volume":"2","author":"M Curley","year":"2004","journal-title":"Reprod Biol Endocrinol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/humrep\/13.1.208","article-title":"Contribution of calcium-sensitive potassium channels to NS1619-induced relaxation in human pregnant myometrium.","volume":"13","author":"RN Khan","year":"1998","journal-title":"Hum Reprod"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1113\/eph8602181","article-title":"Potassium channels in the human myometrium.","volume":"86","author":"RN Khan","year":"2001","journal-title":"Exp Physiol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1085\/jgp.200509346","article-title":"Gating and ionic currents reveal how the BK(Ca) channel&apos;s Ca<sup>2+<\/sup> sensitivity is enhanced by its beta1 subunit.","volume":"12","author":"L Bao","year":"2005","journal-title":"J Gen Physiol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1085\/jgp.200509370","article-title":"Structural determinants for functional coupling between the beta and alpha subunits in the Ca<sup>2+<\/sup>-activated K<sup>+<\/sup> (BK) channel.","volume":"127","author":"P Orio","year":"2006","journal-title":"J Gen Physiol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"27712","DOI":"10.1074\/jbc.M000974200","article-title":"Regulation of the Ca<sup>2+<\/sup>-sensitive domains of the maxi-K channel in the mouse myometrium during gestation.","volume":"275","author":"NA Benkusky","year":"2000","journal-title":"J Biol Chem"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1469-7793.2000.t01-1-00339.x","article-title":"Pregnancy switches adrenergic signal transduction in rat and human uterine myocytes as probed by BKCa channel activity.","volume":"524","author":"XB Zhou","year":"2000","journal-title":"J Physiol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s004240050761","article-title":"Carboxyeosin decreases the rate of decay of the [Ca<sup>2+<\/sup>]<sub>i<\/sub>, transient in uterine smooth muscle cells isolated from pregnant rats.","volume":"437","author":"A Shmigol","year":"1998","journal-title":"Pflugers Arch"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"C832","DOI":"10.1152\/ajpcell.00268.2006","article-title":"Myometrial expression of small conductance Ca<sup>2+<\/sup>-activated K<sup>+<\/sup> channels depresses phasic uterine contraction.","volume":"292","author":"A Brown","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1477-7827-5-41","article-title":"The role of voltage-gated potassium channels in the regulation of mouse uterine contractility.","volume":"5","author":"RC Smith","year":"2007","journal-title":"Reprod Biol Endocrinol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1095\/biolreprod.107.066423","article-title":"Overexpression of SK3 channels dampens uterine contractility to prevent preterm labor in mice.","volume":"78","author":"SL Pierce","year":"2008","journal-title":"Biol Reprod"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1582-4934.2010.01021.x","article-title":"The contribution of Kv7 channels to pregnant mouse and human myometrial contractility.","volume":"15","author":"LA McCallum","year":"2011","journal-title":"J Cell Mol Med"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1007\/BF00586540","article-title":"Single channel Cl<sup>\u2212<\/sup> and K<sup>+<\/sup> currents from cells of uterus not treated with enzymes.","volume":"410","author":"HA Coleman","year":"1987","journal-title":"Pflugers Arch"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0143-4160(96)90104-9","article-title":"Ca<sup>2+<\/sup> sparks and Ca<sup>2+<\/sup> waves activate different Ca<sup>2+<\/sup>-dependent ion channels in single myocytes from rat portal vein.","volume":"20","author":"J Mironneau","year":"1996","journal-title":"Cell Calcium"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1177\/1933719109334965","article-title":"Calcium-activated chloride currents prolongs the duration of contractions in pregnant rat myometrial tissue.","volume":"16","author":"RC Young","year":"2009","journal-title":"Reprod Sci"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1677\/joe.1.06747","article-title":"Steroid hormone regulation of Clca3 expression in the murine uterus.","volume":"189","author":"JW Jeong","year":"2006","journal-title":"J Endocrinol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1095\/biolreprod.108.071258","article-title":"Cloning and characterization of a calcium-activated chloride channel in rat uterus.","volume":"80","author":"J Song","year":"2009","journal-title":"Biol Reprod"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1085\/jgp.108.1.35","article-title":"Activation of calcium-dependent chloride channels in rat parotid acinar cells.","volume":"108","author":"J Arreola","year":"1996","journal-title":"J Gen Physiol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1085\/jgp.200609507","article-title":"Mechanism of the inhibition of Ca<sup>2+<\/sup>-activated Cl<sup>\u2212<\/sup> currents by phosphorylation in pulmonary arterial smooth muscle cells.","volume":"128","author":"JE Angermann","year":"2006","journal-title":"J Gen Physiol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00424-003-1175-z","article-title":"Identification of a non-selective cation channel current in myometrial cells isolated from pregnant rats.","volume":"447","author":"H Miyoshi","year":"2004","journal-title":"Pflugers Arch"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0006-3495(83)84335-5","article-title":"Dependence of cellular potential on ionic concentrations. data supporting a modification of the constant field equation.","volume":"43","author":"DC Chang","year":"1983","journal-title":"Biophys J"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1113\/jphysiol.1995.sp020889","article-title":"Non-selective cation current of guinea-pig endocardial endothelial cells.","volume":"487","author":"K Manabe","year":"1995","journal-title":"J Physiol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/0024-3205(69)90268-9","article-title":"Evidence for an electrogenic sodium pump in smooth muscle.","volume":"8","author":"GS Taylor","year":"1969","journal-title":"Life Sci"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1085\/jgp.56.3.360","article-title":"Characteristics of electrogenic sodium pumping in rat myometrium.","volume":"56","author":"GS Taylor","year":"1970","journal-title":"J Gen Physiol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/0006-291X(92)91357-V","article-title":"The activity of Na<sup>+<\/sup>\/K<sup>+<\/sup>-ATPase and abundance of its mRNA are regulated in rat myometrium during pregnancy.","volume":"188","author":"A Turi","year":"1992","journal-title":"Biochem Biophys Res Commun"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1067\/mob.2003.166","article-title":"Changes in the isoforms of the sodium pump in the placenta and myometrium of women in labor.","volume":"188","author":"MS Esplin","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.ajog.2006.05.009","article-title":"Alterations in uterine sodium pump abundance may contribute to the onset and progression of term and preterm labor in mice.","volume":"195","author":"CJ Vance","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1085\/jgp.94.3.539","article-title":"[Na] and [K] dependence of the Na\/K pump current-voltage relationship in guinea pig ventricular myocytes.","volume":"94","author":"M Nakao","year":"1989","journal-title":"J Gen Physiol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1469-7793.1999.0203o.x","article-title":"Sodium-potassium pump current in smooth muscle cells from mesenteric resistance arteries of the guinea-pig.","volume":"519","author":"Y Nakamura","year":"1999","journal-title":"J Physiol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0143-4160(97)90018-X","article-title":"Agonist mobilization of sarcoplasmic reticular calcium in smooth muscle: Functional coupling to the plasmalemmal Na<sup>+<\/sup>\/Ca<sup>2+<\/sup> exchanger?","volume":"22","author":"MJ Taggart","year":"1997","journal-title":"Cell Calcium"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1469-7793.1999.00153.x","article-title":"The role of the sarcoplasmic reticulum as a Ca<sup>2+<\/sup> sink in rat uterine smooth muscle cells.","volume":"520 Pt 1","author":"AV Shmigol","year":"1999","journal-title":"J Physiol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1085\/jgp.117.2.119","article-title":"Allosteric regulation of Na\/Ca exchange current by cytosolic Ca in intact cardiac myocytes.","volume":"117","author":"CR Weber","year":"2001","journal-title":"J Gen Physiol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1113\/jphysiol.1971.sp009426","article-title":"Effects of changing the ionic environment on passive and active membrane properties of pregnant rat uterus.","volume":"214","author":"Y Abe","year":"1971","journal-title":"J Physiol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"C1250","DOI":"10.1152\/ajpcell.1997.272.4.C1250","article-title":"Tissue specificity and alternative splicing of the Na<sup>+<\/sup>\/Ca<sup>2+<\/sup> exchanger isoforms NCX1, NCX2, and NCX3 in rat.","volume":"272","author":"BD Quednau","year":"1997","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1196\/annals.1387.063","article-title":"Three types of muscles express three sodium-calcium exchanger isoforms.","volume":"1099","author":"DO Levitsky","year":"2007","journal-title":"Ann NY Acad Sci"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"17434","DOI":"10.1016\/S0021-9258(17)32458-4","article-title":"Cloning of the NCX2 isoform of the plasma membrane Na<sup>+<\/sup>-Ca<sup>2+<\/sup> exchanger.","volume":"269","author":"Z Li","year":"1994","journal-title":"J Biol Chem"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"C423","DOI":"10.1152\/ajpcell.1998.275.2.C423","article-title":"Differential inhibition of Na<sup>+<\/sup>\/Ca<sup>2+<\/sup> exchanger isoforms by divalent cations and isothiourea derivative.","volume":"275","author":"T Iwamoto","year":"1998","journal-title":"Am J Physiol"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"C415","DOI":"10.1152\/ajpcell.1998.274.2.C415","article-title":"Functional comparison of the three isoforms of the Na<sup>+<\/sup>\/Ca<sup>2+<\/sup> exchanger (NCX1, NCX2, NCX3).","volume":"274","author":"B Linck","year":"1998","journal-title":"Am J Physiol"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1113\/jphysiol.1988.sp017251","article-title":"Studies of the sodium-calcium exchanger in bull-frog atrial myocytes.","volume":"403","author":"DL Campbell","year":"1988","journal-title":"J Physiol"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"8078","DOI":"10.1016\/S0021-9258(18)68444-3","article-title":"The Na<sup>+<\/sup>\/Ca<sup>2+<\/sup> antiporter in aortic smooth muscle cells.","volume":"263","author":"P Vigne","year":"1988","journal-title":"J Biol Chem"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"C47","DOI":"10.1152\/ajpcell.1986.250.1.C47","article-title":"Electrophysiological characterization of single pregnant rat myometrial cells in short-term primary culture.","volume":"250","author":"P Mollard","year":"1986","journal-title":"Am J Physiol"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"C216","DOI":"10.1152\/ajpcell.1984.246.3.C216","article-title":"Activity of circular muscle of rat uterus at different times in pregnancy.","volume":"246","author":"B Bengtsson","year":"1984","journal-title":"Am J Physiol"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-2999(79)90045-1","article-title":"Effect of isoproterenol on the isolated pregnant rat myometrium.","volume":"60","author":"KD Meisheri","year":"1979","journal-title":"Eur J Pharmacol"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1196\/annals.1389.002","article-title":"In situ calcium signaling. no calcium sparks detected in rat myometrium.","volume":"1101","author":"T Burdyga","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/j.ejogrb.2009.02.017","article-title":"Temporal and spatial variations in spontaneous Ca events and mechanical activity in pregnant rat myometrium.","volume":"144","author":"T Burdyga","year":"2009","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref105","first-page":"148","article-title":"Electrophysiology of the human myometrium.","author":"T Kawarabayashi","year":"1994"},{"key":"ref106","first-page":"2P","article-title":"Simultaneous measurements of electrical activity, intracellular calcium and contraction in smooth muscle.","volume":"509.P","author":"HW Mankouri","year":"1998","journal-title":"J Physiol"},{"key":"ref107","first-page":"78A","article-title":"The pregnancy dependent expression profile of the genomic complement of K channels in human myometrial smooth muscle and vasculature.","volume":"17","author":"J Zhang","year":"2010","journal-title":"Reprod Sci"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"R919","DOI":"10.1152\/ajpregu.00704.2007","article-title":"Patterns of electrical propagation in the intact pregnant guinea pig uterus.","volume":"294","author":"WJEP Lammers","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"R525","DOI":"10.1152\/ajpregu.00153.2009","article-title":"Are animal models relevant to key aspects of human parturition?","volume":"297","author":"BF Mitchell","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"Pt 1","key":"ref110","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1113\/jphysiol.1996.sp021289","article-title":"Depolarization-evoked increases in cytosolic calcium concentration in isolated smooth muscle cells of rat portal vein.","volume":"492","author":"T Kamishima","year":"1996","journal-title":"J Physiol"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1098\/rspb.1982.0097","article-title":"A binding-site model for calcium channel inactivation that depends on calcium entry.","volume":"217","author":"NB Standen","year":"1982","journal-title":"Proc R Soc Lond B Biol Sci"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1113\/jphysiol.1993.sp019697","article-title":"Effects of pH and inorganic phosphate on force production in alpha-toxin-permeabilized isolated rat uterine smooth muscle.","volume":"465","author":"CA Crichton","year":"1993","journal-title":"J Physiol"},{"key":"ref113","doi-asserted-by":"crossref","DOI":"10.1137\/1.9780898718195","article-title":"Simulating, analyzing, and animating dynamical systems: a guide to XPPAUT for researchers and students","author":"GB Ermentrout","year":"2002"}],"updated-by":[{"DOI":"10.1371\/annotation\/d317e049-4927-4906-95a5-cd0198a3feb9","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2011,10,7]],"date-time":"2011-10-07T00:00:00Z","timestamp":1317945600000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0018685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T10:36:21Z","timestamp":1637577381000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0018685"}},"subtitle":[],"editor":[{"given":"Thomas","family":"Preiss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2011,4,29]]},"references-count":113,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,4,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0018685","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,29]]}}}